(1S,9S)-1-Amino-9-Ethyl-5-Fluoro-9-Hydroxy-4-Methyl-1,2,3,9,12,15-Hexahydro-10H,13H-Benzo[De]Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-10,13-Dione Methanesulfonate Hydrate (1:1:2)

(This is to explain the structure of the chemical in an ancient classical style, trying to present its characteristics and compositions.)
This compound is named [ (1S, 9S) -1 -amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15 -hexahydro-10H, 13H -benzo [De] pyrano [3 ', 4': 6,7] indolo [1,2-B] quinoline-10,13-diketone methanesulfonate dihydrate (1:1:2) ].
Looking at its chemical structure, there is a specific spatial configuration in the molecule, and its stereochemistry is determined by (1S, 9S). Contains amino groups, which are active and reactive groups, often involved in various chemical transformations. 9-Ethyl, 4-methyl and 5-fluorine, are substitution of different hydrocarbon groups with halogen atoms, which affects the physical and chemical properties of molecules. 9-Hydroxy is a hydrophilic group, or affects solubility and reactivity.
The molecular core is a polycyclic system composed of the fused benzo [De] pyrano [3 ', 4': 6,7] indolo [1,2-B] quinoline. This complex and unique structure endows the molecule with special stability and activity. 10,13-diketone is a carbonyl functional group with certain reactivity and electronic effects.
Furthermore, the salt form is methanesulfonate, which forms or improves the solubility and stability of the compound. And contains dihydrates, water molecules bind to the main structure in a specific ratio, or affect the crystal structure and physicochemical properties. The structure of this compound is unique, and the interaction between each group and the structural fragment determines its special chemical properties and potential applications.

(1S, 9S) -1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H, 13H-benzo [De] pyrano [3 ′, 4 ′: 6,7] indolicino [1,2-B] quinoline-10,13-diketone methanesulfonate dihydrate (1:1:2), this is a complex organic compound. Its main uses are mostly related to the field of medicine.
The ancient medicine, tasting natural herbs and gold stones as medicine, with its nature and taste to heal diseases. Now this compound, or as a key component of pharmaceuticals, has been delicately synthesized and has a unique pharmacology. Or it can regulate human physiological functions, such as acting on specific cell receptors, interfering with cell signaling, and treating diseases.
Or it is effective in anti-tumor, and by virtue of its structural properties, it hinders the proliferation and metastasis of tumor cells, induces their apoptosis, and contributes to the development of anti-cancer drugs. Or it can play a role in the treatment of neurological diseases, regulating neurotransmitters, repairing damaged nerves, and alleviating symptoms.
In addition, it may also be used for immune regulation, enhancing the body's immunity, resisting the invasion of external evil, and protecting the health of the human body. This compound is like a precise key, opening the door of medical unknown, and contributing extraordinary power to human health and well-being.

