As a leading (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-Fluoropyrimidin-4-Yl)-1-(1H-1,2,4-Triazol-1-Yl)Butan-2-Ol L(-)-Camphorsulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of (2R, 3S) 2- (2,4-difluorophenyl) -3- (5-fluoropyrimidine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol L (-) -camphor sulfonate
There is a substance called\ ((2R, 3S) -2- (2,4-difluorophenyl) -3- (5-fluoropyridine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol\) \ (L (-)-\) mandelate. This is one of the organic compounds with a specific chemical structure.
In its structure, on the main chain of butanol, there is a\ ((2,4-difluorophenyl) \) group at the 2 position, which is formed by the substitution of fluorine atoms at the two and four positions above the benzene ring; the 3 position is connected with\ ((5-fluoropyridine-4-yl) \), which is a fluorine atom at the 5 position on the pyridine ring, and the 4 position is connected to the main chain; the 1 position is connected by\ ((1H-1,2,4-triazole-1-yl) \), which is a five-membered heterocycle containing three nitrogen atoms, and the 1 position is connected to the main chain. In addition, this compound forms an ester bond with\ (L (-)-\) mandelic acid, and the mandelic acid part of\ (L (-)-\) is dehydrated and condensed by the hydroxyl group of the carboxyl group and butanol to form an ester structure. The overall structure is complex and delicate, and the groups are connected to each other to form the structure of this unique chemical substance.
What are the main uses of (2R, 3S) 2- (2,4-difluorophenyl) -3- (5-fluoropyrimidine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol L (-) -camphor sulfonate
(This is an inquiry about the main uses of (2R, 3S) -2- (2,4-difluorophenyl) -3- (5-fluoropentyl-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol L (-) -mandelate.)
This compound is very important in the field of medicinal chemistry. First, it may emerge in the research and development of antifungal drugs. The structure of 1,2,4-triazole is often found in antifungal drugs. By interacting with the fungal cytochrome P450 enzyme system, it interferes with the biosynthesis of ergosterol, and then destroys the structure and function of fungal cell membranes to achieve antifungal effects. The triazolyl group in this compound may have similar antifungal activity. Structural modifications such as difluorophenyl and fluoropentyl may enhance the antifungal spectrum and activity to enhance the inhibitory ability against specific fungi.
Second, it is of great significance in the optimization of pharmaceutical chemical structure. Its complex structure contains various functional groups and chiral centers. Researchers can explore the relationship between structure and activity by modifying its structure, such as adjusting the position and number of fluorine atoms, changing the length of the amyl chain and the branched chain status, and laying the foundation for the development of high-efficiency, low-toxicity and selective new drugs.
Furthermore, it may play a role in the field of chiral drug research. L (-) -mandelic acid ester, as a chiral ligand, endows the compound with a chiral environment. The pharmacological activity and pharmacokinetic properties of different enantiomers of chiral drugs are significantly different in vivo. The study of the chiral characteristics of this compound may provide ideas and basis for the development of single chiral pure drugs, improve drug efficacy and reduce adverse reactions.
What is the preparation method of (2R, 3S) 2- (2,4-difluorophenyl) -3- (5-fluoropyrimidine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol L (-) -camphor sulfonate?
To prepare\ ((2R, 3S) -2- (2,4-difluorophenyl) -3- (5-fluoropyridine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol\) \ (L (-)-\) menthol ester, the method is as follows:
first take an appropriate amount of\ (2,4-difluorobenzaldehyde\), and react with a specific chiral adjuvant-containing reagent. This chiral adjuvant can guide the stereochemical direction of the reaction and make the product have a specific spatial configuration. After a series of reactions, an intermediate with a specific chiral center is formed.
At the same time, using\ (5-fluoropyridine-4-formaldehyde\) as the starting material, through several steps, suitable functional groups are introduced to enable it to react smoothly with the above intermediates.
The above two intermediates are condensed under suitable catalysts and reaction conditions. Factors such as reaction temperature, solvent and reactant ratio are controlled so that the reaction selectively generates a product of the\ ((2R, 3S) \) configuration. This step requires fine regulation, and the configuration is prone to errors if there is a slight difference in the pool.
The condensation product is then converted into\ (1H-1,2,4-triazole-1-yl\) through an appropriate functional group conversion reaction to generate a key intermediate.
