As a leading (2R,3S)-2-[(1R)-L-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)-Morpholine, 4-Methylbenzenesulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzenesulfonate
Looking at the name of this compound, it is called\ ((2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) pentyl, 4-methylbenzenesulfonate\). To know its chemical structure, it is necessary to analyze the meaning of each part in the name in detail.
First words\ ((2R, 3S) \) and\ ((1R) \), this is the configuration identification of chiral carbon. With three-dimensional chemical rules, the chiral carbon is surrounded by group priority. If it is in the clockwise\ (R\) configuration, it is the\ (S\) configuration counterclockwise. There are three chiral carbons in this compound, and their spatial arrangement is determined according to this rule.
"\ (2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy]\) ", indicating that on the second carbon of the main chain, there is an ethoxy group connected. The ethyl part of this ethoxy group, the carbon connected to the oxygen is of the\ ((1R) \) configuration, and the ethyl group is connected to a phenyl group containing\ (3,5-bis (trifluoromethyl) \) substitutions, "\ (L -\) " or indicates the specific spatial orientation or biogenesis of this part.
"\ (3- (4-fluorophenyl) \) " refers to the third carbon of the main chain with a\ (4-fluorophenyl\) attached. "Pente" indicates that the main chain is a chain-like structure of five carbons.
At the end of "\ (4-methylbenzenesulfonate\) ", it indicates that at a suitable position on the main chain (inferred by the naming convention), there is a\ (4-methylbenzenesulfonate substituent, which is obtained by esterification of\ (4-methylbenzenesulfonate with a hydroxyl group in the main chain.
In summary, the chemical structure of this compound is based on the pentacarbon chain, the second carbon is connected to a specific ethoxy group, the third carbon is connected to\ (4-fluorophenyl\), and contains a\ (4-methylbenzenesulfonate substituent, each chiral carbon is arranged according to the\ (2R, 3S) \) and\ ((1R) \) configurations, and each substituent is connected to the main chain according to the above relationship, together forming its unique chemical structure.
What are the main uses of (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzene sulfonate
(2R, 3S) - 2 - [ (1R) - L - [3,5-bis (trifluoromethyl) phenyl] ethoxy] - 3 - (4-fluorophenyl) pentene, 4-methylphenylmalonic anhydride This substance has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of specific drugs. Due to its unique chemical structure, it can precisely fit with specific biological targets, helping to develop innovative drugs for specific diseases, such as some highly targeted anti-cancer drugs. It is used to build a unique chemical framework to improve drug efficacy and reduce side effects.
In the field of materials science, it also has its uses. It can participate in the preparation of functional materials with special properties, such as optical materials that are sensitive to specific wavelengths of light, or polymer materials with excellent electrical conductivity. This is because chemically active groups can play a unique role in the synthesis of materials, regulating the microstructure of materials and endowing materials with special properties.
In the field of organic synthetic chemistry, it is an indispensable and important reagent. It is often used as a starting material or a key reaction intermediate in the synthesis of many complex organic compounds. Due to its structural properties, various complex and novel organic compounds can be derived through various organic reactions, such as nucleophilic substitution, addition reactions, etc., providing a rich material basis and diverse synthesis paths for the development of organic synthetic chemistry.
What is the synthesis method of (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzene sulfonate
To prepare (2R, 3S) - 2 - [ (1R) - L - [3,5 - bis (trifluoromethyl) phenyl] ethoxy] - 3 - (4 - fluorophenyl) pentene, 4 - methylbenzenesulfonate, the following ancient method can be used.
Take the appropriate starting material first. This starting material needs to have a specific three-dimensional configuration in order to guide to the (2R, 3S) configuration required by the target product. Reaction of a reagent containing (1R) -L- [3,5 -bis (trifluoromethyl) phenyl] ethoxy with another compound having a reactive check point capable of nucleophilic substitution or similar reaction with the above reagent to introduce [ (1R) -L- [3,5 -bis (trifluoromethyl) phenyl] ethoxy] fragments.
