Products

1,3-Di-Boc-2-(Trifluoromethylsulfonyl)Guanidine

Lingxian Chemical

Specifications

HS Code

820312

Chemical Formula C15H26F3N3O6S
Molecular Weight 431.44
Appearance Solid (Typical)
Purity Typically High Purity
Melting Point Data Depends on Purity
Solubility Soluble in Organic Solvents like Dichloromethane
Stability Stable Under Normal Conditions, Protect from Moisture
Packing & Storage
Packing 100 g of 1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl)Guanidine packaged in a sealed bottle.
Storage 1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl)Guanidine should be stored in a cool, dry place, away from heat sources and direct sunlight. It is best kept in a tightly sealed container to prevent moisture absorption and potential degradation. Store it in a chemical - resistant cabinet, isolated from incompatible substances like strong acids, bases, and reducing agents.
Shipping 1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl)Guanidine is shipped with strict adherence to chemical safety regulations. It is carefully packaged to prevent damage and ensure containment during transit to customers.
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1,3-Di-Boc-2-(Trifluoromethylsulfonyl)Guanidine
General Information
Historical Development
1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine is also a product of chemistry. In the past, there was no such thing, but it was developed by later generations. In the past, the industry of chemistry was not as prosperous as it is today, and all kinds of materials and techniques were limited. However, the heart of a scholar is always unknown. Everyone has been working hard and exhausted all kinds of methods. After a long time, after many trials and mistakes, this product has appeared. The method of its preparation is gradually optimized, from the beginning of simplicity to the present day. From this perspective, the development of this product is the unremitting progress of chemists, and it is also a drop in the long river of chemical evolution. Witness the road of exploration in the past and open up a new path for future research.
Product Overview
1,3-Di-tert-butoxycarbonyl-2 - (trifluoromethanesulfonyl) guanidine is an important compound involved in chemical research. Its structure is exquisite and has unique chemical properties. In the field of organic synthesis, this product is often used as a key intermediate to assist in the construction of various complex molecules. The introduction of tert-butoxycarbonyl can effectively protect specific functional groups, make the reaction follow a predetermined path, and improve the purity and yield of the product. The presence of trifluoromethanesulfonyl also significantly affects the electron cloud distribution of the molecule, giving it special reactivity. Our research aims to clarify its properties and reaction mechanism, with the hope of expanding its application in various fields such as organic synthesis and drug development, and contributing to the progress of chemistry, so that it can have greater functions and be used by the world.
Physical & Chemical Properties
1, 3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine The physical and chemical properties of this substance are crucial. Looking at its morphology, it may be in a specific state at room temperature, or in a solid state, or in a liquid state, which is related to the characteristics of its intermolecular interactions. Its melting point and boiling point are also of characterization significance. The melting point is high or low, and the lattice stability of the molecule can be observed; the number of boiling points can be used to know the difficulty of the molecule breaking free from the liquid phase.
In terms of solubility, it varies in different solvents. It may be well dissolved in polar solvents or poorly soluble in non-polar solvents, which is related to the polarity of the molecule. In terms of chemical activity, because it contains specific functional groups, or can participate in various reactions, or interact with nucleophiles and electrophiles, it may have unique uses in the field of organic synthesis, which is worth exploring in detail in chemical research.
Technical Specifications & Labeling
Today there is a thing called 1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine. Its technical regulations and identification (commodity parameters) are the key.
To make this thing, you need to follow a specific method. The raw materials are selected, the ratio is accurate, and the operation is orderly. When reacting, the temperature, humidity and duration must be appropriate, and there must be a slight difference or poor quality.
In terms of identification, the name is consistent and the parameters are conclusive. Its purity, properties, molecular weight, etc. should be clearly marked so that the user can understand it. This is the essence of the technical regulations and identification of the thing, which is related to quality and application, and must not be ignored.
