As a leading 4-[(4-Methyl-1-Piperazinyl)Methyl]-N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-Benzamide Monomethanesulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] benzamide monomethylsulfonate?
This is a rather complex problem of organic chemistry nomenclature interpretation. To solve this problem, it is necessary to follow the organic chemistry nomenclature rules and gradually analyze the given expression.
First, "4 -% 5B% 284 - ethyl - 1 - heptyl% 29ethyl% 5D - N -% 5B4 - ethyl - 3 -% 5B% 5B4 - (3 - pentyl) - 2 - propyl% 5D amino% 5D phenyl% 5D phenylacetamide".
For the naming of organic compounds, the main chain is usually determined first. In this expression, "phenylacetamide" indicates that the main chain core structure is phenylacetamide, which is the parent structure of the entire compound.
Then look at the substituent. "4- (4-ethyl-1-heptyl) ethyl", this part indicates that a more complex substituent is connected at position 4 of the phenyl ring of the phenylacetamide parent structure. This substituent is composed of an ethyl group and a "4-ethyl-1-heptyl", that is, "4-ethyl-1-heptyl" is connected to the ethyl group, and then connected to the 4 position of the phenyl ring.
Then look at "N- (4-ethyl-3- (4- (3-pentyl) -2-propyl) aminophenyl) ", which indicates that a substituent is attached to the nitrogen atom (N) of the amide. This substituent consists of a phenyl group with an ethyl group at position 4 of the phenyl group and a "4- (3-pentyl) -2-propyl" amino group connected at position 3. That is, there is a structure of "4- (3-pentyl) -2-propyl" connected to the amino group, and then the amino group is connected to the phenyl group at position 3.
In summary, the structure of this compound is based on the phenylacetamide parent, which is connected to many specific substituents on the phenyl ring and nitrogen atom. This complex nomenclature accurately describes the specific structure of the organic compound, reflecting the importance of organic chemical nomenclature for accurately expressing the structure of the compound. With this nomenclature, chemists can clearly know the specific composition of the compound, so as to study its properties and synthesis methods.
What are the uses of 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] benzamide monomethanesulfonate?
4 - [ (4 - methyl - 1 - amino) methyl] - N - [4 - methyl - 3 - [4 - (3 - pyridyl) - 2 - quinolinyl] amino] phenyl] benzamide, this compound can be used in the field of medicine for the development of anti-tumor drugs, through a specific mechanism of action, inhibit the proliferation and metastasis of tumor cells. In the field of pesticides, or can be made into insecticides, by interfering with the physiological process of pests to achieve pest control. In the field of materials science, it may be involved in the synthesis of functional materials, such as optoelectronic device materials, giving materials unique optical and electrical properties.
The structure of this compound is endowed with a variety of chemical activities due to its unique structure, which can precisely bind to specific targets in organisms and exhibit excellent pharmacological activity. In the process of anti-tumor, it is like a delicate key, which fits the activity check point of tumor cell-related proteins or enzymes, hinders key cellular processes, such as cell cycle progression, signal transduction pathways, and thus inhibits the crazy growth and spread of tumor cells.
As for the field of pesticides, they interact with specific biomolecules in pests, or disrupt the normal function of the pest's nervous system, or disrupt the balance of its digestive system, achieving the purpose of efficient pest control. In the field of materials science, its special structure can regulate the properties of materials at the molecular level, inject new characteristics into optoelectronic device materials, and open up new directions for material applications. Therefore, this compound has important application potential in many fields and is indeed a key object of chemical research and application.
What are the side effects of 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] benzamide monomethanesulfonate?
4 - [ (4 - methyl - 1 - pyridyl) methyl] - N - [4 - methyl - 3 - [[4 - (3 - methoxy) - 2 - propoxy] benzyl] benzyl] benzyl] phenylacetamide, which is a phenylacetamide compound with various potential functions.
First, in the field of pharmacological research, its chemical structure contains specific active groups, or can be combined with specific targets in organisms. For example, the structural parts such as pyridyl and benzyl can conform to the spatial structure of some receptors, thereby regulating the corresponding signaling pathways. Taking compounds with similar structures as a reference, they may have an impact on the proliferation and differentiation process of cells, so they may have potential value in the field of anti-tumor drug research and development, or they can inhibit the growth and spread of cancer cells by interfering with their signal transduction.
Second, in neurological related studies, the structural characteristics of such compounds may endow them with the ability to cross the blood-brain barrier. Once entering the central nervous system, they may act on the metabolism and transmission of neurotransmitters. Groups such as methoxy and propoxy contained in it may regulate the fluidity of nerve cell membranes and affect the conduction of nerve impulses. They may have potential neuroprotective and functional regulatory effects in the treatment of neurological diseases, such as Alzheimer's disease and Parkinson's disease.
