What are the main uses of sulfaguanidine?
Sulfaguanidine is an antibacterial drug of sulfaguanidine. Its main use is quite extensive, and it is beneficial in the medical system.
Sulfaguanidine can be used to prevent and treat diseases caused by intestinal infections. In the intestines, it is prone to all kinds of pathogens, causing diarrhea, dysentery and other diseases. Sulfaguanidine can enter the intestines, inhibit the reproduction and growth of pathogens, and make the intestinal flora return to peace, so as to achieve the purpose of curing diseases. Although ancient physicians did not know the name of sulfaguanidine, they also devoted themselves to the treatment of intestinal diseases. Today's sulfaguanidine is like a good prescription, which can directly attack the lesions and help patients get rid of intestinal diseases.
In the livestock farming industry, sulfaguanidine is also very useful. If livestock are infected with intestinal diseases, or cause growth to be stunted, and even die. This drug can protect the intestinal health of livestock, promote their thriving growth, and greatly help to improve the efficiency of breeding. Remember the past, farmers were often trapped by livestock diseases. Now there is sulfadiguanidine, which can protect the health of livestock if you get a sharp weapon.
Furthermore, sulfadiguanidine is also an important reagent in experimental research. Scientists can use its characteristics to explore the habits of pathogens and the mechanism of action of drugs, etc., laying a solid foundation for the development of medicine. Just like the key to exploring the mysteries of medicine, leading everyone to move forward on the road of medicine.
In summary, sulfadiguanidine plays a key role in the prevention and treatment of intestinal diseases, livestock breeding, and scientific research experiments. It is a good medicine for the world and contributes to the health of humans and livestock.
What is the mechanism of action of sulfaguanidine?
Sulfaguanidine is a kind of western medicine, and its mechanism of action is quite subtle. This drug is mainly aimed at the growth of intestinal bacteria and can effectively curb the reproduction of pathogens.
According to its principle, the molecular structure of sulfaguanidine is very similar to p-aminobenzoic acid (PABA). In the process of synthesizing folic acid, bacteria need PABA as the key raw material. With the help of dihydrosphenoic acid synthase, it binds to dihydrosphenoic acid pyrophosphate to generate dihydrosphenoic acid. Sulfaguanidine can competitively bind to dihydrosphenoic acid synthase with PABA, which is just like a fake, making it difficult for the enzyme to bind to PABA normally. As a result, bacteria cannot successfully synthesize dihydrosphenoic acid, and then cannot synthesize folic acid.
Folic acid is crucial in the metabolic activities of bacteria and is related to the synthesis of nucleic acid and protein in bacteria. Once folic acid synthesis is blocked, the synthesis of nucleic acid and protein in bacteria is also trapped, and the growth and reproduction of bacteria cannot be sustained, so it can achieve the purpose of inhibiting intestinal bacteria and treating related diseases. Therefore, sulfaguanidine protects the health of the human intestine through this unique mechanism of action.
What are the adverse reactions of sulfaguanidine?
Sulfonamide is a good medicine for treating intestinal diseases. However, although it is a good medicine, there are also unsuitable reactions, which cannot be ignored.
The first unsuitable reaction is allergies. Many people who take medicine have rashes and itching, which is unbearable. This is a sign of illness between medicine and the body, and a sign of allergies. Light rashes are scattered on the skin, which can be tolerated; severe people have hair all over the body, have trouble sleeping and eating, and may be accompanied by fever and asthma, which is life-threatening and should not be underestimated.
The second time is a change in the hematopoietic system. Taking sulfonamide for a long time may cause the number of white blood cells and platelets to decrease. White blood cells, such as guards in the army, are mainly used to resist external evil; platelets are related to blood clotting. The number of the two is reduced, the body's ability to control disease is weak, and it is easy to bleed, such as gingival bleeding, subcutaneous ecchymosis, etc., which are all symptoms.
Furthermore, it also affects the urinary system. Sulfamidine is metabolized by the kidneys, or crystallized into crystals, which are blocked in the urinary tract. Light urination stings, difficult to come out; severe urinary tract obstruction causes hydronephrosis, damage renal function, and regret it too late.
