N-Methyl-N-Nitro-N'-Nitrosoguanidine

Lingxian Chemical

Specifications

HS Code	256619
Chemical Formula	C2H6N4O3
Molar Mass	122.096 g/mol
Appearance	Yellow - orange solid
Solubility In Water	Slightly soluble
Solubility In Organic Solvents	Soluble in acetone, dimethylformamide
Melting Point	118 - 122 °C
Decomposition Temperature	Decomposes on heating
Stability	Unstable, decomposes over time
Hazard Class	Carcinogenic, mutagenic
Use	Mutagen in genetic research
Cas Number	70-25-7

Packing & Storage

Packing	1 - gram vial of N - Methyl - N - Nitro - N’ - Nitrosoguanidine, sealed in amber glass bottle.
Storage	N - Methyl - N - Nitro - N' - Nitrosoguanidine should be stored in a cool, dry, and well - ventilated area, away from heat sources and ignition points. It should be kept in a tightly - sealed container, preferably in a chemical - resistant and opaque vessel due to its light - sensitivity. Store it separately from incompatible substances like reducing agents to prevent dangerous reactions.
Shipping	N - Methyl - N - Nitro - N’ - Nitrosoguanidine is a hazardous chemical. Shipping requires strict compliance with safety regulations, likely in special containers, with proper labeling indicating its dangerous nature and handling precautions.

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General Information

Historical Development

N - Methyl - N - Nitro - N '- Nitrosoguanidine, the development of this product has a long history. In the early years, various sages pursued more and more chemical research, wanting to obtain powerful mutagenic agents. At that time, scientific research was difficult, and everyone worked tirelessly to explore.
After years of research, N - Methyl - N - Nitro - N' - Nitrosoguanidine has emerged. Its mutagenic ability is very different from others, and it has helped a lot in the field of microbial genetic research. Scientists rely on its strength to gain insight into the mysteries of genetics, and many breakthroughs have their merits.
Since the present world, this agent has been widely used, but its latent risks have also been observed. People then use it cautiously, hoping to use its long and avoid its short, so that the road of scientific research will be more prosperous, adding to the progress of chemistry and biology.

Product Overview

N - Methyl - N - Nitro - N '- Nitrosoguanidine, a chemical reagent. Its shape may be powder, and its color is nearly light yellow. It has the ability to mutate and is widely used in the genetic research of microorganisms and plants. It can cause genetic mutation to open the door to the cultivation of new species and the exploration of genetic mechanisms.
When used, when following the procedures, it is potentially harmful. Interacting with substances can lead to changes in the structure of nucleic acids, resulting in changes in genetic information. In the process of scientific research, it is a powerful tool to explore the genetic mysteries of life, but it also needs to be treated with caution and prevent problems before they occur, in order to do its best and promote the progress of science.

Physical & Chemical Properties

N - Methyl - N - Nitro - N '- Nitrosoguanidine is also a chemical substance. Its physical and chemical properties are specific. Looking at its shape, it is a yellowish powder under normal conditions, with a fine texture. Smell it, slightly special odor. In terms of its solubility, it is slightly soluble in water, but slightly soluble in organic solvents such as ethanol.
In terms of chemical properties, this substance has high reactivity. When heated or in a specific chemical environment, it is easy to decompose and release nitrogen-containing active groups. It is often used as an important reagent in chemical synthesis and has made great contributions to the field of organic synthesis. Due to its unique physical and chemical properties, it is necessary to carefully follow relevant regulations during storage and use to prevent accidents and ensure the safety of experiments and the accuracy of results.

Technical Specifications & Labeling

Today, there is N - Methyl - N - Nitro - N '- Nitrosoguanidine, which is related to its technical specifications and identification (product parameters). Its technical specifications need to clearly define the precise content of the ingredients, and the physical and chemical properties such as melting point, boiling point, solubility, etc. should also be detailed. In terms of identification, the product name must be accurate, the ingredients must be clearly marked, and the warning label should be set according to regulations to inform users of latent risks. In production and application, strict adherence to this technical specification and identification (product parameters) can ensure its high quality, safe use, and compliance with industry standards.

Preparation Method

N - Methyl - N - Nitro - N '- Nitrosoguanidine, the synthesis method is related to the raw materials and production process, reaction steps and catalytic mechanism. To make this substance, first take the appropriate raw materials, through delicate proportions. For example, based on an organic compound, react with a specific reagent in sequence. The first step is to make the raw materials interact under a specific temperature and pressure to start the reaction. In the meantime, it is crucial to control the reaction rate and accurately grasp the temperature.
The reaction steps are rigorous and orderly, and each step requires fine operation. Or fully mix in the solution, or apply heating and cooling means to promote the complete reaction. In the catalytic mechanism, a high-efficiency catalyst is selected to reduce the energy barrier of the reaction and accelerate the reaction process. In this way, after various steps, N-Methyl-N-Nitro-N '-Nitrosoguanidine is finally obtained. This preparation method requires strict compliance with procedures to ensure the quality and quantity of the product.