Preparation Method
The method of making 1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine is related to the raw materials and production process, reaction steps and catalytic mechanism. First take the specific raw materials and mix them according to the precise ratio. The raw materials need to be pure and free of impurities in order to maintain the quality of the product.
Put the raw materials into a special reactor and control the appropriate temperature and pressure. In the initial stage, the temperature rise needs to be slowed, and when the reactants are fused, the temperature is accelerated to the optimum temperature of the reaction. In this process, the reaction state is closely observed.
The reaction step is first combined to make the raw materials initially combined, followed by the catalytic method to add a high-efficiency catalyst to accelerate the reaction. The amount of catalyst must be strictly controlled. Many reactions are too fast, and few are slow.
The catalytic mechanism depends on the interaction between the catalyst and the reactants, so that the activation energy of the reaction is reduced and the reaction is easy. After the reaction is completed, the pure 1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine product is obtained through fine separation and purification. This method can ensure the purity and yield of the product.
Chemical Reactions & Modifications
The chemical refinement in modern times has deepened the study of compounds. 1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine This compound, its chemical reaction and modification are worth exploring.
To observe its reaction, it depends on various reagents and conditions. At a suitable temperature and pressure, with a specific catalyst, it can promote its smooth reaction. And the rate and yield of the reaction are closely related to environmental factors.
As for modification, it is designed to adjust its properties to meet various needs. Or change its structure, increase its stability; or change its group, give it new energy. After clever modification, this compound can be used in the fields of medicine and materials to show its extraordinary effects.
The way of chemistry is an endless exploration. The reaction and modification of 1, 3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine should also be continuously studied to open up new paths and benefit the world.
Synonyms & Product Names
There is a chemical substance called "1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine". It is used in the industry, or has other names, such as the name of the trade name, and also refers to each other. Although it is the same thing, its name is different, like a tree in the mountain and forest, its shape is the same, and its name is different.
This chemical substance is used in all fields. Scholars explore its nature, and craftsmen apply it to art. The difference between its same name and the name of the commodity is either for the convenience of distinguishing its use, or because of inheritance. The name of the ancient people, although it refers to one person, and the name is different, all want to express its characteristics and show its function. Therefore, we know that "1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine", the distinction between the same name and the trade name, is an interesting phenomenon in the chemical world, and it also has its subtle use in scientific research.
Safety & Operational Standards
1, 3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine is an important chemical product, which needs to be detailed in terms of its safety and operating practices.
When preparing and using this product, all safety matters should be kept in mind. Its chemical properties are active, and it may react violently in case of heat, open flame or oxidizing agent. Therefore, it must be stored in a cool, dry and well-ventilated place, away from fire and heat sources. During the use process, the operator should be strictly guarded, wearing professional protective clothing, protective gloves and goggles to prevent the product from contacting the skin and eyes, causing burns and other injuries.
Operating norms should not be ignored. In the laboratory preparation stage, precise control of the reaction conditions is crucial. A slight difference in temperature, reaction time, and the proportion of reactants may affect the purity and yield of the product. The reaction device needs to be stable and well sealed to prevent the escape of harmful gases. If a solvent is involved, the selected solvent should be adapted to the product, and the operation should be carried out in a fume hood to discharge volatile gases in time.
During the purification stage of the product, the methods used must be appropriate, such as recrystallization, column chromatography, etc., to ensure that the product meets the required purity standards. At the same time, the waste during operation cannot be discarded at will, and should be properly disposed of in accordance with chemical waste treatment specifications to avoid polluting the environment.
In industrial production scenarios, it is even more necessary to strengthen safety management and operation norms. Production equipment needs to be regularly maintained and tested to ensure normal operation. Operators should be professionally trained and familiar with the process flow and emergency treatment measures. In the event of a leak and other accidents, emergency plans should be activated immediately, irrelevant personnel should be evacuated quickly, and effective leak plugging and cleaning measures should be taken.