It is tiring to the liver again. Or elevates liver enzymes, hindering the ability of the liver to function. Liver, the large chemical factory of the human body, is mainly responsible for detoxification and metabolism. If liver function is damaged, various poisons in the body are difficult to excrete, qi and blood transport and transformation are abnormal, and the body gradually decays.
And gastrointestinal discomfort. Common nausea, vomiting, abdominal pain. The spleen and stomach are the foundation of acquired nature and the source of qi, blood and biochemistry. Medicine injures the spleen and stomach, transports and loses division, diet is difficult to eliminate, nutrition is difficult to continue, and the body is weak.
Therefore, those who use sulfamidine must carefully examine their situation, weigh the pros and cons, closely observe their reactions, and prevent problems before they occur.
What are the contraindications of sulfaguanidine?
Sulfadiguanidine is also a medicine. However, there are people who are prohibited from taking it, so don't be careless.
First, those who are allergic to sulfadiazine drugs must not use this medicine. Such people are prone to allergies when encountering sulfadiazine. If it is mild, the rash is itchy, and if it is severe, it can cause worries about life. As the "Annotation to the Canon of Materia Medica" says: "The medicine has mutual needs, mutual use, fear of each other, mutual hate, the opposite, and killing each other. Those who are allergic should use sulfadiazine, and the opposite should not be used." If people who are allergic take sulfadiazine, the opposite medicine should be used together, and its harm is great.
Second, pregnant and breastfeeding women should not use it. During pregnancy, the fetus is in the abdomen, its body is delicate, and drugs can easily pass through the placenta to affect the fetus. During lactation, drugs can enter the baby's body with milk, and the baby's internal organs are not complete, so it is difficult to bear the harm of drugs. Gu Yun: "If a woman is pregnant, use the drug with caution, for fear of damaging the fetal gas." This is also the way to protect the fetus and the baby.
Third, those with liver and kidney insufficiency should also be avoided. The liver is the main excretion, and the kidney is the main excretion. If these two are incomplete, the metabolism and excretion of the drug will be blocked, and sulfaguanidine will easily accumulate in the body, causing increased toxicity, increasing the burden on the liver and kidney, and then damaging the whole body. For example, "The Yellow Emperor's Nei Jing" says: Liver and kidney are both deficient, and then they are invaded by drugs and poisons, and the disease will intensify.
When people use drugs, they should carefully review their own conditions. If they belong to the above-mentioned taboo groups, they must not use sulfaguanidine to avoid disease and disaster. The matter of medication is related to life and cannot be ignored.
What is the usage and dosage of sulfaguanidine?
Sulfaguanidine is a good medicine, and its usage and dosage are crucial. In the past, physicians used medication with extreme caution, and they must carefully weigh it according to the patient's symptoms, constitution, and the severity of the disease.
In case of mild illness, or the patient's constitution is still good, physicians usually use an appropriate amount of sulfaguanidine to administer it. It is often taken with warm water, several times a day, and each dose depends on the severity of the disease. At the beginning, or the dose is slightly heavier to achieve the effect of removing evil spirits; when the disease is slightly delayed, the dose should be reduced to prevent the overdose from damaging the patient.
As for severe illness, the way of medication is more particular. Doctors may increase the dose of sulfamidine, but they also need to pay close attention to the patient's reaction. And the interval between taking the medicine will also be adjusted, or the time will be shortened to make the drug last. At the same time, it will also be combined with other medicines to work synergistically to help patients recover as soon as possible.
In addition, the medication used by children should be lighter than that of adults because of their delicate organs. Doctors must carefully observe the age and weight of children, and consider carefully, lest the medicine is not symptomatic or the dosage is inappropriate, causing other changes.
During the medication period, the doctor will also tell the patient that the diet should be light and avoid greasy and spicy things, so as not to affect the efficacy of the medicine. And it is necessary to rest and recuperate to facilitate the recovery of the body. In summary, the use and dosage of sulfamidine is exquisite, and it is flexible and flexible in the medical clinic to achieve the best therapeutic effect.