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What is the use of 3- [ (4,5-dihydro-1H-imidazole-2-yl) methyl] (4-methylphenyl) amino] -monomethanesulfonate (salt)
3- [ (4,5-dihydro-1H-pyrrole-2-yl) ethyl] (4-ethylphenyl) amino] -monoethyl succinic anhydride (anhydride) is an organic compound with a wide range of uses.
In the field of organic synthesis, this compound can be used as a key intermediate. Because its structure contains specific functional groups, it can be cleverly combined with other organic molecules through a series of chemical reactions, such as nucleophilic substitution and addition reactions, to construct more complex and diverse organic compounds, which is of great significance in new drug development, materials science and many other aspects. For example, in medicinal chemistry, it is possible to obtain new drug molecules with specific biological activities and pharmacological properties by modifying and modifying their structures.
In the field of materials science, it may also play an important role. Because of the functional groups it contains, it may endow materials with unique physical and chemical properties, such as improving the solubility, thermal stability and mechanical properties of materials. For example, introducing it into the structure of polymer materials may change the interaction between polymer chains, thereby improving the comprehensive properties of materials, providing the possibility for the development of new functional materials.
In chemical research, as a typical organic compound, it provides an excellent model for exploring the mechanism of organic reactions. Scientists can gain in-depth insight into key issues such as the specific process of the reaction, influencing factors, and product selectivity by studying various reactions based on it, which is of great significance for enriching the theoretical knowledge of organic chemistry and guiding the practice of organic synthesis.
What are the chemical properties of 3- [ (4,5-dihydro-1H-imidazole-2-yl) methyl] (4-methylphenyl) amino] -monomethanesulfonate (salt)
The chemical properties of 3 - [%[( 4,5-dihydro-1H-pyrrole-2-yl) ethyl] (4-ethylphenyl) amino] -monoethyl anhydride (anhydride) are quite important. Let me explain in detail.
This compound contains specific groups such as (4,5-dihydro-1H-pyrrole-2-yl) ethyl and (4-ethylphenyl) amino. Its chemical properties are the first to be reactive, because there are amino and anhydride groups in its structure, both of which have high reactivity. Acid anhydrides can undergo hydrolysis in contact with water to form corresponding carboxylic acids. If there is water in the environment, this 3 - [%[( 4,5 -dihydro-1H -pyrrole-2-yl) ethyl] (4 -ethylphenyl) amino] -monoethyl anhydride (anhydride) will gradually hydrolyze. This hydrolysis process may be affected by factors such as temperature and pH.
Furthermore, the presence of amino groups makes it possible to react with a variety of electrophilic reagents. For example, reacting with acyl halides can generate amide compounds, which are often used in organic synthesis to construct structures containing amide bonds. And due to the existence of benzene ring and pyrrole ring, the compound has certain aromatic properties and can participate in aromatic electrophilic substitution reactions. When encountering suitable electrophilic reagents, new substituents can be introduced on the benzene ring or pyrrole ring. The position of this substitution reaction is related to the localization effect of the original substituents on the benzene ring and pyrrole ring.
In addition, the compound may have certain physical properties, such as specific solubility in a specific solvent, and solubility will affect the chemical reactions it participates in. In organic solvents, the reaction rate, reaction selectivity, etc. may be different from that in water. And because of the characteristics of molecular structure, it may have a certain stability, but when environmental conditions change, such as high temperature, strong acid and alkali, etc., its stability or damage, triggering structural changes and chemical reactions.
In short, this 3 - [%[( 4,5 -dihydro-1H -pyrrole-2-yl) ethyl] (4 -ethylphenyl) amino] -monoethyl anhydride (anhydride) has rich and diverse chemical properties and may have important applications in organic synthesis and related fields.
What is the preparation method of 3- [ (4,5-dihydro-1H-imidazole-2-yl) methyl] (4-methylphenyl) amino] -monomethanesulfonate (salt)
To obtain 3 - [ (4,5 - dihydro - 1H - pyrrole - 2 - yl) ethyl] (4 - ethylbenzyl) amino] - monoethylsuccinic anhydride (anhydride), the method is as follows:
First take an appropriate amount of (4,5 - dihydro - 1H - pyrrole - 2 - yl) ethanol, which is alkylated with an appropriate halogenated ethane under alkali catalysis to obtain (4,5 - dihydro - 1H - pyrrole - 2 - yl) ethyl halide. During the reaction, it is necessary to pay attention to the control of the reaction temperature and time. The temperature should be maintained at about [X] ° C, and the reaction time is about [X] hours to ensure that the reaction is sufficient.
At the same time, 4-ethylbenzylamine is prepared. Take 4-ethylbenzylhalogen and react with ammonia or a suitable aminating agent in a suitable solvent to obtain 4-ethylbenzylamine. This reaction solvent can be selected from [specific solvent], and the reaction conditions need to be precisely controlled so that the reaction can be carried out efficiently.
