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What is the main use of this 2- (bis (tert-butoxycarbonyl) amino) -5-bromopyridine-3-yl 4-methylbenzene sulfonate?
2 - (Bis (tert-butoxycarbonyl) amino) - 5 - methoxypyridine - 3 - yl + 4 - methylbenzenesulfonamide, which is widely used.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of specific drugs. The functional groups contained in it can be cleverly linked to other compounds through many organic chemical reactions, thereby constructing drug molecules with more complex structures and specific pharmacological activities. For example, when developing some small molecule drugs targeting specific disease targets, this compound can be chemically modified to allow the resulting drug to precisely act on diseased cells and achieve the purpose of treating diseases.
In the field of materials science, it also has applications. Due to its structural properties, it may endow materials with unique physical and chemical properties. For example, introducing it into polymer materials may improve the solubility, thermal stability and mechanical properties of materials. For example, when preparing high-performance polymer films, adding an appropriate amount of this compound may improve the flexibility and heat resistance of the film, thereby broadening the application of materials in different environments.
In organic synthetic chemistry, it is an extremely important synthetic building block. Chemists can synthesize a series of organic compounds with diverse structures by designing different reaction paths according to their structural characteristics. This not only enriches the variety of organic compounds, but also provides many possibilities for the development of new functional materials and drugs. With this compound, chemists can carry out various reactions, such as nucleophilic substitution, coupling reactions, etc., to synthesize many organic molecules with potential application value.
What are the synthesis methods of 2- (bis (tert-butoxycarbonyl) amino) -5-bromopyridine-3-yl 4-methylbenzene sulfonate
To prepare 2 - (bis (tert-butoxycarbonyl) amino) -5 -methoxy-3 -pyridyl-4 -methylbenzoic anhydride, the synthesis method is as follows:
The starting material can be selected from a suitable pyridine derivative, and the multi-step reaction can achieve the goal. The first step is to methoxylate the specific position of the pyridine ring. A suitable methoxy-containing reagent can be selected. Under appropriate reaction conditions, such as a suitable base as a catalyst and a suitable solvent system, the methoxy group can be successfully connected to the pyridine ring to obtain the methoxylated pyridine intermediate.
Then, methyl groups are introduced at another position of the pyridine ring. Select a suitable methylation reagent, such as iodomethane, in an alkaline environment, through nucleophilic substitution reaction, the methyl group is successfully attached to the pyridine ring, and the pyridine product containing methoxy and methyl is obtained.
Furthermore, the amino group on the pyridine ring is protected by bis (tert-butoxy carbonyl). Select bis (tert-butoxy carbonyl) reagent, under mild reaction conditions, such as organic base catalysis and low temperature reaction, to ensure that the amino group is precisely protected to form a pyridine derivative with a protective group.
Then, carboxylation reaction is carried out at a specific position on the pyridine ring. Using a suitable carboxylation reagent, in a suitable reaction system, the carboxyl groups are successfully linked to obtain a pyridine compound containing protective amino groups, methoxy groups, methyl groups and carboxyl groups.
Finally, the carboxyl group is converted into an acid anhydride. With the help of a dehydrating agent, at a suitable temperature and reaction time, the carboxyl group is dehydrated to form an acid anhydride, thereby successfully synthesizing 2- (bis (tert-butoxycarbonyl) amino) -5 -methoxy-3 -pyridyl-4 -methylbenzoic anhydride. Each step of the reaction requires strict control of the reaction conditions and fine purification of the product to ensure the efficient and smooth progress of the reaction and improve the purity and yield of the product.
2- (Bis (tert-butoxycarbonyl) amino) -5-bromopyridine-3-yl 4-methylbenzene sulfonate What are the precautions during storage?
If you want to store di- (ethoxy) acetyl) - 5 - ethoxy - 3 - yl + 4 - methylbenzenesulfonic acid, you should pay attention to it when you store it.
The first heavy environment. This should be used in a dry, refreshing and good place. If the environment is humid, it is easy to cause the product to get damp, cause it to become humid, or cause it to be modified, and the utility will be reduced. It is refreshing, which can prevent the product from accelerating decomposition or degradation due to high temperature. Good quality, can avoid harmful polymerization, and affect the product.
The second time the container. It is necessary to use suitable containers, usually those with good sealing performance. The seal can prevent the intrusion of foreign objects such as air and moisture, so that the product can be isolated from external undesirable factors. For example, glass bottles with tight stoppers, or plastic containers, but the materials are not used to protect the product from contamination.
