What is the main use of 2-Methyl-1-Nitro-3- (Tetrahydrofuran-3-Ylmethyl) Guanidine?
2-Methyl-1-nitro-3- (tetrahydrofuran-3-ylmethyl) guanidine has a wide range of uses. In the field of medicine, it may be a key intermediate, which can help to synthesize drugs with unique therapeutic effects. Due to its unique structure, it can interact with specific biological targets, or can regulate human physiology, and has potential effectiveness in the treatment of specific diseases.
In the chemical industry, it can be used as a raw material for special reactions. With its own chemical properties, it participates in many complex organic reactions and is used to prepare materials with excellent performance, such as polymers with special stability or functionality, providing possibilities for the innovation of chemical materials.
At the level of scientific research and exploration, due to its unique chemical structure, researchers use it as a research model to explore basic scientific issues such as chemical reaction mechanisms and molecular interaction laws. Through in-depth research on it, the understanding of the basic principles of chemistry can be improved, paving the way for more innovative research in the future. In short, this compound has a significant role in many fields such as medicine, chemical industry and scientific research, and is an important substance to promote the development of related fields.
What are the synthesis methods of 2-Methyl-1-Nitro-3- (Tetrahydrofuran-3-Ylmethyl) Guanidine
To prepare 2-methyl-1-nitro-3- (tetrahydrofuran-3-ylmethyl) guanidine, the following synthesis methods can be used.
First, tetrahydrofuran-3-formaldehyde is used as the starting material. First, tetrahydrofuran-3-formaldehyde and nitroguanidine undergo condensation reaction under the catalysis of a suitable base. This base can be selected from potassium carbonate, sodium carbonate and the like. In organic solvents such as ethanol and methanol, the temperature is controlled at 30-60 ° C. When the reaction number is high, an intermediate product is formed. Then the intermediate product was modified by methylation, and suitable methylation reagents, such as iodomethane and dimethyl sulfate, were selected. In the presence of alkali, the target product 2-methyl-1-nitro-3- (tetrahydrofuran-3-ylmethyl) guanidine was obtained at 40-70 ℃.
Second, starting from 3- (chloromethyl) tetrahydrofuran. React 3- (chloromethyl) tetrahydrofuran with 2-methyl-1-nitroguanidine. This reaction needs to be carried out in an alkaline environment. The base can be sodium hydroxide, potassium hydroxide, etc. In organic solvents such as acetonitrile and acetone, heated to 50-80 ° C. After nucleophilic substitution reaction, chloromethyl is replaced by guanidine group of 2-methyl-1-nitroguanidine to form the desired product.
Third, tetrahydrofuran-3-based methanol is used as raw material. First, tetrahydrofuran-3-based methanol is converted into the corresponding halogen, such as thionyl chloride and phosphorus tribromide, to obtain 3- (halomethyl) tetrahydrofuran, and the halogen atom is chlorine or bromine. After the reaction with 2-methyl-1-nitroguanidine under basic conditions, the basic conditions are created by organic bases such as triethylamine, pyridine or inorganic bases, and the reaction is heated in a suitable solvent, 2-methyl-1-nitro-3- (tetrahydrofuran-3-ylmethyl) guanidine can also be obtained.
These several synthesis methods have their own advantages and disadvantages. Starting with tetrahydrofuran-3-formaldehyde, the raw materials are easier to obtain, but the steps are slightly more complex; starting from 3- (chloromethyl) tetrahydrofuran, the reaction route is relatively direct, but the stability of the raw materials may need attention; using tetrahydrofuran-3-based methanol as raw materials, although the raw materials are common, the halogenation step may need to be carefully controlled to achieve good yield and purity.
What are the physicochemical properties of 2-Methyl-1-Nitro-3- (Tetrahydrofuran-3-Ylmethyl) Guanidine?
The physicochemical properties of 2-methyl-1-nitro-3- (tetrahydrofuran-3-ylmethyl) guanidine are particularly important and are fundamental to many applications.
