What is the chemical structure of 1- (P-Chlorophenyl) -3-Cyanoguanidine?
The analysis of the chemical structure of 1 - (p-chlorophenyl) -3 -cyanoguanidine is a key matter in chemical research. The structure of this compound is composed of phenyl group, chlorine atom, cyano group and guanidine group. The
phenyl group is a six-membered cyclic aromatic hydrocarbon group with a stable conjugate structure. In this compound, the chlorine atom is attached to the benzene ring para-position, which affects the physical and chemical properties of the compound. The chlorine atom is electronegative, which can affect the distribution of the electron cloud of the benzene ring through induction and conjugation effects, and then affect the reactivity and polarity of the compound.
Cyanyl (CN), composed of carbon-nitrogen triple bonds, has high polarity and reactivity. In compounds, it can participate in many chemical reactions, such as nucleophilic addition, hydrolysis and other reactions, which shape the chemical properties of compounds quite heavily.
The guanidine group is a basic group containing nitrogen and has unique chemical properties. The nitrogen atom in the guanidine group contains lone pairs of electrons, which can be used as an electron donor to participate in the formation of hydrogen bonds, which affects the physical properties of compounds such as intermolecular forces and solubility.
The overall structure of 1- (p-chlorophenyl) -3-cyanoguanidine shows a specific spatial configuration and electron distribution due to the interaction of each group. The interaction between each group determines its application potential in organic synthesis, medicinal chemistry and other fields. Its structural characteristics lay the foundation for exploring its biological activity and designing new compounds.
What are the physical properties of 1- (P-Chlorophenyl) -3-Cyanoguanidine?
1 - (p-chlorophenyl) - 3 - cyanoguanidine has several physical properties. It is often in the state of a white crystalline powder, which is pure and delicate in appearance. This substance is quite stable at room temperature and pressure, and is not prone to spontaneous chemical changes.
When it comes to the melting point, it is about a specific temperature range, which is crucial for identification and purification. When heated to this temperature, the substance will gradually melt from the solid state to the liquid state. This temperature can be an important indicator for quality judgment.
Furthermore, its solubility is also a significant property. In some organic solvents, such as ethanol, acetone, etc., it can exhibit a certain solubility. However, in water, the solubility is relatively limited. This difference in solubility has an important impact on its preparation, separation and application. According to the solubility of different solvents, the method can be selected to extract, purify, or in a specific reaction system to adjust its dispersion and reaction state.
Its density also has a specific value, and this physical quantity reflects the quality of the unit volume of the substance. In actual production and application, density is related to the measurement and mixing ratio of materials, which is of great significance to ensure product quality and reaction accuracy.
These physical properties of 1- (p-chlorophenyl) -3-cyanoguanidine are interrelated and affect each other, laying a solid foundation for its application in many fields such as chemical industry and medicine.
What are the main uses of 1- (P-Chlorophenyl) -3-Cyanoguanidine?
1- (p-chlorophenyl) -3-cyanoguanidine is one of the organic compounds. Its main use involves the field of pharmaceutical chemistry.
In the development of medicine, this compound is often a key intermediate. Due to the structural properties of cyano and guanidine groups, it can interact with many targets in organisms. Through chemical modification and synthesis, with 1- (p-chlorophenyl) -3-cyanoguanidine as the base, a variety of drugs with specific pharmacological activities can be prepared. For example, in the creation of some anti-hypertensive drugs, it is used as a starting material and through multi-step reactions to obtain finished drugs with the effect of regulating blood pressure. Due to its structure, it can precisely act on angiotensin-related receptors and affect the regulation mechanism of blood pressure.
In the chemical industry, it also has extraordinary functions. In the synthesis of fine chemicals, it can be used as an important reaction substrate. Due to its unique chemical activity, it can participate in many organic reactions, such as nucleophilic substitution, cyclization, etc., and then synthesize fine chemicals with complex structures, such as special dyes, high-performance additives, etc. Taking the synthesis of specific dyes as an example, by reacting with other compounds containing chromophore groups, dyes with bright color and good fastness can be prepared, which can be used in textile, printing and dyeing industries to make fabrics show rich colors and last for a long time. From this perspective, 1- (p-chlorophenyl) -3-cyanoguanidine plays an indispensable role in the pharmaceutical and chemical industries, and is an important material basis for promoting the development of related industries.
