What are the main uses of (3-bromophenyl) guanidine?
(3 - Toad Crisp Foundation) Pills, its main use is quite critical. "Tiangong Kaiwu" has a cloud, this thing is in the way of medicine, and its effect is very different.
The pills made by Toad Crisp Foundation are the first to be used medicinally. Its nature is warm, it tastes refreshing, and it is poisonous. However, after being processed into the pills, it can have the ability to detoxify, reduce swelling, and relieve pain. In many sores and swelling diseases, such as carbuncle, sputum nucleus, etc., this pill is often relied on for treatment. When sores begin to arise, qi and blood are stagnant, and poisonous evils gather. This pill is applied or taken internally to promote blood circulation and dissipate blood stasis, so that poisonous evils dissipate, and relieve the pain of sw
Furthermore, it is also effective in the disease of swollen and sore throat. The throat is the key point, and it is vulnerable to evil invasions, causing redness, swelling and pain, and it is difficult to swallow. (3 - Toad Crisp Base) Pills can open and close the throat, dissipate fire poison, make the throat unobstructed, and reduce pain.
It also has strengths in the disease of toothache. When there is a toothache, the pain is unbearable. This pill can relieve pain and reduce swelling, and slow down the disease between the teeth.
And in ancient times, it was also used in some emergencies, such as swelling and abdominal pain. In case of such emergencies, qi and blood are reversed, filthy and turbid internal resistance, (3-toad crisp foundation) pills can detoxify filth and detoxify, clear the orifice and wake up the mind, make the qi machine smooth, and relieve abdominal pain.
However, you need to pay attention, because it is poisonous, when using it, you must follow the doctor's instructions, make it accurately, and control the dose to avoid other diseases. Cover medical things, use them properly, save people from pain; use them inappropriately, it will harm yourself.
What are the synthesis methods of (3-bromophenyl) guanidine?
There are many ways to synthesize (3-bromobenzyl) ethers.
One of them can be prepared by the reaction of alcohol and halogenated (3-bromobenzyl) under basic conditions. For example, the alcohol and (3-bromobenzyl) halides are heated and stirred in a suitable solvent, such as acetone and acetonitrile, in an environment where basic substances such as potassium carbonate exist. The alkali can capture the hydroxyl hydrogen of the alcohol and form alcohol negative ions. Its nucleophilicity is strong, and it will attack the carbon atoms attached to the halogen atom of the (3-bromobenzyl) halide, and the halogen atom leaves to form the (3-bromobenzyl) ether. The reaction conditions are relatively mild, the operation is relatively simple, and the yield is also considerable.
Second, the phenolic compound is reacted with (3-bromobenzyl) halides. Although the phenolic hydroxyl group is more acidic than the alcohol hydroxyl group, it also needs the help of the alkaline environment when reacting with (3-bromobenzyl) halides. Strong bases such as sodium hydroxide and potassium hydroxide can be selected. First, phenol is converted into sodium phenol or potassium phenol to enhance its nucleophilicity, and then nucleophilic substitution with (3-bromobenzyl) halides to obtain the target product. This approach is suitable for the synthesis of (3-bromobenzyl) ethers containing phenolic structures and is widely used in the fields of drug synthesis and material preparation.
Third, it can also pass a variant of the Williamson synthesis method. Using (3-bromobenzyl alcohol) as the starting material, it is first converted into the corresponding sulfonate, such as methanesulfonate or p-toluenesulfonate. The leaving group of the sulfonate has excellent performance, and then reacts with alcohol or phenol under basic conditions to synthesize (3-bromobenzyl) ether efficiently. The advantage of this method is that the preparation of sulfonate esters is relatively easy, and the reaction selectivity is good, which can effectively avoid the occurrence of some side reactions.
In short, different synthesis methods have their own advantages and disadvantages, and it is necessary to choose a suitable synthesis path according to actual needs, such as the structural characteristics of the target product, the availability of raw materials, and the difficulty of controlling the reaction conditions. In order to achieve the purpose of high-efficiency and high-quality synthesis of (3-bromobenzyl) ether.
What are the physical and chemical properties of (3-bromophenyl) guanidine?
The physical and chemical properties of (three amalgams) are particularly specific. Amalgam is an alloy of mercury and other metals.
Mercury is liquid, often a silver shiny fluid, with good fluidity and high density. When combined with other metals as amalgam, the properties vary from metal to metal.
