(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)-2-Butanol L(-)-Camphorsulfonate

(2R, 3S) 2- (2,4-difluorophenyl) -3- (5-fluoropyridine-4-yl) -1- (1H-1,2,4-triazole-1-yl) -2 -butanol L (-) -mandelate, which is an organic compound. To know its chemical structure, it can be disassembled and analyzed.
First, the main part, (2R, 3S) -2 -butanol, which is a chain alcohol containing four carbons, has a specific stereoconfiguration at positions 2 and 3, which are R and S configurations, respectively. The 2-position connection has (2,4-difluorophenyl), that is, the 2,4-position of the benzene ring is replaced by a fluorine atom; the 3-position connection (5-fluoropyridine-4-group) indicates that the 5-position of the pyridine ring has a fluorine atom, and the 4-position is connected to the main body; the 1-position connection (1H-1,2,4-triazole-1-group) means that the 1-position of the 1,2,4-triazole ring is connected to the main body.
Looking at the L (-) -mandelate part again, L (-) -mandelic acid is a chiral compound, which is connected to the host (2R, 3S) -2 -butanol through esterification reaction. In this structure, each group is connected by covalent bonds to construct a specific three-dimensional spatial structure. The electronic effect of different atoms and groups, the spatial resistance and other factors will affect the physical, chemical and biological activities of the compound. Its three-dimensional configuration and substituent properties may determine its performance in specific chemical reactions and biological interactions.

(2R, 3S) - 2 - (2,4 - difluorophenyl) - 3 - (5 - fluoropyridine - 4 - yl) - 1 - (1H - 1,2,4 - triazole - 1 - yl) - 2 - butanol L （ - ） - mandelate, which has a wide range of uses. It is often used as a key intermediate in the synthesis of medicine and can participate in the creation of many specific drugs. Taking antifungal drugs as an example, with their unique chemical structure and series of reactions, they can synthesize drugs that have strong inhibition of fungi and help overcome fungal infections.
In the field of organic synthesis, it also plays an important role. Because it contains specific functional groups, it can trigger a variety of chemical reactions, such as nucleophilic substitution, addition, etc., providing an effective path for the construction of complex organic molecules, and assisting in the synthesis of novel structures and excellent properties of organic compounds.
Furthermore, in the field of asymmetric synthesis, this compound can induce the reaction to proceed in a specific chiral direction due to the existence of chiral centers, which greatly enhances the chiral purity of the target product. It is of great significance for the preparation of high-purity chiral drugs and chiral functional materials. It is like a precise key to open the door to chiral synthesis.

To prepare (2R, 3S) - 2 - (2,4 - difluorophenyl) - 3 - (5 - fluoropyridine - 4 - yl) - 1 - (1H - 1,2,4 - triazole - 1 - yl) - 2 - butanol L （ - ） - mandelate, the method is as follows:
First take an appropriate amount of 2,4 - difluorobenzaldehyde, placed in a clean reaction vessel, add a specific organic solvent to make a uniform solution. After pretreatment of (S ） - （ - ） - 1 - phenyl - 2 - (1H - 1,2,4 - triazole - 1 - yl) ethanol, slowly poured into the above solution, while adding an appropriate amount of base catalyst, control the reaction temperature in a specific interval, stirring the reaction for several hours, so that the two condensation reaction occurs sufficiently to generate key intermediates.
Then, the obtained intermediate product is transferred to another reaction device, and a reagent containing 5-fluoropyridine-4-group is added, and a specific metal catalyst and ligand are added. Under certain temperature and pressure conditions, the coupling reaction is carried out. During the reaction process, the reaction process needs to be closely monitored, and the reaction is confirmed to be complete by suitable analytical means.
After the reaction is completed, the reaction mixture is post-treated. First, the organic phase is extracted with an organic solvent, and then the impurities are removed by washing and drying. Subsequently, the product is purified by column chromatography or recrystallization, and a suitable eluent or solvent is carefully selected to obtain high-purity (2R, 3S) -2- (2,4-difluorophenyl) -3- (5-fluoropyridine-4-yl) -1- (1H-1,2,4-triazole-1-yl) -2-butanol.
Finally, this product is esterified with L （ - ） - mandelic acid under specific temperature conditions in the presence of suitable dehydrating agents and catalysts. After the reaction is completed, post-treatment and purification operations are carried out again to obtain the target product (2R, 3S) - 2 - (2,4 - difluorophenyl) - 3 - (5 - fluoropyridine - 4 - yl) - 1 - (1H - 1,2,4 - triazole - 1 - yl) - 2 - butanol L （ - ） - mandelate. The whole process needs to pay attention to the precise control of each reaction condition, as well as the connection and operation specifications between each step to ensure high yield and purity.

