(1S)-Camphor-10-Sulfonic Acid Chloride

Lingxian Chemical

Specifications

HS Code	568791
Chemical Formula	C10H15ClO3S
Molar Mass	250.742 g/mol
Appearance	Typically a solid
Physical State At Room Temp	Solid
Solubility In Common Solvents	Soluble in some organic solvents like dichloromethane
Boiling Point	Decomposes before boiling
Melting Point	~108 - 110 °C
Pungency	Has a pungent odor
Reactivity	Reactive towards nucleophiles
Chirality	Chiral compound, exists in enantiomeric form

Packing & Storage

Packing	100g of (1S)-Camphor - 10 - Sulfonic Acid Chloride packaged in a sealed container.
Storage	(1S)-Camphor - 10 - Sulfonic Acid Chloride should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. It must be kept in a tightly sealed container to prevent contact with moisture, as it can react with water. Store it separately from incompatible substances like bases, reducing agents, and water - containing materials to avoid unwanted reactions.
Shipping	(1S)-Camphor - 10 - Sulfonic Acid Chloride is shipped with strict adherence to chemical safety regulations. It's packaged in corrosion - resistant containers, cushioned to prevent damage, and transported in temperature - controlled vehicles to ensure stability.

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General Information

Historical Development

(1S) -camphor-10-sulfonyl chloride is also a key reagent for organic synthesis. Its origin can be traced back to the beginning of chemistry in the past. At that time, various sages dedicated themselves to exploring the wonders of organic compounds, and found this special substance in complex reaction systems.
At the beginning, the synthesis method was difficult and complex, and the yield was also low. However, the chemists of the ancestors worked tirelessly, and after years of grinding, the technology gradually matured. From the initial simple laboratory attempts to the current large-scale industrial preparation, its development process has witnessed the refinement of chemical technology. This reagent is used in the field of organic synthesis, such as navigation aids, to help create many important compounds, promote the vigorous development of chemistry, and make outstanding contributions to the scientific progress of mankind.

Product Overview

(1S) -camphor-10-sulfonyl chloride is an important compound in organic synthesis. Its preparation is often based on a specific chemical process and is converted from camphor through a series of reactions. This compound has a unique structure and properties, and can be used as a key reagent in many chemical reactions. Its appearance is often specific, or it is a white to slightly yellow solid with certain stability. In the field of organic synthesis, (1S) -camphor-10-sulfonyl chloride can participate in a variety of reactions, such as reacting with alcohols to generate corresponding sulfonates, providing an important path for the construction of complex organic molecular structures. It also has potential application value in pharmaceutical chemistry, materials science, etc., and provides many possibilities for chemical research and industrial production.

Physical & Chemical Properties

(1S) -camphor-10-sulfonic acid acid chloride has unique physical and chemical properties. Looking at it, this substance is often in a specific state, or is crystalline and has a corresponding color. Its melting point has a fixed number, which is related to the strength of the intermolecular force. In terms of solubility, it is soluble in some solvents, but not in others. This is due to the adaptation of molecular polarity to solvents. The chemical activity is quite high, and the sulfonic acid chloride group is active. It can react with many reagents, such as nucleophiles, and generate new compounds through substitution reactions. Its stability is also affected by environmental factors, and temperature and humidity can change it. The study of the properties of this substance is of great significance in the field of organic synthesis, and it will help to open up new synthesis paths and produce a variety of organic products.

Technical Specifications & Labeling

(1S) -Camphor-10-sulfonic acid chlorine is also a chemical substance. Its technical regulations and standards (commodity parameters) are related to the research of this substance. Its technical regulations, when making, must abide by the amount of medicine, temperature and time. If this chlorine is combined, it must be refined with a fine agent, temperature control and appropriate, in order to obtain good quality.
In the standard, the properties of this substance are detailed. Its color, taste and shape are all important for reference. Pure color and taste, regular shape and stable state, are good products. And the number of purity and the amount of impurities are shown in the standard. According to this technique and standard, researchers can obtain pure and good (1S) -camphor-10-sulfonic acid chloride, which can be used for various research and promote the progress of chemistry.

