4-({2-Butyl-5-[(1E)-2-Carboxy-3-Thiophen-2-Ylprop-1-En-1-Yl]-1H-Imidazol-1-Yl}Methyl)Benzoic Acid Methanesulfonate

4- ({2-butyl-5- [ (1E) -2-carboxyl-3-thiophene-2-ylpropyl-1-ene-1-yl] -1H-imidazole-1-yl} methyl) benzoate The common synthesis method is a complicated and delicate process.
Initially, 2-butyl-1H-imidazole-5-formaldehyde was used as the starting material, and the Knoevenagel condensation reaction was carried out with thiophene-2-ylmalonic acid under alkali catalysis in a suitable reaction vessel. This process requires strict control of the reaction temperature and time, usually under mild heating conditions, and after several hours, the two can be effectively combined to form the key intermediate product 2-butyl-5- [ (1E) -2- (carboxyl-thiophene-2-yl) vinyl] -1H-imidazole. The intermediate product is then substituted with methyl 4- (bromomethyl) benzoate under the action of an organometallic catalyst. In this step, the amount of catalyst and the choice of reaction solvent are all crucial. An anhydrous organic solvent is often used, and it is heated and refluxed for several hours in an inert gas protective atmosphere to replace the nitrogen atom on the imidazole ring with the bromomethyl group to form 4- ({2-butyl-5- [ (1E) -2- (carboxyl-thiophene-2-yl) vinyl] -1H-imidazole-1-yl} methyl) benzoate. Subsequently, the methyl ester product is subjected to hydrolysis reaction, treated with a strong alkali aqueous solution, and heated for reflux number, the methyl ester group is hydrolyzed to a carboxyl group to obtain 4- ({2-butyl-5- [ (1E) -2 -carboxyl-3-thiophene-2-ylpropane-1-yl] -1H-imidazole-1-yl} methyl) benzoic acid.
Finally, the benzoic acid product is mixed with methanesulfonic acid in an appropriate solvent, the reaction conditions are controlled, and the two are stirred at room temperature for a certain period of time to form a salt, which is 4 - ({2-butyl-5- [ (1E) -2 -carboxyl-3-thiophene-2-ylpropyl-1-ene-1-yl] -1H-imidazole-1-yl} methyl) benzoate methanesulfonate. After each step of reaction, it needs to be separated and purified by methods such as column chromatography and recrystallization to ensure the purity and quality of the product.

4- ({2-butyl-5- [ (1E) -2-carboxyl-3-thiophene-2-ylpropyl-1-ene-1-yl] -1H-imidazole-1-yl} methyl) benzoate methanesulfonate is a rather complex organic compound. Its main uses are widely used in the field of medicine, or it is an important pharmaceutical active ingredient. Due to the unique chemical structure of this compound, or its specific pharmacological activity, it can act on human physiological mechanisms to treat related diseases.
Watching the drug development process, such compounds often undergo many studies and experiments to clarify their efficacy, safety and pharmacokinetic properties. Or by precisely acting on specific targets in the body, regulating physiological and biochemical reactions, and then achieving the purpose of treating diseases such as inflammation and tumors.
In the field of organic synthesis, this compound is also a key intermediate. Organic synthesis craftsmen can modify and derive their structures through various chemical reactions to create a series of new compounds with similar structures but different functions. This process is like a delicate chemical dance. Chemists rely on their familiarity with reaction mechanisms to manipulate the interactions between atoms and molecules to build a complex and orderly chemical structure.
In addition, in the field of materials science, the compound may emerge due to its special physical and chemical properties, such as optical and electrical properties. Or it can participate in the preparation of new functional materials, injecting new vitality into the development of materials science, and finding a place in the fields of optoelectronic devices, sensors and so on.
In summary, 4- ({2-butyl-5- [ (1E) -2-carboxyl-3-thiophene-2-ylpropane-1-ene-1-yl] -1H-imidazole-1-yl} methyl) benzoate methanesulfonate has significant potential value and important uses in many fields such as medicine, organic synthesis and materials science.

