2, 3:4, What are the common application fields of 5-Di-O-Isopropylidene-Beta-D-Fructopyranose Sulfamate?
2% 2C3% 3A4% 2C5 - Di - O - Isopropylidene - Beta - D - Fructopyranose Sulfamate, this compound is often used in the field of medicinal chemistry and organic synthesis.
In medicinal chemistry, due to its unique chemical structure, it can be used as a key intermediate to create new drugs. In the process of drug development for specific diseases, it is necessary to use this compound to construct special active groups to achieve precise effects on disease targets. For example, in the early research stage of some antiviral and anti-tumor drugs, this compound will be used to build a basic structure framework, and then modified and optimized to improve drug activity and selectivity.
In the field of organic synthesis, it is like an important cornerstone. Organic synthesis aims to build complex organic molecules, which can participate in the construction of more complex and functional organic compounds through specific reactions, such as nucleophilic substitution, redox, etc. When synthesizing carbohydrate derivatives with special optical or biological activities, it can be used as a starting material and converted through a series of reactions to generate target products with diverse structures, which greatly enriches the types and structures of organic compounds and provides important support for the development of organic synthesis chemistry.
2, 3:4, What is the preparation method of 5-Di-O-Isopropylidene-Beta-D-Fructopyranose Sulfamate?
2% 2C3% 3A4% 2C5 - Di - O - Isopropylidene - Beta - D - Fructopyranose Sulfamate is 2,3:4,5 - Di - O - Isopropylidene - β - D - Furofructose Aminosulfonate, which is prepared as follows:
First take an appropriate amount of β - D - Furofructose and place it in a clean reaction vessel. Dissolve it in an appropriate amount of organic solvent, such as dichloromethane, chloroform, etc., so that β - D - Furofructose is evenly dispersed in it.
Then, add a certain amount of 2,2-dimethoxypropane as an isopropylation reagent, and add an appropriate amount of acidic catalyst, such as p-toluenesulfonic acid. The amount of this catalyst needs to be precisely controlled. If it is too small, the reaction will be slow, and if it is too much, it may cause more side reactions. Stir continuously at a moderate temperature, such as 25 ° C to 40 ° C. During this process, closely observe the reaction process, which can be monitored by thin-layer chromatography (TLC) method. When β-D-fructose is fully reacted with 2,2-dimethoxypropane, 2,3:4,5-di-O-isopropylene - β - D-fructose is generated.
Subsequently, the reaction system is cooled to 0 ° C to 5 ° C, and the sulfamic acid or its active derivative, such as sulfamyl chloride, is slowly added dropwise. The dropwise addition process must be slow to prevent the reaction from being too violent. After the dropwise addition is completed, gradually heat up to room temperature and continue to stir for several hours. During this period, the sulfamic acid or its derivative reacts with 2,3:4,5-di-O-ipropylenyl - β - D-fructose to form the target product 2,3:4,5-di-O-ipropylenyl - β - D-fructose sulfamate.
After the reaction is completed, the reaction mixture is post-processed. First, an appropriate amount of alkaline solution, such as sodium bicarbonate solution, is washed to neutralize the remaining acidic substances. Then the organic phase is extracted with an organic solvent to collect the organic phase. The organic phase is dried with a desiccant such as anhydrous sodium sulfate to remove the moisture. Finally, the organic solvent is removed by vacuum distillation to obtain a crude product. Further purification by column chromatography or recrystallization can obtain a high purity of 2,3:4,5-di-O-isopropylene - β - D-fructose furan sulfonate.
2, 3:4, What are the physical and chemical properties of 5-Di-O-Isopropylidene-Beta-D-Fructopyranose Sulfamate?
2% 2C3% 3A4% 2C5 - Di - O - Isopropylidene - Beta - D - Fructopyranose Sulfamate, the physical and chemical properties of this substance, let me tell you one by one.
Looking at its properties, at room temperature, it may be white to white crystalline powder, uniform and delicate. Its color is pure, just like the whiteness of the first snow, without noise.
Talking about the melting point, after many researchers have investigated, it is about a specific temperature range, which is the critical temperature for it to change from solid to liquid. When the external temperature gradually rises to this domain, the orderly arrangement of the lattice of this substance is gradually broken, and the thermal motion of the molecules intensifies, so it melts from solid to liquid.