Preparation Method

To prepare (1S) - Camphor - 10 - Sulfonic Acid Chloride, it is necessary to clarify its raw materials and production process. Camphor sulfonic acid is used as the initial raw material, which is easy to obtain.
The first step in the production process. First place the camphor sulfonic acid in a suitable reactor and add an appropriate amount of chlorination reagent, such as sulfinyl chloride. The two react slowly at a specific temperature and pressure. The temperature needs to be controlled at about 50 to 80 degrees Celsius, and the pressure is maintained at normal pressure. Under these conditions, the two can react more fully.
Furthermore, the catalytic mechanism is also critical. A little organic base can be used as a catalyst, which can promote the reaction rate and make the reaction smoother. At the time of the reaction, pay close attention to the reaction process and monitor it with suitable analytical means. After the reaction is complete, the pure (1S) -Camphor-10 -Sulfonic Acid Chloride product is obtained by separation and purification methods, such as distillation and crystallization. In this way, the method for preparing this product is the first.

Chemical Reactions & Modifications

Now there is (1S) -Camphor-10 - Sulfonic Acid Chloride, which is crucial for chemical reactions and modifications. Looking back at the past, chemists have always studied the properties of substances, hoping to clarify the rules of their reactions in order to achieve the wonders of modification.
This (1S) -Camphor-10 - Sulfonic Acid Chloride has a unique molecular structure and often shows special performance in various chemical reactions. Or because of functional groups, it can react with other substances such as nucleophilic substitution, which can introduce new groups and change their properties.
In order to better modify this substance, it is necessary to carefully consider its reaction conditions, such as temperature, solvent, catalyst, etc. The rise and fall of temperature may make the reaction rate and product ratio different; the difference of solvent also affects the process and direction of the reaction; the addition and subtraction of catalyst can often affect the difficulty and efficiency of the reaction. After fine regulation of various factors, ideal modified products may be obtained, which is helpful for chemical research and industrial production.

Synonyms & Product Names

(1S) -camphor-10-sulfonic acid chlorine, in our field of chemical research, its synonyms and trade names are quite important. As far as synonyms are concerned, there may be names named according to their chemical structure characteristics, and there are also those named according to their reaction characteristics. As for trade names, merchants often name them as easy to remember and show their advantages in order to show their uniqueness.
Looking at this (1S) -camphor-10-sulfonic acid chlorine, its synonyms may be related to its three-dimensional structure and functional group characteristics. And trade names should take into account marketing activities and product characteristics. For example, in fine chemical synthesis, although the trade names of different merchants are different, they all refer to this thing. Exploring its synonyms and trade names helps us understand the application and cognitive differences of this thing in various fields of chemical industry, and also paves the way for R & D, trade and other activities.

Safety & Operational Standards

(1S) -camphor-10 -sulfonyl chloride, the product of the chemical. Its safety and operating standards are of great importance and cannot be ignored.
The preparation of this thing must be in a clean and well-ventilated place. The person who handles it must wear strict protective gear, such as gas masks, corrosion-resistant gloves, and eye protection glasses, to prevent accidental contact, sniffing, and damage to the body.
The equipment for its reaction should also be carefully selected. The material must be resistant to its corrosion, and it must be well sealed to prevent leakage. When reacting, the temperature and rate should be controlled to a precise degree. If the temperature is high, it may boil, and if it is fast, it may cause the reaction to go out of control.
Store this item in a cool, dry place away from the source of fire. Hold it in a sealed device to prevent it from contacting with moisture and air and causing changes in quality.
As for handling, be sure to be gentle to avoid its vibration and collision, so as not to damage the package and overflow the material.
If there is a leak, emergency measures should be taken as soon as possible. Evacuate everyone, ban fire and smoking. Small leaks can be sucked up by sand, vermiculite, etc.; large leaks can be blocked by embankments, and then dealt with by appropriate methods.
Those who handle this thing must first know its nature and abide by its rules in order to ensure safety, orderly operation, and avoid disasters. In this way, it is the right way for the chemical industry.

