What is the chemical structure of 3,3 '-Piperazine-1,4-Diylbis (2-Hydroxypropane-1-Sulfonic Acid)?
The chemical substance corresponding to 3% 2C3% 27 - Piperazine - 1% 2C4 - Diylbis% 282 - Hydroxypropane - 1 - Sulfonic Acid% 29 is 3,3 '-piperazine-1,4-dimethyl bis (2-hydroxypropane-1-sulfonic acid). Its chemical structure is described below in the classical Chinese format of Tiangong Kaiwu:
The core of this substance is a piperazine ring, and its six-membered heterocycle contains two nitrogen atoms relatively distributed, with a stable cyclic structure. The 1,4 nitrogen atoms of the piperazine ring are each extended to connect to a specific group. The linked group is 2-hydroxypropane-1-sulfonic acid. In this group, the main chain of propane is connected to three carbons to form a chain, and the one-carbon-linked sulfonic acid group (-SO-H), the sulfonic acid group is strongly acidic and hydrophilic, which can make the molecule have good solubility in water. The other carbon-linked hydroxyl group (-OH), the hydroxyl group has active hydrogen, which can participate in a variety of chemical reactions and increase the chemical activity of the molecule. Two identical 2-hydroxypropane-1-sulfonic acid groups are bridged by nitrogen atoms at 1,4 positions of the piperazine ring to form a symmetrical monolithic structure. This structure may have unique performance in many chemical and biological systems because it contains sulfonic acid groups and hydroxyl groups, and has both acidic, hydrophilic and active chemical properties.
What are the main uses of 3,3 '-Piperazine-1,4-Diylbis (2-Hydroxypropane-1-Sulfonic Acid)
3,3 '-Piperazine-1,4-diyl bis (2-hydroxypropane-1-sulfonic acid), this substance has a wide range of uses. In the field of biochemical research, it can be used as a buffer. Because of its specific acid-base properties, it can effectively maintain the pH value of the solution in a stable range, thus ensuring that various biochemical reactions can proceed smoothly. For example, in protein crystallization experiments, a suitable and stable pH environment is essential for the formation of protein crystals. This compound can play a key buffering role, helping proteins to be arranged in a regular lattice, and finally successfully crystallized.
In the field of pharmaceutical research and development, it also has its own uses. In the process of drug preparation, it can adjust the pH value of the microenvironment in which the drug is located, and enhance the stability and solubility of the drug. Some drugs can show the best activity and curative effect under specific pH conditions. This substance can create suitable acid-base conditions and improve the bioavailability of drugs.
It is also indispensable in industrial production such as electroplating, printing and dyeing. Adding to the electroplating solution can adjust the pH value of the electroplating solution, promote the uniform deposition of metal ions, and improve the quality and gloss of the coating. During the printing and dyeing process, it can assist in adjusting the pH value of the dyeing bath to ensure that the dye is evenly dyed on the fabric, and improve the uniformity and fastness of dyeing.
What are the physical properties of 3,3 '-Piperazine-1,4-Diylbis (2-Hydroxypropane-1-Sulfonic Acid)
3% 2C3% 27 - Piperazine - 1% 2C4 - Diylbis% 282 - Hydroxypropane - 1 - Sulfonic Acid% 29, the Chinese name is often 3,3 '-piperazine-1,4-dimethyl bis (2-hydroxypropane-1-sulfonic acid), its physical properties are as follows:
This substance is mostly white crystalline powder at room temperature, and its texture is fine. Its melting point is quite high, between 290 ° C and 300 ° C. Such a high melting point allows it to maintain a stable solid state at common ambient temperatures. In terms of solubility, it is easily soluble in water. After being integrated into water, the solution is clear and transparent, which makes it very convenient for many applications in aqueous systems. At the same time, it has poor solubility in organic solvents, such as common ethanol, ether and other organic solvents, and its solubility is very small, which is helpful for operation in specific separation and purification processes.
From the perspective of appearance stability, under normal storage conditions, in a dry and cool place, the substance can maintain its own properties for a long time, and is not prone to deliquescence, agglomeration and other phenomena. And under normal lighting conditions, it will not undergo chemical changes due to the action of light, and has good photostability.