In this way, during the entire life cycle of 1, 3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine, strict adherence to safety and operating standards can ensure personnel safety, environmental harmlessness and smooth production.
Application Area
Wenfu 1, 3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine is very good in the field of various uses. It can be used in organic synthesis and is a key material for many exquisite synthesis. With its unique characteristics, when building a complex organic structure, if it can be used well, it can achieve twice the result with half the effort.
It is also useful in the field of pharmaceutical research and development. Or it is the cornerstone of the synthesis of special drugs to help overcome difficult diseases. It can be accurately guided in the reaction, so that the product can be produced according to wishes, and it is of great significance for the improvement of drug activity and the optimization of structure.
Looking at its wide range of uses and deep impact, it is a must-see presence in chemical materials. It is like a shining star in many fields such as synthesis and medicine, illuminating the way forward for exploration.
Research & Development
Today there is a product called "1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine". As researchers, we devote ourselves to studying this compound. In the process of research, we study its properties and structure in detail, explore synthesis methods, and strive to improve.
This compound has a wide range of applications, or has made achievements in the field of medicine, or has contributed to the research and development of materials. We make unremitting efforts to expand its application boundaries and explore new values. Although the road ahead is long, the heart of scientific research is like an arrow, and we are determined to promote the development of this compound, contribute to the academic community and industry, and live up to the mission of scientific research.
Toxicity Research
The study of taste and smell of material properties is related to the importance of people's livelihood. Today there is 1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine, and the study of its toxicity cannot be ignored.
In this case, it is also necessary to observe its nature in detail. Observe its structure, explore its quality, and examine its contact with other things. Test it with ancient methods, observe its response to entering the body, touch it on the skin, suck it in the mouth and nose, and accept it in the stomach, all of which are recorded in detail.
The study of toxicity is related to health. Or observe its effect on life, insects, livestock, can be tested. Observe the difference of its behavior, the change of life and breath, in order to understand its harm. I hope to be able to fully know the toxicity of this thing, to use it for good, to avoid evil, to ensure the safety of all living beings, and to balance the whole ecology, which is the essence of material nature research.
Future Prospects
The prospect of the future is what our researchers want. Today, there are 1,3 - Di - Boc - 2 - (Trifluoromethylsulfonyl) Guanidine, and its limitations may be. In the future, it may be able to be made with its special characteristics, and it can be exposed in many domains. Or it can be used in the research of new types of materials, with its characteristics, or it can be used in the research of diseased cells, or it can be used in new ways. Or in the field of materials science, it can be used to give new properties of materials, such as increasing their quality and weather resistance. Such unforeseen prospects need our support and in-depth research, so that this compound can be used in the world and benefit the people.
Frequently Asked Questions
What are the main uses of 1,3-di-tert-butoxycarbonyl-2- (trifluoromethylsulfonyl) guanidine?
The main use of 1% 2C3 -di-tert-butyl-2 - (trifluoromethylsulfonyl) hydrazine is related to many fields. In the field of organic synthesis, it is an extremely critical reagent.
The cover can participate in a variety of key reactions due to its unique chemical structure. For example, in the reaction of constructing carbon-carbon bonds and carbon-heteroatomic bonds, it can be used as an effective coupling reagent. With exquisite reaction design, different organic fragments can be cleverly connected, paving the way for the synthesis of complex organic molecules with specific functions. This is of great significance in the field of medicinal chemistry, enabling the synthesis of compounds with novel structures and potential biological activities, providing a wealth of candidate molecules for the development of new drugs.
Furthermore, in the field of materials science, it also shows unique functions. It can participate in the preparation of organic materials with special properties, such as materials with excellent photoelectric properties. By precisely regulating the reaction conditions, the reaction properties of the compound are used to endow the material with unique electrical and optical properties, thereby meeting the needs of high-performance materials in fields such as organic Light Emitting Diodes and solar cells.
