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What is the chemical structure of the compound (1R, 2R, 1'R, 2'R) -2,2 '- {pentane-1,5-diylbis [oxy (3-oxopropane-3,1-diyl) ]} bis [1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bisphenyl sulfonate?
This is an extremely complex chemical substance, and its naming shows the rigor and delicacy of chemical naming rules. Looking at its name " (1R, 2R, 1'R, 2'R) -2,2 '- {piperidine-1,5-dimethyl bis [oxy (3-oxopropyl) ]} bis [1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline] bisbenzoate", its chemical structure needs to be analyzed step by step.
The first three-dimensional configuration, " (1R, 2R, 1'R, 2'R) " indicates the specific arrangement of atoms in space, laying the foundation for understanding the structure. "2,2 '- {Piperidine-1,5-diyl bis [oxy (3-oxopropyl) ]}" part, the piperidine ring is the core, and the 1,5-diyl group is connected with a bis [oxy (3-oxopropyl) ] structure, which is like a bridge to build a molecular local structure.
Look again at "Bis [1 - (3,4 - dimethoxybenzyl) -6,7 - dimethoxy - 2 - methyl - 1,2,3,4 - tetrahydroisoquinoline]", the two similar structures are connected in some way. The first position is connected with 3,4 - dimethoxybenzyl, the 6,7 position has dimethoxy, and the second position is methyl, and contains tetrahydroisoquinoline mother nucleus. This part forms the main framework of the molecule and affects the chemical and physical properties.
"Dibenzoate" indicates that there are benzoate groups attached at both ends of the molecule, giving it specific chemical activity and reaction characteristics. The structure of this chemical substance is complex, and each part interacts with each other to determine its unique chemical properties and potential applications. Although it is difficult to find the exact graphic structure in words, according to this naming convention, chemists can outline in their minds and even determine the true structure through experimental means, which is of great significance in the fields of chemical research and drug development.
(1R, 2R, 1'R, 2'R) -2,2 '- {pentane-1,5-diyl bis [oxy (3-oxopropane-3,1-diyl) ]} bis [1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bisbenzene sulfonate In what fields are they used?
(1R, 2R, 1 ′ R, 2 ′ R) - 2,2 ′ - {Piperidine-1,5-diyl bis [oxy (3-oxopropyl-3,1-diyl) ]} bis [1- (3,4-diethoxybenzoyl) -6,7-diethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline] dibenzoate has important applications in the field of medicine, especially in the development of drugs for neurological diseases.
In the era of "Tiangong Kaiwu", although there is no such precise chemical synthesis, it can be compared to the process of traditional drug processing and discovery. Ancient healers searched for herbs in nature, and after countless attempts, they understood their taste and efficacy. This chemical substance, if viewed from the perspective of ancient methods, may be regarded as a special "medicine" that needs to be delicately "processed" to obtain.
Today, this substance may be of great use in the drug research of neurological diseases such as Parkinson's and Alzheimer's disease. Its unique structure may be able to precisely act on specific targets of nerve cells, regulate neurotransmitter transmission, and reduce neuroinflammation, just like the ancients used different herbs to combine to achieve the purpose of eliminating diseases. "Processing" and synthesizing this substance through modern scientific means is expected to bring good news to patients with neurological diseases, just as the ancients discovered new herbal formulas and expanded the way to treat and save people.
What are the physicochemical properties of this compound (1R, 2R, 1'R, 2'R) -2,2 '- {pentane-1,5-diylbis [oxy (3-oxopropane-3,1-diyl) ]} bis [1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bisphenylsulfonate?
The physical and chemical properties of this compound ((1R, 2R, 1'R, 2'R) -2,2 '- {piperidine-1,5-diyl bis [oxy (3-oxopropyl) ]} bis [1- (3,4-diethoxybenzoyl) -6,7-diethoxy-2-ethyl-1,2,3,4-tetrahydroisoquinoline] bis hydrochloride) are as follows:
Its appearance may be white to off-white crystalline powder. In terms of solubility, because it is in the form of hydrochloride, it should have a certain solubility in water, and can form an ionic state to disperse in polar solvents. The melting point will be within a certain range due to the specificity of the compound structure, but it needs to be accurately determined by experiments. In terms of stability, the structure of the compound contains a variety of functional groups, such as piperidinyl, benzoyl, ethoxy, etc. The piperidinyl nitrogen atom has a certain alkalinity, and the formation of hydrochloride salt can be stabilized in an acidic environment, but under strong alkaline conditions, deprotonation may occur, which affects its structural stability. The carbonyl and ethoxy groups in the benzoyl group also have certain requirements for the chemical environment. Conditions such as high temperature, high humidity or light may prompt chemical reactions such as oxidation and hydrolysis. In addition, the compound has large molecules and complex structures, and intermolecular forces will also affect its physical properties, such as crystal structure and density in the solid state.