Then, for the introduction of 3- (4-fluorophenyl) moiety, suitable reagents containing 4-fluorophenyl can be found. Through appropriate organic reactions, such as nucleophilic addition, substitution, etc., the 4-fluorophenyl group can be connected to the appropriate position to construct the carbon skeleton of the target product. In this process, attention should be paid to the control of reaction conditions, such as temperature, solvent, catalyst and other factors, which have a significant impact on the stereochemistry and yield of the reaction.
As for the formation of 4-methylbenzenesulfonate, the conversion of sulfonate can be achieved at a suitable stage by reagents such as 4-methylbenzenesulfonyl chloride and suitable hydroxyl groups in the product. This process also requires careful selection of reaction conditions to ensure the selectivity and efficiency of the reaction, avoid the occurrence of side reactions, and ensure that the purity and configuration of the final product meet the requirements. In this way, through various reactions and operations, the target (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) pentene, 4-methylbenzenesulfonate can be obtained.
What are the physicochemical properties of (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzene sulfonate
(2R, 3S) - 2 - [ (1R) - L - [3,5 -bis (trifluoromethyl) phenyl] ethoxy] - 3 - (4 -fluorophenyl) piperidine, 4 -methylbenzenesulfonate is a complex organic compound, and its physicochemical properties are worth investigating.
Looking at its physical properties, this compound may be a solid at room temperature. Because of its structure, it contains many aromatic rings and complex substituents, and the intermolecular force is strong. The melting point may vary depending on molecular regularity and interaction. The presence of aromatic rings causes molecular stacking to be tight, or has a high melting point. Its solubility is also affected by the structure. Due to the fluorine atom and sulfonate group, it may have a certain solubility in organic solvents such as dichloromethane and chloroform. Due to the lipophilic of fluorine atoms, sulfonate group can form a weak interaction with organic solvents. However, the solubility in water is low or low, because of its overall structure hydrophobic.
On its chemical properties, the benzene ring in the compound is aromatic and can undergo electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. The nitrogen atom of piperidine ring has lone pairs of electrons, which are alkaline to a certain extent and can form salts with acids. The ethoxy group and sulfonate group are active functional groups, and the oxygen atom in the ethoxy group can be used as a nucleophilic reagent to participate in the reaction; the sulfonate group is a good leaving group, which is prone to nucleophilic substitution reactions, such as reacting with nucleophilic reagents such as alcohols and amines to form new compounds. The fluorine-containing substituents make the compounds have unique chemical stability and electronic effects, which affect the reactivity and selectivity.
What is the market availability of (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzene sulfonate?
Today, there are\ ((2R, 3S) -2- [ (1R) -L- [3,5 -bis (trifluoromethyl) phenyl] ethoxy] -3- (4 -fluorophenyl) butyl, 4 -ethylbenzenesulfonate\). How is the supply situation of this compound in the market? Let me tell you one by one.
The structure of this compound is slightly complicated, and its preparation may require multiple steps of organic synthesis. Due to the availability of the market, it depends on many factors. First, if this compound is widely used, such as in the field of pharmaceutical research and development, as a key intermediate for specific drugs, or has unique properties in materials science, it can be used for material improvement, the demand may be high, and the supply may be sufficient. Relevant pharmaceutical companies and chemical companies may focus on production due to market needs.
However, if its application is limited, it only exists in the laboratory research stage, or the synthesis is extremely difficult, the reaction conditions and raw material purity are demanding, the cost is high, and the market supply may be scarce. There may even be only a few professional chemical reagent companies, in order to meet specific scientific research needs, limited preparation.
Or due to factors such as environmental protection, policies and regulations, its production process may be affected, resulting in supply changes. Therefore, in order to know the exact market supply situation, it is necessary to check the chemical product database, consult professional reagent suppliers, or search relevant industry reports to clarify.