(3-Aminophenyl)Benzenesulfonate

(3-Hydroxybenzyl) benzyloxy anhydride is mainly used in many fields. It plays a key role in the synthesis of medicine. With this material, a series of compounds with specific biological activities can be synthesized, laying the foundation for the creation of new drugs. For example, in the development of anti-tumor drugs, (3-hydroxybenzyl) benzyloxy anhydride can be used as an important intermediate. Through a series of chemical reactions, a molecular structure that can precisely act on tumor cell targets can be constructed, helping to improve the efficacy and specificity of drugs.
In the field of organic synthesis, it is also an extremely useful reagent. With its unique chemical properties, it can participate in a variety of organic reactions, such as esterification reactions, condensation reactions, etc. By ingeniously designing the reaction path, the use of (3-hydroxybenzyl) benzyloxy anhydride can realize the construction of complex organic molecules, enrich the variety and structure of organic compounds, and provide key raw materials for materials science, natural product total synthesis and other fields.
In the field of materials science, this compound can be introduced into polymer materials after appropriate modification and reaction, giving the material unique properties. For example, it can improve the solubility, thermal stability or optical properties of the material, and expand the application of the material in different scenarios, such as the preparation of high-performance optical films, thermally stable polymer materials, etc.
In conclusion, (3-hydroxybenzyl) benzyloxy anhydride has shown important application value in the fields of medicine, organic synthesis and materials science. With the deepening of research, its potential application prospects are expected to be further expanded.

Barium (3-aminophenyl) benzenesulfonate is a white crystalline powder, odorless. Its melting point is high, and the phase change will only occur at a certain temperature.
This substance is slightly soluble in water and has limited solubility in water. However, it has relatively good solubility in some polar organic solvents, such as ethanol and acetone. In organic solvents, it can be dispersed more uniformly to form a stable dispersion system.
(3-aminophenyl) barium benzenesulfonate has certain chemical stability. Under normal temperature and pressure, it will not react rapidly in contact with common acid-base substances without special conditions. However, under the harsh conditions of strong acid or strong base and heating, some chemical bonds in its molecular structure may be affected and reactions such as breaking or rearrangement may occur. For example, under the action of concentrated sulfuric acid, the amino groups on the benzene ring may undergo substitution reactions such as sulfonation.
It is sensitive to light, and long-term exposure to light, especially ultraviolet radiation, may cause changes in the molecular structure, which in turn affects its physical and chemical properties. In terms of electrical properties, it has a certain ionic conductivity, which is derived from the ionic properties of the barium sulfonate part of the molecular structure. In a specific electrolyte system, it can play a certain role in ion conduction.

The preparation method of (3-aminophenyl) benzenesulfonic anhydride covers the following:
First, 3-aminobenzenesulfonic acid is used as the starting material and can be obtained by dehydration and condensation. First, place an appropriate amount of 3-aminobenzenesulfonic acid in a clean reactor, and add an appropriate amount of dehydrating agent, such as phosphorus pentoxide or phosphorus oxychloride. Control the reaction temperature to a suitable range, usually between 100-150 degrees Celsius, and stir slowly to make the reaction fully proceed. During this process, the dehydrating agent reacts with the hydroxyl group in 3-aminobenzenesulfonic acid to remove water, which in turn prompts intermolecular condensation to form an acid anhydride structure. After the reaction is completed, (3-aminophenyl) benzenesulfonic anhydride can be obtained by cooling, separation, purification and other steps.
Second, 3-nitrobenzenesulfonic acid can also be used as a raw material. 3-aminobenesulfonic acid is obtained by reduction reaction first, and then dehydrated and condensed to prepare anhydride. Dissolve 3-nitrobenzenesulfonic acid in a suitable solvent, such as ethanol or ethyl acetate, etc., add an appropriate amount of reducing agent, such as the combination of iron powder and hydrochloric acid, or use palladium carbon as a catalyst for reduction under catalytic hydrogenation conditions. After the nitro group is successfully converted to an amino group, the solvent is evaporated to obtain 3-aminobenesulf The subsequent operation is no different from the above dehydration and condensation steps using 3-aminobenzenesulfonic acid as the starting material, and the target product can be obtained.
Third, the compound with the appropriate substituent on the benzene ring is used as the starting material to construct the acid anhydride structure through a multi-step reaction. For example, a suitable halogenated benzene derivative is selected, the amino group and the sulfonic acid group are introduced through a nucleophilic substitution reaction, and then a series of functional group conversion and dehydration and condensation reactions can also achieve the purpose of preparing (3-aminophenyl) benzenesulfonic acid anhydride. Although this method is a little complicated, it has certain flexibility in terms of raw material selection and product structure modification.
All methods have their own advantages and disadvantages. In actual preparation, it is necessary to comprehensively consider factors such as raw material availability, cost, reaction conditions and product purity requirements to choose the appropriate method.