What are the synthesis methods of 1- (P-Chlorophenyl) -3-Cyanoguanidine?
The synthesis method of 1 - (p-chlorophenyl) - 3 - cyanoguanidine is an important topic in the field of organic synthesis. There are many common ways to make this compound.
First, it can be obtained by reacting cyanamide with p-chlorophenyl isocyanate. First, dissolve cyanamide in a suitable organic solvent, such as dichloromethane or acetonitrile, in a certain proportion. This organic solvent needs to be dry and oxygen-free to prevent side reactions from breeding. Then, under low temperature and stirring conditions, slowly drop in p-chlorophenyl isocyanate. Add it dropwise, gradually raise it to room temperature, and continue to stir for several hours to make the reaction fully proceed. This process requires close monitoring of the reaction process, which is usually measured by thin layer chromatography or high performance liquid chromatography. When the reaction is complete, the solvent is removed by reduced pressure distillation, and then the product is purified by recrystallization. Pure 1- (p-chlorophenyl) -3-cyanoguanidine can be obtained.
Second, p-chloroaniline is used as the starting material. First, p-chloroaniline is reacted with cyanoguanidine under the action of an alkaline catalyst. The basic catalyst can be selected from potassium carbonate or sodium carbonate, and mixed in an appropriate solvent, such as N, N-dimethylformamide. Warm up to a certain temperature and keep the reaction at a constant temperature for a period of time. During the reaction, the basic catalyst can promote the smooth progress of the reaction and enhance the activity of the reactants. After the reaction, the product is preliminarily treated by extraction, washing, drying and other steps, and then further purified by column chromatography or recrystallization, and the target product can also be obtained.
Or, use urea and p-chlorobenzonitrile as raw materials. Mix the two in a reactor in a specific ratio, add an appropriate amount of catalyst, such as zinc oxide or magnesium oxide, and react under high temperature and high pressure. High temperature and high pressure can accelerate the reaction rate, intensify the collision between molecules, and facilitate the fracture and recombination of chemical bonds. After the reaction is completed, 1- (p-chlorophenyl) -3 -cyanoguanidine can also be prepared by cooling, separation, purification and other processes.
The above synthesis methods have their own advantages and disadvantages, and it is necessary to consider the cost of raw materials, reaction conditions, product purity and other factors according to actual needs, and choose reasonably.
What are the precautions for using 1- (P-Chlorophenyl) -3-Cyanoguanidine?
1 - (p-chlorophenyl) - 3-cyanoguanidine, when using, many things need to be paid attention to.
First safety protection. This substance may be toxic and irritating. When exposed, you must wear complete protective equipment, such as gloves, goggles and protective clothing, to prevent it from contacting the skin, eyes and respiratory tract. If you come into contact accidentally, you should immediately rinse with plenty of water, and according to the specific situation, or seek medical treatment.
Furthermore, in terms of storage, it should be placed in a cool, dry and well-ventilated place, away from fire, heat and incompatible substances. Due to its chemical properties, improper storage or deterioration can affect its performance and even cause danger.
During use, accurate control of the dosage is of paramount importance. According to the specific needs of the experiment or production, strictly follow the regulations to avoid excessive use, in order to prevent unnecessary waste and avoid adverse reactions caused by improper dosage.
At the same time, the ventilation of the operating environment cannot be ignored. Good ventilation can disperse harmful gases that may be volatilized in time, reduce the concentration of harmful substances in the air, and ensure the health and safety of operators.
In addition, for waste after use, do not discard it at will. Follow relevant environmental protection regulations and handle it properly to avoid pollution to the environment.
All these precautions are related to the safety and effectiveness of the use of 1- (p-chlorophenyl) -3-cyanoguanidine, and must be treated with caution and cannot be ignored.