What is the chemical structure of 2- (4-Pyridyl) Ethanesulphonic Acid?
2-% (4-pyridyl) ethanesulfonic acid, its chemical structure is composed of a pyridine ring and an ethanesulfonic acid group. The pyridine ring is aromatic and consists of five carbon atoms and one nitrogen atom to form a six-membered heterocyclic structure. In the field of organic chemistry, this ring system has unique properties and is often used as a key part of bioactive molecules and organic synthesis intermediates.
Linked to the fourth position of the pyridine ring is the ethanesulfonic acid group. Among them, the ethane part is a saturated alkyl chain containing two carbon atoms, which acts as a bridge connecting the pyridine ring and the sulfonic acid group. The sulfonic acid group (-SOH) is highly acidic because its sulfur atom is connected to three oxygen atoms, and one of the oxygen atoms is bound to the sulfur atom in the form of a double bond, and the other two oxygen atoms are connected to the hydrogen atom. This structure gives the compound good water solubility and ionic properties.
In the overall structure of the compound, the pyridine ring and the ethanesulfonic acid group are connected by carbon-carbon bonds, so that the molecule has both the aromatic characteristics of the pyridine ring and the acidic and water-soluble of the sulfonic acid group. This unique combination of structures allows 2-% (4-pyridyl) ethanesulfonic acid to exhibit unique chemical properties and application value in many fields, such as in organic synthesis, it can be used as a catalyst or intermediate for specific reactions, and may be used in biochemistry to modify biomolecules, affecting their activity and solubility.
What are the main uses of 2- (4-Pyridyl) Ethanesulphonic Acid?
2-%284-Pyridyl%29Ethanesulphonic Acid is 2- (4-pyridyl) ethanesulfonic acid, which has a wide range of uses.
In the field of medicinal chemistry, it can be used as an important intermediate in organic synthesis. The unique structure of geinpyridyl and sulfonic acid groups allows it to participate in various chemical reactions and help to construct complex drug molecular structures. By condensation and substitution with other compounds, drugs with specific pharmacological activities can be prepared, such as some innovative drugs for the treatment of cardiovascular diseases and neurological diseases, which are of great significance in the process of new drug development.
In the field of materials science, it can be used to prepare functional materials. For example, by compounding with polymer materials, it can give materials special properties. Due to its hydrophilicity, the sulfonic acid group can improve the hydrophilicity of the material, making the material used in the field of biomedical materials, such as tissue engineering scaffolds, drug sustained-release carriers, etc., which is conducive to cell adhesion and proliferation, and contributes to the controlled release of drugs.
In biochemical research, 2- (4-pyridyl) ethane sulfonic acid can be used as a buffer. Because it can maintain a stable pH environment at a specific pH, it provides suitable conditions for many biochemical reactions. For example, enzymatic reactions, the activity of enzymes is often sensitive to environmental pH. This substance can ensure that enzymes function within the optimal pH range, ensure the smooth progress of the reaction, and help researchers accurately explore the mechanism of biochemical reactions.
In addition, in the field of surfactants, its structural characteristics make it have a certain surface activity. It can reduce the surface tension of liquids, play a role in industrial processes such as emulsion polymerization and washing, and help emulsify and disperse, improving product quality and production efficiency.
From this perspective, 2- (4-pyridyl) ethane sulfonic acid has key uses in many fields such as medicine, materials, biochemistry and industry, and has made great contributions to promoting technological development and innovation in various fields.
What are the physical properties of 2- (4-Pyridyl) Ethanesulphonic Acid?
2-%284-Pyridyl%29Ethanesulphonic Acid is 2- (4-pyridyl) ethanesulfonic acid, the physical properties are as follows:
Its shape is usually white to off-white crystalline powder, which is pure and fine in texture. In terms of solubility, it is quite soluble in water, and can quickly disperse and form a uniform solution in water. This characteristic is due to the strong hydrophilicity of the sulfonic acid group in its molecular structure. In organic solvents, the solubility is slightly different. Some polar organic solvents can have a certain solubility, but in non-polar organic solvents, it is almost insoluble.