Chemical Reactions & Modifications

I tried to study the chemical changes of N-Methyl-N-Nitro-N '-Nitrosoguanidine. The chemical reaction of this substance is specific and has the ability to modify. Under specific conditions, the molecular structure is changeable, and the functional groups are also changed accordingly. This change or new substance, or physical modification, is the main problem of real chemical research.
Looking at the reaction, the cleavage of chemical bonds is regular, and the transition of groups is orderly. Either through nucleophilic substitution or free radical reaction, it all changes according to the environment. And its modification effect can be used in the fields of material optimization, drug creation, etc., with broad prospects.
The study of the chemical reaction and modification of this substance is beneficial to all branches of chemistry, which can clarify the reaction mechanism, expand the synthesis path, and contribute to the improvement of chemistry.

Synonyms & Product Names

N-Methyl-N-Nitro-N '-Nitrosoguanidine is a chemical mutagenic agent. Its alias is methyl nitro-nitrosoguanidine, and its trade name is often called this. This agent has a wide range of uses in chemical research, can cause genetic mutations, and has made a lot of contributions to microbial genetic research and other fields. Its characteristics are unique, mostly light yellow powder, which is easy to decompose when heated and exposed to light. In past studies, many scholars relied on this to explore genetic mysteries, because it can change biological genetic information, and then detect changes in biological traits. At present, although new mutagenesis methods have emerged, N-Methyl-N-Nitro-N '-Nitrosoguanidine still occupies a place in specific studies, and is a classic agent for chemical mutagenesis, which is often valued by researchers.

Safety & Operational Standards

N - Methyl - N - Nitro - N '- Nitrosoguanidine is also a chemical substance. During the study, it is essential to ensure safe operation.
This chemical substance has a certain degree of danger, and its sexual activity is easy to cause many accidents. Therefore, it is necessary to keep it safe. The first thing is to use it in a good place to prevent air flow and prevent it from evaporating and accumulating, causing harm. And in the operation, it must be used to prevent it, such as anti-clothing, gloves, eyes, etc., to separate its body and connect it.
Furthermore, the preservation of this chemical substance also has a strict requirement. It should be placed in a dry place, a source of ignition, and an oxidizing place, and sealed tightly to prevent its properties from changing, or causing danger due to environmental factors. When using it, it is more necessary to follow the precise operation process, and do not act hastily. When measuring the equipment, use the equipment used, and operate it carefully according to the required amount to avoid its leakage or waves.

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Therefore, in the research and use of N-Methyl-N-Nitro-N '-Nitrosoguanidine, safe operation and safety are essential. Only by following this path can we ensure the benefits of research and the safety of people.

Application Area

N - Methyl - N - Nitro - N '- Nitrosoguanidine, the application field of this agent is quite extensive. In the field of agronomy, it is often used to mutate crop seeds in order to obtain excellent mutants and increase crop resistance and yield. Watchers used to farm in the past, and good seeds were scarce, and harvests depended on the sky. This agent is used to mutate, or to obtain drought-tolerant and disease-resistant varieties. Agriculture is abundant, and people's food is worry-free.
In medical research, it is used to induce cell mutation and explore the pathogenesis of diseases. Diseases are hidden, and doctors are struggling to find the root cause. With its power of mutation, it can detect cell mutations, clarify the principle of disease, and find new ways for treating diseases.
In microbial research, microbial genes can be modified to produce special metabolites. In the past, the yield of microorganisms was not good, but now this agent has been used for mutagenesis, and the ability of microorganisms to produce useful substances has greatly increased. It is beneficial to industrial production and many other aspects, benefiting people's lives and promoting business prosperity.

Research & Development

Modern chemical refinement, there is a name N - Methyl - N - Nitro - N '- Nitrosoguanidine. We devoted ourselves to studying it, observing its properties, and exploring its uses. The reactions of this substance are unique, and it often plays a key role in the synthesis.
At the beginning, the road of inquiry was full of thorns, and many attempts were made, or failed, or the effect was not significant. However, we are determined, repeated experiments, and detailed changes. Gradually gain something, knowing that under specific conditions, it can lead to a reaction trend and form a different structure.
After long-term research, the application path is gradually widening. In pharmaceutical research and development, it can assist in the creation of new agents; in material innovation, it can also promote the power. We hope to continue this research, promote its development, and add luster to the field of chemistry for the benefit of all.