What is the synthesis method of 3,3 '-Piperazine-1,4-Diylbis (2-Hydroxypropane-1-Sulfonic Acid)
The synthesis of 3,3 '-piperazine-1,4-diyl bis (2-hydroxypropane-1-sulfonic acid) is an important topic in the field of organic synthesis. To obtain this compound, there are many common methods.
First, it can be obtained by condensation reaction between a compound containing piperazine structure and a raw material containing hydroxypropane sulfonic acid groups. First, the piperazine compound is properly activated to make its nitrogen atom more nucleophilic. If piperazine is treated with an appropriate base, its electron cloud density is enhanced. At the same time, a suitable halogen or sulfonate containing hydroxypropane sulfonic acid is selected as another raw material. In suitable organic solvents, such as acetonitrile, dichloromethane, etc., the nucleophilic substitution reaction occurs at a certain temperature and reaction time. The reaction temperature may be between 40-80 degrees Celsius, and the reaction continues for several hours to more than ten hours, depending on the specific reaction process monitoring. The reaction is tracked by TLC (thin layer chromatography) and other means. When the raw material reaction is complete, it is then post-processed, such as extraction, washing, drying, column chromatography, etc., to purify the product.
Second, the strategy of gradually constructing the molecular structure can also be used. The intermediate containing part of the target structure is first synthesized, and then the intermediate is further reacted and linked. For example, the intermediate with piperazine nitrogen atom connecting part of hydroxypropanesulfonic acid fragment at one end is first prepared. After separation and purification, it is reacted with another linked group to gradually increase the carbon chain and introduce another hydroxypropanesulfonic acid part. This process requires precise control of the reaction conditions. The pH, temperature, solvent, etc. of each step of the reaction conditions have a great influence on the selectivity and yield of the reaction. The purity of the reagents and raw materials involved in the reaction needs to be strictly controlled to ensure the smooth progress of the reaction, and a high-purity 3,3 '-piperazine-1,4-diyl bis (2-hydroxypropane-1-sulfonic acid) is finally obtained.
3,3 '-Piperazine-1,4-Diylbis (2-Hydroxypropane-1-Sulfonic Acid) What are the precautions during use
3% 2C3% 27 - Piperazine - 1% 2C4 - Diylbis% 282 - Hydroxypropane - 1 - Sulfonic Acid% 29, that is, 3,3 '-piperazine-1,4-diyl bis (2-hydroxypropane-1-sulfonic acid), this is a special chemical substance. During use, there are several precautions to be paid attention to.
The first is about its solubility. This substance has good solubility in water, but it may have limited solubility in some organic solvents. Therefore, before use, it is necessary to study its solubility characteristics in specific solvents in detail, so as to ensure that it is evenly dispersed in the system to achieve the desired effect. If the dissolution is not obtained, or the local concentration is too high, causing unnecessary side reactions.
times are related to its stability. This substance has good stability under normal storage conditions. In case of extreme environments such as high temperature, high humidity or strong light, it may be at risk of decomposition. Therefore, when storing, it should be placed in a cool, dry and dark place to prevent its deterioration.
Furthermore, the impact of pH value cannot be ignored. The chemical properties of this substance may vary under different pH environments. In specific application scenarios, precise regulation of pH value is essential to maintain its activity and stability. For example, in some biological experiments, slight changes in pH value, or changes in its interaction with biomolecules, affect the experimental results.
Again, safety is also key. Although the toxicity of this substance may be low, it is still necessary to avoid direct contact with the skin and eyes. In case of inadvertent contact, rinse with plenty of water and seek medical attention as appropriate. When operating, it is advisable to wear appropriate protective equipment, such as gloves, goggles, etc., for safety.
Last rule, when using this substance, the dosage should also be precisely controlled. Excessive use may increase costs and cause negative effects; if the dosage is insufficient, it will be difficult to achieve the desired effect. Therefore, rigorous experiments and calculations should be conducted before use to determine the most appropriate dosage.