N,N'-Bis(Tert-Butoxycarbonyl)Guanidine

Lingxian Chemical

Specifications

HS Code	984916
Chemical Formula	C11H21N3O4
Molecular Weight	259.30
Appearance	White to off - white solid
Melting Point	125 - 129 °C
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Purity	Typically high purity, e.g., >95%
Stability	Stable under normal conditions, avoid strong acids and bases
Hazard Class	Non - hazardous for most common uses

Packing & Storage

Packing	100 - gram bottle of N,N'-Bis(Tert - Butoxycarbonyl)Guanidine with sealed packaging.
Storage	N,N'-Bis(Tert - Butoxycarbonyl)Guanidine should be stored in a cool, dry place away from direct sunlight. Keep it in a well - closed container to prevent moisture absorption and contamination. The chemical is typically stored at a temperature between 2 - 8 °C in a refrigerator to maintain its stability, as certain conditions can lead to degradation or reactivity changes.
Shipping	N,N'-Bis(Tert - Butoxycarbonyl)Guanidine should be shipped in well - sealed, corrosion - resistant containers. Ensure proper labeling with hazard warnings. Ship via carriers compliant with chemical transportation regulations to maintain product integrity.

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General Information

Historical Development

N, N '-bis (tert-butoxycarbonyl) guanidine is also a key reagent for organic synthesis. Looking back in the past, when the chemical technology was not refined, the preparation of this compound was difficult and complicated. In the past, the craftsmen in the dark workshop used crude equipment to explore the way of synthesis. Although they went through mistakes, they did not change their minds.
Later, as the chemical knowledge gradually increased, the instruments gradually refined, and the synthesis method gradually became more refined. Researchers analyze its structure, explore its mechanism, and optimize the process. From the initial ignorance and exploration, to the precise control in the future, every step is infused with hard work. Today, the synthesis technology of N, N '-bis (tert-butoxycarbonyl) guanidine has reached maturity and is widely used in various fields such as medicine and materials. It has added a strong touch to the long river of chemical development.

Product Overview

Today there is a substance called N, N '-bis (tert-butoxycarbonyl) guanidine. The preparation of this substance has gone through all kinds of ingenious methods. Its shape is either powder or crystal, and the color is pure and the quality is good.
Its properties are stable, and it is not easy to mutate at room temperature. Its chemical properties are lively and organized, and it is very useful in the field of organic synthesis. It can be used as a key agent to participate in various reactions and help the construction of compounds.
When preparing, it is necessary to precisely control the conditions, and the ratio of temperature, pressure and agent must be appropriate. In this way, this good product can be obtained. It has potential in the pharmaceutical, materials and other industries, and can lead to various new paths, contributing to the advancement of scientific research and the prosperity of industry. The prospects are quite promising.

Physical & Chemical Properties

The physical and chemical properties of N, N '-bis (tert-butoxycarbonyl) guanidine are particularly important. Looking at its shape, it is a white powder under normal conditions, and the texture is fine. Regarding its melting and boiling point, the melting point is suitable, about a specific range, to ensure its stable existence under certain conditions; the boiling point also has characteristics, reflecting its thermal stability. In terms of solubility, it is soluble in some organic solvents and exhibits unique solubility characteristics, which is related to its dispersion in the reaction system and the degree of participation in the reaction. And its chemical activities are different. Under specific conditions, functional groups can initiate a series of chemical reactions, or replace or add with other reagents, which has potential application value in the field of organic synthesis and can provide a key path for the creation of new compounds.

Technical Specifications & Labeling

The technical specifications and identification (product parameters) of N, N '-bis (tert-butoxycarbonyl) guanidine are the key to the study of chemical products. Its preparation requires a specific process, the ratio of raw materials must be accurate, and the reaction conditions such as temperature and duration must be carefully controlled. As far as technical specifications are concerned, the operation of each step must comply with scientific standards, and there must be no discrepancies. In terms of identification, product parameters should be clearly marked, from purity to molecular structure, all must be accurate. In this way, it can ensure the high quality of this product, play its due role in scientific research and industrial applications, and contribute to the development of the chemical field.

Preparation Method

The key to the preparation of N, N '-bis (tert-butoxycarbonyl) guanidine is the raw materials, production process, reaction steps, and catalytic mechanism. First, take an appropriate amount of potassium tert-butoxide, dissolve it in anhydrous tetrahydrofuran, and stir at low temperature. This is the initial step. Continue to add cyanoguanidine slowly, control the temperature, observe the reaction process carefully, and fine-tune the conditions according to the state. After the reaction is completed, neutralize it with dilute acid, and then purify the product through extraction, drying, and vacuum distillation. The production process needs to be precisely controlled, each reaction step is orderly, and the temperature and time genera need to be strictly observed. The catalytic mechanism depends on the activity of potassium tert-butoxide to promote the efficient reaction. In this way, high-purity N, N '-bis (tert-butoxycarbonyl) guanidine products can be obtained.