Toxicity Research

The taste of chemical substances is related to people's livelihood, but there are also toxic ones among them. In this sentence, N-Methyl-N-Nitro-N '-Nitrosoguanidine is very important for the study of toxicity.
This substance is also occasionally involved in chemical experiments and industrial applications. When studying its toxicity, we must use scientific methods to observe its impact on organisms. Observe its entry into the body, or damage the viscera, and disrupt the normal order of the body. In animal tests, we can see signs of lesions, or cause aberrations, or disturb metabolism.
Although the progress of chemistry depends on various substances, the study of toxicity should not be ignored. It is necessary to investigate its nature in detail and clarify its harm, so as to protect the safety of the living and avoid disasters before they arise. Make workers and researchers aware of its risks, and use it carefully, so as to obtain the benefits of chemistry, but far from its harm.

Future Prospects

The promise of the future can be seen. Today there is N - Methyl - N - Nitro - N '- Nitrosoguanidine, which is used in the way of research and development, and has great capabilities.
Its characteristics are unique, and the reverse is many, or it can be the foundation of new research. In the next few days, we can study its principles carefully, or we can expand the new environment of things, save the world and save people, and the amount of merit.
And it can also be expected in the field of materials. Or assist in the research of special materials, which are thin and thin, and can be used in general equipment to make the equipment exquisite and durable.
We who study this way are diligent. I hope to make unremitting efforts to obtain this object, which will not be widely used, become the wing of technology, and benefit the people. This is the aspiration of my heart, and the grandeur of the future.

Frequently Asked Questions

What is the use of N-Methyl-N-Nitro-N '-Nitrosoguanidine?

N-Methyl-N-Nitro-N '-Nitrosoguanidine (MNNG), a powerful mutagenic agent, is widely used in the field of scientific research.
MNNG can carefully modify DNA molecules through alkylation, and then precisely induce gene mutations. Its mechanism of action is profound and delicate, and it can introduce alkyl groups into DNA bases, resulting in specific changes in DNA structure and sequence.
In the vast world of microbial genetics research, MNNG is very useful. It can efficiently induce gene mutations in bacteria, fungi and other microorganisms, and help scholars to deeply explore gene functions, metabolic pathways and genetic regulation mechanisms. For example, by mutagenizing specific bacterial strains with MNNG, scholars can precisely screen out mutant strains with special metabolic ability or anti-stress characteristics, which is of great significance for the mining and application of microbial resources.
In the field of tumor research, MNNG also plays a key role. Because it can induce cell gene mutations, it can be used to construct tumor animal models. With the help of MNNG to induce carcinogenesis in cells of experimental animals, scholars can gain in-depth insight into the complex process of tumor occurrence and development, and explore effective strategies and methods for tumor prevention and treatment.
MNNG must be used with extreme caution due to its strong mutagenic activity and potential carcinogenicity. During the experimental operation, researchers must strictly follow safety regulations and take comprehensive protective measures to prevent MNNG from causing harm to themselves and the environment.

What are the physicochemical properties of N-Methyl-N-Nitro-N '-Nitrosoguanidine?

N-methyl-N-nitro-N '-nitrosoguanidine, this material property is special, related to chemistry, and has a deep meaning. It is a white crystal, or slightly yellow, and is stable at room temperature. However, when heated or impacted, it is easy to decompose and release harmful gases, and the risk is known.
In terms of solubility, this substance dissolves slightly in water, but it is soluble in organic solvents such as acetone. This property is considered in chemical preparation and application. Its melting point is about 118 to 122 degrees Celsius, and when heated to this temperature range, a phase change will occur.
In terms of chemical activity, N-methyl-N-nitro-N '-nitrosoguanidine is highly reactive and is a powerful mutagenic agent. In biochemical research, it is often used to induce gene mutation, by interacting with DNA to change the gene structure, so as to study the function and genetic mechanism of genes.
In addition, it is also an important reagent in the field of organic synthesis. It can participate in many chemical reactions to construct complex organic molecular structures. Due to its high reactivity, it is necessary to operate with extreme caution and follow strict procedures to prevent accidents.
In summary, N-methyl-N-nitro-N '-nitrosoguanidine has unique physical and chemical properties. Although it is of great value in scientific research and chemical industry, it must be used with caution to ensure safety due to its potential danger.

What is the preparation method of N-Methyl-N-Nitro-N '-Nitrosoguanidine?

