(2S-Trans)-3-Amino-2-Methyl-4-Oxo-1-Azetidine Sulfonic Acid(Side Chain For Aztreonam)

(2S-trans) -3-amino-2-methyl-4-oxo-1-azacyclobutane sulfonic acid (aztreonam side chain) is widely used in the field of medicine. Atrionam is a monocyclic beta-lactam antibiotic with antibacterial properties. This side chain is the key raw material for the synthesis of aztreonam, which is related to the structure and activity of aztreonam.
In the preparation of antibacterial drugs, this side chain is used to construct the molecular structure of aztreonam. After chemical synthesis, it reacts with other reagents to eventually form aztreonam. Aztreonam has powerful antibacterial activity against Gram-negative bacteria, such as Escherichia coli and Klebsiella pneumoniae, and can be used to treat infections caused by these bacteria, such as respiratory tract infections, urinary tract infections, and abdominal infections.
And this side chain is also of great significance in pharmaceutical research and development. By studying its relationship with aztreonam, researchers can optimize the synthesis process of aztreonam, improve yield and purity; or explore new beta-lactam antibacterial drugs, broaden the antibacterial spectrum, enhance antibacterial efficacy, and provide more options for clinical treatment of bacterial infections. Therefore, (2S-trans) -3-amino-2-methyl-4-oxo-1-azacyclobutane sulfonic acid plays an important role in the synthesis, research and development of antibacterial drugs and the clinical treatment of infectious diseases.

The production process of (2S-trans) -3-amino-2-methyl-4-oxo-1-azacyclobutane sulfonic acid (aztreonan side chain) is a complicated and delicate process.
The selection of initial raw materials is extremely critical. It is necessary to select high-quality and high-purity starting materials, which are mentioned before ensuring the quality of the product. All raw materials are finely measured and compatible according to specific proportions, just like the ancient drug adjustment, which is not bad.
After the material is fed into the reactor, the control of the reaction conditions, such as temperature, pressure, reaction time, etc., must be accurate. Temperature, high or low, can cause the reaction to deviate from the expected path. The regulation of pressure is also related to the smooth process of the reaction. This process is like manipulating a precise celestial phenomenon, with the slightest difference, thousands of miles away.
During the reaction process, close monitoring is required. With modern analytical methods, such as high performance liquid chromatography, mass spectrometry, etc., real-time insight into the progress of the reaction can ensure that the reaction follows the established route. In case of deviation, adjust immediately, just like a helmsman correcting the course in the vast sea.
After the reaction is completed, the product separation and purification follow one after another. This is the process of removing waste and storing cyanine. Extraction, crystallization, chromatography and other methods are used to remove impurities one after another, so that the purity of the product reaches a very high level. Every step of the operation requires caution. If you are not careful, all your efforts will be wasted.
The final result (2S-trans) - 3-amino-2-methyl-4-oxo-1-azacyclobutane sulfonic acid needs to undergo strict quality inspection. All indicators meet the standards before they are qualified products, which can be used for the synthesis of aztreonam. The whole production process is interconnected and indispensable, showing the delicacy of chemical technology.

(2S - trans) - 3 - amino - 2 - methyl - 4 - oxo - 1 - azacyclobutane sulfonic acid (aztreonan side chain), its market price situation is quite complicated, it is difficult to determine.
In the past, this compound was in the market, and the price fluctuated with the change of supply and demand and the change of seasons. When the raw materials are abundant and there are many producers, the price may become more affordable. Because of the competition in the market from the same industry, they all want to sell their goods quickly, so the price is reduced to attract customers. If the raw materials are rare, it is not easy to harvest, and there are few producers but many applicants, the price will rise.
Moreover, its price is also related to the quality. Refined ones have few impurities, good performance, and high prices; rough ones have flaws in quality, and the price may be inferior. Furthermore, regional differences also have an impact. The capital is large, with convenient commerce and smooth logistics, and prices may be stable or decline; in remote places, transportation is difficult, costs are increased, and prices are often high.
Looking at the cities, the price varies, or tens of thousands of gold per ton, or to hundreds of thousands of gold, it is difficult to hide it. Businesses need to constantly check the market conditions and review the situation over time before they can get the right price.

The Quality Standard for (2S-trans) -3-amino-2-methyl-4-oxo-1-azacyclobutane sulfonic acid (aztreonam side chain) is an important criterion for measuring the quality of this compound. The Quality Standard often contains various provisions.
In terms of appearance, it is mostly required to be in a specific form, or a white to off-white crystalline powder with uniform texture, no impurities or foreign matter visible to the naked eye, pure in appearance, and normal in color. This is the apparent basis for preliminary judgment of its quality.
In terms of purity, it is extremely critical. It is usually required to have a high purity to ensure that too many impurities are not introduced in subsequent applications such as the synthesis of aztreonam. Generally, accurate analytical methods such as high performance liquid chromatography (HPLC) are used to determine the purity, which often needs to reach more than 99%. The specific value may vary slightly according to different production requirements. Such a high purity can meet the strict requirements of drug synthesis on raw materials.
The inspection of related substances is also indispensable. It is necessary to detect relevant impurities that may exist, including intermediates and by-products produced in the process. The content of these impurities must be strictly controlled below the specified limit, so as not to affect the quality, safety and effectiveness of the final product of aztreonam.
There are also standards for moisture content. The appropriate moisture content helps to maintain the stability and physical properties of the compound. Usually determined by drying weight loss method, etc., the moisture is generally required to be controlled within a certain range, such as between a few percent and a few percent, depending on the material characteristics and application scenarios.
In addition, physical properties such as melting point are also part of the Quality Standard. Its melting point should be within a specific temperature range, which can provide a reference for identifying the authenticity and purity of the compound. By accurately measuring the melting point and comparing it with the standard value, it can be judged whether its quality is up to standard. In summary, these Quality Standards guarantee the quality of (2S-trans) -3-amino-2-methyl-4-oxo-1-azetanesulfonic acid for the synthesis of aztreonam and related pharmaceutical applications.

(2S-trans) -3-amino-2-methyl-4-oxo-1-azacyclobutane sulfonic acid (aztreonam side chain) has many points to be paid attention to during storage and transportation. The properties of this compound are relatively special and need to be careful.
When storing, the first environment. It should be placed in a cool, dry and well-ventilated place, and must not be exposed to direct sunlight, due to light or its properties change. Temperature also needs to be controlled. Too high or too low can affect its stability. Generally, room temperature is appropriate, but the specific temperature range depends on the relevant instructions. Furthermore, humidity is also critical. Excessive humidity can easily cause deliquescence, so the dryness of the environment must be ensured.
During transportation, the packaging must be sturdy. Appropriate packaging materials are required to protect it from vibration and collision. During transportation, attention should also be paid to maintaining stability and avoiding severe bumps. And relevant transportation regulations must be strictly followed to ensure the safety of transportation.
In addition, whether it is stored or transported, it needs to be isolated from other chemicals to prevent chemical reactions. Operators should also have the corresponding professional knowledge and skills, and wear appropriate protective equipment during operation to ensure safety. Only by paying attention to all the details can we ensure that (2S - trans) - 3 - amino - 2 - methyl - 4 - oxo - 1 - azetanesulfonic acid (aztreonam side chain) is stable during storage and transportation without causing accidents.