What is the chemical structure of 2- { (3α, 5β, 7β, 8o, 9o, 12α, 14o) -3,7,12-trihydroxy-24-oxycholane-24-yl] amino} ethanesulfonic acid
2-% { (3α, 5β, 7β, 8O, 9O, 12α, 14O) -3,7,12-triterpenoid-24-oxo-cholesterol-24-yl} ethoxy acid, the chemical structure of this compound needs to be explained by a lot of chemical knowledge and analytical means.
Analysis of the chemical structure of the husband, the identification of the first weight of each group. Looking at this formula, (3α, 5β, 7β, 8O, 9O, 12α, 14O) This part is the three-dimensional configuration of the molecule. Symbols such as α and β indicate the spatial orientation of the substituent. 3α means the α configuration at the 3-position substituent, and so on.
"Triterpenoid group", is a polycyclic structure with a specific carbon skeleton, common in natural products, with diverse biological activities. 3,7,12-triterpenoid group, with a triterpenoid structure at positions 3, 7, and 12.
"24-oxo cholesterol-24-yl", cholesterol structure is a typical skeleton of steroid compounds, 24-oxygen represents a carbonyl group at position 24 (C = O), and 24-group is shown at position 24 with a specific group.
And "ethoxy acid", the significant molecule contains ethoxy (-O-C ² H) and carboxyl (-COOH).
In summary, 2-% { (3α, 5β, 7β, 8o, 9o, 12α, 14o) -3,7,12-triterpenoid-24-oxocholesterol-24-yl} The structure of ethoxy acids is on a specific steroid skeleton, sequentially connected with triterpenoid groups and oxy groups with specific stereoconfigurations, and connected through specific carbon sites, terminating with ethoxy acid parts, forming a complex chemical structure. This structure or due to the interaction of various groups, the compound has unique physical, chemical and biological properties.
What is the main use of 2- { (3α, 5β, 7β, 8o, 9o, 12α, 14o) -3,7,12-trihydroxy-24-oxycholane-24-yl] amino} ethanesulfonic acid
2-% { (3α, 5β, 7β, 8o, 9o, 12α, 14o) -3,7,12-tricarbonyl-24-oxycholesterol-24-yl} ethyl ester acid, this compound has important uses in the field of medicine. Its main uses are as follows:
First, it can be used as a key intermediate in drug development. Many drugs for the treatment of cardiovascular diseases need to be structurally modified and modified on this basis in the synthesis process. Due to its unique chemical structure, it can impart specific activities to drug molecules, which helps to improve the affinity and selectivity of drugs to related targets in the cardiovascular system, so as to develop better cardiovascular drugs with less side effects.
Second, it is of great significance in the preparation of steroid hormone drugs. Steroid hormones play a key regulatory role in human growth, development, metabolism and other physiological processes. As an important steroid structural unit, this compound can be converted into different types of steroid hormone drugs through a series of chemical reactions for the treatment of endocrine disorders, autoimmune diseases, etc. For example, some steroid hormone drugs used in the treatment of rheumatoid arthritis may be synthesized using it as the starting material, and steroid hormone molecules with anti-inflammatory and immunomodulatory activities may be constructed through multi-step reactions.
Third, in the field of biochemical research, it can be used as a tool compound. Scientists use its structure and characteristics to study the metabolic pathways and mechanisms of action of steroids in biological bodies. By labeling the compound and tracking its metabolic process in vivo, we can gain a deeper understanding of the mechanisms of steroid transport, transformation, and interaction with receptors in cells, providing important data support for basic research in life sciences.
What is the safety of 2- { (3α, 5β, 7β, 8o, 9o, 12α, 14o) -3,7,12-trihydroxy-24-oxycholane-24-yl] amino} ethanesulfonic acid
2-%7B%283%CE%B1%2C5%CE%B2%2C7%CE%B2%2C8%CE%BF%2C9%CE%BF%2C12%CE%B1%2C14%CE%BF%29-3%2C7%2C12-%E4%B8%89%E7%BE%9F%E5%9F%BA-24-%E6%B0%A7%E4%BB%A3%E8%83%86%E7%83%B7-24-%E5%9F%BA%5D%E6%B0%A7%E5%9F%BA%E4%B9%99%E7%A3%BA%E9%85%B8%E7%9A%84%E5%AE%89%E5%85%A8%E6%80%A7%E5%A6%82%E4%BD%95%EF%BC%9F
Looking at this chemical substance, its structure and characteristics are related to safety. Among them, 2 - { (3α, 5β, 7β, 8Ω, 9Ω, 12α, 14Ω) - 3,7,12 - trihydroxy - 24 - oxidized cholesterol - 24 - yl} aminoacetic acid, although its details are not known, the chemical principle determines its structure and its properties are related to safety.
From its structure, trihydroxy, oxidation and other groups may cause it to have active chemical properties. Hydroxyl groups are easily involved in reactions, and the state of oxidation also affects their stability. If this substance is involved in production and storage, it must be handled with caution.
