As a leading 2-Deoxy-2,2,-Difluoro-D-Erythro-Pentofuranose-3,5-Dibenzoate-1-Methanesulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 2-Deoxy-2,2, -Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate
2-Deoxy-2,2-difluoro-D-red-pentafuran-3,5-dibenzoate-1-methanesulfonate, this is an organic compound. Its chemical properties are unique and have the following properties.
From the structural point of view, the compound contains a furan sugar ring, which gives it a specific spatial configuration and reactivity. The second position is deoxidized and connected with a difluorine atom. The fluorine atom has strong electronegativity, which causes the polarity of the molecule to change, which affects its physical and chemical properties. The fluorine substituent can enhance the stability and fat solubility of the compound. Because the fluorine atom and the carbon form a C-F bond with high bond energy, the molecular structure is more stable, and the hydrophobicity of the fluorine atom increases the fat solubility. The benzoate group at position 3,5 has a certain conjugate structure, which can enhance the rigidity and stability of the molecule. This group also affects the solubility and reactivity of the compound. Because the carbonyl group in the benzoate can participate in hydrogen bonding and chemical reactions, it can undergo ester exchange and other reactions under certain conditions. The methanesulfonate group at position 1 is a good leaving group, which endows the compound with high reactivity and is prone to nucleophilic substitution. When the nucleophiles attack, the methanesulfonate group is easy to leave and form new compounds, which are often used in the field of organic synthesis to construct carbon-carbon bonds or carbon-hetero bonds.
In addition, the solubility of the compound is affected by various groups. In general, due to the presence of benzoate and fluorine atoms, it has good solubility in organic solvents such as dichloromethane and chloroform, but poor solubility in water. In terms of thermal stability, due to the existence of C-F bonds and conjugate structures, it is relatively high, and it needs to reach a certain temperature when heated before decomposition or rearrangement occurs.
What are the main uses of 2-Deoxy-2,2, -Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate
2-Deoxy-2,2-difluoro-D-erythrofuranose-3,5-dibenzoate-1-methanesulfonate This compound has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. With this compound, drug molecules with complex structures and specific biological activities can be constructed through many delicate chemical reactions. In the long journey of new drug research and development, it is like an important cornerstone, providing the possibility for the creation of new therapeutic drugs.
Looking at the development of medicine in the past, many drugs with significant efficacy rely on such key intermediates. Taking a new anti-cancer drug as an example, in its synthesis path, 2-deoxy-2,2-difluoro-D-erythrofuran-3,5-dibenzoate-1-methanesulfonate participated in the key steps. After a series of carefully designed reactions, it finally successfully obtained an anti-cancer drug with excellent activity.
In addition, it is also useful in the field of fine chemistry. Or it can be used to prepare materials with special functions, and its unique chemical structure gives the material different properties. For example, in the synthesis of some functional polymer materials, this compound can be used as a modifier to optimize the properties of the material, such as improving the stability and solubility of the material, so as to meet the requirements of different fields for the specific properties of the material.
What is the preparation method of 2-Deoxy-2,2, -Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate
The preparation of 2-deoxy-2,2-difluoro-D-red-pentafuran-3,5-dibenzoate-1-methanesulfonate is a delicate and multi-step process.
At the beginning, it is often necessary to use a suitable sugar compound as the base material. Starting from a common sugar, its specific hydroxyl group is first protected. In a suitable reaction system, benzoic anhydride and a catalytic amount of base are used to participate in the reaction, and the 3rd and 5th hydroxyl groups of sugars can be esterified to form 3,5-dibenzoate derivatives. This step requires attention to the reaction temperature, time and the ratio of reactants. If the temperature is too high or the time is too long, side reactions may occur, which will affect the purity and yield of the product.
After the protection of the 3,5 hydroxyl groups is completed, the 2 hydroxyl groups are modified. After specific deoxygenation and difluoride substitution reactions, special deoxygenation reagents and fluorine-containing reagents are used in this process. Under strict anhydrous and anoxic conditions and precise control of the reaction conditions, the structural transformation of 2-deoxygenation-2,2-difluoride is achieved. In this step, the reagent has very high activity and strict requirements on the reaction environment. Trace amounts of water or oxygen can cause reaction deviations.
