As a leading 2-Deoxy-2,2-Difluoro-D-Erythro-Pentofuranose-3,5-Dibenzoate-1-Methanesulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the use of 2-Deoxy-2, 2-Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate?
2-Deoxy-2,2-difluoro-D-red-pentafuran-3,5-dibenzoate-1-methanesulfonate, this is an organic compound. It has a wide range of uses and is a key intermediate in the field of organic synthesis.
The process of organic synthesis, the creation of many complex and delicate natural products and compounds with specific biological activities, often rely on this compound as a starting material. Due to its unique structure, it contains difluorine atoms, benzoate ester groups and methanesulfonate ester groups, giving it special reactivity and selectivity.
Taking the reaction of building a carbon-carbon bond as an example, methanesulfonate group can be used as an excellent leaving group. In nucleophilic substitution reactions, it can be cleverly combined with various nucleophilic reagents, such as organometallic reagents, etc., to expand the carbon chain and build a complex molecular structure.
Furthermore, in the field of pharmaceutical chemistry, this compound has also emerged. After structural modification and derivatization, a series of compounds with potential biological activities can be designed and synthesized. Or it can be used as a lead compound to lay the foundation for the development of new drugs. Because of its fluorine atom, it can significantly change the physical and chemical properties of the compound, such as lipophilic, metabolic stability, etc., thereby affecting the interaction between the drug and the target, and improving the efficacy and drug-forming properties of the drug.
In the field of materials science, the properties of benzoate groups may enable them to participate in the synthesis of polymer materials. By rationally designing the polymerization reaction, this compound is introduced into the main chain or side chain of the polymer, giving the material unique optical, thermal or mechanical properties, opening up a way for the development of new functional materials.
What are the synthesis methods of 2-Deoxy-2, 2-Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate
The synthesis method of 2-deoxy-2,2-difluoro-D-red-pentafuran-3,5-dibenzoate-1-methanesulfonate, although the ancient book "Tiangong Kaiwu" does not directly describe the synthesis of this specific compound, it contains a lot of chemical process wisdom, which can be used for reference.
To synthesize this compound, you can follow the general method of organic synthesis and use suitable sugars as starting materials. Sugars have a polyhydroxy structure, and those with a pentose structure are selected first, such as D-red-pentose. The 2-hydroxyl group of the pentose is deoxidized and a difluoro group is introduced, which can be achieved by nucleophilic substitution and other reactions. The fluorine-containing reagent is reacted with the pentose, and the reaction conditions are adjusted so that the 2-hydroxyl group is replaced by the difluoro. In this step, attention should be paid to the selectivity and reactivity of the reagents to obtain the desired 2-deoxy-2,2-difluoro-D-red-pentose intermediate.
After obtaining this intermediate, the 3,5-hydroxybenzoate is estered. Benzoic anhydride or benzoyl chloride reacts with the intermediate under the catalysis of an appropriate base. The base can bind the acid, which prompts the reaction to proceed forward, forming a 3,5-dibenzoate structure, which enhances the stability and specific reactivity of the compound.
Finally, the 1-hydroxyl group is esterified with methanesulfonate. Methanesulfonyl chloride reacts with the above product under the action of a suitable solvent and base, and the methanesulfonyl group replaces the 1-hydroxyl group to form 2-deoxy-2,2-difluoro-D-red-pentafuran-3,5-dibenzoate-1-methanesulfonate. After each step of the reaction, suitable separation and purification methods, such as column chromatography, recrystallization, etc., are required to obtain high-purity products to ensure the smooth progress of the next step of the reaction. After careful design and operation of multiple steps, the target compound can be obtained.
What are the physical properties of 2-Deoxy-2, 2-Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate
2-Deoxy-2,2-difluoro-D-red-pentafuran-3,5-dibenzoate-1-methanesulfonate This material has unique physical properties. Its color state is often white to off-white crystalline powder, which is due to the regular molecular structure, resulting in an orderly arrangement between molecules, and light scattering shows this color state.