The method of preparing N-methyl-N-nitro-N '-nitrosoguanidine requires specific raw materials and conditions. The method is as follows:
First, take an appropriate amount of N-methyl guanidine and place it in a clean reaction vessel. N-methyl guanidine is the starting material of the reaction, and its purity and dosage have a great influence on the product.
Next, slowly add concentrated nitric acid to it. When adding acid, care should be taken because nitric acid is highly corrosive and oxidizing. In this step, concentrated nitric acid reacts with N-methyl guanidine as a nitrifying agent. The reaction temperature needs to be carefully controlled, generally controlled in the low temperature range, to prevent the reaction from being too violent and causing more side reactions. Usually, concentrated nitric acid can be slowly added dropwise in an ice-water bath, and stirred while adding, so that the reaction system can be mixed evenly.
After the concentrated nitric acid is added, continue to stir the reaction for a period of time to ensure that the reaction is fully carried out. In this process, N-methylguanidine reacts with nitric acid to gradually form an intermediate product.
Then, add sodium nitrite solution. Sodium nitrite is a nitrosation reagent in this reaction. When adding, also pay attention to the speed and temperature to maintain the stability of the reaction environment. After adding, continue to stir to promote the further completion of the reaction, and finally form N-methyl-N-nitro-N '-nitrosoguanidine After the
reaction is completed, the product is separated and purified. Filtration, washing, recrystallization and other methods can be used to obtain high-purity N-methyl-N-nitro-N '-nitrosoguanidine. When recrystallizing, it is crucial to select a suitable solvent, which needs to be selected according to the solubility characteristics of the product. After multiple recrystallization, the purity of the product meets the requirements.

What are the hazards of N-Methyl-N-Nitro-N '-Nitrosoguanidine to the human body?

N-methyl-N-nitro-N '-nitrosoguanidine, this is a highly toxic substance that is deeply harmful to the human body and must not be ignored.
It has strong mutagenic properties and can cause gene mutations. In experiments, it is often used to induce microbial gene mutations. However, once it invades the human body, it will also change the genes wantonly, greatly increasing the risk of cancer. Long-term exposure or careless ingestion can cause a variety of malignant tumors, such as lung cancer, stomach cancer, liver cancer, etc.
Furthermore, it also damages the human body's immune system. The immune system is the body's defense against foreign enemies. If it is damaged, the human body is vulnerable to bacteria, viruses and other invasions, and various diseases will follow one after another, such as frequent colds, repeated attacks of infectious diseases, etc.
Not only that, N-methyl-N-nitro-N '-nitrosoguanidine also has adverse effects on the reproductive system. It may affect the normal development of reproductive cells and cause reproductive dysfunction. For people of childbearing age, it may cause infertility; if pregnant women are inadvertently exposed, it may affect the normal development of the fetus and cause serious consequences such as fetal malformation.
In short, N-methyl-N-nitro-N '-nitrosoguanidine is widely and seriously harmful to the human body. When using and contacting, it is necessary to strictly follow safety procedures and take protective measures to prevent irreparable damage to your own and others' health.

What to pay attention to when storing and transporting N-Methyl-N-Nitro-N '-Nitrosoguanidine

N-methyl-N-nitro-N '-nitrosoguanidine, this substance is highly toxic and has a strong mutagenic effect. When storing and shipping, you need to pay great attention to the following numbers:
First, the storage place should be cool, dry and well ventilated. This substance is easily decomposed by heat and even causes danger, so it must be kept away from heat and fire sources, and must not be placed in direct sunlight. The temperature should be controlled within a specific range to prevent deterioration.
Second, because it is extremely sensitive to humidity and easily deliquescent, the packaging must be tight. It should be stored in a sealed container, which can be supplemented with a desiccant to ensure a dry internal environment and avoid contact with moisture in the air.
Third, when transporting, it is necessary to follow strict specifications and procedures. Professional transportation tools need to be selected, and transporters should be familiar with their characteristics and emergency treatment methods. The packaging should be firm and reliable to prevent damage and leakage due to collision and vibration during transportation.
Fourth, this substance has strong toxic and mutagenic properties, and the storage and transportation place must strictly restrict the entry and exit of personnel, and strictly prohibit unrelated personnel from approaching. Operators must take protective measures, such as wearing protective clothing, protective gloves and masks, to prevent contact poisoning.
Fifth, it needs to be stored and transported separately from other chemicals, especially oxidizing substances, acids, alkalis, etc., to avoid chemical reactions and cause danger. At the same time, it is necessary to prepare corresponding emergency treatment equipment and materials, and in case of leakage and other accidents, they can be properly disposed of in a timely manner.