In addition, in some catalytic reaction systems, 1% 2C3 -di-tert-butyl-2 - (trifluoromethylsulfonyl) hydrazine can act as a ligand or auxiliary agent, which affects the activity and selectivity of the catalyst. With its electronic effect and steric hindrance effect, it can optimize the catalytic reaction process, improve the reaction efficiency and the purity of the product, which is of great value in practical application scenarios such as chemical production, and can achieve a more efficient and green chemical synthesis process.
What are the synthesis methods of 1,3-di-tert-butoxycarbonyl-2- (trifluoromethylsulfonyl) guanidine?
The synthesis method of 1% 2C3 -di-tert-butyloxycarbonyl-2- (trifluoromethylsulfonyl) imidazole has been around for a long time. To make this substance, you can start from various paths.
First, take an appropriate amount of imidazole as a base, place it in a clean reactor, add a suitable solvent, such as dichloromethane, N, N-dimethylformamide, etc., so that it can be fully dissolved to form a uniform solution. Then, slowly add tert-butyl dimethylchlorosilane, use an acid binding agent such as triethylamine, etc., to regulate the pH of the reaction, and stir the reaction at a suitable temperature, such as 0 ° C to room temperature. The purpose of this step is to introduce tert-butyl dimethylsilyl on imidazole to protect a specific activity check point. After the reaction is completed, the product is purified by washing with water, liquid separation, drying, column chromatography, etc. In this product, trifluoromethanesulfonic anhydride is added, and the reaction is carried out at a low temperature, such as -78 ° C. For several times. After the reaction is complete, the target product can be obtained by post-processing steps, such as extraction, concentration, etc. 1% 2C3 -di-tert-butyloxycarbonyl-2 - (trifluoromethylsulfonyl) imidazole.
Second, start with 2-halomethazole. Take 2-halo imidazole, such as 2-chlorimidazole or 2-bromimidazole, and potassium tert-butoxide in a suitable solvent, such as tetrahydrofuran, and heat the reaction to form 2-tert-butoxyimidazole intermediates. This reaction requires attention to temperature control, usually at 60 ° C - 80 ° C. Then, carbon dioxide gas is introduced into the reaction system, so that it reacts with intermediates to generate corresponding carboxyl derivatives. After acylation, trifluoromethanesulfonic anhydride is used as an acylation reagent, and pyridine is used as a catalyst. React at room temperature to obtain the target product. After purification by distillation, recrystallization, etc., pure 1% 2C3 -di-tert-butyloxycarbonyl-2 - (trifluoromethyl sulfonyl) imidazole can be obtained.
All synthesis methods have their own advantages and disadvantages, and they need to be used according to actual conditions, such as the availability of raw materials, cost considerations, and difficulty of reaction.
What are the physical properties of 1,3-di-tert-butoxycarbonyl-2- (trifluoromethylsulfonyl) guanidine?
1% 2C3 -di-tert-butyl-2 - (trifluoromethylsulfonyl) imidazole is an organic compound. Its physical properties are as follows:
This compound is usually in solid form. Under normal temperature and pressure, its stability is considerable due to its unique molecular structure. Because its structure contains specific groups such as tert-butyl and trifluoromethylsulfonyl, it has some special physical properties.
In terms of melting point, due to the steric resistance effect of tert-butyl and the strong electron absorption of trifluoromethylsulfonyl, the intermolecular force changes, resulting in a specific melting point range. In general, the melting point of this substance is relatively high, which helps to maintain its solid state under some high temperature reaction conditions, providing convenience for related reaction operations.
In terms of solubility, due to the poor hydrophilicity of trifluoromethylsulfonyl, while tert-butyl also has a certain hydrophobicity, its solubility in water is very low. However, in some organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc., the interaction between molecules and organic solvent molecules shows good solubility. This solubility property is of great significance in reaction operations in organic synthesis and product separation and purification. The density of
is also affected by the molecular structure. The molecule contains atoms with relatively large atomic mass such as fluorine atoms, and the specific molecular arrangement makes its density higher than that of some common organic compounds.