Third, this compound can be used as an important research model in the exploration of the structure-activity relationship of pharmaceutical chemistry. By systematically modifying and transforming the methyl, methoxy, propoxy and other substituents in its structure, the effects of different groups on the activity, selectivity and pharmacokinetic properties of compounds can be deeply understood. This not only helps to optimize the properties of existing compounds, but also provides key theoretical and practical guidance for the design and development of novel structural types of drugs.
4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] benzamide monomethylsulfonate How to use?
To solve this question about 4 - [ (4 - methyl - 1 - naphthyl) methyl] - N - [4 - methyl - 3 - [4 - (3 - pyridyl) - 2 - quinolinyl] amino] phenyl] benzamide, it is necessary to clarify its structure and properties. This is an organic compound containing a complex atomic arrangement of hydrocarbon nitrogen.
View its structure, many groups interact, affecting its physical and chemical properties. To use it, first know its characteristics. If used in chemical synthesis, consider the reaction conditions, the proportion of reactants and the choice of catalyst. Due to its complex structure, the reaction may be selective and specific, and it needs to be precisely controlled.
If it is used in drug development, its biological activity, toxicity and pharmacokinetic properties must be tested. Cell experiments and animal experiments can be used to explore its effect on specific targets and to see if it has therapeutic potential.
Although such compounds are not detailed in "Tiangong Kaiwu", the "properties of things are all natural". This compound also follows the laws of nature, and when used, its properties should be followed. If it is synthesized, according to chemical principles, select the method and conditions; if it is used for medicinal purposes, according to biological laws, explore its efficacy and safety.
In short, the use of this compound, the first to clarify its properties, according to the purpose, according to scientific laws and principles, and the selection of appropriate methods and approaches, in order to achieve the expected effect and avoid adverse consequences caused by misoperation.
What is the preparation method of 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] benzamide monomethanesulfonate?
To prepare 4 - [ (4 - methyl - 1 - piperidinyl) methyl] - N - [4 - methyl - 3 - [4 - (3 - pyridinyl) - 2 - pyrimidinyl] amino] phenyl] benzamide monohydrochloride anhydride, the method is as follows:
First take an appropriate amount of 4 - methyl - 1 - piperidinyl raw material, add specific reagents and catalysts in a suitable reaction vessel, and under precisely controlled temperature and pressure conditions, make it condensate with related reactants to generate (4 - methyl-1-piperidinyl) methyl intermediates. This process requires close attention to the reaction process and a variety of testing methods to ensure that the degree of reaction is just right.
Then, take another 4-methyl-3- [[4- (3-pyridyl) -2-pyridyl] amino] phenyl raw material, and combine it with the intermediate obtained above. In another reaction system, a suitable promoter and solvent are added again, and in a specific reaction environment, the amidation reaction is carried out to construct 4- [ (4-methyl-1-piperidinyl) methyl] - N - [4-methyl-3- [4 - (3-pyridyl) - 2-pyrimidinyl] amino] phenyl] benzamide structure. In this step, the control of the reaction conditions is extremely critical, and a slight deviation may affect the purity and yield of the product.
After the above product is formed, it is dissolved in a specific organic solvent, slowly introduced into hydrogen chloride gas, and the gas flow and reaction time are controlled to convert the benzamide structure into monohydrochloride form. This process requires real-time monitoring and adjustment of the pH, temperature and other parameters of the reaction system.
Finally, the resulting mixture is subjected to a series of post-processing operations, such as filtration, washing, recrystallization, etc., to obtain high-purity 4- [ (4-methyl-1-piperidinyl) methyl] -N - [4-methyl-3- [[4 - (3-pyridinyl) -2 -pyrimidinyl] amino] phenyl] benzoamide monohydrochloride acid anhydride product. The whole preparation process, each step is interconnected, and the requirements for reaction conditions and operation details are very high. Only precise control can obtain the ideal product.
What is the chemical structure of 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4 - (3-pyridyl) -2 -pyrimidinyl] amino] phenyl] -benzamide monomethanesulfonate?
This is an inference question about the chemical structure of a specific compound in organic chemistry. Although A, B, C, etc. are used as part of the group in the question, we can analyze it according to the basic principles and reaction laws of organic chemistry.
First view "4- [ (4-methyl-1-isopropyl) methyl] -N- [4-methyl-3- [4- (3-butyl) -2-pentyl] amino] phenyl] -phenylacetamide". The main chain of the preliminary analysis, "phenylacetamide" indicates that the main structure is phenyl ring-linked acetamide.
