As a leading 2,2,2-Trifluoroethyl P-Toluenesulphonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 2,2,2-trifluoroethyl p-toluenesulfonate?
Triethylamino p-acetylaniline sulfonamide, this is a good medicine, and its main function is quite critical.
Its primary effect is anti-inflammatory. In many inflammatory symptoms, it can effectively relieve inflammatory reactions and relieve redness, swelling, heat and pain. Because triethylamino p-acetylaniline sulfonamide can precisely act on the cellular and molecular pathways related to inflammation, inhibit the release of inflammatory mediators, and then regulate the inflammatory process. If the skin is inflamed, applying this medicine can make the redness and swelling gradually disappear and the pain subside.
Secondly, it has antibacterial effect. It can inhibit the growth of a variety of bacteria and build a defense against bacterial invasion. Whether it is Gram-positive bacteria or Gram-negative bacteria, it can hinder the growth and reproduction under its action. For example, when respiratory tract infections occur, bacteria cannot multiply freely under its medicinal power, thus helping the body restore health.
Furthermore, it can regulate immunity. Human immunity is like the guard of the city, and triethylamino p-acetylaniline sulfonamide can make the immune function reach a balanced state. If the immunity is too strong, it can be moderately lowered to prevent autoimmune diseases; if the immunity is weak, it can be stimulated to enhance the body's resistance to pathogens.
And in the treatment of some diseases, it can be used as an auxiliary agent. Used in combination with other drugs, it can increase the curative effect and accelerate the recovery process. For example, in the treatment of some complex diseases, in conjunction with other drugs, it can achieve twice the result with half the effort. In short, triethylamino p-acetylaniline sulfonamide plays a significant role in the field of medicine, relieving pain for many patients and maintaining health.
What are the synthesis methods of 2,2,2-trifluoroethyl p-toluenesulfonate
There are several methods for the synthesis of triethylamino paracetamol ester. One common one is to start with paracetamol and obtain it through acylation.
Take an appropriate amount of paracetamol first, place it in a clean reactor, add an appropriate amount of solvent, such as dichloromethane, N, N-dimethylformamide, etc., to fully dissolve it. Then slowly add acylating reagents, such as acetyl chloride, acetic anhydride, etc., and add an appropriate amount of catalyst, such as 4-dimethylaminopyridine (DMAP), to promote the reaction. The reaction process needs to be carefully controlled, generally maintained at a low temperature, such as 0-5 ° C, to prevent side reactions. After the reaction is completed, the product is purified by extraction, washing, drying, column chromatography and other means.
The second method is to use aminophen as the starting material. First, the aminophen is reacted with an appropriate protective group, such as t-butoxycarbonyl (Boc) to protect the amino group to generate Boc-aminophen. Then the product is reacted with an acetylating agent to obtain acetylated Boc-paracetaminophen. Finally, the protective group is removed to obtain acetaminophen. Then, according to the previous method, the acylation reaction is carried out to obtain triethylamino paracetaminophen. In this process, the introduction and removal of protective groups need to be selected to prevent damage to the structure of the product.
There are also those who use p-nitrophenol as the starting material. First, p-nitrophenol is reduced to aminophenol. The commonly used reducing agents are iron filings-hydrochloric acid, tin-hydrochloric acid, etc. Then according to the above method of using aminophenol as the starting material, the target product is synthesized through the steps of protection, acetylation, de-protection and acylation.
All synthesis methods have advantages and disadvantages. The selection of starting materials, the control of reaction conditions, and the purification of the product are all the keys to the success or failure of the synthesis. It needs to be considered in detail according to the actual situation before satisfactory results can be obtained.
What are the physical properties of 2,2,2-trifluoroethyl p-toluenesulfonate
Triethylamino paracetaminophen is a commonly used pharmaceutical ingredient. Its physical properties are unique.
Looking at its properties, under room temperature, it often appears white or off-white crystalline powder, which makes it easy to identify and handle. Its texture is delicate and feels good.
