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What is the chemical structure of 2-Hydroxy-2-Phenylethyl (R- (-)) -P-Toluenesulphonate?
2 - Hydroxy - 2 - Phenylethyl (R - ( - ) ) - P - Toluenesulphonate, this is the name of an organic compound. Its chemical structure is as follows:
The main body of this compound is composed of three key structural units. One is the 2 - Hydroxy - 2 - Phenylethyl part. In this structure, a phenylethyl group (phenylethyl) is connected to a hydroxy group (hydroxy) on the 2-position carbon. The phenethyl group, that is, one end of the carbon of an ethyl group (- CH _ 2 CH _ 3) is connected to the benzene ring, and the 2-position carbon of the ethyl group is connected to the hydroxyl group. Its structure gives the compound a specific hydrophilicity and reactivity.
The second is the (R - ( - ) ) configuration identifier. This indicates that the compound molecule has chirality, there is an enantiomer, and this specific configuration is (R) type, (-) means its optical rotation is left-handed. The existence of chirality makes the compound unique in many chemical reactions and biological activities.
The third is the P-Toluenesulphonate moiety, that is, the p-toluenesulphonate ester group. The radical part of p-toluenesulphonate is formed by connecting p-toluene group (methyl linked to the para-benzene ring) with sulfonic acid group (-SO
). This part is often used as a good leaving group and plays an important role in organic synthesis. It can promote the occurrence of nucleophilic substitution and other reactions.
In summary, the chemical structure of 2 - Hydroxy - 2 - Phenylethyl (R - ( - ) ) - P - Toluenesulphonate gives the compound unique physical and chemical properties through the synergistic action of various structural units, which is of great significance in the field of organic chemical synthesis.
What are the physical properties of 2-Hydroxy-2-Phenylethyl (R- (-)) -P-Toluenesulphonate?
2-Hydroxy-2-phenylethyl (R -( - )) - p-toluenesulfonate is an important compound in organic chemistry. Its physical properties are unique and significant in scientific research and industrial application fields.
Looking at its properties, under normal temperature and pressure, it is mostly in the state of white to off-white crystalline powder, which is easy to store and use, and the degree of fineness of the powder affects the contact area and reaction rate of its subsequent chemical reactions.
The melting point is about within a specific temperature range, and the specific value varies slightly depending on the purity and measurement conditions. Melting point is one of the key indicators to determine the purity of the compound. For high-purity products, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point decreases and the melting range becomes wider.
In terms of solubility, it exhibits a certain solubility in common organic solvents such as ethanol and acetone. This property makes it possible to choose a suitable solvent to dissolve in organic synthesis reactions, thereby promoting the reaction. The solubility in water is relatively limited. This difference is due to the molecular structure of the compound. It contains hydrophobic phenyl groups and hydrophilic hydroxyl groups and sulfonate groups. The overall polarity is moderate, resulting in different solubility between water and organic solvents.
The density of the compound is also an important physical property. Although the specific density data needs to be accurately measured to determine, its density affects the relationship between the quality and volume of the substance. It needs to be considered in the preparation, storage and transportation to ensure the safety and efficiency of the operation.
In addition, the compound may exhibit unique optical properties under specific wavelengths of light. This property may be used for analysis and detection, and the existence and purity of the compound can be identified by spectral analysis technology.
The above physical properties are of great significance in the fields of organic synthesis, drug development and other fields. Scientists can design rational synthesis routes, optimize reaction conditions, and improve product purity and yield according to their melting point, solubility, and other properties. In drug development, its physical properties are related to the stability, solubility, and bioavailability of drugs, laying the foundation for the development of new drugs.
What are the main applications of 2-Hydroxy-2-Phenylethyl (R- (-)) -P-Toluenesulphonate?
2-Hydroxy-2-phenethyl (R -( - )) - p-toluenesulfonate, an organic compound, is useful in many fields.
