As a leading [(2R,4R)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-Triazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methyl Methanesulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of [ (2R, 4R) -2- (2,4-dichlorophenyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxy-4-yl] methylmethanesulfonate
I look at this question, which is about the chemical structure of [ (2R, 4R) -2- (2,4-difluorobenzyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxolane-4-yl] methylmethanesulfonate. This is a difficult problem in the field of organic chemistry. To solve this question, we need to follow the basic principles and rules of organic chemistry.
First of all, the stereochemical label " (2R, 4R) ", which indicates the spatial configuration of a specific atom in a molecule. " R ", according to the Cahn-Ingold-Prelog rule, means that the atomic connection order of the chiral center is clockwise.
" 2- (2,4-difluorobenzyl) ", this part indicates that at position 2 of the main structure, there is a connection of 2,4-difluorobenzyl. Benzyl is benzyl, that is, benzene ring is connected to methylene, and the benzene ring on this methylene is replaced by fluorine atoms at positions 2 and 4.
"2- (1H-1,2,4-triazole-1-ylmethyl) ", which means that there is also 1H-1,2,4-triazole-1-ylmethyl at position 2 of the main structure. 1H-1,2,4-triazole is a five-membered heterocycle containing three nitrogen atoms, and 1-ylmethyl means that the number 1 position of the heterocycle is connected to the methylene, which is then connected to the main structure.
"1,3-dioxane-4-group", this is a five-membered ring structure, the 1 and 3 positions in the ring are oxygen atoms, and the 4 position participates in the main structure connection.
"Methanesulfonate" indicates that the main structure is connected to methyl methanesulfonate group, the sulfur atom in methanesulfonate is connected to the main structure, and the oxygen atom of the sulfonate group is connected to the methyl group.
Overall, the chemical structure of [ (2R, 4R) -2- (2,4-difluorobenzyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxolane-4-yl] methylmethanesulfonate is composed of a main ring with a specific three-dimensional configuration, which is connected with difluorobenzyl and triazole methyl, and is connected to methyl-containing methanesulfonate groups at the 4th position on the ring. This structure integrates a variety of functional groups and may have important uses in the fields of organic synthesis and medicinal chemistry.
What are the main uses of [ (2R, 4R) -2- (2,4-dichlorophenyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxy-4-yl] methylmethanesulfonate
[ (2R, 4R) -2- (2,4-difluorophenyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxy-amyl-4-yl] methyl methanesulfonate, although not directly recorded in Tiangong Kaiwu, it has a wide range of uses in today's chemical field.
It is often a key intermediate in the synthesis of medicine. The 1,2,4-triazole and dioxy-amyl ring contained in the Gain structure have unique reactivity and spatial configuration. Based on this, chemists can carefully construct complex drug molecular structures, which are particularly prominent in the creation of antifungal drugs. After ingenious derivation and modification, compounds with high affinity and inhibitory activity for specific fungal enzymes can be obtained to treat various fungal infections.
In the field of materials science, it has also made a name for itself. Due to its specific chemical structure, it can participate in the synthesis and modification of polymer materials. It can also be a functional monomer for polymerization reactions, endowing materials with special physical and chemical properties, such as improving the thermal stability and mechanical properties of materials, or even endowing them with unique optical and electrical properties, opening up new avenues for the research and development of new functional materials.
In organic synthetic chemistry, it is an important building block. Chemists use their diverse reaction check points to carry out various organic reactions, such as nucleophilic substitution, redox, etc., to prepare structure-rich organic compounds, contribute to the development and innovation of organic synthetic chemistry, and provide powerful tools for exploring the relationship between structure and function of new organic molecules.
What is the preparation method of [ (2R, 4R) -2- (2,4-dichlorophenyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxy-4-yl] methylmethanesulfonate
To prepare [ (2R, 4R) -2- (2,4-difluorobenzyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxane-4-yl] methyl methanesulfonate, you can follow the following method.
First take an appropriate amount of (2R, 4R) -2- (2,4-difluorobenzyl) -1,3-dioxane-4-methanol and place it in a clean reaction vessel. Add a suitable organic solvent, such as dichloromethane, and stir to disperse the material evenly. To this solution, slowly add methanesulfonyl chloride, and at the same time add an appropriate amount of organic bases, such as triethylamine, to neutralize the hydrogen chloride generated by the reaction. The reaction process needs to be carried out in a low temperature environment, such as between 0 ° C and 5 ° C, which can make the reaction occur smoothly and reduce the generation of side reactions.
