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What is the chemical structure of 2-Deoxy-2, 2-Difluoro-D-Ribofuranose-3, 5-Dibenzoate-1-Methanesulfonate?
This is a complex organic compound named "2-deoxy-2,2-difluoro-D-furan-ribose-3,5-dibenzoate-1-methanesulfonate". To clarify its chemical structure, follow the principles of organic chemistry and analyze its name to deduce the structure.
"2-deoxy-2,2-difluoro-D-furan-ribose", this indicates the core sugar structure. "2-deoxy", that is, the hydroxy group (-OH) at position 2 of ribose is missing, and a hydrogen atom is used instead. " 2,2-Difluoro "indicates that the carbon atom at position 2 is connected with two fluorine atoms (-F)." D-furan ribose "indicates that this sugar has a furan sugar ring structure and the configuration is D type.
" 3,5-dibenzoate "refers to the esterification reaction between the hydroxy group at position 3 and position 5 of the sugar ring and benzoic acid to form the benzoate structure, that is, -OOC-aryl (the remaining part after the benzoic acid removes the hydroxyl group in the carboxyl group).
" 1-methanesulfonate "means that the hydroxy group at position 1 of the sugar ring reacts with methanesulfonic acid to form the methanesulfonate structure, that is, -OSO _ CH.
In summary, this compound is composed of D-furan ribose as the core, deoxygenated and difluorinated at position 2, benzoate at position 3 and 5, and methanesulfonate at position 1. Its structure is complex and orderly, and the groups are connected according to organic chemical rules to jointly construct the unique chemical structure of this organic molecule.
What are the physical properties of 2-Deoxy-2, 2-Difluoro-D-Ribofuranose-3, 5-Dibenzoate-1-Methanesulfonate?
2-Deoxy-2,2-difluoro-D-furan-ribose-3,5-dibenzoate-1-methanesulfonate, this is a fine organic compound. Its physical properties are quite critical and affect many application scenarios.
First, the appearance is usually presented in white to off-white crystalline powder, with a fine and uniform texture. The appearance is quite regular. This morphology is conducive to uniform dispersion and reaction in many reactions and preparation of preparations. The melting point of
is an important physical parameter, which is about [X] ° C to [X] ° C. The stability of the melting point reflects its purity and molecular structure stability. If impurities exist, the melting point may be deviated.
In terms of solubility, it shows good solubility in common organic solvents such as dichloromethane and chloroform, which facilitates the construction of the reaction system in the organic synthesis reaction, allowing the reactants to be fully contacted and accelerating the reaction process. However, the solubility in water is poor. Due to the large proportion of hydrophobic groups in the molecular structure, the interaction with water is weak.
The compound has a density of about [X] g/cm ³, which is indispensable in material measurement and process design, affecting its filling amount and reaction concentration in the reaction vessel.
In addition, it has a certain degree of hygroscopicity and absorbs a small amount of moisture in a humid environment, so it needs to be kept in a dry environment during storage to prevent quality changes due to moisture absorption and affect subsequent use performance.
In summary, these physical properties of 2-deoxy-2,2-difluoro-D-furan-ribose-3,5-dibenzoate-1-methanesulfonate are of great significance in the fields of organic synthesis, drug development, etc., and can only be better applied if accurately grasped.
What is the main use of 2-Deoxy-2, 2-Difluoro-D-Ribofuranose-3, 5-Dibenzoate-1-Methanesulfonate?
2-Deoxy-2,2-difluoro-D-furan-ribose-3,5-dibenzoate-1-methanesulfonate, the use of this substance is quite critical. In the field of pharmaceutical synthesis, it often acts as a key intermediate. With exquisite chemical means, it can construct complex molecular structures with specific biological activities. In the process of creating new drugs, it is like the cornerstone of building a magnificent building, and has a profound impact on the drug research and development process.
In the field of organic synthesis, its unique chemical structure endows special reactivity, providing an effective path for the synthesis of novel organic compounds. Chemists can control the transformation of their functional groups to achieve the construction of diverse organic molecules, broaden the boundaries of organic synthesis, and make it possible to explore and synthesize new materials.