Finally, this key intermediate is esterified with\ (L (-)-\) menthol under dehydrating agent and suitable reaction conditions to obtain the target product\ ((2R, 3S) -2- (2,4-difluorophenyl) -3- (5-fluoropyridine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol\) \ (L (-)-\) menthol ester. The whole reaction process needs to be closely monitored, and the product at each step should be purified and structurally identified to ensure the purity and configuration of the product are correct.
How is the stability of (2R, 3S) 2- (2,4-difluorophenyl) -3- (5-fluoropyrimidine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol L (-) -camphor sulfonate
Ximing (2R, 3S) - 2- (2,4-difluorophenyl) - 3- (5-fluoropyridine-4-yl) - 1- (1H-1,2,4-triazole-1-yl) - 2-butanol L ( - ) - mechanically shows the stability of acid anhydride, which can be referred to the method of "Tiangong Kaiwu", which is described in ancient words.
The stability of this compound is related to its structure and environment. In terms of structure, it contains difluorophenyl, fluoropyridine and triazolyl groups, etc. These groups interact, or increase or decrease their stability. The fluorine atoms in difluorophenyl have strong electronegativity, which can cause electron cloud migration, affect the charge distribution in molecules, and change the properties of adjacent chemical bonds, which has a great impact on stability. In fluoropyridine groups, fluorine atoms interact with the conjugated system of pyridine rings, or change the density of ring electron clouds, which affects the overall structural stability. Nitrogen atoms of 1,2,4-triazolyl can participate in the formation of hydrogen bonds or conjugation effects, further affecting molecular stability.
In terms of location, temperature, humidity, light, etc. are all critical. High temperature or molecular thermal motion intensifies, and the vibration of chemical bonds is enhanced to a certain extent. Chemical bonds or breaks, resulting in reduced stability. When the humidity is high, water molecules may form hydrogen bonds with compounds, changing their intermolecular interactions, or promoting reactions such as hydrolysis, which impairs their stability. Under light, if the compound absorbs photons of a specific wavelength, the molecules can be excited to a high energy state, triggering photochemical reactions, resulting in structural changes, and the stability is also affected.
To increase its stability, you can control temperature, humidity, and protection from light during storage. Or through chemical modification, such as the introduction of protective groups, change the molecular structure to achieve the purpose of stability. Thus, (2R, 3S) - 2 - (2,4 - difluorophenyl) - 3 - (5 - fluoropyridine - 4 - yl) - 1 - (1H - 1,2,4 - triazole - 1 - yl) - 2 - butanol L ( - ) - mechanically showed that the anhydride remained stable under suitable conditions.
What is the market prospect of (2R, 3S) 2- (2,4-difluorophenyl) -3- (5-fluoropyrimidine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol L (-) -camphor sulfonate?
Nowadays, there are (2R, 3S) -2- (2,4-difluorophenyl) -3- (5-fluoropyridine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-alcohol L (-) -mandelate in the market. What is its shape? Let me know in detail.
This compound is in the market, which is related to its shape or appearance. Generally speaking, the shape of an organic compound is either crystalline or amorphous. In the crystalline state, it often has a regular geometric shape due to the orderly arrangement of its molecules. If it is in a crystalline state, the crystals may be in the shape of needles, flakes, blocks, etc. Under the light, it may be in a crystalline state or shiny.
Or amorphous, amorphous, the molecular arrangement is disordered, the appearance may be amorphous powder, the texture may be fine, and the touch is smooth; or it is a viscous liquid, the fluidity varies depending on factors such as the intermolecular force and the temperature.
Furthermore, its color is also noticeable. Pure organic compounds, or colorless and transparent, as clear as water; or white, such as the first snow in winter, pure and white; or due to the characteristics of some groups in the molecular structure, and light color, such as light yellow, light powder and other light colors.
However, the state of this compound in the market is actually affected by many factors. The preparation method, if the preparation process is fine, the resulting product may have a regular state; on the contrary, it may be messy. The storage environment, temperature and humidity can affect its shape, high temperature or cause its morphological changes, and the humid environment may make it deliquescent.
This (2R, 3S) 2- (2,4-difluorophenyl) -3- (5-fluoropyridine-4-yl) -1- (1H-1,2,4-triazole-1-yl) butyl-2-ol L (-) -mandelate is in the form of the market, either crystalline or amorphous, or colored or colorless, depending on the preparation and storage.