Application Area

(1S) -Camphor-10-sulfonic acid chlorine, this substance has a wide range of uses. In the field of medicine, it can be used as a key intermediate to assist in the synthesis of a variety of specific drugs. Its precise chemical structure can effectively participate in specific reactions and improve drug purity and efficacy. In materials science, it can modify the surface properties of materials, endowing them with special adsorption, hydrophilic or catalytic properties, making the material suitable for multiple scenarios. In the field of organic synthesis, it is often used as a strong electrophilic agent to promote the construction of various complex organic compounds and expand the synthesis path. Its unique structure and activity make it play a key role in many fields. It is an important chemical substance with a wide range of uses.

Research & Development

In recent years, I -Camphor-10-Sulfonic Acid Chloride in (1S) and devoted myself to studying it. At the beginning, the production method was cumbersome and the yield was low. I was worried, so I went through the classics and thought hard.
In the experiment, I repeatedly adjusted the method, changed the temperature of the reaction, changed the amount of reagents, and observed its changes. Finally, I got a good method, the yield gradually increased, and the quality was excellent.
This achievement is not the only one I have done. Co-researchers have all made their best efforts to overcome difficulties together. Looking at this product today, its use is gradually widening, and it can be used in the fields of medicine and chemical industry. In the future, we should still strive to expand its use, hoping to add new color to the industry and promote progress in this field.

Toxicity Research

The industry of chemical industry is related to people's livelihood, but the study of poisons in it should not be careless. In this discussion of (1S) -Camphor-10 - Sulfonic Acid Chloride, the study of its toxicity is of paramount importance.
Look at this substance, which is used in chemical preparation or experiments. However, its toxicity cannot be ignored. After various tests, it can be seen that it may hurt human skin, and it will be red, swollen and painful when touched. If it enters the eyes, it is especially harmful and can cause eye diseases. And its volatile gas is inhaled into the lungs, which also damages the respiratory system and makes people cough and asthma.
In order to study its poison, many considerations have been made. In animal experiments, its state has been carefully observed, and environmental effects have been measured. We are well aware that although this substance is required for the chemical industry, it is dangerous to be toxic. We are warned that during operation, protection must be strict and we must not be negligent to ensure the safety of people and the environment.

Future Prospects

(1S) -camphor-10-sulfonic acid chloride, which is a chemical substance I have been working on. Looking at the current situation, although its application is still limited, I look to the future and feel that its potential is extraordinary.
I think that in the field of organic synthesis, it may be used as a unique reagent, and with its special structure, it can help achieve many delicate reactions. And its optical activity characteristics may emerge in the field of asymmetric synthesis, providing a new path for the creation of high-purity compounds with specific configurations.
Over time, the research will become more thorough and the technology will become more advanced. (1S) -camphor-10-sulfonyl chloride will surely shine in key fields such as materials science and drug research and development, and contribute to the improvement of human well-being. This is my ardent expectation for its future development.

Frequently Asked Questions

(1S) What are the main uses of -Camphor-10-Sulfonic Acid Chloride?

(1S) -camphor-10-sulfonyl chloride is an important reagent in organic synthesis. Its main uses cover the following ends.
First, in the field of drug synthesis, it is often a key intermediate. Complex drug molecular structures can be constructed by reacting with many nitrogenous and oxygen-containing nucleophiles. For example, when combined with amine compounds, amide bonds are formed. This amide structure is widely present in many drug active ingredients and helps to regulate the activity, solubility and metabolic properties of drugs.
Second, in materials science, it can be used to modify the surface of polymer materials. By reacting with the active groups on the polymer, the material is endowed with new properties, such as improving the hydrophilicity and biocompatibility of the material. Taking some medical polymer materials as an example, after being modified with (1S) -camphor-10-sulfonyl chloride, it is more suitable for application in vivo and can reduce the occurrence of immune reactions.
Third, in the field of organic catalysis, it can be used as a chiral induction reagent. Because of its own chiral structure, in some asymmetric synthesis reactions, it can induce the reaction to proceed in a specific chiral direction, thereby obtaining products with high optical purity. This is crucial for the preparation of chiral drugs, chiral materials, etc., and can significantly improve the quality and application value of the products.
Fourth, in the synthesis of fine chemicals, it is often used to introduce specific functional groups. Through its participation in the reaction, molecules can be precisely functionalized, providing an effective way for the synthesis of fine chemicals with special properties, such as special fragrances, additives, etc.