Chemical Reactions & Modifications

Nowadays, there is a chemical substance N, N '-bis (tert-butoxycarbonyl) guanidine, which is worth studying in chemical reactions and modifications. The appearance of its reaction is related to the wonders of chemical changes. When looking for its reaction law, observe its change with the phase and phase of various substances.
In the way of modification, we hope to change its properties and increase its effectiveness. Or adjust its structure, or add other agents, in the hope of better performance. When this substance reacts, the control of conditions is very important, and the ratio of temperature, pressure, and agent can all affect its effect.
When modifying, we must consider whether it is stable or not, and how the activity increases or decreases. In order to achieve optimum efficiency, it is necessary to study the details of the reaction in detail, and to view it with ancient methods, it is also necessary to borrow modern techniques to explore the secrets of its reaction and modification, so as to contribute to the progress of chemistry.

Synonyms & Product Names

Although the name of N, N '-bis (tert-butoxycarbonyl) guanidine is different, it is actually a key product in chemical preparations. In the industry, there may be other names, but they all refer to the same thing. Its nickname and trade name, such as various names, are intertwined to identify this unique chemical substance.
In the field of chemistry, there are many different names but the same, and this N, N' -bis (t-butoxycarbonyl) guanidine is no exception. Or because of its different preparation processes, or because of the different uses, many names are derived. However, the root cause is this unique chemical substance, which plays an indispensable role in scientific research, production, and many other aspects. With its unique properties, it helps the exploration and development of the chemical field.

Safety & Operational Standards

N, N '-Bis (tert-butoxycarbonyl) guanidine is a matter of safety and operating standards, and is extremely important. When preparing
, all raw materials must be carefully selected and pure. All utensils used must be clean to prevent impurities from mixing in and damaging their quality. In the operation room, the air circulation should be smooth, and the temperature and humidity should be precisely adjusted to meet the needs of the reaction.
When reacting, the amount of drug dose must be accurately weighed according to the established procedures. The reaction rate should be stable and orderly, not rushed. Looking at its phenomena, such as color changes and temperature rises, are all key. If there is a slight abnormality, quickly check the cause and deal with it properly.
The method of separation and purification of the product to be formed is also fixed. Or extract, or distillate, or recrystallize, choose the appropriate one and use it. During the process, be careful not to lose the product, and to prevent it from being contaminated with impurities.
When storing, it should be placed in a cool and dry place, away from fire and heat sources. Seal must be tight to prevent it from contacting air, moisture, etc., causing it to deteriorate.
When taking it, you must wear protective equipment, such as gloves, goggles, etc. according to the prescribed process to ensure your own safety. After using the equipment, clean it up in time, and dispose of the residue properly. Do not discard it at will to avoid polluting the environment and causing harm.
In short, the safety and operation specifications of N, N '-bis (tert-butoxycarbonyl) guanidine products are interconnected, and they all need to be treated strictly.

Application Area

Today there is a thing called N, N '-bis (tert-butoxycarbonyl) guanidine, which is widely used in various fields. In the genus of medicine, it can be used as an intermediate to help the creation of new drugs, to treat various diseases and make the disease better. In the field of materials, or as a modification aid, optimize the material to make it better and more widely used. In addition, in the field of fine chemicals, it is an important material for the synthesis of specific compounds and adds color to chemical products. It can develop its strengths in various fields, help the industry advance, and promote the prosperity of science and technology, just like the stars shining in the sky of various industries, which is indispensable.

Research & Development

Nowadays, there is a product of N, N '-bis (tert-butoxycarbonyl) guanidine. As a chemical researcher, we are exploring its research and development status. This compound has potential uses in the field of organic synthesis. Its structure is unique, and the synthesis method is also the focus of our research.
Initially, explore its synthesis path, and try many times different reaction conditions, such as temperature, solvent and catalyst selection. After repeated tests, a more suitable method is finally obtained, which can improve the purity and yield of the product.
Furthermore, consider its stability and reactivity, and observe its changes in different environments. Studies have shown that it exhibits good chemical stability under specific conditions, laying the foundation for subsequent application.
Looking to the future, this product is expected to make a name for itself in the fields of medicine, materials, etc. We will continue to study it, expand its application scope, promote its further development, and contribute to the chemical field.

