What is the chemical structure of (E) -1- (2-chloro-5-thiazolyl methyl) -3-methyl-2-nitroguanidine?
(E) - 1 - (2 - tritium - 5 - aldehyde methoxy methyl) - 3 - methyl - 2 - carbonyl hydrazine The chemical structure of this compound is involved in the field of organic chemistry. To clarify its details, it is necessary to analyze it according to the rules and principles of organic chemistry.
Looking at its name, " (E) " shows that its configuration is a trans configuration, which is related to the spatial arrangement of groups on both sides of the double bond in the molecule. Numbers such as "1", "2", "3" and "5" are used to identify the positions of atoms on the main chain or parent structure of the compound.
"-1 - (2-tritium-5-aldehyde methoxy methyl) ", where "tritium" is an isotope of hydrogen with special nuclear properties. "Aldomethoxy methyl", aldehyde-CHO is a highly reactive functional group, methoxy-OCH is connected to methyl-CH ² -, and the whole is connected to the No. 2 position connected to the No. 1 position of the main chain.
"-3-methyl", that is, the main chain is connected to the methyl-CHH-group at position 3. "-2-carbonyl hydrazine", carbonyl C = O is an important functional group, with polarity and reactivity, is connected to hydrazine-NHNH ², and this part is connected to the main chain at position 2.
In the ancient Chinese saying of "Tiangong Kaiwu", it can be said as follows: "The configuration of this compound is trans. Above the main chain, there is a group at position 1, which is connected to tritium at position 2, and aldehyde methoxy methyl at position 5. The 3rd position is connected to methyl, and the 2nd position is connected to carbonyl hydrazine. Each group is named in sequence to form this unique chemical structure. In its structure, the functional groups such as aldehyde, carbonyl, and hydrazine have their own characteristics and interact with each other, resulting in the unique chemical properties and reactivity of the compound, which may be important in organic synthesis and related fields. "
What are the main uses of (E) -1- (2-chloro-5-thiazolyl methyl) -3-methyl-2-nitroguanidine?
(E) - 1 - (2 - cyanogen - 5 - methoxyphenyl) - 3 - methyl - 2 - furanoformamide, which is a key intermediate in organic synthesis, is widely used in medicine, pesticides and other fields.
In the field of medicine, it is the cornerstone of many drug creations. For example, when developing new anti-tumor drugs, this is the starting material, and through subtle chemical modification and structural modification, compounds with specific biological activities can be obtained. Due to its unique structure, it can precisely act on specific targets in tumor cells or interfere with tumor cell signaling pathways, thereby inhibiting tumor cell proliferation and inducing apoptosis, opening up new paths for the development of anti-tumor drugs. In the development of antibacterial drugs, with the help of their structural characteristics, drugs with strong inhibitory activity against specific pathogens can be designed and synthesized, and antibacterial effects can be exerted by destroying the cell wall or cell membrane synthesis of pathogens and interfering with their protein and nucleic acid metabolism.
In the field of pesticides, it is also an important synthetic building block. It can be used to create new pesticides with high efficiency, low toxicity and environmental friendliness. For example, for common crop pests, through rational molecular design, its structure is integrated into pesticide molecules, so that pesticides can specifically act on the nervous system or digestive system of pests, effectively kill pests, and reduce the harm to non-target organisms and the environment, ensuring the sustainable development of agriculture.
From the above, (E) -1- (2-cyanogen-5-methoxyphenyl) -3-methyl-2-furanformamide, with its unique structure and diverse reactivity, plays an indispensable role in the research and development and synthesis of medicines and pesticides, which is of great significance to promote the development of related fields.
What are the synthesis methods of (E) -1- (2-chloro-5-thiazolyl methyl) -3-methyl-2-nitroguanidine?
To prepare (E) -1- (2-cyano-5-methoxyphenyl) -3-methyl-2-butenonitrile, the synthesis method is as follows:
can be achieved by a series of ingenious reaction steps with suitable starting materials. First, an aromatic hydrocarbon with the corresponding substituent is selected, and a cyano group and a methoxy group are introduced at a specific position through a suitable nucleophilic substitution reaction to obtain a phenyl ring structure intermediate containing 2-cyano-5-methoxy.
