As a leading 2-Deoxy-2,2-Difuoro-D-Ribofuranose-3,5-Dibenzoate -1-Methane Sulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 2-Deoxy-2,2-Difuoro-D-Ribofuranose-3, 5-Dibenzoate -1-Methane Sulfonate
2-Deoxy-2,2-difluoro-D-furan-ribose-3,5-dibenzoate-1-methanesulfonate This compound has a wide range of uses. In the field of medicinal chemistry, it is often a key traditional Chinese medicine for synthesizing compounds with unique pharmacological activities. Because its structure contains special fluorine atoms and ester groups, it can significantly change the physical and chemical properties of compounds, such as improving fat solubility, facilitating drug penetration through biofilms, and enhancing bioavailability.
In the field of organic synthesis, as an important intermediate, it can construct complex carbon-carbon bonds and carbon-heteroatomic bonds through various chemical reactions. Such as nucleophilic substitution reaction, it can interact with different nucleophiles to derive products with rich structures. At the same time, in the field of materials science, materials synthesized from this substance as a starting material may have special optical and electrical properties, opening up new avenues for the research and development of new functional materials.
Furthermore, in the process of drug development, it may help to explore new targets and mechanisms of action of drugs, providing the possibility to overcome difficult diseases. Through structural modification and optimization, it is expected to obtain innovative drugs with better efficacy and fewer side effects.
What are the chemical properties of 2-Deoxy-2,2-Difuoro-D-Ribofuranose-3, 5-Dibenzoate -1-Methane Sulfonate
2-Deoxy-2,2-difluoro-D-furan-ribose-3,5-dibenzoate-1-methanesulfonate, this is an organic compound with unique chemical properties.
Its physical properties are mostly solid at room temperature. Due to strong intermolecular forces, the melting point is quite high. The molecule contains benzoyl groups, which make it crystalline. The appearance is often white crystalline powder, and the solubility varies in organic solvents. For example, in polar organic solvents, such as dichloromethane and chloroform, the solubility is good; in non-polar solvents, such as n-hexane, the solubility is poor.
In terms of chemical properties, methanesulfonate groups have high activity and are excellent leaving groups for nucleophilic substitution reactions. When encountering nucleophilic reagents, such as alcohols and amines, nucleophilic substitution is prone to form new carbon-oxygen or carbon-nitrogen bonds. The reaction conditions are mild and are often used in organic synthesis to construct complex molecular structures. At the same time, benzoyl groups can undergo hydrolysis, aminolysis and other reactions. Under basic conditions, benzoyl groups are easily hydrolyzed to form benzoic acid and corresponding alcohols. This reaction can be used for compound structure modification and transformation. In addition, fluorine atoms in molecules change the distribution of electron clouds, enhance their stability and lipophilicity, and affect the reactivity and biological activity of compounds. They are widely used in the field of medicinal chemistry. The introduction of fluorine atoms can adjust the metabolic stability, lipophilicity and biological activity of drugs.
What is the production method of 2-Deoxy-2,2-Difuoro-D-Ribofuranose-3, 5-Dibenzoate -1-Methane Sulfonate?
The production method of 2-deoxy-2,2-difluoro-d-furanosyl-3,5-dibenzoate-1-methanesulfonate can be carried out according to the following ancient method.
First, the selection of starting materials is very critical. Usually, the furanosyl derivative with a specific configuration is selected, and this derivative needs to have an activity check point that can be carried out in the subsequent reaction.
Then, for the 2-position deoxygenation and difluorine substitution reaction. Deoxygenation of the 2-position hydroxyl group can be achieved by using suitable deoxygenation reagents, such as specially treated phosphorus reagents, under carefully controlled reaction conditions, such as specific temperature, reaction duration and solvent environment. Subsequently, a fluorine-containing reagent is introduced into a suitable catalytic system. This process requires precise regulation of the reaction conditions to prevent side reactions.