In terms of solubility, it varies in common organic solvents. In some polar organic solvents, such as alcohols, it may exhibit a certain solubility and can interact with solvent molecules through hydrogen bonds and other forces to disperse uniformly. However, in non-polar solvents, such as alkanes, its solubility is very small, because the molecular polarity is quite different from that of non-polar solvents, and it is difficult to miscible with each other.
Stability is also an important property. Under normal storage conditions, in a dry and cool place, this substance is relatively stable and the molecular structure is not easy to change. However, if exposed to high temperature, high humidity or strong light environment, its structure may be affected and decomposition or other chemical reactions occur. For example, at high temperatures, chemical bonds within molecules may break due to excessive energy, causing chemical changes and altering their original properties.
The physical and chemical properties of this substance are of great significance in many fields such as chemistry and medicine, laying the foundation for related applications.
2, 3:4, what is the demand for 5-Di-O-Isopropylidene-Beta-D-Fructopyranose Sulfamate in the market?
In today's world, the demand situation of 2% 2C3% 3A4% 2C5 - Di - O - Isopropylidene - Beta - D - Fructopyranose Sulfamate in the market is quite complex. This product is useful in chemical, pharmaceutical and other fields.
In the chemical industry, or as a key raw material for the synthesis of specific compounds, its unique structure can lead to the birth of novel compounds, providing possibilities for the innovation of chemical products. Therefore, the chemical industry has considerable demand for its purity and output. It is hoped that its supply will be stable and of high quality, so as to facilitate the smooth chemical production process.
In the pharmaceutical field, or involved in drug research and development. Its chemical properties may become the active ingredients of new drugs or play an important intermediate role in the drug synthesis process. It is a pharmaceutical developer who has extremely strict quality control, and needs or focuses on precise chemical properties and extremely low impurity content to ensure the effectiveness and safety of drug development.
However, looking at the market, its demand is also influenced by many factors. With the advance of technology, if there are new synthesis methods or alternatives in the world, the demand may change. The ups and downs of the economic situation will also affect the intensity of enterprises' investment in R & D and production, which in turn affects the market demand for this product. Furthermore, the regulation of the chemical and pharmaceutical industries by regulations and policies will also have an impact on the demand of 2% 2C3% 3A4% 2C5 - Di - O - Isopropylidene - Beta - D - Fructopyranose Sulfamate. Or due to the issuance of new regulations, enterprises need to adjust their production processes, and their needs will also change. In short, its demand in the market is actually a dynamic change, influenced by multiple forces such as technology, economy, and policy.
2, 3:4, What safety matters need to be paid attention to when using 5-Di-O-Isopropylidene-Beta-D-Fructopyranose Sulfamate
2% 2C3% 3A4% 2C5 - Di - O - Isopropylidene - Beta - D - Fructopyranose Sulfamate is a special chemical substance. When using, all safety matters need to be paid attention to.
Bear the brunt first, and the protective equipment must be comprehensive. This substance may be harmful to the human body, so the experimenter can resist the splash of chemicals in front of suitable protective clothing to protect the body. Wear protective gloves to avoid contact with the hand skin and cause adverse reactions. Eye protection is also indispensable. Protective glasses or masks can protect the eyes from damage.
Furthermore, the operating environment is extremely critical. It is suitable for a well-ventilated place. If it is in a confined space, the volatile gaseous components or accumulation of the substance will not only increase the risk of poisoning, but also the risk of explosion. Ventilation equipment can disperse harmful gases in time to keep the air fresh.
And the properties of the substance should also be known in detail. Understand its chemical activity, stability, etc., in order to avoid improper operation. If it is heated, easy to decompose or explode in an open flame, keep away from heat sources and fire sources. Handle it with care during operation to prevent accidents due to impact and friction.
After the operation is completed, it is also important to clean it up properly. Residual substances should not be discarded at will. Dispose of them in accordance with relevant regulations to prevent pollution to the environment. The utensils used also need to be washed for next use. In conclusion, when using 2% 2C3% 3A4% 2C5 - Di - O - Isopropylidene - Beta - D - Fructopyranose Sulfamate, all safety matters should be treated with caution to ensure the safety of personnel and the environment.
