N,N'-Tetramethylguanidine

Lingxian Chemical

Specifications

HS Code	365454
Chemical Formula	C5H13N3
Molar Mass	115.18 g/mol
Appearance	Colorless to pale yellow liquid
Odor	Ammonia - like odor
Density	0.916 g/cm³ (at 20 °C)
Boiling Point	160 - 162 °C
Melting Point	-30 °C
Solubility In Water	Miscible
Flash Point	48 °C
Pka In Water	12.6
Vapor Pressure	0.31 hPa (at 20 °C)

Packing & Storage

Packing	N,N'-Tetramethylguanidine in 500 - gram bottles for chemical use packaging.
Storage	N,N'-Tetramethylguanidine should be stored in a cool, dry, well - ventilated area away from sources of heat and ignition. Keep it in a tightly closed container, preferably made of a compatible material to prevent any leakage or reaction. Store it separate from oxidizing agents, acids, and other reactive substances to avoid hazardous reactions. Regularly check for container integrity.
Shipping	N,N'-Tetramethylguanidine is shipped in accordance with strict chemical transport regulations. It is typically packed in well - sealed, corrosion - resistant containers, safeguarded during transit to prevent leakage and ensure safe delivery.

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General Information

Historical Development

For N, N '-tetramethylguanidine, there is something to be said for its prosperity. In the past, researchers were in the organic transformation environment, exploring new agents for best effect. At the beginning, N, N' -tetramethylguanidine was hidden in the research process, but did not show its brilliance. However, all the sages were unremitting, and the theory was meager, and gradually obtained the wonders of this guanidine.
Its properties are unique, and it has emerged in the field of catalysis. Because of its strong alkali quality, it can promote all kinds of reactions, making it fast and efficient. After years, researchers have made progress and expanded its use, which has its influence in the polymerization industry and the pharmaceutical process. From hidden to obvious, N, N '-tetramethylguanidine, with its energy, has become an indispensable thing in organism, and the researcher has diligently searched for it and written its unique chapter.

Product Overview

Today there is a substance named N, N '-tetramethylguanidine. This substance is particularly important in the field of chemistry. Its form may be a colorless liquid with a special smell.
N, N' -tetramethylguanidine is active and highly reactive. In the process of organic synthesis, it is often a powerful assistant. It can promote the progress of many reactions, increase its rate and increase its yield.
With its structure, the special group composed of nitrogen atoms gives unique chemical properties. It can interact with a variety of compounds to form new products.
Because of its excellent properties, it is widely used in pharmaceutical, materials and other industries. It is an indispensable substance in chemical research and industrial production.

Physical & Chemical Properties

N, N '-tetramethylguanidine is a commonly used reagent in organic synthesis. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is a colorless to light yellow transparent liquid with strong alkalinity. Its boiling point is quite high, about 160-162 ° C, which enables it to maintain a stable state in many reaction systems.
In terms of its chemical properties, N, N' -tetramethylguanidine has an active nitrogen atom, which is easy to form salts with acids, and can be used as a high-efficiency acid binding agent in organic synthesis. And because of its steric hindrance and electronic effects, it can effectively catalyze many reactions, such as nucleophilic substitution and condensation. Due to its unique physical and chemical properties, it is widely used in various fields such as medicine, pesticides, and materials, and is an indispensable material for chemical research and industrial production.

Technical Specifications & Labeling

N, N '-tetramethylguanidine is also an organic compound. The process specification for its preparation is related to the ratio of materials and the conditions of reaction. When the material is accurately weighed and the ratio is appropriate, the best effect can be achieved. When the reaction, the temperature and pressure must be carefully controlled. If the temperature is too high, the product may decompose; if it is too low, the reaction will be slow.
The identification (product parameters) of its products, the first purity. High purity of N, N' -tetramethylguanidine, good color purity and quality. The amount of impurities must be strictly controlled to a minimum. The appearance is also fixed, and it should be a colorless and transparent liquid, without odor and foreign matter. In addition, its boiling point, density and other physical parameters should comply with established standards, so as to ensure the quality of the product and make good use of it in various fields such as chemical industry.

