What is the chemical structure of -3-Bromocamphor-10-Sulfonic Acid Hydrate?
(+) -3-bromo-camphor-10-sulfonic acid hydrate, its chemical structure is derived from camphor as the basic structure. The structure of camphor is a camphene-like dicyclic compound with a specific rigid cage-like skeleton. On this basic structure, bromine atoms are introduced at 3 positions, and the existence of this bromine atom changes the distribution of molecular electron clouds and spatial steric resistance. The 10 position is connected to the sulfonic acid group -SO-H, which has strong hydrophilicity and can increase the solubility of the compound in water. And this compound has a hydrate form, which means that a certain proportion of water molecules are bound to its crystal structure, and the water molecules are maintained with the host compound through weak interactions such as hydrogen bonds. Overall, the unique chemical structure of the compound endows it with specific application properties in organic synthesis, chiral catalysis, etc. The groups in the structure interact with each other to jointly determine its physical and chemical properties.
(+) In which chemical reactions is -3-Bromocamphor-10-Sulfonic Acid Hydrate commonly used?
(+) -3-bromocamphor-10-sulfonic acid hydrate is often an essential reagent in many organic synthesis reactions. This compound has made outstanding achievements in the field of asymmetric synthesis due to its unique structure and properties.
In asymmetric catalytic reactions, it often acts as a chiral catalyst or auxiliary agent. The Gain molecule has a chiral center, which can induce the reaction to form a product of a specific configuration, which greatly improves the enantioselectivity of the reaction. For example, in some nucleophilic addition reactions ,(+) - 3-bromo camphor-10-sulfonic acid hydrate can cleverly interact with the substrate, so that the nucleophilic reagent selectively attacks from a specific direction, resulting in a single chiral product of high purity, which is of great significance in drug synthesis and other fields that require strict optical purity.
In addition, this compound is also useful in organic acid-base catalytic reactions. Its sulfonic acid group is acidic, which can provide proton-catalyzed specific reactions, and the chiral environment can endow the reaction with unique selectivity, which contributes to the construction of complex chiral molecular structures. In some reactions involving the formation of carbon-carbon bonds, such as the Diels-Alder reaction ,(+) - 3-bromocamphor-10-sulfonic acid hydrate can affect the energy and configuration of the transition state of the reaction through chiral induction, and promote the reaction towards the generation of the target chiral product. It opens up an effective way for organic synthesis chemists to prepare compounds with specific biological activities or functions.
What are the physical properties of -3-Bromocamphor-10-Sulfonic Acid Hydrate?
(+) -3-bromocamphor-10-sulfonic acid hydrate is a kind of organic compound. Its physical properties are quite unique, and I will describe them in detail.
This substance is usually in the shape of white crystals, with regular morphology and soft crystal surface luster, just like delicately carved jade. Looking at its color, it is white and pure, with little variegation. This pure state is a sign of its excellent quality.
When it comes to the melting point, it is between 198 and 200 degrees Celsius. In this temperature range, the substance gradually melts from a solid state to a liquid state. This transformation process requires heat absorption to overcome the lattice energy, weaken the intermolecular force, and intensify the molecular activity, thereby causing the morphological change.
Solubility is also an important physical property. It is soluble in water, and its molecular structure contains sulfonic acid groups. This group is hydrophilic and can form hydrogen bonds with water molecules, so it can be dispersed evenly in water. However, in non-polar organic solvents, the solubility is not good. Due to the weak force between non-polar solvents and molecules containing hydrophilic groups, it is difficult to overcome the original force between molecules and make them dissolve.
In addition, the density of this substance also has a specific value, which is related to the degree of molecular packing compactness and relative molecular mass. The characteristics of density affect its settling and floating behaviors in different media, which are parameters that cannot be ignored in practical applications and research.
In summary, the physical properties of (+) -3-bromocamphor-10-sulfonic acid hydrate, such as appearance, melting point, solubility, density, etc., are all key considerations in the fields of organic synthesis and drug development, which can provide an important basis for related research and applications.
(+) What is the market price of -3-Bromocamphor-10-Sulfonic Acid Hydrate?
The market price of " (+) -3-bromo camphor-10-sulfonic acid hydrate" is difficult to determine for many reasons. These compounds have a wide range of uses and are often used as chiral catalysts in the field of organic synthesis to assist in asymmetric reactions; in the field of medicine and chemical industry, or in the preparation of pharmaceutical intermediates.
Its price fluctuates, mainly due to purity. If the purity is high, impurities are rare, and it is suitable for high-end scientific research and precision synthesis, the price will be high; on the contrary, if the purity is slightly lower, the price will also drop. Furthermore, market supply and demand determine its price. Demand is strong, supply is scarce, and the price is skyrocketing; if supply exceeds demand, the price will be in a downward state. The origin and the manufacturer also have an impact. Different origins have different raw material costs and preparation processes, and the price is different.
Looking at the market, the price span of this compound is quite large. Those with a purity of about 98% may sell for tens of yuan per gram; those with a high purity of more than 99% are specially customized for high-end scientific research. The price per gram may exceed 100 yuan or even higher. Buyers should compare the quotations of each supplier in detail according to the purity and dosage they need, and weigh the quality and price to obtain a cost-effective one.
(+) What are the preparation methods of -3-Bromocamphor-10-Sulfonic Acid Hydrate?
The method of preparing (+) -3-bromo camphor-10-sulfonic acid hydrate has been studied by many ancient parties. One method starts with camphor, and first combines camphor with sulfuric anhydride to obtain camphor sulfonic acid. This process needs to be carried out at a suitable temperature and duration, and temperature control is quite critical. If it is too high, side reactions will occur, and if it is too low, the reaction will be slow.
Then, the obtained camphor sulfonic acid is brominated with liquid bromine. In the meantime, the solvent is very heavy, and glacial acetic acid is often used as a solvent to make the reaction uniform and smooth. And when brominating, it is necessary to pay attention to the amount of bromine. Excessive amount will cause impurities to increase, and if the amount is small, the bromide will be insufficient.
There is another method, using other substances as the starting material, through multi-step conversion to obtain intermediaries containing specific structures first, and then through sulfation, bromination and other steps, the product can also be obtained. However, this process is complicated and each step needs to be carefully controlled. From the purity of the raw material, the reaction conditions to the separation and purification, a slight difference in the pool will affect the quality and quantity of the product.
Purification is also indispensable. The method of recrystallization is often used to select suitable solvents, such as ethanol-water mixed solvents, to remove impurities at different temperatures to obtain pure (+) -3-bromocamphor-10-sulfonic acid hydrate. In short, the preparation of this compound requires careful care in each step to achieve success.