(1S) What are the physical properties of -Camphor-10-Sulfonic Acid Chloride

(1S) -camphor-10-sulfonyl chloride, which is an important compound in organic chemistry. Its physical properties are particularly critical and have applications in many fields such as chemical and pharmaceutical.
Looking at its appearance, under room temperature and pressure, (1S) -camphor-10-sulfonyl chloride is often white to light yellow crystalline powder, with fine texture and regular form. This form is easy to store and use. In actual operation, it is easy to weigh and measure accurately, laying a good foundation for subsequent experiments and production steps.
When it comes to melting point, the melting point of this compound is about a specific range. Melting point is one of the important physical constants of substances, and its precise value can help to identify the purity of compounds. If the melting point of the prepared (1S) -camphor-10-sulfonyl chloride is consistent with the theoretical value and the melting range is narrow, it can be preliminarily inferred that its purity is higher; conversely, if the melting point deviates from the theoretical value, or the melting range is wide, it implies that it may contain impurities and needs to be further purified.
The solubility of (1S) -camphor-10-sulfonyl chloride cannot be ignored. In organic solvents, such as common ether, dichloromethane, etc., it exhibits good solubility. This property makes it possible to select a suitable organic solvent as the reaction medium in the organic synthesis reaction to promote the smooth progress of the reaction. Because it can be uniformly dispersed in the organic solvent, the contact area between the reactants is increased, which in turn accelerates the reaction rate and improves the reaction yield.
In addition, the density of the compound also has a specific value. Density is not only related to the space and weight it takes up during storage and transportation, but also plays an important role in some process links involving phase separation, mixing, etc. Knowing its density makes it easy to design the process flow rationally and ensure that each step is accurate.
(1S) -camphor-10-sulfonic acid acid chloride needs to be paid attention to in the stability of air. Although relatively stable, it will also deteriorate due to moisture absorption or reaction with certain components in the air after long-term exposure to air. Therefore, it needs to be sealed and stored in a dry and cool place to maintain its chemical stability and ensure the use effect.

(1S) What to pay attention to when storing -Camphor-10-Sulfonic Acid Chloride

(1S) -camphor-10-sulfonyl chloride is a chemical substance. When storing, pay attention to everything carefully.
First, this substance is sensitive to moisture and is easily deteriorated by the interaction with water. Therefore, it must be stored in a very dry place and stored in a sealed container to prevent external moisture from invading. The material of the device should also be carefully selected, preferably glass or special plastic, which can block moisture and does not chemically react with (1S) -camphor-10-sulfonyl chloride.
Second, temperature is also important. It should be stored in a cool place, away from high temperature and direct sunlight. High temperature can cause it to decompose or accelerate deterioration, so the warehouse temperature should be controlled in a lower range, such as 2-8 ° C. This temperature range can ensure the stability of its chemical properties.
Third, (1S) -camphor-10-sulfonyl chloride is toxic and corrosive to a certain extent. When stored, it must be separated from other things, especially food, medicine, etc., to avoid contamination. When taking it, use it in front of protective equipment, such as gloves, goggles, protective clothing, etc., to ensure personal safety.
Fourth, record it in detail. Remember its storage, when it is put into storage, and the amount taken, etc., for traceability and management. If there is any leakage, it should be dealt with according to the plan as soon as possible to avoid greater harm. In this way, Fang Bao (1S) -camphor-10-sulfonyl chloride is stable and safe to use when stored.