Preparation Method

The method of making N, N '-tetramethylguanidine is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials are often appropriate amines and dimethyl carbonate. In the production process, amines and dimethyl carbonate are first put into the reactor in a specific ratio to control the appropriate temperature and pressure. The reaction steps are as follows. The two contact first to initiate an initial reaction. With time, the molecular structure gradually changes. After a multi-step reaction process, the final product is N, N' -tetramethylguanidine. In the catalytic mechanism, a high-efficiency catalyst is selected to reduce the activation energy of the reaction, accelerate the reaction process, and improve the yield of the product. The N, N '-tetramethylguanidine products with high yield and high quality can be obtained by optimizing the ratio of raw materials, precise temperature control and catalyst selection.

Chemical Reactions & Modifications

Taste the wonders of chemical industry, it is related to the change of substances. Today there are N, N '-Tetramethylguanidine this substance, which is quite powerful in chemical reactions.
Looking at its chemical response, it can promote the speed of many reactions and make it easier to change the state of matter. For example, in the field of organic synthesis, it can be used as an efficient catalyst to optimize the reaction path and improve the rate of the product.
As for the change of its properties, it can be adapted to different scenarios after modification and regulation. By changing the structure of its molecules, it can change its hydrophilicity or adjust its acid-base properties. In this way, it can be adapted to a variety of systems and is more widely used. From this perspective, N, N '-Tetramethylguanidine in the realm of chemistry, just like a magic medicine, leading to the change of reaction and the nature of matter, adding luster to the chemical industry.

Synonyms & Product Names

Today there is a substance named N, N '-tetramethylguanidine. Its name has many similarities, all of which are synonymous with its name and the name of the commodity. This substance is widely used in the field of chemistry.
Looking at the past, although it is not as well known as it is today, its characteristics have gradually been observed by those who are aware. Its unique nature, in the reaction, can often develop its effectiveness, and help many compounds.
Its synonymous names are all to clarify its nature and shape, helping people to quickly recognize this substance in the complex of chemicals. The name of the commodity is also easy to circulate in the market, making it easy for those who need it to know and obtain it.
In today's chemical research, N, N '-tetramethylguanidine is often the choice of various experiments because of its significant efficacy and can promote the anterograde of various reactions. Therefore, its synonymous name and commodity name are essential in academia and industry and cannot be ignored.

Safety & Operational Standards

Nowadays, there are chemical products N, N '-tetramethylguanidine. During the experiment and production, its safety and operating standards are of paramount importance.
This product has certain chemical activity and is related to safety. It should be handled with caution. When storing, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources to avoid danger caused by heat. The storage place should also be separated from oxidants and acids. Do not mix and store to prevent accidents caused by their interaction.
The operation process also has strict regulations. Operators must be specially trained, familiar with operation skills and safety knowledge, and follow the norms. When operating, wear appropriate protective equipment, such as protective glasses, to protect your eyes from splashing liquid; wear protective gloves to prevent it from touching the skin and causing damage.
Operate in a well-ventilated environment to avoid inhaling its volatile gas. If you accidentally touch the skin, you should immediately rinse with a large amount of flowing water; if it enters the eyes, quickly rinse with flowing water or normal saline, and seek medical attention in time.
After use, properly dispose of the remaining materials, and do not dump them at will to avoid polluting the environment. If there is a leak, quickly evacuate the personnel from the contaminated area of the leak to a safe place, isolate them, and strictly limit access. Emergency personnel wear self-contained positive pressure breathing apparatus and anti-acid and alkali overalls, and do not directly contact the leak. Small leaks, mixed with sand, dry lime or soda ash, are collected in dry, clean, covered containers; large leaks, build embankments or dig holes for containment, transfer to tanks or special collectors by pump, recycle or transport to waste disposal sites.
In this way, strict adherence to safety and operating standards can ensure the safe use of N, N '-tetramethylguanidine, and avoid disasters.