Then, on the basis of this intermediate, a methyl-containing alkenyl fragment is introduced through a carbon-carbon bond formation reaction. This step may be a classic carbon-carbon double bond construction method such as the Wittig reaction. The carbon-carbon double bond in the target molecule can be precisely constructed by Wittig reaction, and the 3-methyl-2-butenonitrile part can be introduced at the same time.
Or consider the allylation reaction strategy. First prepare a suitable allylation reagent, react with the previously synthesized benzene-containing intermediate under the action of a suitable catalyst to achieve allylation, and then adjust the structure to meet the structural requirements of the target molecule through an appropriate oxidation or rearrangement reaction.
Furthermore, a coupling reaction strategy catalyzed by transition metals can also be tried. Select suitable halogenated aromatics and alkenyl halides or alkenyl borates and other reagents, under the catalysis of transition metal catalysts such as palladium and nickel, a coupling reaction occurs to construct the skeleton structure of the target molecule, and then through subsequent modification reactions, improve the molecular structure, and finally obtain (E) -1- (2-cyano-5-methoxyphenyl) -3-methyl-2-butenonitrile.
What are the physical and chemical properties of (E) -1- (2-chloro-5-thiazolyl methyl) -3-methyl-2-nitroguanidine?
(This compound) (E) -1 - (2 - chloro - 5 - methoxyphenyl) - 3 - methyl - 2 - furanone has the following physical and chemical properties:
This substance is solid in appearance, and its melting point, boiling point and other melting point data will show specific values due to intermolecular forces. From the perspective of molecular structure, functional groups such as chlorine atoms, methoxy groups, methyl groups, and carbonyl groups on furan rings give it unique properties. Chlorine atoms have a certain electronegativity, which will affect the polarity of molecules, which in turn affects their solubility. In some polar organic solvents such as ethanol and acetone, there may be a certain solubility, but the solubility in water may be low, because the overall non-polar part of the molecule is larger.
Methoxy group is the power supply substitution group, which can affect the electron cloud density of the benzene ring and change its chemical activity. When the electrophilic substitution reaction occurs, the electron cloud density of the benzene ring adjacent to and para-site will increase relatively, and it is easier to react at these positions. The presence of methyl also changes the molecular space structure and electron cloud distribution, and affects the intermolecular forces and the melting boiling point. The carbonyl group on the
furan ring is a highly active functional group, which is prone to nucleophilic addition reaction, and can react with nucleophilic reagents containing active hydrogen such as water, alcohol, amine, etc. Under basic or acidic conditions, its reactivity and reaction path will be different. And the compound may have certain stability, but in the presence of high temperature, strong acid and base or specific catalysts, the molecular structure may change, and reactions such as decomposition and rearrangement may occur.
What are the precautions for (E) -1- (2-chloro-5-thiazolyl methyl) -3-methyl-2-nitroguanidine during use?
(E) 1 - (2 - deuterium - 5 - bromopyridyl) - 3 - methyl - 2 - furanyl ketone should pay attention to the following points during use:
First, because it contains special atoms and groups, such as deuterium atoms and bromine, methyl, furan, etc., it should avoid contact with strong oxidants during operation. Strong oxidants may react violently with these groups, or cause dangerous conditions such as combustion and explosion. As the ancients said: "Water and fire are incompatible, so are strong oxygen and heterogroups."
Second, due to the complexity of its structure, it is quite sensitive to temperature and humidity. High temperature may change the molecular structure, causing it to lose its original properties; high humidity environment may cause reactions such as hydrolysis. Just as Tiangong Kaiwu pays attention to the preservation environment of various materials, this compound also needs to be stored in a cool and dry place.
Third, be sure to take protective measures during operation. Because of its unique chemical properties, it may cause irritation to the skin, eyes, respiratory tract, etc. Wear suitable protective clothing, gloves, goggles and masks to avoid contact or inhalation and damage to the body.
Fourth, when conducting chemical reactions, it is necessary to precisely control the reaction conditions. Due to the different activities of different groups in the structure, the reaction conditions are slightly deviated, and the products may be unexpected or accompanied by many side reactions. Just like ancient alchemy, if the heat is slightly improper, the medicinal pills will become waste, and the reaction of this compound also needs to be cautious.