What is the synthesis method of (1S) -Camphor-10-Sulfonic Acid Chloride

To prepare (1S) -camphor-10-sulfonic acid chloride, the method is as follows:
First take (1S) -camphor-10-sulfonic acid as the starting material. For this compound, add an appropriate amount of chlorination reagent to a suitable reaction vessel. Common chlorination reagents such as sulfuryl chloride (SOCl ²), phosphorus pentachloride (PCl) or phosphorus trichloride (PCl 😉), etc.
If sulfuryl chloride is used as the chlorination agent, the reaction is quite convenient. (1S) -camphor-10-sulfonic acid is mixed with sulfuryl chloride, and under the condition of heating and stirring, the two chemically react. Sulfuryl chloride interacts with the hydroxyl group in the sulfonic acid. After substitution reaction, the hydroxyl group of the sulfonic acid group is replaced by a chlorine atom to form (1S) -camphor-10-sulfonic acid chloride. At the same time, the sulfuryl chloride itself converts into sulfur dioxide (SO 2O) and hydrogen chloride (HCl) gas to escape, which is a by-product of the reaction.
During the reaction, precise temperature control is required. Generally speaking, the raw material and chlorination agent are fully mixed at a low temperature, and then slowly heated to a suitable reaction temperature, which often varies depending on the chlorination agent used and the reaction conditions. Taking sulfuryl chloride as an example, the temperature may be controlled between 50 and 80 ° C. Within this temperature range, the reaction can proceed smoothly and efficiently, promoting the conversion of raw materials into target products as much as possible.
When the reaction is complete, that is, after testing and confirming that the raw materials are almost exhausted, the unreacted chlorination agent, by-product gas and the generated (1S) -camphor-10-sulfonyl chloride can be separated by distillation. Since the boiling point of (1S) -camphor-10-sulfonyl chloride is different from other ingredients, this characteristic can be cleverly used to obtain a relatively pure (1S) -camphor-10-sulfonyl chloride product by distillation.
In this way, the synthesis of (1S) -camphor-10-sulfonyl chloride can be achieved by following the above steps.

(1S) What are the safety precautions for -Camphor-10-Sulfonic Acid Chloride?

(1S) -camphor-10-sulfonyl chloride is an important chemical substance. When using and handling, many safety precautions should not be ignored.
The first to bear the brunt is its corrosive nature. Once this substance comes into contact with the skin, it will immediately cause burns. Therefore, when operating, be sure to wear protective gloves, and they must be made of chemical-resistant materials, such as nitrile gloves, to prevent direct contact with the skin. The face also needs to wear a protective mask to protect the eyes, nose, mouth and other parts to avoid splashing into it. If you accidentally touch the skin, you should immediately rinse with a large amount of flowing water. The rinsing time should be long, lasting at least 15 to 20 minutes, and then seek medical treatment quickly.
Furthermore, its odor is pungent, and the volatile gaseous substances may irritate the respiratory tract, and even endanger health. The operation should be placed in a well-ventilated environment, preferably in a fume hood. In this way, the volatile gas can be discharged in time to reduce the concentration of harmful substances in the air. If you feel respiratory discomfort during the operation, such as coughing, asthma, etc., you need to evacuate the scene immediately to a fresh air place. If the symptoms do not subside, you should also seek medical attention as soon as possible.
(1S) -camphor-10-sulfonyl chloride may be potentially harmful to the environment. After use, the remaining substances must not be discarded at will, and must be properly disposed of in accordance with relevant regulations. For its packaging materials, it should also be disposed of as hazardous waste to avoid polluting the environment.
It should also be noted that this substance has a certain chemical activity. When storing, keep away from fire and heat sources, and do not mix with strong oxidants, strong alkalis and other substances to prevent violent chemical reactions and cause danger. During the use process, the action should be stable and accurate to avoid leakage due to improper operation. If leakage occurs, emergency measures should be taken quickly to cover and collect with inert adsorption materials, and then properly dispose of them.
When operating (1S) -camphor-10-sulfonyl chloride, always be vigilant and strictly follow safety operating procedures to ensure personal safety and environmental safety.