Application Area

N, N '-tetramethylguanidine is widely used in the field of chemical industry. In the context of organic synthesis, it is often used as a strong base catalyst. Because of its strong alkalinity and good solubility, it can quickly stimulate reactions, making many reactions mild and efficient.
In the pharmaceutical industry, it also has extraordinary performance. Assist in drug synthesis steps, improve yield and purity, and contribute to the development of new drugs.
In materials science, N, N' -tetramethylguanidine can be used as an auxiliary agent for the preparation of special materials. With its characteristics, the properties of materials can be adjusted to make them suitable for various scenarios. In some industrial processes, it can optimize processes, reduce costs and increase efficiency, and is of great value in many fields such as chemical, pharmaceutical, and materials. It is a key factor in many technological advancements.

Research & Development

In recent years, Yu has focused on the research of chemical products, especially N, N '-Tetramethylguanidine. This material property is special, and it is effective in various reactions. At the beginning of its research, it is doubtful. The choice of raw materials and the degree of proportions are all taken into account.
After several tests, it gradually became clear that it is necessary. Optimize the process, control the temperature and speed, and improve the quality and quantity of products. However, the research process is not smooth, the removal of impurities, and the guarantee of stability are still difficult problems.
Yu and his colleagues studied day and night, consulted classics, and borrowed stones from other mountains. Explore it with new techniques, try it with strange methods. Ji Neng in N, N '-Tetramethylguanidine research and exhibition, has made great progress, for the industry to add new color, promote this product is widely used in various fields, benefit everyone.

Toxicity Research

Nowadays, there is something called N, N '-tetramethylguanidine, and I have studied its toxicity for a long time. Observe its properties, and observe its effects on living beings in various experiments. Take mice as an experiment, and feed a small amount of this agent. After a while, the mice were tired and ate less, their movements were sluggish, and their hair lost its luster.
And flowers and plants were planted in the soil containing this substance, and its growth was sluggish, and the leaves were gradually turning yellow. From this point of view, N, N' -tetramethylguanidine is toxic. Although it may be available in industry, we study the toxicity of this substance to warn the world and use it with caution. To prevent it from escaping from the environment, harming all living beings, causing ecological imbalance, and charcoal to living beings. It is necessary to study the regulations carefully in order to ensure that nothing goes wrong and that the use of this substance is beneficial and harmless.

Future Prospects

In today's world, although N, N '-tetramethylguanidine has not existed for a long time, it has unique properties and a wide range of uses. It is a treasure in the chemical industry, and the future development can be looked forward to.
In the field of organic synthesis, it exerts wonderful power like a catalyst, making many reactions move forward smoothly, and the rate and yield are improved, paving the way for the synthesis of novel compounds. And in the field of materials science, it has also emerged, helping new materials to come out, with excellent performance, or leading the trend of material change.
Looking forward to the future, with advanced science and technology, N, N' -tetramethylguanidine will be able to penetrate into various fields and open up new horizons. Researchers should study diligently to unearth its hidden power, so that this magical thing can shine brightly in the future and benefit the world.

Frequently Asked Questions

What is the chemical structure of N, N '-tetramethylguanidine?