If combined with sodium as sodium amalgam, its chemical activity is slightly slower than that of sodium alone. Sodium reacts violently when it encounters water, and the explosive potential is rapid. However, after forming sodium amalgam, it reacts with water, although it still releases hydrogen, it is milder. Due to the existence of mercury, the active environment of sodium atoms is changed at the microscopic level, resulting in different reaction rates.
From the perspective of physical properties, the melting point of amalgam is often lower than that of the pure metals. For example, zinc amalgam, the melting point of zinc is quite high, but when combined with mercury, the melting point decreases significantly. This is because mercury atoms are embedded in the lattice structure of zinc atoms, disturbing the original regular arrangement, so that the lattice energy is reduced and the energy required for melting is reduced.
The conductivity of amalgam also changes. Although mercury is a good conductor, when it forms amalgam with some metals, its conductivity may increase or decrease due to changes in the distribution of electron clouds. Taking copper amalgam as an example, copper is an excellent conductor. After forming an amalgam, if the mercury content increases, the electronic conduction path will be disturbed, and the conductivity may decrease slightly; if the mercury content is appropriate, the conductivity may be improved due to the rearrangement of electron clouds.
The color of amalgam also varies depending on the composition. Pure mercury is silver white, and it is in harmony with some non-ferrous metals. The color of amalgam may have a unique tone, such as gold amalgam with gold amalgam, which is pale yellow in color and has a metallic luster. This is related to the interaction of gold and mercury atoms affecting the light reflection and absorption characteristics.
All of these indicate that the physical and chemical properties of the coating (triamalgam) exhibit unique and complex changes due to the combination of mercury and other metals.
What is the price range of (3-bromophenyl) guanidine in the market?
"Tiangong Kaiwu" says: " (3 - Calamine) covers the market, what is the price?" Calamine is an important raw material for smelting zinc. In the city, its price varies according to time, place and quality.
In ancient times, calamine was prolific in places where the price was slightly lower. If the origin is nearby, the transportation is convenient, and the transportation cost is low, the price in the market may be between a few and more than ten yuan per catty. However, if it is in a remote place or a difficult place to transport, due to the cost of transshipment, the price should rise, or up to twenty or more yuan per catty.
And its quality is also the key to the price. The calamine with pure quality and high content is more suitable for smelting and is liked by craftsmen, and its price must be higher than that of impurities. If the demand for zinc smelting is strong, such as coinage and other industries increase the amount of zinc, the supply of calamine will exceed the demand, and the price will also rise. When the demand for zinc smelting is flat, its price may drop slightly.
Therefore, in order to know the exact price of (3 - calamine) in the market, it is difficult to generalize. It is necessary to carefully consider the origin, transportation, quality, supply and demand at that time, etc., in order to obtain a more accurate price.
What are the precautions for (3-bromophenyl) guanidine during use?
In the course of use, it is necessary to pay attention to a number of things. First, this involves the use of mercury, which is a toxic substance. Its evaporation and inhalation can easily cause chronic poisoning, and the spiritual system, digestive system, etc. The operation is very good. If it is well handled, it needs to be properly applied, such as through a hood, etc., to ensure that the mercury evaporation is quickly discharged, not in the room.
Second, the use of mercury and phase operations needs to be done with care. The mercury liquid has good fluidity. Once it falls, it can be collected, and it is easy to form small mercury beads, which can be inserted into various gaps. If it falls accidentally, it will be immediately covered with sulfur powder to form mercury sulfide from mercury sulfide, reduce toxicity, and clean it up properly.
Third, the utensils used also need to be investigated. Containers containing mercury must be made of high-quality materials to prevent mercury from penetrating or rotting the container and causing leakage. And before use, it is necessary to check whether the container is in good condition, cracked or broken. The tools used in the operation should also be dried and damaged, so as not to stain mercury or affect the effect of mercury.
Fourth, the operator should be familiar with the characteristics, hazards and emergency treatment methods of mercury. Wear anti-mercury, such as gloves, masks, anti-mercury clothing, etc., and may be directly connected by people with less mercury.
Fifth, the operation process should follow the established process. The degree, temperature, and material ratio of each step have strict requirements and must not be changed without authorization. If there is a slight difference, it will not affect the mercury results, and it is more likely to cause danger. If there is a problem during the operation, such as the smell, the sudden change, etc., stop the operation immediately, investigate the cause, and wait for the solution.