(3S)-10-(1-Aminocyclopropyl)-9-Fluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylic Acid Methanesulfonate

"Tianwen Creation": (3S) -10- (1-hydroxycyclopropyl) -9-deuterium-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] What is the chemical structure of fluorescent-6-carboxybenzoic anhydride?
This is a rather complex organic compound. To clarify its structure, follow the rules of organic chemistry and nomenclature. " (3S) " shows its three-dimensional configuration, which is an S-type chiral center. " 10- (1-hydroxycyclopropyl) "table has a 1-hydroxycyclopropyl group attached at the 10th position of the main chain, and the cyclopropyl group is a ternary carbon ring with hydroxyl substitution on it." 9-deuterium "means that the 9th position hydrogen is replaced by deuterium (an isotope of hydrogen)." 3-methyl "means that the 3rd position of the main chain has a methyl group (-CH 🥰)." 7-oxo "indicates that the 7th position is a carbonyl group (C = O)." 2,3-dihydrogen "shows double bond hydrogenation between the 2nd and 3rd positions." 7H - [1,4] oxazino [2,3,4-ij] fluorescence "means that the compound contains [1,4] oxazino [2,3,4-ij] fluorophore nucleus and has hydrogen at the 7th position." 6-carboxybenzoic anhydride "represents the structure of benzoic anhydride containing carboxyl groups at specific positions. This compound is composed of many groups and is constructed by organic synthesis reaction. Its structure is complex, and each group interacts with each other, or affects the physical, chemical and biological activities of the compound.

The pharmacological effects of (3S) -10- (1-hydroxycyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[ 1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid methyl ester are as follows:
This drug has antibacterial effect and can inhibit and kill many germs. Its mechanism of action is that it acts on specific targets of bacteria and interferes with key metabolic processes and physiological functions of bacteria, such as hindering the replication, transcription and protein synthesis of bacterial DNA, so as to achieve antibacterial purposes.
As far as the antibacterial spectrum is concerned, it is effective for both Gram-positive and Gram-negative bacteria. Among them, it can effectively inhibit the growth and reproduction of common Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus; for Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae, it can also show good antibacterial activity.
In addition, the drug also has good tissue permeability, which can reach effective concentrations in various tissues and body fluids of the human body, and then exert full antibacterial effect on the infected site. At the same time, its metabolism in the body is relatively stable, which can maintain a longer-lasting drug effect, which is conducive to the treatment of infectious diseases.
However, it may also have certain side effects. During use, close attention should be paid to the patient's reaction to ensure the safety and effectiveness of the medication.

(The description of this chemical substance is quite complicated, so it is temporarily called a spiritual substance.) Although the preparation and use of this spiritual substance are not directly stated in ancient books, according to the methods and principles of "Tiangong Kaiwu", the following inferences can be made.
Its preparation may require delicate processes. ( 3S) - 10 - (1 - hydroxycyclopropyl) - 9 - fluoro - 3 - methyl - 7 - oxo - 2,3 - dihydro - 7H - [1,4] oxazino [2,3,4 - ij] quinoline - 6 - ethyl carboxylate components, when converged in a specific order. For example, in the art of smelting, the materials are put into the tripod first, and if they are wrong, they will fall short. Or make some active groups meet first and initiate a reaction, just like calcining ore, removing its impurities and leaving its essence. This process requires precise control of the heat and time, just like those who burn porcelain. The temperature of the fire and the duration of time are all related to the quality of the finished product.
As for the use, such compounds containing nitrogen heterocycles and multi-functional groups may show their capabilities in the field of medicine. Imitating the idea of drug preparation in "Tiangong Kaiwu", its structure is unique, or it can be matched with specific targets of bacteria, such as the combination of mortise and tenon, which prevents the reproduction of bacteria and achieves the effect of curing diseases. Or because of its structural stability and reactivity, it can give unique color fastness and color to dyes in fine chemicals, such as dye synthesis, similar to the modulation of pigments in "Tiangong Kaiwu", which enhances its characteristics.
Although there is no exact ancient book confirmation, it is based on the scientific thinking and technological wisdom of "Tiangong Kaiwu". From the preparation to the application, this spiritual object contains the delicate integration of natural science and technological skills. From ancient times to the present, it is a good example of exploring material mysteries and applications.

(3S) -10- (1-hydroxycyclopropyl) -9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H - [1,4] oxazino [2,3,4-ij] quinoline-6-carboxylic acid methyl ester The efficacy of this derivative is as follows:
This derivative has significant efficacy in the field of antibacterial. First, it shows strong inhibitory activity against many Gram-positive and Gram-negative bacteria. Taking Staphylococcus aureus as an example, it can effectively interfere with the synthesis of its cell wall, causing its growth and reproduction to be hindered, and it is difficult to multiply wantonly in the host. For Gram-negative bacteria such as Escherichia coli, it can act on its cell membrane and nucleic acid metabolism process, destroy its normal physiological function, and then inhibit the growth of bacteria.
Second, it has prominent advantages in drug-resistant bacteria. At present, the problem of bacterial drug resistance is serious, and the derivative has a good inhibitory effect on some common drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Its unique chemical structure can avoid the common drug resistance mechanisms of drug-resistant bacteria, such as changing the target of drug action, enhancing the function of the efflux pump, etc., and can penetrate deep into the bacteria and continue to exert
Third, it has good pharmacokinetic properties in vivo. After oral administration of the derivative, it can be rapidly absorbed in the gastrointestinal tract, rapidly distributed to various tissues and organs of the body, and maintained at a certain effective concentration in the body for a long time. This allows it to effectively reach the infected site when treating systemic infectious diseases, play an antibacterial effect for a long time, and ensure the therapeutic effect.
Fourth, the derivative has good safety and tolerability. After a number of preclinical studies, it has no significant toxic and side effects on normal cells and tissues of the body at effective antibacterial doses, and will not cause serious adverse reactions, laying a solid foundation for clinical application.

The metabolic pathways of (3S) -10- (1-hydroxycyclopropyl) -9-deuterium-3-methyl-7-oxo-2,3-dihydro-7H- [1,4] diazonaphthalene [2,3,4-ij] phenanthrene-6-carboxylic acid methyl ester in vivo are as follows:
The structure of this compound is relatively complex, and its metabolism in vivo may change multiple check points. First, the hydroxycyclopropyl moiety, the hydroxyl group may undergo a binding reaction, such as binding to glucuronic acid, to generate the corresponding glucuronidine binding. This binding reaction can increase the water solubility of the compound and facilitate its excretion from the body. The methyl group may undergo an oxidation reaction to be oxidized to a carboxyl group, which increases the polarity of the compound. The chemical bonds near the oxo structure are also more active, and reactions such as hydrolysis may occur, resulting in ring opening or bond breaking of the structure, resulting in the formation of different metabolites.
Dihydrogen and the structure of diazonaphthalene and phenanthrene, the nitrogen atom may oxidize to form metabolites such as N-oxides, or the ring structure may undergo a ring opening reaction, changing the overall structure and properties of the molecule.
The deuterium atom is relatively stable, but under some extreme metabolic conditions, deuterium-hydrogen exchange reactions may occur, but this situation is relatively rare. These metabolic reactions are intertwined, causing the compound to form a variety of metabolites in the body, which are excreted in urine, bile, and other pathways.