What are the main uses of N, N '-diphenylguanidine monohydrobromide?
N, N '-dibenzylethylenediamine diacetate is widely used in the field of medicine. It is often the key excipient of penicillin long-acting preparations.
Although capillary penicillin has significant antibacterial effect, its metabolism in the body is rapid, and frequent administration is required to maintain the effective blood concentration, which is quite inconvenient for patients. When N, N' -dibenzylethylenediamine diacetate is combined with penicillin, it can form an insoluble salt, which slows down the dissolution and absorption rate of penicillin in the body, thereby prolonging its action time.
Taking benzathine penicillin as an example, it is the salt of penicillin and N, N '-dibenzylethylenediamine diacetate. After intramuscular injection of this drug, it is slowly dissolved and absorbed locally, which can maintain an effective antibacterial concentration in the body for a long time, and the number of dosing times is greatly reduced, which is greatly convenient for patients. For example, when treating syphilis, benzathine penicillin usually only needs to be administered at intervals of a certain period of time, without daily injection, to improve patient compliance with medication.
In addition, in the process of drug development and production, N, N '-dibenzylethylenediamine diacetate can also be used as an additive for the control of certain drug crystal forms, which affects the stability, solubility and bioavailability of drugs, helps to optimize drug quality and improve drug efficacy. Therefore, it is of great value in the pharmaceutical industry and plays an indispensable role in protecting human health.
What are the physicochemical properties of N, N '-diphenylguanidine monohydrobromide?
N, N '-dibenzylethylenediamine diacetate, its physical and chemical properties are as follows:
In terms of view, this is a white crystalline powder, odorless and slightly sweet. It is relatively stable in the air, but it changes slightly when it is wet or hot topic. Its solubility is quite specific and soluble in water. Because there are groups that can interact with water molecules in the molecular structure, such as the salt form of carboxyl groups, it can be better dispersed in water. It is slightly soluble in organic solvents such as ethanol and chloroform. This is because the overall polarity of the molecule is moderate and the interaction with organic solvents is limited.
The melting point is between 188 and 192 degrees Celsius. At this temperature, the lattice can be overcome, the crystal structure disintegrates, and the substance changes from solid to liquid. Its stability is quite good under normal storage conditions, but if exposed to strong acid and alkali environments, the molecular structure will be damaged. The cover contains parts that are easy to react with acid and alkali, such as amino groups and carboxylate parts. And in high temperature, high humidity and aerobic environments, it will also slowly oxidize or undergo other chemical reactions, resulting in a decrease in its quality.
This compound has applications in many fields due to its physicochemical properties. In the field of medicine, it is often used as a carrier or additive for certain drugs, leveraging its solubility and stability to enhance the effectiveness of drugs. In the chemical industry, it can also be used as an intermediate in organic synthesis to participate in various reactions and prepare more complex organic compounds through its structural properties.
What is the production method of N, N '-diphenylguanidine monohydrobromide?
N, N '-dibenzyl ethylenediamine diacetate, the preparation method is as follows:
First take an appropriate amount of ethylenediamine and place it in a clean reactor. Ethylenediamine is the basic raw material for this synthesis. Its chemical properties are active, with two amino groups, and it can react with a variety of reagents.
The benzyl halide is slowly dripped into the kettle. The benzyl halide is preferably benzyl chloride or benzyl bromide, and its activity is suitable for the reaction. When dripping, close attention should be paid to the reaction temperature, which is preferably low temperature, usually between 0 and 10 degrees Celsius. This is because the reaction is a nucleophilic substitution reaction, and low temperature can make the reaction smooth and reduce the occurrence of side reactions. The amino group of ethylenediamine acts as a nucleophile to attack the benzyl carbon of the benzyl halide, and the halogen ions leave to form N, N '-dibenzylethylenediamine.
When the reaction is completed, the reaction mixture is washed with a dilute acid solution. This is to remove impurities such as unreacted benzyl halide and generated ammonium halide. After washing, the organic phase is separated and dried with anhydrous sodium sulfate to remove moisture.
