3-[(2-Chloro-1,3-Thiazol-5-Yl)Methyl]-2-Methyl-1-Nitro-Guanidine

This is a question to explore the chemical properties of a specific chemical substance. The substance involved is 3- [ (2-cyano- 1,3-diene-5-yl) methyl] - 2-methyl-1-naphthyl ketone.
In this compound, cyano (-CN) has strong electron-absorbing properties, which can change the distribution of molecular electron clouds and affect its reactivity. In nucleophilic substitution or addition reactions, cyano can attract nucleophiles to attack. The 1,3-diene structure contains conjugated double bonds, which give the molecule special electronic delocalization properties. The conjugated system enhances the stability of the molecule, and at the same time, under light or heating conditions, the electrocyclization reaction and the Diels-Alder reaction are prone to occur. Methyl (-CH 🥰) as the power supply group will increase the electron cloud density of the connected carbon atoms, which has an impact on the molecular polarity and spatial structure, and changes the physical and chemical properties of the compound to a certain extent. The naphthyl ketone part, the naphthalene ring is aromatic and has relatively stable properties, but it can also occur typical reactions of aromatic compounds such as electrophilic substitution. Carbonyl (C = O) is polar, carbon is partially positively charged, and oxygen is partially negatively charged. It is susceptible to attack by nucleophiles, and nucleophilic addition reactions occur, such as forming acetals or ketals with alcohols, and imines with amines.
In summary, 3- [ (2-cyanogen-1,3-diene-5-yl) methyl] -2-methyl-1-naphthyl ketones exhibit rich chemical properties due to the interaction of various functional groups, which has potential application value in the field of organic synthesis.

This is the compatibility of blindly traditional Chinese medicine prescriptions. Each medicinal material has its unique effect and use. It is compatible with each other and plays the effect of curing diseases.
3 - [ (2 - Qiang Huo - 1,3 - Duhuo - 5 - Chuanxiong) methyl] - 2 - methyl - 1 - anthraquinone, among which Qiang Huo has a hard taste and a warm nature. It mainly enters the bladder meridian and kidney meridian. It has the ability to relieve surface cold, remove wind and dampness, and relieve pain. It is quite commonly used for the syndrome of exogenous cold and dampness, severe cold and fever, no sweat on the surface of the muscles, strong headache, and limb soreness. It is good at removing upper rheumatism, and it has excellent curative effect on the pain of the head, shoulders and back.
It works alone, but it also tastes hard, and the sex is lukewarm. It belongs to the kidney meridian and bladder meridian. It has the effect of removing rheumatism, relieving pain, and relieving the surface. For wind cold and dampness paralysis, pain in the waist and knee, and headache with less yin and wind, the effect is significant. It is better than removing lower rheumatism, and it is often used for those with pain in the waist, knee, leg and foot joints.
Chuanxiong, Taste Xin, Temperature in Nature, and belongs to the meridians of liver, gallbladder and pericardium. It has the power of promoting blood circulation and qi, removing wind and relieving pain. It is And the leader of the ascending, for the treatment of headache, whether wind cold, wind heat, rheumatism, blood deficiency, blood stasis headache, can be used with the syndrome.
2-methyl, 1-anthraquinone although not in the traditional sense of common Chinese herbal medicines, but in the compatibility of formulas, or due to chemical structure characteristics, synergy with various medicines, or affect drug metabolism, or enhance pharmacological activity.
Compatibility of various medicines, or used to remove wind and dehumidification, clear collaterals and relieve pain, treat wind cold and dampness evil invasion of the human body, stagnation of meridians and collaterals joints, arthritis syndrome caused by poor flow of qi and blood, joint pain, unfavorable flexion and extension, etc. Or it can solve the surface cold and dissipate the cold, and be used for the surface syndrome of exogenous wind cold and dampness. The specific application should be used reasonably after being treated by professional physicians according to the specific symptoms and constitution of the patient.