When storing and transporting (3-hydroxybenzyl) benzyloxy anhydride, many precautions need to be paid attention to.
First, it concerns the storage environment. This substance should be stored in a cool, dry and well-ventilated place. The cool environment can prevent its chemical properties from changing due to excessive temperature, and avoid the risk of decomposition or deterioration; the dry state can prevent adverse reactions such as hydrolysis caused by moisture intrusion; good ventilation can disperse harmful gases that may be generated in time, ensuring a safe and secure storage environment. And be sure to keep away from fire and heat sources, which can easily cause combustion or even explosion, which is extremely threatening.
Second, about packaging requirements. It is necessary to use suitable packaging materials, such as containers with good sealing performance, to prevent air, moisture, etc. from contacting with substances. The packaging material itself should be chemically stable and not chemically react with (3-hydroxybenzyl) benzyloxy anhydride to ensure stable material properties.
Third, when transporting, there are also many precautions. When transporting vehicles, they should be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment. The driving process must be smooth, and violent actions such as sudden braking and sharp turns should be avoided to prevent material leakage caused by damage to the packaging. During transportation, pay close attention to weather changes, and take corresponding protective measures in case of bad weather such as rain, snow, and high temperature. At the same time, transportation personnel must undergo specialized training to familiarize themselves with the hazardous characteristics of the substance and emergency treatment methods, so as to respond to various emergencies during transportation and ensure safe transportation.

When (3-aminophenyl) benzenesulfonic anhydride is used, there are hidden risks and safety measures, as detailed below:
latent risk
1. ** Toxic hazard **: This substance may be toxic. If it is inhaled, ingested or in contact with the skin, it may damage health. Inhalation of its dust can cause respiratory irritation, such as cough, asthma, shortness of breath, etc.; ingestion or gastrointestinal discomfort, such as nausea, vomiting, abdominal pain, etc.; long-term skin contact, or cause skin allergies, redness, swelling, itching.
2. ** Explosion risk **: Although it is not highly flammable, it may still burn in case of open flames and hot topics. Its powder reaches a certain concentration in the air, or forms an explosive mixture, which will explode in case of fire, endangering the safety of the site.
3. ** Environmental risk **: If it is not handled properly, it will flow into the environment, or cause pollution to water, soil, etc. It degrades slowly in the environment, or accumulates through the food chain, endangering the ecosystem.
Safety precaution deployment
1. ** Personal protection **: When working, be sure to wear appropriate protective equipment. Such as wearing a self-priming filter dust mask to prevent dust inhalation; wearing chemical safety glasses to protect the eyes from splashing; penetrating work clothes with anti-toxins to prevent skin contact; wearing rubber gloves to strengthen hand protection.
2. ** Operation Specifications **: The operation should be carried out in a well-ventilated place to avoid dust diffusion. Keep away from fire and heat sources, and use explosion-proof ventilation systems and equipment. When handling, pack lightly and unload lightly to prevent package damage.
3. ** Storage Management **: Store in a cool and ventilated warehouse, away from fire and heat sources. It should be stored separately from oxidants and edible chemicals, and should not be mixed. The storage area should be prepared with suitable materials to contain leaks.
4. ** Emergency Response **: If there is a leak, quickly evacuate the personnel from the contaminated area to the safe area, isolate, and strictly restrict access. Emergency responders wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Small leaks should be collected in a dry, clean, covered container with a clean shovel. If there are large leaks, build a dike or dig a pit to contain them, and transfer them to a tanker or special collector for recycling or transportation to a waste disposal site for disposal.