In appearance, it often presents a white to light yellow crystalline powder, which is convenient for observation and identification in experimental operations.
These physical properties are interrelated and affect its application in many fields such as organic synthesis and catalysis. For chemical researchers, a full understanding of these properties is the key prerequisite for the rational use of this compound to carry out various chemical reactions.
What are the chemical properties of 1,3-di-tert-butoxycarbonyl-2- (trifluoromethylsulfonyl) guanidine
1% 2C3 -di-tert-butyloxycarbonyl-2 - (trifluoromethanesulfonyl) hydrazine, this is an organic compound with unique chemical properties and great value for investigation.
First of all, the tert-butyloxycarbonyl it contains is relatively stable in nature and can act as a protective group for amino groups in many organic reactions. Under suitable conditions, the tert-butyloxycarbonyl can be removed to restore the reactivity of the amino group, and then participate in subsequent reactions such as amidation and alkylation. This property is widely used in the field of peptide synthesis, which can help to accurately construct peptide sequences and avoid unnecessary side reactions.
Furthermore, the presence of trifluoromethanesulfonyl groups endows the compound with strong electron-absorbing properties. This not only affects the electron cloud distribution of the molecule, but also significantly enhances its electrophilicity. As a result, the compound is easier to react with electron-rich reagents, such as amines and alcohols with solitary pairs of electrons, and then generate a series of new organic compounds. In addition, the strong electron-absorbing properties of trifluoromethanesulfonyl groups also affect the physical properties of the compound, such as melting point, boiling point, solubility, etc. Usually, the polarity of the compound will be changed, and the solubility in specific organic solvents will also change.
Moreover, the hydrazine structure in the 1% 2C3 -di-tert-butyloxycarbonyl-2- (trifluoromethanesulfonyl) hydrazine molecule also has certain reactivity. Hydrazine can not only participate in the condensation reaction, but also form hydrazone derivatives with carbonyl compounds such as aldides and ketones. Under appropriate oxidation conditions, oxidation reactions may also occur to generate products with different functional groups.
In summary, 1% 2C3-di-tert-butyloxycarbonyl-2- (trifluoromethanesulfonyl) hydrazine has potential and wide application prospects in the field of organic synthetic chemistry due to its unique structure and a variety of chemical properties. It can be used as a key intermediate for the synthesis of various organic compounds with special functions and structures.
What are the precautions for using 1,3-di-tert-butoxycarbonyl-2- (trifluoromethylsulfonyl) guanidine?
1% 2C3 -di-tert-butyloxycarbonyl-2 - (trifluoromethanesulfonyl) imidazole has several ends to be paid attention to during use.
First, this substance has a specific chemical activity, and during operation, it is necessary to ensure that the reaction environment is suitable. For example, the pH and temperature control of the reaction system are essential. If the temperature is too high, it may cause it to decompose, which will damage the reaction effect; if the temperature is too low, the reaction may be delayed or even stagnant. It must be carefully regulated according to the specific reaction needs to ensure a smooth reaction.
Second, because it contains special functional groups, the selection and proportion of reactants need to be carefully allocated. Trifluoromethanesulfonyl has high activity and is easy to react with many substances. Therefore, it is necessary to accurately calculate the amount of reactants to avoid the growth of side reactions and improve the purity and yield of products.
Third, the substance may be toxic and corrosive, and protective measures are essential during operation. Wear protective clothing, protective gloves and goggles to prevent contact with skin and eyes. If you come into contact accidentally, rinse with plenty of water immediately and seek medical attention according to the specific situation.
Fourth, you should also pay attention when storing. It should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants. Due to its active chemical properties, improper storage or deterioration will affect the use efficiency.
Finally, during the experimental operation, the monitoring of the reaction process cannot be ignored. TLC, liquid chromatography and other means can be used to track the reaction progress in real time and adjust the reaction conditions in time to achieve the best reaction effect.