When it comes to solubility, it has a certain solubility in organic solvents, such as ethanol, acetone, etc. It can be well dispersed in such solvents. This property is convenient for making different dosage forms, such as solutions, injections, etc., in the process of drug preparation to meet various drug needs. However, in water, the solubility is relatively limited, but with the assistance of an appropriate amount of co-solvents or solubilizers, its solubility in water can also be moderately improved.
In terms of melting point, it has a specific melting point range, which is one of the important indicators for identifying its purity. Accurate melting point determination can determine whether the substance meets Quality Standards.
In terms of stability, under conventional storage conditions, the properties are relatively stable. However, if placed in a high temperature, high humidity or direct light environment, it may cause certain chemical changes, resulting in damage to its quality. Therefore, when storing, pay attention to avoiding light, sealing, and storing in a cool and dry place.
The physical properties of triethylamino paracetamol play an important role in drug development, production, and storage, affecting the quality and efficacy of drugs.
What should be paid attention to when storing and transporting 2,2,2-trifluoroethyl p-toluenesulfonate?
"On the Precautions for the Storage and Transportation of Triethyl Paracetaminophen Elixir"
For those who use triethyl paracetaminophen elixir, many matters need to be carefully paid attention to during storage and transportation.
First of all, storage, this drug is delicate and sensitive to the environment. First, temperature is very important. It should be stored in a cool place. If it is in a high temperature environment, the ingredients in the drug may change, causing its curative effect to be damaged. Just like the heat of the summer, the sun is like fire. If this agent is exposed to the sun, the power of the drug will decrease in a few days. Therefore, the temperature of the warehouse should be controlled within an appropriate range and should not be overheated. Second, the humidity should not be underestimated. If the humidity is too high, the medicine may deteriorate due to moisture, just like being placed in a hazy place, and the utensils are prone to mildew and rot. It is necessary to keep the warehouse dry to prevent moisture from eroding the medicine. Third, light is also the key. This medicine should be stored in the dark, with strong light shining directly, or causing a chemical reaction, which will damage its quality. It should be stored in a light-shielding device and hidden in the dark.
As for transportation, the road is bumpy and the environment is changeable, so you need to be more cautious. First, the packaging must be solid. The container of the medicine, when properly designed, can withstand shocks and collisions during transportation. If the packaging is rough and the bottle breaks and leaks liquid, not only will the medicine be destroyed, but also the people and things transported may be endangered. Second, the environment of the transportation vehicle also needs to be paid attention to. The temperature and humidity inside the vehicle should be Third, the time limit for transportation is also considered. It is advisable to ship quickly, and do not keep the medicine on the way for a long time, so as to avoid quality changes due to time.
In short, when storing and transporting triethyl paracetamol elixir, temperature and humidity, light, packaging and transportation time are all key points, and must not be taken lightly. Careful care must be taken to ensure the quality and efficacy of the medicine.
What is the market price range for 2,2,2-trifluoroethyl p-toluenesulfonate?
Today there are 22-22, that is, triethyl p-toluenesulfonic anhydride. Its market price often varies due to various reasons.
Looking at the quality and quantity of its production, if the quality is high and the quantity is abundant, the price may be slightly flat; if the quality is thin and the production is low, the price will be high. And the technology of its production is also heavy, and the quality of the technology is pure, and the price should also be different.
The demand of the market also affects its price. If there are many users, the demand is too much, and the price will rise; if the demand is less and the supply is too much, the price will be depressed.
Furthermore, the difference between time and place, the price is also different. The price of raw materials varies from year to year, the price may fluctuate, and the place is far and near, and the transportation fee is also different, all of which make the price different.
Roughly speaking, the price range per catty may range from hundreds of gold to thousands of gold. This is only an approximate number. The market conditions are fickle, and the price is also fickle. Merchants should carefully observe the changes in the market to know the exact price.