Finally, for the 1-position hydroxyl group, it is reacted with methanesulfonyl chloride in the presence of a suitable base, thereby introducing the methanesulfonate group to obtain the target product 2-deoxy-2,2-difluoro-D-erythyl-pentafuranose-3,5-dibenzoate-1-methanesulfonate. After each step of the reaction, it needs to be separated and purified by means such as column chromatography and recrystallization to ensure the purity of the product, which can lay a good foundation for subsequent research or application.
What is the market price of 2-Deoxy-2,2, -Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate
What you are inquiring about is the market price of 2 - Deoxy - 2,2 - Difluoro - D - Erythro - Pentofuranose - 3,5 - Dibenzoate - 1 - Methanesulfonate. However, this substance is quite professional and uncommon, and the quantity circulating in the market is very rare. Its price is determined by many factors.
First, the cost of raw materials. To make this substance, the rarity of the raw materials used and the difficulty of obtaining it are closely related to the price. If the raw materials are rare, the price must be high. Second, the preparation process. If its preparation requires delicate and complicated processes, the requirements for equipment and technology are very high, and it requires a lot of manpower and material resources, the cost will rise, and the price will also rise. Third, the supply and demand of the market. If the demand for this product in a specific field is quite large, but the supply is limited, the price will rise; on the contrary, if the demand is small, the price will not be considerable.
Because it is a highly specialized chemical, it is often used in specific industries such as scientific research and pharmaceuticals. In scientific research institutions, or as key materials for the development of new drugs and the exploration of new chemical synthesis paths, the quality requirements such as purity are extremely high, and those with such high purity will be expensive. In pharmaceutical companies, if it is an intermediate for the preparation of a specific drug, because it is related to the quality and efficacy of the drug, its quality is strictly controlled, and the price should not be underestimated.
It is not easy to know the specific market price. Or you need to consult suppliers and distributors who specialize in such chemical transactions, or inquire from many parties in professional chemical trading platforms and industry exhibitions. Or you can communicate with relevant scientific research institutions and pharmaceutical companies to find out their purchase prices and market conditions. With such multi-party search, you can expect to obtain more accurate market price information.
2-Deoxy-2,2, -Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate What are the precautions when storing and transporting?
2 - Deoxy - 2,2 - Difluoro - D - Erythrofuranose - 3,5 - Dibenzoate - 1 - Methanesulfonate This compound needs to pay attention to many key matters during storage and transportation.
First, temperature control is crucial. This compound is quite sensitive to temperature, and high temperature can easily cause its chemical structure to change and damage its quality. Therefore, it should be stored in a cool place, usually at 2 - 8 ° C. If transported in a high temperature environment, cold chain transportation is required to keep the temperature stable and prevent it from decomposing or deteriorating due to excessive temperature.
Second, the influence of humidity should not be underestimated. High humidity environment can easily make the substance absorb moisture, or cause moisture, hydrolysis and other conditions, thus changing its chemical properties. Therefore, the storage place must be kept dry, and a desiccant can be placed in the storage container to absorb water vapor. When transporting, it is also necessary to ensure that the package is well sealed and protected from external moisture.
Third, light will also have an effect on it. Long-term light exposure or accelerate its chemical reaction will affect the quality. Storage should be placed in a light-shielded container, or stored in a dark place. During transportation, avoid direct sunlight, and light-shielding packaging materials can be used to prevent light from causing damage to it.
Fourth, the package must be solid and stable. This substance has a certain chemical activity, and poor packaging is prone to leakage, causing safety problems. The storage container should be made of suitable materials to ensure that it does not react with the compound. When transporting, the outer package should have good pressure resistance and shock resistance to prevent the package from being damaged due to collision and extrusion.
Finally, it needs to be stored and transported separately from other chemicals. Due to its special chemical properties, it may react with other substances and cause danger. Therefore, when storing, it should be classified and stored, and incompatible chemicals should be avoided during transportation to ensure safety.