What is the chemical structure of (3E) -7- [ (4,6-dichloro-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-sulfophenyl) hydrazinyl] -3,4-dihydronaphthalene-2-sulfonic acid
The chemical structure of this compound is as follows:
(3E) -7- [ (4,6-dioxy-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-hydroxybenzyl) imino] -3,4-dihydroquinazoline-2-carboxylic acid.
The structure of this compound is relatively complex and consists of several different structural fragments. As a whole, it contains the quinazoline parent nuclear structure. Wherein, (3E) indicates that the configuration of the double bond is E-type, located at position No. 3; position No. 7 is connected to a substituent containing a triazine structure fragment. The triazine structure (1,3,5-triazine) is oxygen atom substituted at positions 4 and 6, and the 2-position is connected to the amino group, which is in turn connected to the No. 7 carbon of quinazoline; position No. 4 is the oxygen generation, that is, there is a carbonyl group; the substituent at position No. 3 is more complex, including an imino group. Among the imino-linked groups, there is another one based on benzyl, and the 2-position of the benzyl group is a hydroxyl-substituted structure; position No. 2 is a carboxylic acid group. These different structural fragments are connected to each other and together constitute the unique chemical structure of the compound.
What are the uses of (3E) -7- [ (4,6-dichloro-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-sulfophenyl) hydrazinyl] -3,4-dihydronaphthalene-2-sulfonic acid
(3E) -7- [ (4,6-dioxy-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-hydroxyphenyl) acetamide] -3,4-dihydropteridine-2-carboxylic acid, a key intermediate in the synthesis of folic acid, plays an indispensable role in many physiological processes such as microbial and plant growth and development, cell proliferation, DNA synthesis and repair. Its uses are mainly reflected in the following aspects:
1. ** Pharmaceutical field **: It is an important raw material for the preparation of antibacterial, antimalarial and anti-tumor drugs. Antibacterial drugs hinder the normal metabolism and reproduction of bacteria by inhibiting the synthesis of folic acid based on this intermediate in bacteria, such as sulfonamides. Antimalarial drugs achieve the purpose of killing Plasmodium by interfering with the folic acid metabolism of Plasmodium. In terms of anti-tumor, some drugs target the folic acid metabolism pathway involved in this intermediate and inhibit the rapid proliferation of tumor cells, such as methotrexate.
2. ** Nutritional fortifiers **: The human body cannot synthesize folic acid by itself and needs to consume it from food. Nutritional fortifiers rich in the related ingredients of this intermediate can prevent and treat folic acid deficiency, which is of great significance to pregnant women and can reduce the risk of birth defects such as fetal neural tube malformations.
3. ** Feed additives **: Added to animal feed, it can improve animal growth performance, enhance immunity, and improve reproductive performance. For poultry and livestock, it can promote growth and development, improve egg production rate and hatching rate. In aquaculture, it can help aquatic animals such as fish and shrimp grow healthily.
What is the preparation method of (3E) -7- [ (4,6-dichloro-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-sulfophenyl) hydrazinyl] -3,4-dihydronaphthalene-2-sulfonic acid
To prepare (3E) -7- [ (4,6-dioxy-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-hydroxybenzyl) benzylidene] -3,4-dihydroquinazoline-2-carboxylic acid, the method is as follows:
First take an appropriate amount of raw materials containing specific substituents and mix them in a clean reaction vessel in precise proportions. Among them, the (4,6-dioxy-1,3,5-triazine-2-yl) amino-related raw materials need to be carefully pretreated to ensure the purity and activity of their activity check points.
Then, a specific reaction solvent is introduced, which must have good solubility to each reactant and can stabilize the reaction environment. The temperature is controlled at a certain precise range, which must meet the requirements of the reaction kinetics, so that the reaction can be advanced at a considerable rate, but not too high to cause the decomposition of the reactants or the clustering of side reactions.
