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What are the chemical properties of 1- (2 '-methyl-4' -sulfonic acid-6 '-chloro) phenyl-3-methyl-5-pyrazolone
1 - (2 '-methyl-4' -hydroxy-6 '-chloro) benzyl-3-methyl-5-p-phenoxybenzoic acid, which is an organic compound with unique chemical properties.
Looking at its structure, it has specific physical and chemical properties due to the presence of methyl, hydroxyl, chlorine atoms and phenoxy groups. The presence of hydroxyl groups makes the compound hydrophilic to a certain extent. Because hydroxyl groups can form hydrogen bonds with water molecules, they may have a certain solubility in polar solvents. The methyl group is alkyl and has certain hydrophobicity, which will affect the solubility and intermolecular forces of the compound in different solvents.
The introduction of chlorine atoms changes the distribution of molecular electron clouds and enhances molecular polarity, which has a great impact on its chemical activity. Chlorine atoms have electron-withdrawing properties, which can reduce the electron cloud density of benzene rings, making the benzene rings connected to them more prone to electrophilic substitution reactions.
Looking at the phenoxy group, this structure endows the compound with a certain rigidity and conjugate system, which has an important impact on its stability and optical properties. The existence of the conjugate system may cause the compound to have specific absorption in the ultraviolet-visible region, or to have a certain color. At the same time, the rigid structure affects the way of molecular accumulation, which in turn affects the physical properties such as melting point and boiling point.
In addition, the overall structure of the compound may cause it to have certain biological activities. In the field of medicine or pesticides, compounds with such structures may be used as potential lead compounds, which can be modified and optimized to develop drugs or pesticide products with specific biological functions.
What is the main use of 1- (2 '-methyl-4' -sulfonic acid-6 '-chloro) phenyl-3-methyl-5-pyrazolone?
1 - (2 '-methyl-4' -hydroxy-6 '-alkyl) phenyl-3-methyl-5-hydroquinone, which is mainly used as an antioxidant. It has important applications in many fields.
In the oil and food industries, it can effectively delay the oxidative rancidity of oil, prolong the shelf life of food, and protect the flavor and quality of food. In the plastics and rubber industries, it can prevent the performance deterioration of polymer materials due to oxidation, such as aging, brittleness, discoloration, etc., and improve the durability and stability of plastic and rubber products. In the field of cosmetics, it can protect the oils, fragrances and other ingredients in cosmetics from oxidation, maintain the stability and efficacy of cosmetics, and protect the skin from free radical damage, which has a certain skin care effect. In the pharmaceutical industry, it can prevent the oxidative deterioration of active pharmaceutical ingredients and ensure the quality and efficacy of medicines.
With its antioxidant properties, this substance plays a key role in many industries, helping to maintain product quality and performance and prolong service life.
What is the synthesis method of 1- (2 '-methyl-4' -sulfonic acid-6 '-chloro) phenyl-3-methyl-5-pyrazolone
To prepare 1 - (2 '-methyl-4' -hydroxy-6 '-chloro) benzyl-3-methyl-5-p-methoxybenzoic acid, the following ancient methods can be used.
First take appropriate raw materials, use 2' -methyl-4 '-hydroxy-6' -chlorobenzoic acid as the starting material, and introduce benzyl groups through specific reaction conditions. This process requires careful selection of reagents and regulation of reaction temperature, time and other factors. First, 2 '-methyl-4' -hydroxy-6 '-chlorobenzoic acid can be placed in a suitable reaction vessel, and an appropriate amount of solvent, such as dichloromethane, N, N-dimethylformamide, etc., can be added to facilitate the reaction to proceed uniformly.
After that, reagents that can provide benzyl groups, such as benzyl halides, are added in the presence of bases to promote nucleophilic substitution reactions. The choice of bases is crucial. Inorganic bases such as potassium carbonate and sodium carbonate are commonly used, or organic bases such as triethylamine, depending on the specific situation of the reaction. Control the reaction temperature, usually between room temperature and moderate heating, and continue to stir to make the reactants fully contact and react. After a certain time of reaction, the reaction process can be monitored by thin layer chromatography. When the raw material point disappears or reaches the expected degree of reaction, the reaction is terminated.
Then the reaction mixture is treated, such as washing with an appropriate acid or alkali solution to remove impurities, and then extraction, drying, concentration and other steps to obtain the preliminary product.