Then, the dried organic phase is transferred to another reaction vessel and an appropriate amount of acetic acid is added. The acetic acid reacts with N, N' -dibenzylethylenediamine to form N, N '-dibenzylethylenediamine diacetate. This reaction is relatively mild, and it can be fully reacted when stirred between room temperature and 50 degrees Celsius for a few times.
After the reaction is completed, the excess acetic acid is removed by reduced pressure distillation, and then recrystallized with suitable organic solvents, such as ethanol, acetone, etc., to obtain pure N, N '-dibenzylethylenediamine diacetate crystallization. After these several steps, the target product can be obtained. The preparation process needs to carefully control the conditions of each step to obtain satisfactory yield and purity.
What are the precautions for the use of N, N '-diphenylguanidine monohydrobromide?
In the case of N, N '-dibenzylethylenediamine diacetate, when using it, there are various things to pay attention to and cannot be ignored.
When storing this medicine, be sure to keep it in a cool and dry place away from direct sunlight. Sunlight, such as the burning of fire, or the change of drug-causing properties, loses its original effect. And the surrounding humidity should also be paid attention to. If the humidity is too high, it may cause the medicine to get damp and mildew.
When using medicine, the control of the dose is the most important thing. Doctors should carefully weigh and determine the appropriate amount according to the severity of the patient's illness, age, physical strength, etc. If the amount is too small, it is like a drop in the bucket, and it is difficult to achieve the effect of treating the disease; if the amount is too large, it will be like overdosing the drug, and it may cause harm and endanger the well-being of the patient.
Furthermore, the user should know their own constitution in detail. If it is an allergic constitution, special caution is required. Before taking the drug, it is advisable to perform an allergy test to see if it has any signs of allergy. If used rashly, it will cause an allergic reaction, mild skin itching, rash, severe or cause shortness of breath, shock and other crises, which are related to life, and should not be careless.
Also, when using this drug, you should also pay attention to the interaction with other drugs. When many drugs are used together, they may increase their effectiveness in each other, or cause harm in each other. Therefore, before taking the medication, the patient should inform the doctor in detail about the other medications he uses, and the doctor should also consider in detail to avoid the harm of drug interactions and ensure the safety of the medication.
During the medication process, the patient himself should also pay attention to the changes in the body. If there is any discomfort, such as nausea, vomiting, dizziness, etc., the doctor should be informed immediately, so that the medication method can be adjusted in time, and the patient can be prevented and kept safe.
What is the market price of N, N '-diphenylguanidine monohydrobromide?
Today, we are inquiring about the market price of N% 2CN% 27 -dibenzylpiperazine monohydrochloride, which is an important material in the field of fine chemicals. The theory of Guanfu's "Tiangong Kaiwu", although it does not directly involve this material, but it is based on the idea of "expensive grains and cheap gold jade", which is practical and practical. This is also instructive for exploring the market price.
The market is impermanent, and the price changes from time to time and varies from situation to situation. The price of this N% 2CN% 27 -dibenzylpiperazine monohydrochloride often depends on the supply and demand ends. If the supply exceeds the demand, such as the flooding of rivers, the price will go down, just like the grain in a good year; if the supply exceeds the demand, the hope of a long drought is sweet rain, and the price will rise, just like the grain in a bad year.
Furthermore, the price is also related to the manufacturing cost. From the purchase of raw materials, if the raw materials are scarce and difficult to find, the price is as high as the mountains, and the price of finished products will also rise; to the complexity of the process, if the process is complicated, the manpower and material resources are required like weaving silk cocoons, and the cost is high, how can the price not be expensive?
Also, the market competition also affects its price. All merchants compete to attract customers for profit, or there is a price cut to win; if you monopolize on one side, the price can be determined as you like, if you have a balance in hand.
Looking at the markets, or if there are differences in the price of quotations, then the approximate range is between [X1] gold and [X2] gold. This is only an estimate for the time being. The market conditions are changing rapidly, and the actual price should be subject to the current inquiry, just like a boat depends on the water situation, and cannot be rigid.