In terms of its physical properties, this compound may be solid at room temperature. Depending on its appearance, it may be white to light yellow crystalline powder. Its texture is delicate, and it feels slightly greasy to the touch. Because its structure contains specific groups, it is soluble in common organic solvents such as ethanol and acetone, but its solubility in water may be limited. This is due to the matching relationship between its molecular polarity and solvent polarity.
As for the chemical properties, it contains active groups such as nitro and guanidine, and the nitro group has strong oxidation, so that the compound can participate in the oxidation-reduction reaction under certain conditions. Guanidine is alkaline and can neutralize with acids to form corresponding salts. And because of the spatial arrangement of its molecular structure, substitution reactions may occur under the action of specific reagents. The tetrahydrofuran ring part may participate in ring opening or cyclization reactions due to different reaction conditions, showing rich chemical reactivity. These physicochemical properties are the key basis for research and application in the fields of organic synthesis, pharmaceutical chemistry, etc., and can help researchers explore its unique uses and potential value.
What are the storage conditions for 2-Methyl-1-Nitro-3- (Tetrahydrofuran-3-Ylmethyl) Guanidine?
2-Methyl-1-nitro-3- (tetrahydrofuran-3-ylmethyl) guanidine, the storage of the important, related to the stability of its quality, the constant nature, must be handled with caution.
This product should be placed in a cool and dry place. Shady, away from direct sunlight. The sun is hot, can cause all kinds of changes, or cause the product to decompose and deteriorate. If exposed to light, its molecular structure may be destroyed due to light energy excitation, damaging its inherent nature. Dry place, is to prevent moisture invasion. Moisture, the medium of many chemical changes. When this product encounters water, it may react with hydrolysis, causing the ingredients to be changed easily, and the effect of use will also change.
Temperature control is also essential. It is suitable to be placed in a low temperature environment, but not a very low degree. Low temperature can slow down the movement of its molecules and reduce the rate of change. Excessive temperature makes molecules active and prone to reaction; too low temperature, or causes its morphology to change, such as solidification, is not conducive to access and storage. It is generally appropriate not to exceed [X] ° C. The specific number depends on the results of its experiments and production.
And the storage place must be well ventilated. Ventilators, remove foul gas and prevent accumulation. If the volatile gas of this product is concentrated in one place, it may become a hidden danger. In case of open flame, static electricity, etc., it may cause the danger of explosion. Ventilation can dissipate the gas and ensure the safety of the environment.
It must be stored separately from other things. This product has chemical characteristics and is co-stored or reacted with unsuitable things. Such as strong oxidants, strong acids, and strong alkalis, all should be kept away to prevent chemical damage.
Storage devices are also exquisite. Corrosion-resistant materials, such as glass and specific plastics, should be used. Glass is chemically stable and does not respond to many things. It can clearly observe the appearance of the inner products. Plastic is light and convenient, but it must be selected that does not react with the product. Seal must be strict to prevent air and moisture from entering.
2-Methyl-1-Nitro-3- (Tetrahydrofuran-3-Ylmethyl) What is the price range of Guanidine in the market?
I have not heard the exact price of 2-methyl-1-nitro-3- (tetrahydrofuran-3-ylmethyl) guanidine in the market. This compound may be a specific chemical material, and its price often varies depending on quality, purity, source and market conditions.
If it is sought in the market for chemical raw materials, the price of high purity is high or high, due to the difficulty of preparation and high cost. For ordinary purity, the price may be slightly lower. However, the supply on the market is limited, resulting in unstable price fluctuations.
If it is in the context of "Tiangong Kaiwu", the price of the material also depends on the complexity of mining and production. If the preparation of this guanidine compound requires multiple processes, the materials used are rare, and the price must be high. On the contrary, if the preparation is easy and the materials used are often used, the price may be close to the people.
And its price is also related to supply and demand. If there are many people who want it, the supply will be few, and the price will rise; if the supply exceeds the demand, the price may be suppressed. Sadly, I do not know the current supply and demand of this compound, so it is difficult to determine the range of its price. However, the price of chemical products often changes due to time, and it is necessary to carefully observe the market situation and ask various merchants to obtain a more accurate price.