Furthermore, pay attention to the shelf life. Each product has its own specific valid period, and this di- ((ethoxy) ethyl) - 5 - its - 3 - group + 4 - methylbenzenesulfonic acid is no exception. It needs to be used according to the instructions and within the valid period. After use, the safety and effectiveness of the product should be guaranteed, or adverse results should be caused.
In addition, the storage of dangerous materials such as fire sources and coal sources should be stored. This product is not flammable and explosive, but accidental fire or accident may also affect the product and cause it to suffer. And do not mix with other chemical products to prevent mutual reaction and affect the quality.
For proper storage of di- (ethoxy) ethyl) -5-its-3-yl + 4-methylbenzenesulfonic acid, pay attention to the environment, container, expiration date and avoid mixed storage to ensure the safety of the product.
What are the physicochemical properties of 2- (bis (tert-butoxycarbonyl) amino) -5-bromopyridine-3-yl 4-methylbenzene sulfonate
2-%28%E5%8F%8C%28%E5%8F%94%E4%B8%81%E6%B0%A7%E7%BE%B0%E5%9F%BA%29%E6%B0%A8%E5%9F%BA%29 - 5 - %E6%BA%B4%E5%90%A1%E5%95%B6 - 3 -% E5% 9F% BA + 4 - %E7%94%B2%E5%9F%BA%E8%8B%AF%E7%A3%BA%E9%85%B8%E7%9B%90%E7%9A%84%E7%89%A9%E7%90%86%E5%8C%96%E5%AD%A6%E6%80%A7%E8%B4%A8%E6%98%AF%E6%80%8E%E6%A0%B7%E7%9A%84%3F
2 - bis (hydroxyethoxy) amino - 5 - phenyl - 3 - propyl - 4 - methylbenzenesulfonate guanidine is one of the organic compounds. The physicochemical properties of this compound are particularly important for its application in various fields.
In terms of its physical properties, at room temperature, this substance is either a solid, its appearance, or a white crystalline powder with a fine texture. The determination of its melting point can be a key indicator for the identification of this substance. The melting point is affected by factors such as intermolecular forces and crystal structure. Generally speaking, organic compounds containing more polar groups have stronger intermolecular forces and relatively high melting points. And this compound contains multiple polar groups, such as hydroxyl groups, amino groups, etc., so it is speculated that its melting point is not low.
As for chemical properties, because its molecular structure contains sulfonic acid groups, it has acidic characteristics. This acidic group can cause the compound to neutralize with bases under specific conditions to generate corresponding salts. At the same time, non-polar groups such as alkyl and phenyl groups in the molecule endow it with certain lipophilicity. This lipophilicity can affect its solubility in different solvents. Usually, it has good solubility in organic solvents such as ethanol and acetone, while its solubility in water, or due to the ionization of sulfonate and the influence of other non-polar groups, shows certain particularity.
Furthermore, the existence of unsaturated bonds or activity check points in its molecular structure allows it to participate in many chemical reactions. Such as substitution reactions with nucleophiles, or under appropriate conditions, participation in addition reactions. Such reactivity provides a broad space for its application in the field of organic synthesis. Chemists can use this to modify its structure to obtain derivatives with specific functions to meet the needs of different fields such as medicine and materials.
What is the price range of 2- (bis (tert-butoxycarbonyl) amino) -5-bromopyridine-3-yl 4-methylbenzene sulfonate in the market?
Nowadays, there are di- (bis (tert-butoxycarbonyl) amino) -5-bromopyridine-3-yl-4-methylphenylborate esters, which are available in the market price range.
The price of these chemical substances is uncertain and often varies for many reasons. First, purity is the key. If the purity is higher, the price will be higher. Second, the purchase quantity also has an impact. If you buy in bulk, you can often get a preferential price, and if the quantity is small, the price will be higher or higher. Furthermore, the supply and demand situation of the market, if there are many applicants and few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will fall. In addition, different suppliers have different prices due to their different costs and management strategies.
To determine the exact price, you can consult various chemical reagent suppliers, such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent (Shanghai) Co., Ltd., etc. They often quote the actual price according to the current situation. Or you can visit a professional chemical product trading platform, where you can view the quotations of various companies to clarify their approximate price range. Generally speaking, the price of this reagent fluctuates greatly due to the difficulty of synthesis and the cost of raw materials. However, without more details, it is difficult to determine its exact price, but after multiple inquiries and comparisons, a more suitable price range can be obtained.