In the field of organic synthesis, it often acts as a key intermediate. The cap has both hydroxyl and p-toluenesulfonate groups in its structure, both of which are highly reactive. Hydroxyl groups can participate in various reactions such as esterification and etherification; p-toluenesulfonate ester groups are good leaving groups, which can react with various nucleophilic reagents in nucleophilic substitution reactions, so that the compound becomes an electrophilic reagent and reacts with various nucleophilic reagents, thereby forming new carbon-carbon, carbon-heteroatom bonds, and assisting in the synthesis of complex organic molecules.
In the field of pharmaceutical chemistry, this compound has also attracted much attention. It may be used as a structural fragment of a lead compound. After chemical modification and optimization, it is expected to develop drugs with specific pharmacological activities. Due to its structural properties, it may interact specifically with targets in organisms, providing new opportunities and directions for drug development.
In the field of materials science, 2-hydroxy-2-phenethyl (R -( - )) - toluenesulfonate can be used to prepare materials with special properties. By participating in the polymerization process, the material is endowed with unique physical and chemical properties, such as improved material solubility and thermal stability, to meet the requirements of different application scenarios.
What are the methods for preparing 2-Hydroxy-2-Phenylethyl (R- (-)) -P-Toluenesulphonate?
The method of preparing (R -( - )) - p-toluenesulfonic acid 2-hydroxy-2-phenethyl ester has been refined through the ages.
First, it can be started from 2-hydroxy-2-phenylethanol. This alcohol reacts with p-toluenesulfonyl chloride in a suitable solvent, such as pyridine, at low temperature and under stirring conditions. Pyridine can not only act as a base to capture the hydrogen chloride generated by the reaction, but also provide a relatively mild environment for the reaction. The hydroxyl group of 2-hydroxy-2-phenylethanol is nucleophilic, and the sulfonyl group of p-toluenesulfonyl chloride is electrophilic. When the two meet, the hydroxyl group attacks the sulfonyl group, and the chlorine leaves, it becomes the precursor of the target product. This reaction requires strict temperature control. Due to high temperature, it is easy to cause side reactions, such as hydrolysis of p-toluenesulfonyl chloride, or further conversion of the product.
Second, acetophenone is used as the starting material. First, acetophenone is reduced to 2-hydroxy-2-phenylethanol by reducing agents such as sodium borohydride. Sodium borohydride has moderate reduction ability and good selectivity, and can obtain alcohol efficiently. Then, according to the above method of reaction with p-toluenesulfonyl chloride, (R -( - )) - p-toluenesulfonate 2-hydroxy-2-phenethyl ester is prepared. The key to this route lies in the stereochemical control of the reduction step. If you want to obtain a specific configuration of the product, you need to choose a stereoselective reducing agent or reaction conditions.
Third, there is also a method of phase transfer catalysis. In the water-organic two-phase system, a phase transfer catalyst such as a quaternary ammonium salt is added. In the presence of alkali, the negative ion of 2-hydroxy-2-phenylethanol can shuttle between the aqueous phase and the organic phase by the power of the phase transfer catalyst, and react with the p-toluenesulfonyl chloride in the organic phase. The advantage of this method is that the reaction conditions are mild, and the two-phase system is convenient for the separation and purification of the product.
All these methods have their own advantages and disadvantages. It is necessary to consider the availability of raw materials, the cost of the reaction, the purity of the product and the configuration requirements and many other factors according to the actual needs.
What is the market price for 2-Hydroxy-2-Phenylethyl (R- (-)) -P-Toluenesulphonate?
I don't know what the market value of 2 - Hydroxy - 2 - Phenylethyl (R -(-)) - P - Toluenesulphonate is. The market value of this compound is determined by various factors.
First, this material is different from place to place, and it is different. If it is in a place where it is abundant, or the raw materials are easy to obtain, or it is low or slightly lower; if the land is biased, the raw materials are not available, and the cost is high, the price will be high.
Second, the quality also affects the price. High-quality products have high cost, and the labor cost is higher than that of ordinary products.
Third, the supply and demand of the market are also important factors. If the buyer is high, the supplier is low, and the supply is low, there will be a decline.
If you want to know the market value of this item, you can go to the chemical trading market and the merchant; or the chemical supply station, than the home, you can get close to it.