From the perspective of its solubility, it can be quite soluble in organic solvents such as dichloromethane and chloroform. Its internal molecular groups and organic solvents can form intermolecular forces, such as van der Waals force, hydrogen bond, etc., to promote dissolution. However, in water, the dissolution is not good. Due to the weak interaction between the polarity of the water molecule and some hydrophobic groups of the substance, it is difficult to break the intermolecular force and disperse in water.
The melting point is about a certain range (assumed to be 120-125 ° C). This is because when the temperature rises to this range, the molecule obtains enough energy to overcome the lattice energy, the lattice structure disintegrates, and the substance changes from solid to liquid. Its melting point is relatively stable, which can be used as an indicator to identify the purity of the substance. If it contains impurities, the melting point may drop and the melting range becomes wider.
The density of the substance is also a specific value (assumed to be 1.3-1.4 g/cm ³). This is determined by the weight of the molecule and the degree of compactness of the molecule, and the density affects its sedimentation and dispersion in different media.
In addition, the substance has certain characteristics of thermal and photostability. In terms of thermal stability, the structure is stable within a certain temperature. If the temperature is too high, the chemical bonds in the molecule may break or rearrange, causing structural changes. In terms of photostability, a specific wavelength of light is irradiated or induced to luminescent chemical reactions to change the structure and properties. This is all due to the interaction of chemical bond energy and light energy in the molecule.
What are the chemical properties of 2-Deoxy-2, 2-Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate
2-Deoxy-2,2-difluoro-D-red-pentafuran-3,5-dibenzoate-1-methanesulfonate, which has special properties and is related to the field of organic chemistry. Its unique chemical properties have attracted much attention in the field of organic synthesis.
Looking at its structure, the introduction of difluorine atoms makes its electron cloud distribution different, resulting in its chemical activity. Fluorine atoms have high electronegativity, which can affect the polarity of molecules and make their solubility different. In organic solvents, or exhibit different solubility characteristics from fluorine-free analogs, which is significant for separation, purification and the creation of reaction environments.
Furthermore, the presence of benzoate groups endows molecules with certain rigidity and steric hindrance. The conjugated system of benzoate structure can affect the stability and reactivity of molecules. It may participate in π-π stacking and play a key role in the crystal structure or molecular self-assembly process.
The methanesulfonate group is a good leaving group. In many nucleophilic substitution reactions, the methanesulfonate group can easily leave, making the molecule an active reaction intermediate, and then react with various nucleophilic reagents. This property provides a variety of strategies and paths for organic synthesis.
In short, 2-deoxy-2,2-difluoro-D-red-pentafuran-3,5-dibenzoate-1-methanesulfonate, due to its unique structure and diverse chemical properties, has broad application prospects in organic synthesis, pharmaceutical chemistry and other fields.
What is the price of 2-Deoxy-2, 2-Difluoro-D-Erythro-Pentofuranose-3, 5-Dibenzoate-1-Methanesulfonate in the market?
I look at what you are asking, it is 2 - Deoxy - 2,2 - Difluoro - D - Erythro - Pentofuranose - 3,5 - Dibenzoate - 1 - Methanesulfonate at the market price. However, this compound is very special and professional, and it is rarely circulated in the market.
Ordinary markets, it is difficult to see its traces, because it is mostly used in specific scientific research fields, and it is comparable to unusual commodities. If you want its price, you should go to a professional chemical reagent trading house, or ask a scientific research reagent supplier.
However, its price is not easy to determine, because it is made by many factors. First, the synthesis is difficult. This compound has a complex structure, a variety of synthesis steps, and requires exquisite skills and expensive raw materials. If so, the cost will be high and the price will be high. Second, the amount of demand. If the scientific research community has a strong demand for this, the price may rise; if the demand is thin, the merchant may also price it not low due to cost considerations. Third, the source is different. From different manufacturers, the quality may be different, and the price is also different.
There may be suppliers who charge high prices, which are difficult for others to match due to unique technologies or patents; or there may be large quantities due to scale effects and slightly reduced prices. To know the exact price, you need to consult the supplier in person and compare their quotations in detail to get a more realistic price.