Due to the characteristics of polyfunctional groups in the structure, this compound has a potential variety of chemical activity check points, and will show different physical and chemical behaviors in different chemical environments. In-depth study of it needs to be combined with various analytical methods and experimental conditions. Accurate exploration.
Synthesis of (1R, 2R, 1'R, 2'R) -2,2 '- {pentane-1,5-diyl bis [oxy (3-oxopropane-3,1-diyl) ]} bis [1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] bisbenzene sulfonate What are the steps?
The method of synthesizing (1R, 2R, 1'R, 2'R) -2,2 '- {thiophene-1,5-diyl bis [oxo (3-oxo thioheterocyclobutane-3,1-diyl) ]} bis [1- (3,4-diethoxybenzoyl) -6,7-diethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline] bisbenzoate, the steps are as follows:
First, all raw materials need to be prepared, such as thiophene-containing structural raw materials with specific configurations, ethoxy-containing benzoyl raw materials, tetrahydroisoquinoline raw materials, etc., to ensure their purity and quality.
The initial reaction is based on the raw material containing the thiophene structure, so that it is combined with the oxo-thioheterocyclic butane raw material containing the appropriate substituent group, in a suitable reaction environment, or in an organic solvent, such as dichloromethane, N, N-dimethylformamide, etc., mixed in a specific ratio, adding an appropriate amount of catalyst, or alkali catalyst, such as potassium carbonate, triethylamine, etc., heated to a suitable temperature, or between 40 and 80 ° C. After several reactions, the two are condensed to obtain an intermediate containing thiophene and oxo-thioheterocyclic butane.
Furthermore, the obtained intermediate and the raw material containing 3,4-diethoxybenzoyl and tetrahydroisoquinoline structures are multiplexed in another reaction system in an appropriate ratio, or in a solvent such as toluene and acetonitrile, a specific reagent is added to promote the reaction, or a condensing agent such as dicyclohexyl carbodiimide (DCC), etc., at an appropriate temperature, or 60-100 ° C, when the reaction number is reached, the benzoyl group and tetrahydroisoquinoline structure are bonded to the thiophene-derived intermediate.
Finally, the above product and benzoic acid reagents, under the catalysis of acid or base, or p-toluenesulfonic acid, sodium hydroxide, etc., are heated and refluxed in suitable solvents, such as ethanol, acetone, etc. When the reaction number is counted, the target product (1R, 2R, 1'R, 2'R) -2,2 '- {thiophene-1,5-diyl bis [oxo (3-oxo thioheterocyclobutane-3,1-diyl) ]} bis [1- (3,4-diethoxybenzoyl) -6,7-diethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline] dibenzoate is purified by post-treatment, such as extraction and column chromatography.
Each step of the reaction requires fine temperature control, time control and control of the proportion of raw materials, and the post-processing must also be precisely operated to make the synthesis smooth and obtain the target product.
(1R, 2R, 1'R, 2'R) -2,2 '- {pentane-1,5-diyl bis [oxy (3-oxopropane-3,1-diyl) ]} bis [1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] What is the market prospect of bisphenylsulfonate?
(1R, 2R, 1'R, 2'R) -2,2 '- {Viper-1,5-diyl bis [oxy (3-oxopropyl-3,1-diyl) ]} bis [1- (3,4-diethoxybenzoyl) -6,7-diethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline] bisbenzoate, which is a rather complex organic compound.
Looking at its market prospects, the field of pharmaceutical research is currently enthusiastic about the exploration of complex organic compounds, and is committed to exploring their unique pharmacological activities to develop new drugs. Such compounds with complex structures may have novel biological activities and mechanisms of action. If they are deeply studied and optimized, they may become potential drugs for the treatment of difficult diseases.
Furthermore, with the rapid development of analysis and detection technology, the analysis of the structure and properties of such complex compounds is more accurate and efficient, laying the foundation for their development and application. The progress of chemical synthesis technology has also made it possible to produce such compounds on a large scale, and the cost is expected to be reduced.
However, its market prospects also have challenges. The synthesis process is complex, requiring high technology and expensive raw materials, and the production cost remains high. And the research and development cycle of new compounds is long, requiring strict safety and efficacy tests, investing huge manpower and material resources, and the risk of failure is also high.
In summary, the market prospect of (1R, 2R, 1'R, 2'R) -2,2 '- {Viper-1,5-diyl bis [oxy (3-oxopropyl-3,1-diyl) ]} bis [1- (3,4-diethoxybenzoyl) -6,7-diethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline] bisbenzoate has both opportunities and challenges. If it can break through the technical and cost bottlenecks, it may emerge in the fields of medicine.