Its melting point is within a certain range, and the exact value can be obtained by precise measurement. This melting point is one of its important physical parameters, which is of great significance for its identification and purity determination. In terms of stability, it is quite stable under normal temperature and pressure and dry environment, and can be stored for a long time without easy deterioration. However, when exposed to extreme conditions such as strong acid, strong alkali or high temperature and high humidity, its structure may change, causing chemical properties to change.
It exhibits specific acid-base properties in solution. Due to the existence of sulfonic acid groups, it can partially ionize hydrogen ions, which is weakly acidic. This property has a significant impact on many chemical reactions and application scenarios. In addition, its density and other physical parameters also have specific values, providing a key basis for the measurement and mixing of materials in actual production and application. Overall, the physical properties of 2- (4-pyridyl) ethane sulfonic acid determine its feasibility and unique advantages in the fields of chemical engineering, medicine, and materials.
What are the Preparation Methods of 2- (4-Pyridyl) Ethanesulphonic Acid?
There are various ways to prepare 2 - (4-pyridyl) ethanesulfonic acid. One method can be prepared by the addition reaction of 4-vinylpyridine with sodium bisulfite. The 4-vinylpyridine is slowly dropped into an aqueous solution containing sodium bisulfite, and the reaction is stirred at a suitable temperature, such as 50 to 70 degrees Celsius. Here, the double bond of 4-vinylpyridine and the sulfite of sodium bisulfite are added to give the crude product of 2 - (4-pyridyl) ethanesulfonic acid. After recrystallization and purification, the high-purity product can be obtained.
Another method uses 4-pyridyl ethanol as the starting material. First, 4-pyridyl ethanol is reacted with p-toluenesulfonyl chloride to obtain the corresponding sulfonate. This reaction needs to be carried out at a low temperature, about 0 to 5 degrees Celsius, in the presence of a base, such as pyridine or triethylamine, to avoid side reactions. The obtained sulfonate is then reacted with sodium sulfite, and the sulfonate ester group is replaced by sulfite to obtain the target product. Subsequent operations such as extraction and distillation can obtain pure 2 - (4-pyridyl) ethanesulfonic acid.
Others use 4-pyridyl acetonitrile as a raw material. First hydrolyze 4-pyridyl acetonitrile to 4-pyridyl acetic acid, which can be achieved under acid or base catalysis. Then 4-pyridyl acetyl chloride is obtained by the reaction of 4-pyridyl acetic acid with thionyl chloride. Next, the reaction with sodium sulfite introduces the sulfonic acid group to generate 2- (4-pyridyl) ethanesulfonic acid. Finally, the purity of the product is improved through the refining step.
What are the Quality Standards for 2- (4-Pyridyl) Ethanesulphonic Acid?
2-%284-Pyridyl%29Ethanesulphonic Acid is 2- (4-pyridyl) ethanesulfonic acid. The Quality Standard of this substance is mostly related to its purity, impurity content, moisture content, etc.
When it comes to purity, this is the key indicator. High purity 2- (4-pyridyl) ethanesulfonic acid can show its effect in many application scenarios. Generally speaking, the purity needs to reach a very high level, such as more than 98%, or even 99%, 99.5%, etc. The impurity content cannot be ignored, such as heavy metal impurities, and its content should be strictly limited to prevent adverse effects on the reaction system or product performance during use.
Moisture content is also an important consideration. Excessive moisture may affect its chemical stability, or when participating in a chemical reaction, interfere with the process and result of the reaction. Therefore, the moisture content is often specified to be within a certain low range, such as less than 0.5%.
Crystal forms may also be part of the Quality Standard. Specific crystal forms may affect their solubility, stability and reactivity. Particle size distribution is also required in some applications. For example, in the field of pharmaceutical preparations, suitable particle size distribution helps to improve the uniformity and bioavailability of the product.
In addition, appearance properties are also covered by the Quality Standard. Usually it should be white crystalline powder or similar form without obvious color and foreign matter. Melting point, boiling point and other physical properties can also be used as a reference for quality determination, and their values should be similar to theoretical values to prove their quality. Such Quality Standards are to ensure the effectiveness and reliability of 2- (4-pyridyl) ethanesulfonic acid in various fields of application.