Furthermore, the esterification reaction of benzoic acid at the 3,5-position is carried out. The treated intermediate product is reacted with benzoic anhydride or benzoic acid chloride in a suitable organic solvent in the presence of a base catalyst. The amount and type of alkali catalyst should be carefully selected to ensure that the reaction proceeds efficiently and selectively to generate 3,5-dibenzoate derivatives.
Finally, for the esterification of methanesulfonic acid at the 1-position. Methanesulfonyl chloride is selected as the donor of methanesulfonic acid group. Under the catalysis of an organic base, it reacts in a low temperature and anhydrous environment to convert the 1-position hydroxyl group into methanesulfonic acid ester group.
During the entire production process, after each step of the reaction, it is necessary to use separation and purification methods such as column chromatography and recrystallization to obtain high-purity products. The connection between the reaction steps also needs to be properly arranged, and the monitoring of the reaction process, such as the use of thin-layer chromatography, nuclear magnetic resonance and other analytical methods, to ensure that each step of the reaction achieves the expected effect, so as to successfully prepare 2-deoxy-2,2-difluoro-D-ribose-3,5-dibenzoate-1-methanesulfonate.
What is the market price of 2-Deoxy-2,2-Difuoro-D-Ribofuranose-3, 5-Dibenzoate -1-Methane Sulfonate
I see what you are asking about the market price of "2 - Deoxy - 2,2 - Difuoro - D - Ribofuranose - 3,5 - Dibenzoate + 1 - Methane Sulfonate". However, the price of this product is difficult to determine.
There are many factors that affect its price. The first one is the cost of raw materials. If the raw materials required for its preparation are scarce or expensive to obtain, the price of the finished product will rise.
Furthermore, the difficulty of the preparation process is also the key. If the preparation of this compound requires complicated steps, special equipment or harsh reaction conditions, the cost of manpower and material resources will increase significantly, and the price will be high.
In addition, the market supply and demand situation also affects its price. If there are many people who want it, but there are few people who supply it, the price will rise; on the contrary, if the market is saturated and the supply is excessive, the price may decline.
In addition, the price set by different manufacturers is also different due to their different technical levels and operating costs.
And if this compound is used in specific high-end fields, such as cutting-edge pharmaceutical research and development, its professionalism and uniqueness may cause the price to remain high.
To sum up, in order to know its exact market price, it is necessary to carefully consider many factors such as raw materials, processes, supply and demand, and manufacturers, which is difficult to conceal.
2-Deoxy-2,2-Difuoro-D-Ribofuranose-3, 5-Dibenzoate -1-Methane Sulfonate What are the precautions during use
2-Deoxy-2,2-difluoro-D-furan-ribose-3,5-dibenzoate-1-methanesulfonate. When using this substance, there are many things to pay attention to and need to be treated with caution.
First, this substance has specific chemical activity and is very easy to react with other substances. Therefore, when storing, make sure that the environment is dry and cool, away from heat and fire sources, to prevent it from changing its chemical properties due to environmental discomfort, or even causing danger. If stored improperly, if placed in a high temperature and humid place, it may deteriorate, affect the subsequent use effect, or cause unpredictable risks.
Second, during use, the operator must take protective measures. It is necessary to wear professional protective clothing, goggles and gloves to avoid direct contact of the substance with the skin and eyes. Due to its chemical properties, if inadvertently contacted, it is very likely to cause chemical burns and other injuries to the human body, endangering personal safety.
Third, the place where the substance is used must have good ventilation conditions. Because of the reaction process, harmful gases may be generated. If the ventilation is not smooth, the accumulation of harmful gases will not only endanger the health of the operator, but also under specific conditions, there may be serious consequences such as explosion.
Fourth, the established procedures and standards must be strictly followed during operation. Each step of the operation has its own reasons and requirements. Changing the operation sequence or conditions at will is very likely to lead to experimental failure or even cause safety accidents. Key parameters such as dosage, reaction time and temperature need to be precisely controlled, and no mistakes should be tolerated.
Fifth, after use, the disposal of remaining substances and related wastes should not be taken lightly. It should be properly classified and disposed of in accordance with relevant regulations, and must not be discarded at will, so as not to cause pollution to the environment and endanger the ecological balance.