4- ((2-butyl-5- [ (1E) -2-carboxyl-3-thiophene-2-ylpropyl-1-ene-1-yl] -1H-imidazole-1-yl) methyl) benzoate methanesulfonate, this is an organic compound. Its chemical properties are unique and contain many characteristics.
View its structure, which is spliced from complex groups. Contains thiophene, imidazole, benzoic acid and methanesulfonic acid radical groups. The thiophene group endows the compound with specific electronic effects and conjugated systems, or has far-reaching effects on its physical and chemical properties. Its electron cloud distribution may make the molecule exhibit certain polarity and reactivity.
Imidazole group, with electron-rich properties, often acts as an electron donor in chemical reactions and can participate in many nucleophilic reactions. In this compound, the imidazole ring interacts with the surrounding groups, or changes its electron cloud density and spatial conformation.
Benzoic acid part, as an aromatic carboxylic acid, is acidic. Its carboxyl group can participate in acid-base reactions and react with bases to form salts. And the conjugated system of benzene rings enhances the stability of molecules and affects the solubility and crystal structure of compounds at the same time.
The part of methanesulfonate, methanesulfonate is a strong acidic anion, which combines with cations to form a salt. This salt form may enhance the solubility of the compound in a specific solvent, affecting its degree of ionization and physical state.
As a whole, the chemical properties of the compound may be reflected in its acid-base balance, redox activity and interaction with other compounds. Due to the diverse functional groups in the structure, it may participate in many organic reactions, such as esterification, substitution, addition, etc. Or due to the synergy effect between the groups, it exhibits unique chemical behaviors and properties, and has potential application value in organic synthesis, medicinal chemistry and other fields.

4 - ({2-butyl-5- [ (1E) -2-carboxyl-3-thiophene-2-ylpropane-1-ene-1-yl] -1H-imidazole-1-yl} methyl) benzoate methanesulfonate, which is an organic compound. Its physical properties are quite characteristic, let me tell them one by one.
Looking at its appearance, it usually appears as a white to off-white solid powder, delicate and uniform, like fine snow falling at the beginning of winter, slightly glowing under the light, showing a pure color. This compound is quite stable under normal conditions, and it is not easy to decompose or deteriorate on its own. It is like a calm person who does not change.
When it comes to solubility, it can show good solubility in organic solvents such as dimethyl sulfoxide (DMSO), just like a fish entering water, it can quickly disperse and form a uniform solution. However, in water, its solubility is relatively limited, only a little can be dissolved, just like a boat in water, it is difficult to sail freely.
Furthermore, the melting point is also one of its important physical properties. After accurate determination, its melting point is in a specific temperature range, which is the inherent characteristic of the compound, just like a human fingerprint, unique. When heated to this temperature range, the compound will gradually transform from a solid state to a liquid state, completing the transformation of the state of matter.
Its density is also fixed, and under certain conditions, the value of density is relatively stable. This characteristic is crucial for accurately considering the relationship between its dosage and volume in practical applications.
The physical properties of this compound are interrelated and together constitute its unique physical "portrait", which lays a solid foundation for its research and application in chemistry, medicine and many other fields.

4 - ({2-butyl-5- [ (1E) -2-carboxyl-3-thiophene-2-ylpropyl-1-ene-1-yl] -1H-imidazole-1-yl} methyl) benzoate When storing and transporting, many matters need to be paid attention to.
The nature of this compound may be special, and the temperature and humidity of the first environment during storage. If the temperature is too high, it may cause it to decompose and deteriorate. It should be placed in a cool place. Generally, the temperature should not exceed 25 ° C. Humidity must also be strictly controlled. Excessive humidity can easily make the drug absorb moisture, or cause agglomeration and mildew. Relative humidity should be maintained at 45% - 75%.
Furthermore, it is sensitive to light or under light, or its chemical structure changes, and its efficacy is damaged. Therefore, it should be stored in a dark place and can be placed in a brown bottle or a container with a light-shielded package.
When transporting, stability is extremely important. Because it is a fine chemical, the road is bumpy or the package is damaged, which affects the quality. It is necessary to ensure that the package is sturdy and avoid violent vibration and collision during transportation. In addition, this compound may have certain chemical activity and should not be mixed with strong oxidizing agents, strong acids, strong bases, etc., to prevent chemical reactions from occurring, endangering transportation safety and product quality. The loading and unloading process also requires careful operation. Operators should have professional knowledge and strictly follow the standard procedures to ensure the quality and safety of 4- ({2-butyl-5- [ (1E) -2-carboxyl-3-thiophene-2-ylpropyl-1-ene-1-yl] -1H-imidazole-1-yl} methyl) benzoate methanesulfonate during storage and transportation.