During the reaction process, closely monitor the changes in the reaction system, and accurately grasp the degree of reaction by means such as thin-layer chromatography. After the reaction reaches the desired stage, a carefully designed subsequent treatment step is performed. This step may involve extraction to separate the product from the reaction by-products and unreacted raw materials; or recrystallization is required to purify the product by taking advantage of the difference in solubility of the product and impurities in a specific solvent at different temperatures, resulting in a high purity of (3E) -7- [ (4,6-dioxy-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2 - (2-hydroxybenzyl) benzylidene] -3,4-dihydroquinazoline-2-carboxylic acid. The whole process requires the craftsman to control every detail with a rigorous attitude and exquisite skills in order to achieve the desired results.
What are the physical properties of (3E) -7- [ (4,6-dichloro-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-sulfophenyl) hydrazinyl] -3,4-dihydronaphthalene-2-sulfonic acid
(3E) -7- [ (4,6-dioxy-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-hydroxyphenyl) acetamido] -3,4-dihydropyrimidine-2-carboxylic acid, this substance has the following physical properties:
Its appearance is mostly white to off-white crystalline powder, which is based on the observation of many related chemical experiments. The substance is relatively stable at room temperature and pressure, and is not easy to undergo rapid chemical reactions with common components in the air such as oxygen and carbon dioxide. This is due to the strong chemical bonds formed between atoms in its molecular structure.
The melting point is within a specific range. According to the detection of precision melting point measurement experimental instruments, its melting point is usually around [specific melting point value]. This melting point characteristic has important guiding significance for its purification and identification in actual production and application.
In terms of solubility, its solubility in water is low, which is mainly due to the presence of more hydrophobic groups in its molecular structure, resulting in weak interaction with water molecules. However, in some organic solvents such as ethanol and dichloromethane, it has a certain solubility, which provides a basis for its participation in organic synthesis reactions and the selection of reaction conditions. In ethanol, with the increase of temperature, its solubility will increase, which is in line with the dissolution law of general organic matter in solvents, that is, when the temperature increases, the thermal motion of molecules intensifies, and the interaction between solute molecules and solvent molecules is enhanced, so that the solubility increases.
In terms of density, after precise density measurement experiments, its density is about [specific density value] g/cm ³. This density value has its specific position in the system of related chemical substances and plays a decisive role in the physical behavior such as stratification and dispersion in the mixed system.
These physical properties are interrelated and affect each other, and together determine the physical state and behavior of (3E) -7- [ (4,6-dioxy-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-hydroxyphenyl) acetamide] -3,4-dihydropyrimidine-2-carboxylic acid in different environments, providing a basic basis for its application in chemical synthesis, drug development and many other fields.
What is the market prospect of (3E) -7- [ (4,6-dichloro-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-sulfophenyl) hydrazylene] -3,4-dihydronaphthalene-2-sulfonic acid?
Looking at this chemical question, it deals with the relationship between many chemicals, Ximing (3E) -7- [ (4,6-dioxy-1,3,5-triazine-2-yl) amino] -4-oxo-3- [2- (2-hydroxybenzyl) phosphinyl] -3,4-dioxane-2-carboxylic acid market prospect.
Today's detailed analysis, this chemical structure is complex, or used in specific chemical and pharmaceutical fields. In the chemical industry, or involved in the synthesis of new materials, if it has unique chemical activity, or can add special properties to the material, such as enhancing stability and changing reactivity, if so, in the material market demand may gradually increase.
As for medicine, or as a potential drug intermediate. If it can be modified into pharmacologically active ingredients and is effective for specific disease targets, with the advancement of pharmaceutical research and development, the market prospect is promising. However, its market is also restricted by many parties, with high research and development costs and long cycles. If research and development is blocked, the market will be difficult to expand. Regulations and supervision are also strict, and multiple rounds of strict trial approval are required, which makes compliance difficult. Peer competition should not be underestimated. If similar substitutes occupy the market first, it will be difficult to promote.
Overall, if we can break through the research and development dilemma, go public in compliance, and show unique advantages in the application field, the market prospect of this compound is broad; otherwise, it may be difficult to make a big difference.