Then, the (4,5-dihydro-1H-pyrrole-2-yl) ethyl halide obtained above is condensed with 4-ethylbenzylamine. This step can be carried out in [specific solvent] in the presence of base. The amount and type of base have a great influence on the reaction. It is advisable to choose [specific base]. The amount is slightly added in excess according to the stoichiometric ratio. The reaction temperature is controlled at [X] ° C, and the reaction time is about [X] hours to obtain 3- [ (4,5-dihydro-1H-pyrrole-2-yl) ethyl] (4-ethylbenzyl) amino] compound.
Finally, this compound is reacted with monoethyl succinic anhydride (anhydride). This reaction can be carried out in [specific solvent] at a suitable temperature. During the reaction process, it is necessary to pay close attention to the reaction process and monitor the reaction endpoint by means of TLC. After the reaction is completed, the target product 3- [ (4,5-dihydro-1H-pyrrole-2-yl) ethyl] (4-ethylbenzyl) amino] -monoethylsuccinic anhydride (anhydride) can be prepared by post-processing, such as extraction, washing, drying, column chromatography, etc. Throughout the preparation process, the intermediates of each step of the reaction need to be properly separated and identified to ensure the purity and yield of the final product.
What are the side effects of 3- [ (4,5-dihydro-1H-imidazole-2-yl) methyl] (4-methylphenyl) amino] -monomethanesulfonate (salt)
"Tiangong Kaiwu" has a saying: 3- [ (4,5-dioxy-1H-pyrrole-2-yl) ethyl] (4-ethylphenyl) amino] -monoethyl succinic anhydride (anhydride) The side effects are as follows.
For this monoethyl succinic anhydride (anhydride), there are three side effects. One, or lead to the disturbance of metabolism in the body. The way of metabolism in the body is complicated, and this anhydride enters the body, like a stone throwing water, rippling. The structure of its molecules is similar to those of various substances or substances in the metabolic pathway, so it is easy to cause the misunderstanding of metabolic enzymes, causing the order of metabolism to be disordered, and the biochemical reaction to be erratic.
Second, it may damage the membrane of the cell. The membrane of the cell, like the wall of the city, protects the inside and the outside. This anhydride has specific chemical properties and can interact with lipids and proteins in the membrane. Such as rodent insects, the structure of the eroded membrane changes the permeability of the membrane. The material that should be left in the cell escapes and should not be invaded. The homeostasis of the cell is destroyed, and the function is also affected by it.
Third, it may disturb the immune system. The system of immunity, the army of the body, protects against external aggression and protects the internal security. This anhydride may cause the misjudgment of immune cells, such as mistransmission by fire, making the immune army move. Or make the immune response overactive, such as the war against itself, causing inflammation; or suppress the ability of immunity, making the army of the body weak, foreign enemies are easy to invade, and the health of the body is worrying.
All these side works are for those who study this anhydride. When using it, they must weigh the pros and cons to ensure its good use and avoid its harm.
What is the application prospect of 3- [ (4,5-dihydro-1H-imidazole-2-yl) methyl] (4-methylphenyl) amino] -monomethanesulfonate (salt) in the field of medicine
Wen Jun inquired about the application prospects of 3- [ (4,5-dihydro-1H-pyrrole-2-yl) ethyl] (4-ethylphenyl) amino] -monoethylsuccinic anhydride (anhydride) in the field of medicine, I will describe in detail.
This compound has a unique structure, and it contains (4,5-dihydro-1H-pyrrole-2-yl) ethyl and 4-ethylphenylamino groups, which endow it with potential biological activity. In pharmaceutical research and development, structure is often closely related to activity, and unique structure may open up new therapeutic avenues.
In terms of drug target binding, such structures may be able to precisely fit specific targets. Targets such as proteins and enzymes play a key role in physiological and pathological processes. If compounds are effectively bound to them, they can regulate physiological functions and intervene in disease processes. For example, some drugs containing pyrrole structures can bind to enzyme activity centers, inhibit enzyme activity, and achieve therapeutic purposes. This compound may also interact with specific targets through unique structures, providing new ideas for disease treatment.
Cell penetration is also a key consideration. Its structure or affect the ability to enter cells. If it can effectively penetrate the cell membrane, it can play a role in the cell. Drugs often need to enter the cell to act on the target when they are effective. The appropriate structure can help the compound cross the cell membrane barrier and achieve the therapeutic effect.
Furthermore, the pharmacokinetic properties are also important. Its absorption, distribution, metabolism and excretion process are affected by structure. Good absorption and distribution can enable the drug to reach the site of action efficiently; rational metabolism and excretion can ensure that the drug maintains an appropriate concentration in the body to avoid accumulation poisoning or poor efficacy. The structure of this compound may have unique effects on these properties and needs to be studied in depth.
However, the use of this compound in medicine also poses challenges. The synthetic process needs to be optimized to ensure purity and yield; safety assessment is indispensable to ensure drug safety; clinical studies should be carefully designed and implemented to verify efficacy and safety. Although
faces challenges, due to its unique structure, 3- [ (4,5-dihydro-1H-pyrrole-2-yl) ethyl] (4-ethylphenyl) amino] -monoethyl succinic anhydride (anhydride) has broad prospects in the field of medicine, and is expected to be further researched and developed to bring benefits to human health.