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(2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate What is the product?
There is a substance named\ ((2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) butyl-4-methylbenzenesulfonate\). This is a specific compound in organic chemistry. Its structure is complex and consists of a combination of various groups.
The name, "\ ((2R, 3S) \) ", indicates the three-dimensional configuration of a specific atom in the compound. " \ (2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) \) ", this part indicates that a specific substituent is attached to the second carbon atom of the main chain. The substituent contains an ethoxy group, and the carbon atom attached to the ethoxy group has a\ ((R) \) configuration, and is connected with\ (3,5-bis (trifluoromethyl) phenyl\)."\ (3- (4-fluorophenyl) \) ", which means that the third carbon atom of the main chain is connected with\ (4-fluorophenyl\). The word" D "indicates that the main chain is a four-carbon chain." \ (4-Methylbenzenesulfonate\) "Then the fourth carbon atom of the main chain of the table is connected to the methylbenzenesulfonate group.
This compound is used in the field of organic synthesis or has specific uses. It can be used as an intermediate to participate in various reactions to prepare more complex organic molecules. Or because of its unique structure, it also has potential applications in medicinal chemistry, materials science, etc., and can use its special three-dimensional configuration and group properties to achieve specific functions. However, its specific use depends on the relevant research and application scenarios.
What is the chemical structure of (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzenesulfonate?
Alas! To know the chemical structure of (2R, 3S) - 2 - (R) - 1 - (3,5 - bis (trifluoromethyl) phenyl) ethoxy) - 3 - (4 - fluorophenyl) morpholine - 4 - methylbenzoate, it is necessary to carefully analyze.
This compound has a complex structure. First of all, its main body is a morpholine ring. At the second position of the morpholine ring, there is a ((R) - 1 - (3,5 - bis (trifluoromethyl) phenyl) ethoxy) group. In this group, the ethoxy group is attached to the morpholine ring at one end, and the ethyl group at the other end has a substituent of the (R) -configuration, that is, 1- (3,5-bis (trifluoromethyl) phenyl). Among them, 3,5-bis (trifluoromethyl) phenyl means that the 3rd and 5th positions of the benzene ring are each connected with a trifluoromethyl group.
Look at the 3rd position of the morpholine ring again, which is connected with a 3- (4-fluorophenyl) group, that is, the 4th position of the benzene ring is connected with a fluorine atom. The 4th position of the morpholine ring is connected with a methylbenzoate group. This is after the benzoic acid is estered with methanol, the benzene ring is connected to the 4th position of the morpholine ring.
In summary, the chemical structure of this compound is composed of a morpholine ring as the core, and multiple different substituents are connected to specific positions on the ring, and each substituent interacts to form its unique chemical structure. Such a complex structure determines its chemical and physical properties, and may have specific uses and reactivity in related chemical fields.
What are the uses of (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate?
There is now a product named (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine-4-yl acetate phenyl ester. This substance has a wide range of uses.
First, it can be used as an active ingredient in the research and development of medicine. The molecular structure is unique, with a specific spatial configuration and chemical group, which can precisely bind to specific targets in organisms, just like the fit of mortise and tenon. Or it can be used to develop drugs for the treatment of specific diseases, such as for some diseases caused by abnormalities of specific biomolecules, through its interaction with the target, it regulates the physiological process in the organism and achieves the purpose of treatment.
Second, it is also useful in the field of organic synthesis. Because of its complex structure and characteristic groups, it can be used as a key intermediate. Organic synthesis is like building a delicate building block. This intermediate can participate in a variety of chemical reactions by virtue of its functional group characteristics, splicing and combining with other organic molecules to construct more complex and novel organic compounds, opening up new paths for organic synthesis chemistry and enriching the variety of compounds.
Third, it may have potential value in the field of materials science. In view of its chemical stability and unique physical properties, with appropriate modification and processing, it may be applied to the preparation of materials with special properties. For example, it may endow materials with unique optical and electrical properties, and be applied to optoelectronic devices and other fields, contributing to the development of materials science.
What is the preparation method of (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate?
To prepare (2R, 3S) - 2 - ((R) - 1 - (3,5 - bis (trifluoromethyl) phenyl) ethoxy) - 3 - (4 - fluorophenyl) butyrolactone - 4 - methylbenzenesulfonate, the method is as follows:
First take (3,5 - bis (trifluoromethyl) phenyl) ethanol and react with halogenated ethane in a suitable reaction vessel with a suitable base as a catalyst to obtain (R) - 1 - (3,5 - bis (trifluoromethyl) phenyl) ethoxyethane. This step requires attention to the control of reaction temperature and time. If the temperature is too high, side reactions will easily occur, and if the time is too short, the reaction may be incomplete.
Another 4-fluorophenylacetic acid is taken and converted into the corresponding acid chloride through a specific acylation reaction. The acid chloride is reacted with a suitable enol ether to obtain an intermediate product. In this reaction process, the choice of solvent is very critical, and it is necessary to choose one that can promote the reaction without causing too many side reactions.
Then the (R) -1 - (3,5 - bis (trifluoromethyl) phenyl) ethoxyethane obtained above is reacted with the intermediate product under suitable catalyst and reaction conditions to gradually construct the basic structure of the target molecule. After the reaction is completed, the impurities are removed by separation and purification.
Finally, the purified product is reacted with methylbenzenesulfonyl chloride, and in a suitable alkaline environment, (2R, 3S) -2- ((R) -1- (3,5 -Bis (trifluoromethyl) phenyl) ethoxy) -3- (4 -fluorophenyl) butyrolactone-4 -methylbenzenesulfonate can be obtained. In this last step of the reaction, the control of the amount of base and the reaction time is related to the purity and yield of the product. The whole preparation process, the conditions of each step of the reaction are finely regulated, and the separation and purification of each intermediate is proper, so that the target product with high purity can be obtained.
What are the physical and chemical properties of (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate?
(2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine-4-methylbenzoate is an organic compound. Its physicochemical properties are particularly important, related to its performance in various reactions and applications.
In terms of its physical properties, generally speaking, this compound has a specific melting point and boiling point. The melting point is the critical temperature for the conversion of solid to liquid state, and its value varies depending on the intermolecular force. In this molecule, the presence of aromatic rings and fluorinated groups makes the intermolecular force present a specific state, and the melting point is within a certain range. The boiling point is also affected by the molecular structure. Due to factors such as molecular mass and polarity, it boils at a specific pressure.
As for chemical properties, this compound contains benzoate ester structure, and the ester group can undergo hydrolysis reaction. Under acidic or basic conditions, the ester bond can be broken to form corresponding acids and alcohols, respectively. And the aromatic ring in the molecule has the typical reactivity of aromatic hydrocarbons, such as electrophilic substitution reaction. Due to the positioning effect of fluorine atoms and trifluoromethyl groups, electrophilic reagents will selectively attack specific positions of aromatic rings. In addition, the morpholine ring also gives it a certain alkalinity and can react with acids to form salts. Its ethoxy group is relatively stable, but it may also undergo chemical transformation under strong oxidation or reduction conditions. The various physical and chemical properties of this compound make it potentially useful in organic synthesis, medicinal chemistry and other fields.