In the "4 - [ (4 - methyl - 1 - isopropyl) methyl]" part, it can be seen that there is a branch chain attached to the benzene ring at position 4, which starts as methyl, and then the methyl is connected with (4 - methyl - 1 - isopropyl) structure, that is, isopropyl is attached to the carbon chain of 4 - methyl.
Look again at "N- [4-methyl-3- [4- (3-butyl) -2-pentyl] amino] phenyl]", which indicates that the nitrogen atom is attached to the benzene ring, which has 4-methyl and 3-[ 4- (3-butyl) -2-pentyl] amino substituents. Among them, [4- (3-butyl) -2-pentyl] amino is a complex substituent, which is connected by pentyl and butyl and is attached to the amino group.
Based on the above analysis, the chemical structure of this compound is phenylacetamide as the main body, and various complex alkyl and amino substituents are connected at different positions of the benzene ring. After constructing this structure, the connection mode and spatial arrangement between the atoms can be clarified, which conforms to the laws of organic chemical structure.
What are the main pharmacological effects of 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4 - (3-pyridyl) -2 -pyridyl] amino] phenyl] -benzamide monomethanesulfonate?
4 - [ (4 - methyl - 1 - isobutyl) methyl] - N - [4 - methyl - 3 - [4 - (3 - pentyl) - 2 - heptyl] oxy] phenyl] -phenylacetamide is an organic compound that has multiple important pharmacological effects in the field of medicine:
First, it can be used as an anti-inflammatory agent. It can effectively inhibit the release of inflammatory mediators and related cell activities, and reduce inflammation symptoms such as redness, swelling, heat and pain. For example, in the treatment of arthritis, it can relieve inflammation at the joints, reduce the pain of patients, and improve joint mobility.
Second, it has antipyretic effect. It can act on the body temperature regulation center, regulate the temperature setting point, and return the elevated body temperature to normal. Like in a cold and fever, this substance can promote the body to increase heat dissipation, reduce heat production, and achieve the purpose of cooling.
Third, it can act as an analgesic. By acting on the pain transmission pathway, it can prevent the transmission of pain signals or reduce the sensitivity of the nervous system to pain, and reduce pain sensation. It has a relieving effect on headache, toothache, neuralgia and other pains.
Fourth, it also has potential value in the prevention and treatment of cardiovascular diseases. Some studies have shown that it may affect the function of vascular endothelial cells, regulate vascular tension, and play a certain role in regulating blood pressure; it may also inhibit platelet aggregation, reduce the risk of thrombosis, and protect the cardiovascular system. Fifth, it has a regulatory effect on the immune system. It can not only enhance the activity of immune cells, improve the body's resistance, and deal with the invasion of pathogens; when the immune is overactive, it can also suppress excessive immune reactions and avoid autoimmune diseases.
What are the clinical application scenarios of 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4 - (3-pyridyl) -2 -pyrimidinyl] amino] phenyl] -benzamide monomethanesulfonate?
This formula seems to be a complex expression related to organic chemistry, but the expression is extremely obscure, and many groups are expressed or referred to as proxies, making it difficult to precisely clarify their chemical structure. According to the text of "Tiangong Kaiwu", I try to make the following explanation for reference only.
Looking at this formula, it seems to involve the characterization of organic synthesis or chemical structure. " 4 -% [ (4 - methyl - 1 - ethyl) methyl] - N - [4 - methyl - 3 - [[4 - (3 - propyl) - 2 - butyl] hydroxyl] phenyl] -phenylacetic acid monoethyl ester ", this structure is quite complicated, in which the groups are connected to each other to construct a unique molecular structure.
In practical application scenarios, monoethyl phenylacetate compounds often appear in the fields of fragrances, medicine and so on. In the fragrance industry, it may endow the product with a unique aroma and increase its flavor richness; in the pharmaceutical field, such structures may have specific physiological activities, such as participating in the design of drug molecules, or being active groups, or assisting in drug transport and metabolism. However, due to the ambiguity of the given structural formulas, it is difficult to accurately determine the exact application scenarios, and this can only be speculated based on common chemical properties and structure-activity relationships.
What are the side effects of 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4 - (3-pyridyl) -2 -pyrimidinyl] amino] phenyl] -benzamide monomethanesulfonate?
This is an extremely complex and chemically related statement with many unfamiliar concepts. To clarify the side effects of "4- [ (4-methyl-1-allyl) methyl] -N - [4-methyl-3- [[4- (3-pentyl) -2-hexyl] oxy] phenyl] -monomethyl phenylacetate" requires profound chemical and medical knowledge.
Although I do not fully understand the specific side effects of this complex compound, I can make a brief inference according to the general principles of chemistry and pharmacology. This compound is complex in structure, contains a variety of functional groups, or interacts with a variety of biological components in the body. For example, its benzene ring structure, benzene ring compounds may have certain lipophilic properties, easy to pass through the biological membrane, or affect the normal biological function of cells. For example, the oxygen, alkyl and other functional groups in it may participate in chemical reactions in the body, which interfere with normal metabolic pathways.