Toxicity Research

Nowadays, there are chemical substances called N, N '-Bis (Tert-Butoxycarbonyl) Guanidine, and the study of its toxicity is crucial. To study toxicity, it is necessary to use scientific methods to observe its properties in detail.
This substance may enter the human body, through the mouth, nose, and skin, invade the viscera. Observe its effect, or disturb the cells, and disrupt the order of metabolism. Taste all kinds of things and observe their reactions. If it is in the body of an animal, observe the changes in its behavior, diet, and physiology.
The study of toxicity is related to people's livelihood. If its toxicity is strong, production and use should be done with caution. Regulations must be set up to ensure people's safety and beauty. Although the research is not complete, it is advancing step by step to clarify the true toxicity and protect sentient beings.

Future Prospects

I have been researching N, N '-bis (tert-butoxycarbonyl) guanidine for a long time. Looking at today, it has begun to show its edge in the synthesis of medicine, creating many new drugs and paving the way. Although it has achieved small success now, it still has a vast future for future development.
I expect that in the future, this product will definitely emerge in the field of fine chemicals and help high-end materials to improve. And in the road of biotechnology, it may become a key key to open a new therapeutic method. When the technology is more refined, the process is better, and the cost is gradually reduced, its application will be scattered like stars and widely spread in all industries.
Over time, N, N '-bis (tert-butoxycarbonyl) guanidine will surely break through the limitations of the present, shine brightly in the unfinished field, and contribute to the advancement of science and industry, developing infinite possibilities and becoming a future chapter.

Frequently Asked Questions

What are the main uses of N, N '-Bis (Tert-Butoxycarbonyl) Guanidine?

N, N '-bis (tert-butoxycarbonyl) guanidine is also an important agent for synthesis. It has many functions in the field of organic synthesis.
First, it is very helpful for the synthesis of peptides. The preparation of peptides requires protection of the amino group to prevent it from participating in the reaction without reason and causing the reaction to proceed in an unfavorable direction. N, N' -bis (t-butoxycarbonyl) guanidine can mask the amino group, and after the reaction is completed, it can be deprotected by a suitable method to obtain a pure peptide product. In this way, the accuracy and yield of peptide synthesis can be improved.
Second, it also plays a pivotal role in the field of medicinal chemistry. In the process of new drug development, the design and synthesis of many drug molecules rely on it. It can modify the structure of drug molecules, increase their stability, or change their solubility, optimize the pharmacokinetic properties of drugs, and make the drug efficacy better.
Third, it also has applications in materials science. For example, when preparing special polymer materials, it can be used as a monomer or reaction intermediate. After ingeniously designing the reaction, it can be polymerized with other monomers, giving the material special physical and chemical properties to meet the needs of different scenarios.
Furthermore, in catalytic reactions, it can be used as a ligand or a base catalyst. Its unique structure can coordinate with metal ions to form an active catalytic center and accelerate the progress of specific reactions. Or in some acid-base catalyzed reactions, play the role of bases to promote the smooth progress of the reaction. In short, N, N '-bis (tert-butoxycarbonyl) guanidine has shown important value in various fields due to its diverse functions, providing a powerful tool for chemical research and industrial production.

What are the synthesis methods of N, N '-Bis (Tert-Butoxycarbonyl) Guanidine

The synthesis of N, N '-bis (tert-butoxycarbonyl) guanidine has many ways in today's chemical technology. One method can start from guanidine and interact with the tert-butoxycarbonylation reagent. Usually, tert-butyl dicarbonate (Boc -2 O) is the source of tert-butoxycarbonyl, and under appropriate reaction conditions, the nitrogen atom in guanidine undergoes nucleophilic substitution reaction with Boc -2 O. This reaction often needs to be carried out in an alkaline environment, such as the selection of triethylamine, N, N-diisopropylethylamine and other organic bases to promote the smooth occurrence of the reaction. The base can first interact with Boc 2O O to form an active intermediate, and then the nitrogen atom of guanidine attacks it to achieve the synthesis of N, N '-bis (tert-butoxycarbonyl) guanidine.
Another method can be started from compounds containing guanidine groups, and the introduction strategy of protective groups can be used. If the basic structural unit of guanidine already exists in the substrate molecule, the target product can be obtained by gradually introducing the tert-butoxycarbonyl protective group. This process also requires precise control of the reaction conditions to prevent overreaction or side reactions. The choice of reaction solvent is very critical. Common organic solvents such as dichloromethane and tetrahydrofuran are often used in such reaction systems because of their good solubility and reaction inertness. The reaction temperature and time also need to be properly regulated. Generally speaking, the reaction at low temperature or room temperature can avoid abnormal decomposition of protective groups or other unnecessary side reactions. After several hours to tens of hours of reaction process, thin-layer chromatography (TLC) can be used to monitor the completion of the reaction, and the reaction can be stopped in a timely manner. After subsequent separation and purification steps, such as column chromatography, a pure N, N '-bis (tert-butoxycarbonyl) guanidine product can be obtained.