To obtain 3 - [ (2 - cyanogen - 1,3 - butadiene - 5 - yl) methyl] - 2 - methyl - 1 - naphthyl ketone, the following ancient method can be used:
Start with 2 - methyl - 1 - naphthyl manone. Add an appropriate amount of alkali, such as sodium hydride, to a suitable reactor to promote its enolization. The amount of alkali needs to be accurately measured, about one and half times the number of moles of 2 - methyl - 1 - naphthyl manone. In this process, the reaction temperature should be controlled at a low temperature, between about -10 ° C and 0 ° C, to ensure the accuracy and stability of the reaction.
After the enolide is formed, slowly add 2-cyanogen-1,3-butadiene-5-methyl halide dropwise. This halide can be a chloride or a bromide, and the rate of dropwise addition should be appropriate for the mildness of the reaction system, and it should not be too fast, which will cause the reaction to be disordered. The amount of halide is slightly excessive compared with the enolide, which is about 1.2 moles. At this stage, the reaction temperature can be gradually raised to room temperature, so that the two can fully react. The reaction takes a long time, about 2 to 3 hours, during which time it needs to be stirred continuously to mix the reactants evenly.
After the reaction is completed, neutralize the system with dilute acid, such as dilute hydrochloric acid, and adjust its pH to about neutral. Then extract the products with organic solvents, such as dichloromethane, ethyl acetate, etc. After extraction, combine the organic phases, dry them with anhydrous sodium sulfate, and remove their moisture. After distillation under reduced pressure, the organic solvent is removed to obtain a crude product.
The crude product needs to be refined by column chromatography. Appropriate silica gel is selected as the stationary phase, and the mixed liquid of petroleum ether and ethyl acetate in a certain proportion is used as the mobile phase, and the ratio is about 10:1 to 5:1, depending on the polarity of the product. After column chromatography separation, the fractions containing the target product are collected, and then concentrated under reduced pressure, pure 3- [ (2-cyano- 1,3-butadiene-5-yl) methyl] -2-methyl-1-naphthyl ketone can be obtained. The whole process requires fine operation and attention to the condition control of each link to obtain satisfactory yield and purity.

Today, there are tris- [ (di-deuterium-one, tri-tritium-five-yl) methyl] -di-methyl-one-chloro derivatives on the market. What is the price?
I look at this chemical substance. If you want to know its price, you need to clarify its quality and its use, and it depends on the supply and demand of the market. However, the information given is not detailed, only the name of its chemical structure is known, and it is difficult to determine its price.
If this substance is an ordinary chemical material, and there are many products, and the market is equal, its price may be easy. Under normal circumstances, such basic chemical raw materials are worth thousands of dollars per ton if they are not specially refined.
If this substance is a special agent, such as used in the production of wonderful medicines and high-precision products, the price will be high. Because it is difficult to make, the price per gram may reach hundreds or even thousands of dollars.
Or this substance is new and has not been widely used, and its price is difficult to determine. At the beginning, or because of the high cost of research and development, the price remains; later, if it can be mass-produced, the number of applicants will gradually increase, and the price may fall.
It is difficult to determine the market price. If you want to know the exact number, you should carefully examine its nature, use, and changes in the market.

There is now a product whose composition is 3- [ (2-cyano- 1,3-pentadiene-5-yl) ethyl] - 2-ethyl-1-chloro derivatives. To know how safe it is.
The safety of the product requires detailed consideration of its chemical properties, reactivity, toxicological properties and other factors. As far as this product is concerned, those containing cyanide groups are mostly toxic. The carbon-nitrogen triple bond in the cyanyl group is very active. Under certain conditions, it may be able to dissociate cyanide ions. This is a highly toxic substance, which can seriously hinder the electron transfer of the respiratory chain in the biological body, cause poisoning in humans and animals, and even endanger life.
Furthermore, the chlorine group also has its characteristics. Chlorine atoms have high electronegativity, or make the derivatives have certain electrophilicity, which is easy to react with electron-rich groups in the biological body, such as amino groups and sulfhydryl groups of proteins, thereby affecting the normal structure and function of proteins, and then affecting the physiological activities of cells.
And 2-ethyl-1,3-pentadiene-5-yl and other hydrocarbon structures, although relatively stable, may also affect the solubility, fat solubility and other physical properties of the substance, and then affect its absorption, distribution, metabolism and excretion in vivo.
Overall, this substance contains active groups such as cyanide and chlorine groups, and its safety is really worrying. During use, storage and disposal, extreme caution should be taken to follow strict safety procedures to prevent endangering life, health and environmental safety.