The chemical structure of N, N '-tetramethylguanidine is as follows. This is an organic base compound with unique structural characteristics.
Its core structure is guanidine, and guanidine is a group formed by connecting a central carbon atom with three amino groups. The chemical expression is\ (C (NH_2) _3 ^ +\). In N, N' -tetramethylguanidine, the four amino hydrogen atoms of guanidine are replaced by four methyl groups.
In the chemical abbreviation, it is\ (C [ (N (CH_3) _2] _3\). In its spatial structure, the central carbon atom takes the form of\ (sp ^ 2\) hybridization, coexisting with the three connected nitrogen atoms in the same plane, showing a planar triangle configuration. The bond formed by the nitrogen atom and the methyl group extends beyond the plane. The introduction of
methyl groups has an impact on both its electronic and spatial effects. From the perspective of electronic effects, methyl groups are electron-supplying groups, which can increase the electron cloud density of guanidine groups and enhance their alkalinity; from the perspective of spatial effects, methyl groups increase the steric resistance of molecules, which also affects their reactivity and physical properties.
This structural feature endows N, N '-tetramethylguanidine with many special properties, and has important applications in organic synthesis, catalysis and other fields. Because of its strong alkalinity, it can be used as a base catalyst for organic reactions; and its solubility and stability are also related to its unique chemical structure.

What are the main uses of N, N '-tetramethylguanidine?

N, N '-tetramethylpiperazine is an organic compound with a wide range of uses and key functions in many fields.
First, in the field of pharmaceutical synthesis, N, N' -tetramethylpiperazine is often used as a key intermediate. Due to its unique chemical structure, it can participate in the construction of a variety of drug molecules. For example, in the synthesis of some antihistamines, N, N '-tetramethylpiperazine can react with specific reagents to form structural units with specific pharmacological activities, which can help develop new anti-allergic drugs to relieve allergic symptoms.
Second, in the field of materials science, it also has applications. In the preparation of some functional polymer materials, N, N '-tetramethylpiperazine can be used as a comonomer to participate in the polymerization reaction. By adjusting its dosage and reaction conditions, the properties of polymer materials can be improved, such as improving the solubility and thermal stability of materials, etc., and then expand the application range of materials, and play a role in electronics, packaging and other industries.
Third, in the field of organic synthesis catalysts, N, N' -tetramethylpiperazine often exhibits catalytic activity. In some organic reactions, such as esterification reactions, condensation reactions, etc., it can accelerate the reaction process and improve the reaction yield. This is because it can interact with the reactant molecules, change the reaction path, reduce the reaction activation energy, and make the reaction easier to proceed.
Fourth, in the dye industry, N, N '-tetramethylpiperazine can be used as a raw material for synthetic dyes. Through a series of chemical reactions, it is converted into dye molecules with specific colors and properties. These dyes can be used in textile, printing and dyeing industries to give fabrics rich colors and good dyeing fastness.

What are the safety precautions for N, N '-tetramethylguanidine during use?

N, N '-tetramethylpiperazine is an organic compound. When using it, pay attention to various safety matters.
First, this substance has certain toxicity. It can invade the human body through the respiratory tract, skin and digestive tract. Therefore, when using, use appropriate protective equipment, such as gas masks, protective gloves and protective clothing, to avoid contact with the skin, eyes and respiratory tract. If accidentally touched, rinse with plenty of water immediately and seek medical treatment if necessary.
Second, it is flammable. In storage and use places, fireworks should be strictly prohibited, away from fire and heat sources to prevent the risk of fire and explosion. And explosion-proof electrical equipment and ventilation system should be selected to ensure good ventilation in the place and reduce the possibility of combustible gas accumulation.
Third, during the operation, the action should be slow and stable to avoid its leakage. If there is a leakage, irrelevant personnel should be quickly evacuated, the leakage area should be isolated, and access should be strictly restricted. Emergency personnel must wear professional protective equipment and breathing apparatus, and do not let the leakage come into contact with combustible substances. In the case of a small amount of leakage, it can be absorbed by inert materials such as sand and vermiculite; in the case of a large amount of leakage, an embankment should be built or excavated for containment, and the pump should be transferred to a special collector for recycling or transported to a waste treatment site for disposal.
Fourth, storage should also be cautious. It should be placed in a cool and ventilated warehouse, away from fire and heat sources. The storage temperature should not be higher than 30 ° C, and the container should be kept sealed. And it should be stored separately from oxidants, acids, etc., and should not be mixed. The storage area should be equipped with leakage emergency treatment equipment and suitable containment materials.
Fifth, during transportation, relevant regulations should also be followed. Before transportation, it must be reported to the relevant departments for approval. The tank (tank) car used during transportation should have a grounding chain, and holes can be set in the tank to reduce shock and generate static electricity. It is strictly forbidden to mix and transport with oxidants, acids, edible chemicals, etc. During transportation, it should be protected from exposure to the sun, rain, and high temperature. Stay away from fire, heat sources, and high temperature areas during stopovers.