To prepare (1S, 9S) -1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H, 13H-benzo [De] pyrano [3 ', 4': 6,7] indolo [1,2-B] quinoline-10,13-dione methanesulfonate dihydrate (1:1:2), the method is as follows:
First take an appropriate amount of (1S, 9S) -1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H, 13H-benzo [De] pyrano [3 ', 4': 6,7] indolo [1,2-B] quinoline-10,13-dione Place in a clean reaction vessel and dissolve with an appropriate amount of organic solvent to form a homogeneous solution. The organic solvent can be selected from dichloromethane, acetonitrile, etc. that do not chemically react with the reactants and products and have good solubility.
Take another appropriate amount of methanesulfonic acid and slowly add it dropwise to the above solution. When adding it dropwise, stir gently, and pay attention to the temperature of the reaction system. Control the temperature in a water bath or ice bath to maintain the temperature within a suitable range, generally about 0-30 degrees Celsius, so as not to cause the product to be impure due to too violent reaction. After adding it dropwise, continue to stir for a period of time to allow the reaction to proceed fully, ranging from a few hours to more than ten hours. The reaction progress can be monitored by thin layer chromatography or high performance liquid chromatography.
When the reaction reaches the desired level The concentration method can be reduced by vacuum distillation to reduce the distillation temperature and avoid the decomposition of the product by heat. Subsequently, an appropriate amount of deionized water is added to the concentrated residue, stirred evenly, and the residual impurities are fully dissolved. Then extract with an appropriate organic solvent, merge the organic phases after multiple extractions, and dry the organic phase with a desiccant such as anhydrous sodium sulfate to remove moisture. After
, the dried organic phase is concentrated again to obtain a crude product. The crude product is purified by recrystallization, and a suitable recrystallization solvent is selected, such as a mixed solvent of ethanol, ethyl acetate and petroleum ether, etc. The crude product is dissolved by heating, filtered while hot, and the filtrate is slowly cooled to crystallize. The precipitated crystals are collected by low temperature centrifugation or filtration, and washed with a cold recrystallization solvent to remove surface adsorbed impurities.
Finally, the resulting crystals were placed under vacuum drying at a suitable temperature to obtain the target product (1S, 9S) -1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H, 13H-benzo [De] pyrano [3 ', 4': 6,7] indolo [1,2-B] quinoline-10,13-diketone methanesulfonate dihydrate (1:1:2). Pay attention to the clean environment throughout the operation to avoid the mixing of impurities and affect the purity of the product.

(1S, 9S) -1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H, 13H-benzo [de] pyrano [3 ', 4': 6,7] indolicino [1,2-b] quinoline-10,13-diketone methanesulfonate dihydrate (1:1:2), although this medicine has the ability to cure diseases, it also has some drawbacks.
It may cause gastrointestinal discomfort, such as nausea, vomiting, abdominal pain, diarrhea, etc. After the drug is introduced into the body, it disturbs the transportation of the stomach, resulting in loss of dialysis, water and gluten do not melt and diarrhea, and stomach gas is reversed and vomiting.
It is also potentially harmful to liver function. Long-term or excessive use can fatigue the liver's function of dredging and detoxification, resulting in abnormal liver function indicators, such as elevated transaminase. The liver is the hub of human metabolism, and the bias of drugs can easily damage its harmony.
And it also affects the nervous system. Patients may feel dizziness, headache, fatigue, drowsiness, etc. Medicine enters the brain and disturbs the gods. If the sun does not rise, it will be dizzy, and if the spirit is suppressed, it will be sluggish and lethargic.
Furthermore, this medicine may cause allergies, such as rash, itching, etc. The defense of the human body and the medicine compete with each other, and the defense is out of harmony. If it occurs on the skin, it is a rash and itching. When taking medication, consider the various reactions carefully and weigh the pros and cons in order to make a comprehensive plan.

Nowadays, there are (1S, 9S) -1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H, 13H-benzo [de] pyrano [3 ', 4': 6,7] indolo [1,2-b] quinoline-10,13-diketone methanesulfonate dihydrate (1:1:2), and its market prospect is worth exploring.
Watching this product, in the field of pharmaceutical research and development, there may be an opportunity to emerge. In today's world, there are various diseases and medical needs are vast. This compound has a unique chemical structure, or it can have a miraculous effect on the treatment of specific diseases. If you can overcome difficult and miscellaneous diseases, you may be able to add a weapon to the doctor.
If you want to enter the market, there are many obstacles. The road to research and development is arduous and long, and it needs to go through layers of trials, from laboratory micro-observations to extensive clinical trials. There is no room for error. And there are many competing products of the same kind, if you want to stand out, you need to have something exceptional. If you can stand out in terms of curative effect, or far exceed others in terms of safety, you are expected to gain a place in the market.
Furthermore, market recognition is also related to many factors. Pricing needs to weigh costs and audience tolerance, and promotion needs to make doctors and patients aware of its advantages. Therefore, the market prospect of (1S, 9S) -1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H, 13H-benzo [de] pyrano [3 ', 4': 6,7] indolo [1,2-b] quinoline-10,13-diketone methanesulfonate dihydrate (1:1:2), although there is dawn ahead, but thorns are also accompanied, only with careful planning and hard work can we have great success.