What are the physical properties of N, N '-Bis (Tert-Butoxycarbonyl) Guanidine

N, N '-bis (tert-butoxycarbonyl) guanidine is an important compound in organic chemistry. Its physical properties are unique and are described in detail by you.
First of all, its appearance is mostly white crystalline powder under normal conditions. This shape is unique among all compounds. It is clear in appearance and delicate in texture. It is like the first snow in the mountains, pure and uniform.
When it comes to the melting point, the melting point of this substance is quite high, about 130-134 ° C. Such a melting point allows the compound to maintain a stable solid state at ordinary temperatures. If it is to melt into a liquid state, a specific heat needs to be applied. Although the number of boiling points has not been widely confirmed, it can be known that its boiling point is not low when compared with similar substances based on its chemical structure. This is because of the intermolecular force. To make it boil and vaporize requires a huge amount of energy.
In terms of solubility, N, N '-bis (tert-butoxycarbonyl) guanidine exhibits specific properties in organic solvents. It is soluble in halogenated hydrocarbon solvents such as dichloromethane and chloroform. This is because the molecular structure of the compound and the polar adaptation of halogenated hydrocarbons can form a moderate interaction between the two, so it is soluble. In common alcoholic solvents such as methanol and ethanol, its solubility is slightly inferior, and it is not completely insoluble, only the degree of solubility is limited. As for water, its molecular polarity is different from that of water, and it contains hydrophobic tert-butyl, so the solubility is extremely low, just like oil floating in water, and it is difficult to blend.
Furthermore, the density of the compound is moderate. Although the exact value is rarely seen in the literature, according to its chemical composition, it can be known that its density is slightly larger than that of water, and it will sink to the bottom when placed in water. And its stability is good. It is not prone to spontaneous chemical reactions at room temperature and pressure under normal conditions, and its structure is stable. It is like a mountain ancient temple, which is immobile after wind and rain. This property makes it more convenient and safe for many chemical operations and storage processes.

What are the chemical properties of N, N '-Bis (Tert-Butoxycarbonyl) Guanidine

N ', N' -bis (tert-butoxycarbonyl) guanidine is an important intermediate in organic synthesis. Its properties are many wonders.
Looking at its physical properties, under normal conditions, it is mostly white to off-white solids, like powder or crystals, which are quite stable in the air. However, it needs to be properly stored to avoid moisture and moisture to prevent qualitative changes.
When it comes to chemical properties, it contains tert-butoxycarbonyl and guanidine, and its activity is extraordinary. Tert-butoxycarbonyl has the ability to protect amino groups. In many reactions, it can protect amino groups from unprovoked changes, and can be easily removed when needed. Reactivity. The guanidine base is quite strong, and it can blend with acids under suitable conditions to form salts. Due to its special structure, it can participate in many reactions such as nucleophilic substitution and condensation, and is widely used in drug synthesis, polypeptide preparation and other fields.
This substance has good solubility in organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. This property helps it to disperse uniformly in the organic synthesis reaction system, fully contact with various reactants, and promote the smooth progress of the reaction. And under mild reaction conditions, it can exhibit good reactivity and selectivity, providing convenience for the synthesis of compounds with specific structures.

What are the precautions for N, N '-Bis (Tert-Butoxycarbonyl) Guanidine in storage and transportation?

N, N '-bis (tert-butoxycarbonyl) guanidine, when storing and transporting, be sure to pay attention to many matters. The impact of this substance on the environment should not be underestimated. When storing, it should be in a dry, cool and well-ventilated place to avoid contact with water and moisture. If it encounters water, it may react, causing changes in properties and even damage its quality. And it is necessary to keep away from fire and heat sources to prevent the risk of accidents, because it may be flammable under certain conditions.
When transporting, you should also be cautious. The packaging must be tight to ensure that there is no leakage, so as to prevent pollution of the surrounding environment. During the handling process, the operator should handle it with care, and do not subject it to violent vibration or impact, which may endanger the safety of transportation due to severe external force or damage to the package.
Furthermore, this substance may be potentially harmful to the human body, so the storage and transportation places should be equipped with corresponding protective equipment and emergency treatment equipment. If there is an accidental leakage, it should be properly disposed of immediately according to the established procedures, and it must not be slack, so as not to cause a disaster. In short, when storing and transporting N, N '-bis (tert-butoxycarbonyl) guanidine, all details need to be carefully taken to ensure safety.