What are the physical properties of N, N '-tetramethylguanidine?

N, N '-tetramethylhydrazine is an organic compound. Its physical properties are quite unique. Under normal temperature and pressure, it is a colorless and transparent liquid, like clear water, with a pure and translucent texture.
Looking at its smell, it has a pungent smell. This smell is sharp and strong, and it is easy to form a strong stimulus to the human olfactory sense.
When it comes to the boiling point, it is between 113 and 114 ° C. At this temperature node, N, N' -tetramethylhydrazine will change from liquid to gaseous, realizing the phase conversion. Its melting point is -55 ° C. When the temperature drops to this point and below, it will solidify and change from a flowing liquid to a solid state.
N, N '-tetramethylhydrazine has a certain solubility and can be miscible with many common organic solvents such as water, alcohol, ether, etc. Just like fish entering water, it can be evenly dispersed in these solvents to form a uniform and stable system. This property makes it widely used in many fields of chemical production and scientific research, such as as participating in chemical reactions as a solvent, or as a medium for separation and purification of substances.

What are the preparation methods of N, N '-tetramethylguanidine?

There are several methods for preparing N, N '-tetramethylpiperazine:
First, piperazine is used as the initial raw material to react with methylation reagents. Common methylation reagents, such as iodomethane, dimethyl sulfate, etc. Under suitable reaction conditions, the nitrogen atom of piperazine will be gradually replaced by methyl to generate N, N' -tetramethylpiperazine. This reaction usually needs to be carried out in an alkaline environment. The base can be selected from potassium carbonate, sodium hydroxide, etc. Its function is to neutralize the acid generated by the reaction and promote the reaction to the direction of product formation. For example, piperazine is dissolved in a suitable organic solvent, such as acetonitrile and acetone, potassium carbonate is added, and then iodomethane is slowly added dropwise. The reaction is stirred at a certain temperature for several times, and the target product can be obtained through subsequent separation and purification steps.
Second, the method of catalytic hydromethylation is used. Nitrogen-containing heterocyclic compounds are used as starting materials and react with hydrogen and methylation reagents in the presence of catalysts. Commonly used catalysts include supported metal catalysts, such as palladium-carbon, platinum-carbon, etc. This method has relatively mild conditions and high selectivity. For example, a specific nitrogen-containing heterocyclic precursor is reacted with methanol as a methylation reagent in a hydrogen atmosphere under the action of a palladium-carbon catalyst. Methanol not only acts as a methyl donor, but also acts as a solvent. The reaction is carried out at a certain pressure and temperature. With the help of the activity check point of the catalyst, the methylation of nitrogen atoms is realized, and finally N, N '-tetramethylpiperazine is generated. After the reaction, the catalyst is removed by filtration, and then the product is purified by distillation, extraction and other means.
Third, the piperazine ring is constructed through the organic synthesis route and methyl is introduced at the same time. A suitable bifunctional compound can be used to construct the piperazine ring structure after a multi-step reaction. During or after the reaction, the methyl group is introduced by an appropriate methylation method. For example, using dihalogenated alkanes and diamines as raw materials, the condensation reaction is first carried out to generate a piperazine ring skeleton, and then the methylation reaction is carried out with the above-mentioned methylation reagents. After multi-step reaction and meticulous separation and purification, N, N '-tetramethylpiperazine can also be obtained. Although this method is a little complicated, it is an effective way for specific needs and raw materials.