For the 3-methyl-5-p-methoxybenzoic acid part, it also needs to be carefully synthesized. First, the corresponding phenolic compound, such as p-methoxyphenol, is introduced into the methyl group by methylation reaction. Methylating reagents such as dimethyl sulfate can be selected to react in an alkaline environment. Then through a series of reactions, the structure of benzoic acid is constructed, which involves the introduction of carboxyl groups and other steps, which can be achieved by classical organic synthesis methods, such as Grignard reagent method or nitrile hydrolysis method.
Finally, the benzyl-containing part and the 3-methyl-5-p-methoxybenzoic acid part are connected through suitable reaction conditions, such as condensation reaction, with dicyclohexyl carbodiimide (DCC) and other condensation agents in the presence of appropriate catalysts, to promote the combination of the two. After subsequent purification, such as column chromatography, the target product 1 - (2 '-methyl-4' -hydroxy-6 '-chloro) benzyl-3-methyl-5-p-methoxybenzoic acid can be obtained. The whole synthesis process requires fine control of the reaction conditions in each step to obtain ideal results.
What are the precautions for storing 1- (2 '-methyl-4' -sulfonic acid-6 '-chloro) phenyl-3-methyl-5-pyrazolone?
If you want to store 1- (2 '-methyl-4' -hydroxy-6 '-alkyl) benzyl-3-methyl-5-p-methoxycinnamic acid, you need to pay attention to all things. This compound has unique structure and properties, and you should be careful when storing it.
The first choice of environment. Its properties may be sensitive to temperature and humidity. If the temperature is high, it may change its molecular activity, cause structural damage, and reduce its medicinal power. Therefore, it is advisable to choose a cool place, so that the temperature is constant in a moderate area, and do not allow heat to invade it. Humidity should also be suitable. If it is too humid, it is easy to deliquescent, and its purity will be damaged. If it is too dry or causes crystalline changes, it will not be good.
Check the quality of the packaging for the second time. Good materials must be used to prevent external intrusion. Choose a container with good air tightness to keep air and water vapor out. Because the air contains oxygen, or causes oxidation, the composition changes. Water vapor also disturbs its stability, and the packaging is not tight, and all previous efforts are wasted.
Furthermore, protection from light is also critical. This substance may be sensitive to light, and light exposure can promote its chemical reaction and destroy its structure. The place where it is hidden should be tightly shielded from light, and do not allow light to penetrate. If it is stored in a dark bottle, or stored in a dark room.
Also, the prevention of impurities from mixing in should not be ignored. The place where it is stored must be clean, and do not allow dust or foreign matter to mix with the compound. Impurities or side reactions can change its properties and affect quality.
In short, the storage of 1- (2 '-methyl-4' -hydroxy-6 '-alkyl) benzyl-3-methyl-5' -p-methoxycinnamic acid needs to be in a place with suitable temperature and humidity, airtight, dark and clean, so as to keep its quality stable, long-lasting and unchanged.
What are the safety risks of 1- (2 '-methyl-4' -sulfonic acid-6 '-chloro) phenyl-3-methyl-5-pyrazolone during use?
"Tiangong Kaiwu" says: Today there are 1- (2 '-methyl-4' -carboxyl-6 '-bromo) benzyl-3-methyl-5-terephthalonitrile, which poses a safety risk during use.
This compound contains bromine, cyanyl and other groups, bromine is toxic and corrosive. If people touch it, it can cause burns to the skin and eyes, if inhaled its volatile gas, or cause damage to the respiratory tract, causing coughing, asthma, and even respiratory distress.
Cyanyl is more toxic, and can release cyanide ions in the body. This ion can inhibit the respiratory chain of cells, making it difficult for cells to obtain energy, and causing tissue and organ failure. Small intake can cause headache, dizziness, nausea, and vomiting; if the amount is slightly larger, it is life-threatening, resulting in respiratory arrest and cardiac arrest.
And many organic compounds are flammable. If this substance encounters open flames, hot topics, or burns, or even explodes, it is necessary to strictly follow safety procedures during production, storage, transportation and use to prevent fires and explosions.
When operating, prepare comprehensive protective equipment, such as gas masks, protective gloves, goggles, etc. It is also necessary to work in a well-ventilated place to prevent the accumulation of harmful gases. Storage should be in a cool, dry and ventilated place, avoiding fire and heat sources, and stored separately from oxidants and acids to prevent mutual reaction.
In this way, it is possible to reduce its safety risks and ensure the safety of personnel and the environment.