Furthermore, in the field of sugar chemistry research, as a modified sugar derivative, it is of great significance for revealing the relationship between the structure and function of sugars. Through the exploration of its reaction characteristics and biological activities, it can deepen the understanding of the mechanism of action of sugars in organisms, providing key clues for the interpretation of sugar-related biological processes, which is like a key to help researchers open the door to the mystery of sugars. In conclusion, 2-deoxy-2,2-difluoro-d-furan-ribose-3,5-dibenzoate-1-methanesulfonate plays a key role in many scientific fields and promotes related research.
What is the preparation method of 2-Deoxy-2, 2-Difluoro-D-Ribofuranose-3, 5-Dibenzoate-1-Methanesulfonate?
The preparation of 2-deoxy-2,2-difluoro-D-furan-ribose-3,5-dibenzoate-1-methanesulfonate is a delicate organic synthesis process. The process needs to follow the principles of organic chemistry, with appropriate raw materials and steps.
Initially, a suitable D-ribose derivative should be used as the starting material. This derivative needs to have a functional group that can be modified and converted into the target structure. First, the 3 and 5 hydroxyl groups of ribose are protected, and the benzoic anhydride or benzoic acid derivative is reacted with ribose under suitable conditions, such as in an inert solvent, catalyzed by a specific catalyst, which can form the benzoate ester structure of the 3 and 5 hydroxyl groups. The purpose of this step is to protect the hydroxyl group from accidental transformation in the subsequent reaction, and to lay the structural foundation for the subsequent reaction.
Next, the 2-position carbon is deoxidized and difluorinated. This is a key step, and specific reagents are often required, such as fluorine-containing reagents and deoxidizing reagents. Or using a reaction mechanism such as nucleophilic substitution, under the control of an appropriate reaction system, such as a specific pH, temperature and reaction time, to achieve the deoxygenation and difluoride substitution of the 2-position carbon, and obtain the intermediate of 2-deoxygenation-2,2-difluoro-D-furan-3,5-dibenzoate.
Finally, for the 1-position hydroxyl group, methanesulfonic acid derivatives such as methanesulfonyl chloride are reacted under alkali catalysis and other conditions to convert the 1-position hydroxyl group into methanesulfonate structure, resulting in 2-deoxy-2,2-difluoro-D-ribose-3,5-dibenzoate-1-methanesulfonate. Each step of the reaction requires strict control of the reaction conditions to ensure the purity and yield of the product, and also requires fine post-processing operations such as extraction, distillation, recrystallization, etc., to purify the product.
2-Deoxy-2, 2-Difluoro-D-Ribofuranose-3, 5-Dibenzoate-1-Methanesulfonate What are the related chemical reactions?
2-Deoxy-2,2-difluoro-D-furan-ribose-3,5-dibenzoate-1-methanesulfonate, this compound is quite rich in related chemical reactions. In the field of organic synthesis, it often involves nucleophilic substitution reactions. Because methanesulfonate groups are good leaving groups, they are easily attacked by nucleophiles, causing C-O bonds to break and new bonds to form.
For example, when encountering nitrogen-containing nucleophiles, such as amines, the nitrogen atom in the amine attacks the carbon atom attached to the methanesulfonate group with its lone pair of electrons, and the methanesulfonate ion leaves to form a new nitrogen-containing substituted compound. This reaction is of great significance in constructing the structure of nitrogen-containing organic molecules.
Or when it encounters with sulfur-containing nucleophiles, such as thiols, the sulfur atom attacks nucleophiles. Through a similar mechanism, sulfur-containing derivatives can be obtained. The unique electronic properties and reactivity of sulfur atoms endow new compounds with different characteristics and uses.
In addition, the ester group site also has reactivity. Under basic conditions, the ester group can undergo hydrolysis reaction to generate corresponding alcohols and carboxylates. This hydrolysis reaction is a common means to regulate the molecular structure and introduce specific functional groups.
Furthermore, benzoyl groups can be transformed through reduction and other reactions, changing the distribution of molecular electron clouds and spatial structure, which has a profound impact on the physical and chemical properties of compounds. The diverse reactions of this compound under different reaction conditions have paved the way for the exploration and innovation of organic synthetic chemistry, through which chemists can create novel compounds with different structures and functions.