The molar ratio of methanesulfonyl chloride to (2R, 4R) 2- (2,4-difluorobenzyl) -1,3-dioxyamyl-4-methanol should be controlled within a certain range, about 1.2:1 to 1.5:1, to ensure that the raw materials are fully reacted. After adding, keep the low temperature and continue to stir for a period of time, about 2 to 4 hours. During this period, the reaction process can be monitored by thin layer chromatography (TLC). When the raw material point basically disappears, the reaction has reached the expected level.
After the reaction is completed, pour the reaction liquid into an appropriate amount of ice water to stop the reaction. The organic phase was then extracted with dichloromethane and collected. The organic phase was washed with a saturated sodium bicarbonate solution and water to remove impurities. After that, the organic phase was dried with anhydrous sodium sulfate and the desiccant was filtered off. The organic solvent was removed by reduced pressure distillation to obtain a crude product.
The resulting crude product was purified by column chromatography and eluted and separated with a suitable eluent, such as a mixture of petroleum ether and ethyl acetate, in a certain proportion. The fractions containing the target product were collected and distilled under reduced pressure again to remove the eluent to obtain a purified [ (2R, 4R) -2- (2,4-difluorobenzyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxyamyl-4-yl] methylmethanesulfonate.
What are the safety and side effects of [ (2R, 4R) -2- (2,4-dichlorophenyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxy-4-yl] methylmethanesulfonate
(The description of the names of the chemical substances involved in this paragraph is extremely complex and professional, and it is quite challenging to explain the properties of modern chemical substances in ancient classical Chinese format. The following attempts to create according to the requirements)
Today there is a product named [ (2R, 4R) -2- (2,4-difluorobenzyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxyamyl-4-yl] methylmethanesulfonate. The safety and side effects of this product are related to the health of the user and cannot be ignored.
In terms of its safety, this product can only be relatively stable under specific environments and conditions. If it is handled perversely, or in case of uncomfortable temperature, humidity, pH, it is afraid of variables. Its molecular structure is exquisite, but therefore, it is vulnerable to external factors, or cause changes in traits, endangering the surrounding.
As for side effects, or disturbing the physiological functions of living beings. After entering the body, or interacting with the viscera and meridians, causing the flow of qi and blood to be blocked. If it damages the spleen and stomach, it will make the food unpleasant and the body will lose weight; or the order of qi and blood will be disordered, causing the head to be dizzy and restless. Or between the skin and the skin, it will cause a rash and itching. And if this thing is involved in the natural environment, it may also disturb the ecological balance and harm insects, fish, plants and trees.
Therefore, those who use this thing must be careful, carefully observe its nature, and act according to reason, so as to keep it safe and not to cause disasters in the world.
[ (2R, 4R) -2- (2,4-dichlorophenyl) -2- (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxy-4-yl] Methylmethanesulfonate What is the competitive situation in the market?
Guanfu [ (2R, 4R) -2 - (2,4-dihydrophenyl) -2 - (1H-1,2,4-triazole-1-ylmethyl) -1,3-dioxane-4-yl] methyl, phenyl, acetate, the competition situation of this product in the market is still related to many parties.
Its structure is unique and cleverly connected by specific groups. However, the competition in the market is like a battlefield, which is related to technology, cost and demand. In the process of technology, if you want to make this product, you need a delicate method. The process of synthesis may require precise control of the reaction conditions in order to obtain the ideal yield and purity. Good manufacturers, if they can produce high-purity products stably and efficiently, will have a head start in the competition.
On the cost side, the price of raw materials and the cost of energy consumption are all key. If you can find cheap and high-quality raw materials and optimize the process to reduce energy consumption, you can reduce costs and compete with the market at the best price.
As for demand, it depends on the downstream use. If this product is in high demand in the fields of medicine, chemical industry, etc., the market is vast. On the contrary, if the demand is weak, even if the skills are exquisite and the cost is low, it is difficult to get out of the predicament.
Therefore, in order to understand its competitive situation, we must look at the skills, costs and demand. Only by considering the overall situation, can we break through the tide of the market and win a place.