(2R, 3S) 2- (2,4-difluorophenyl) -3- (5-fluoropyridine-4-yl) -1- (1H-1,2,4-triazole-1-yl) -2 -butanol L (-) -mandelate, this is an organic compound. Its physical and chemical properties are quite important and have a significant impact in many fields.
First of all, the appearance properties of this compound are usually white to off-white crystalline powder, with fine and uniform texture, just like fresh snow in the early winter, pure and regular shape. This appearance feature not only reflects its purity, but also has great significance for its subsequent processing and application. In the pharmaceutical process, uniform powder is conducive to the preparation of pharmaceutical preparations, which can ensure stable drug quality and accurate dosage.
As for the melting point, it has a specific melting point range, which is about [X] ° C - [X] ° C. The melting point is the inherent property of the substance, just like the unique fingerprint of each person. The precise melting point not only provides a key basis for the identification of the compound, but also an important indicator for controlling the purity and quality of the product during the production process. If the melting point deviates from the normal range, it is like a ship deviating from the established route, suggesting that the product may be mixed with impurities, and the production process needs to be adjusted in time.
In terms of solubility, the compound exhibits a certain solubility in organic solvents such as ethanol and dichloromethane, but it is difficult to dissolve in water. This property is like a double-edged sword. In the organic synthesis reaction, its solubility in organic solvents can be used to make the reaction more complete and efficient, just like a fish in water. However, in the development of drugs, low water solubility may pose challenges for drug preparations. It is necessary to improve its water solubility through specific technical means to ensure the absorption and efficacy of drugs in the body.
In terms of stability, under normal temperature and dry environment, the compound is relatively stable, like a constant star in a quiet night sky. However, once exposed to high temperature, high humidity or strong light, it is prone to chemical changes and structural damage. Therefore, environmental conditions need to be strictly controlled during storage to ensure that its quality is not affected.
The above physical and chemical properties are interrelated, and together they build the "characteristic building" of the compound, which plays an indispensable role in the fields of organic synthesis and drug development, laying a solid foundation for scientists to explore its potential applications.

Nowadays, there are (2R, 3S) -2- (2,4-difluorophenyl) -3- (5-fluoropyridine-4-yl) -1- (1H-1,2,4-triazole-1-yl) -2-butanol L (-) -mint sulfonate in the market, and its prospects are quite promising. This compound has great potential for pharmaceutical research and development.
It contains special structures, such as 2,4-difluorophenyl, 5-fluoropyridine-4-yl and 1,2,4-triazolyl, which endow it with unique pharmacological activity. In the creation of antifungal drugs, it may emerge. Its chiral structure and peppermint sulfonate part have a profound impact on drug activity and metabolism in the body, or can improve drug selectivity and affinity, and reduce adverse reactions.
Looking at the market, the demand for medicine is on the rise, and the search for high-efficiency and low-toxicity new drugs has never stopped. This compound has a unique structure and potential activity, which has attracted the attention of many pharmaceutical companies and researchers. During the research and development process, if we can overcome the synthesis problem and improve the yield and purity, we will be able to occupy a place in the antifungal drug market, bringing good news to patients, and the future is bright.