During production, the proportion of materials and reaction conditions need to be precisely controlled. Temperature, pressure, catalyst and other factors can change the reaction path, or things outside the business, causing potential safety hazards. A slight carelessness, or a violent reaction, such as the risk of combustion or explosion.
Storage also requires caution. Because it has specific chemical properties, or is sensitive to the environment. Temperature and humidity, light, and contact with other things all need to be considered. If stored in an improper place, or cause deterioration, lose its effectiveness, or even more, or cause dangerous reactions.
When using, it is also necessary to strictly abide by the procedures. Operators need to understand its nature and protect it well. Due to the unknown exact effects on the human body, improper contact can damage the skin, respiratory organs, or even endanger life.
In summary, this 2- { (3α, 5β, 7β, 8Ω, 9Ω, 12α, 14Ω) -3,7,12-trihydroxy-24-oxidized cholesterol-24-yl} aminoacetic acid, from production to use, all links must be in accordance with scientific methods, with caution to ensure safety.
What are the preparation methods of 2- { (3α, 5β, 7β, 8o, 9o, 12α, 14o) -3,7,12-trihydroxy-24-oxycholane-24-yl] amino} ethanesulfonic acid
To prepare di- { (3α, 5β, 7β, 8ω, 9ω, 12α, 14ω) -3,7,12-trihydroxy-24-oxocholesterol-24-yl} oxalic acid, the following ancient methods can be followed.
First, cholesterol is used as the beginning, and the 3-hydroxyl group is first oxidized to carbonyl. Commonly used oxidizing agents, such as Jones reagent, can convert the 3-hydroxyl group of cholesterol into the corresponding carbonyl compound under appropriate reaction conditions. Subsequently, side chains are introduced. A suitable organometallic reagent, such as Grignard reagent, reacts with a carbonyl-containing cholesterol derivative to construct a carbon skeleton of the side chain. During the reaction, it is necessary to pay attention to the reaction temperature, solvent and other conditions to promote the smooth reaction. After that, the side chain is oxidized and modified to obtain a 24-oxo structure. Oxidants such as chromic acid can be used to oxidize the side chain to a carbonyl group in an appropriate position. After condensation reaction, two modified cholesterol derivatives are condensed with oxalic acid derivatives to form the target oxalate. In this process, the choice of condensation agent is very critical, such as dicyclohexyl carbodiimide (DCC) with 4-dimethylaminopyridine (DMAP), which can efficiently promote the condensation reaction.
Second, the natural steroid compound is used as the starting material. If its structure is similar to the target, it can be obtained by the conversion of selective functional groups. First protect the functional groups on the steroid parent nucleus and side chain to prevent them from changing unprovoked in subsequent reactions. Use suitable protective groups, such as silicon ethers, to protect the alcohol hydroxyl groups. Next, carry out oxidation, reduction, substitution and other reactions on the places to be modified. For example, with an appropriate oxidizing agent, adjust the hydroxyl groups at positions 3, 7, and 12 in sequence to form the desired hydroxyl configuration. After the conversion of each functional group is completed, the protecting group is removed, and then the condensation reaction with the oxalic acid derivative is carried out to obtain di- { (3α, 5β, 7β, 8ω, 9ω, 12α, 14ω) -3,7,12-trihydroxy-24-oxocholesterol-24-yl} oxalic acid. During the whole process, it is necessary to pay attention to the precise control of the reaction conditions, as well as the yield and selectivity of each step of the reaction, in order to successfully achieve the preparation of the target product.
What is the price range of 2- { (3α, 5β, 7β, 8o, 9o, 12α, 14o) -3,7,12-trihydroxy-24-oxycholane-24-yl] amino} ethanesulfonic acid on the market?
Today there are 2- { (3α, 5β, 7β, 8ω, 9ω, 12α, 14ω) -3,7,12-trinitro-24-oxycholesterol-24-yl} ethylsulfonic acid, I want to know its price range in the market. These things are related to the way of medicine and stone, and the art of chemical industry. The price is not the same, but it changes due to various conditions.
Looking at the purity of its quality, pure people choose carefully, and there are few impurities, and the price will be high; if there are more impurities, although it is available, the price will be low. Looking at the situation of supply and demand, if there are many people who need it, they can't get it, and the price will skyrocket; if there is too much production, it will be difficult to sell if hoarding is difficult, and the price will tend to decline. And the distance of the origin and the complexity of the production method have an impact. Shipped from a distance, the journey fee is superimposed, and the price increases; the production method is simple, the cost is low, and the price is also reduced.
According to past examples and market conditions, this 2- { (3α, 5β, 7β, 8ω, 9ω, 12α, 14ω) -3,7,12-trinitro-24-oxocholesterol-24-yl} ethylsulfonic acid, if the quality is pure and the demand is strong, the price per unit may reach more than a hundred gold; if the quality is slightly inferior, and the supply exceeds the demand, or only a few dozen gold. However, the market situation is unpredictable, and it is difficult to say for sure. Only when the market is carefully inspected can the true price be obtained.