Furthermore, from the perspective of drug development and toxicology, new compounds must undergo rigorous experiments before entering clinical application. In general, it may have an impact on liver and kidney function, because it is an important metabolic and detoxification organ in the body, complex compounds or increase its metabolic burden. Or affect the nervous system, because nerve cells are extremely sensitive to chemicals, compounds or interfere with neurotransmitter transmission. In addition, the immune system may also be affected, or immune-related reactions such as allergies may be triggered.
However, the above is only a speculation based on chemical structure and common pharmacological and toxicological laws. To know its side effects for sure, it is necessary to consult professional chemical and medical literature, or refer to relevant drug clinical trial data to draw accurate conclusions.
What are the pharmacokinetic properties of 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4 - (3-pyridyl) -2 -pyrimidinyl] amino] phenyl] -benzamide monomethanesulfonate?
The drug is called 4- [ (4-methyl-1-piperidinyl) methyl] -N - [4-methyl-3- [[4 - (3-pyridyl) -2-pyrimidinyl] amino] phenyl] benzamide, and its pharmacokinetic properties are as follows:
Absorption, after oral administration, the drug is absorbed into the bloodstream from the gastrointestinal tract. However, the rate and degree of absorption depend on many factors. The characteristics of the drug preparation, such as the rate of disintegration of the tablet and the rate of dissolution of the capsule, affect the initiation and process of absorption. The physiological state of the gastrointestinal tract is also critical, the speed of gastrointestinal peristalsis, pH changes, or increases or decreases absorption efficiency. The presence or absence of food also plays a role. High-fat foods may delay the absorption of some drugs, but may promote the absorption of lipophilic drugs.
Distribution, after entering the blood, there are differences in the binding of drugs to plasma proteins. Some drugs are highly bound to proteins, and only a small amount of free drugs exert pharmacological effects. Drug lipid solubility, molecular size and tissue affinity determine its distribution in the body. Those with high lipid solubility easily penetrate the biofilm and distribute in fat-rich tissues; those with high affinity to specific tissues have high concentrations in the corresponding tissues. This drug is widely distributed in various tissues in the body, and can enter the central nervous system through the blood-brain barrier, or because of its special chemical structure and fat solubility, it is conducive to crossing the barrier.
Metabolic link, mainly in the liver catalyzed by a variety of enzyme systems. Cytochrome P450 enzymes are often involved in it, and different individuals have different enzyme activities due to genetic factors, which affect the rate of drug metabolism. Some individuals have high specific enzyme activity, and the drug metabolism is fast, and the efficacy may be affected; while the enzyme activity is low, the drug is easy to accumulate, increasing the risk of adverse reactions. In addition, other enzymes and metabolic pathways may also be involved, and the co-metabolites may have pharmacological activity or affect the pharmacological properties of the original drug.
When excreted, metabolites and some prototypes of drugs are excreted Whether the kidney function is sound or not has a significant impact on excretion. In patients with renal insufficiency, the excretion of drugs or metabolites is blocked, and the concentration in the body increases. Some drugs are excreted into the intestines through bile, and some can be reabsorbed to form hepatointestinal circulation, prolonging the residence time of drugs in the body and affecting the aging of drug action.
Overall, the pharmacokinetic properties of this drug are complex and influenced by multiple factors. In clinical application, these characteristics must be fully considered. According to the individual conditions of the patient, such as age, liver and kidney function, etc., the dosage and regimen of the drug should be reasonably adjusted to ensure the safety and effectiveness of the drug.
4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] -benzamide, what is the chemical structure of monomethanesulfonate
In order to understand the chemical structure of this substance, the given symbolic information needs to be analyzed in detail. Here "4 - [ (4-methyl-1-hydroxyethyl) methyl] - N - [4-methyl-3 - [[4 - (3-butyl) -2-propyl] amino] phenyl] -phenylacetamide", this is the way to describe the molecule by systematic nomenclature.
First view of the main structure, "phenylacetamide" shows that its core is a structure in which the phenyl ring is connected to the acetamide group. The phenyl ring is a six-membered carbon ring with special aromatic properties. The acetamide group is formed by connecting the acetyl group (CH
to the amino group (-NH < 2), that is, CH < CONH
on the benzene ring, with multiple substituents. "4- [ (4-methyl-1-hydroxyethyl) methyl]", this table is connected with a substituent at the No. 4 position of the benzene ring, which is a complex structure. First, look at (4-methyl-1-hydroxyethyl), which is an ethyl group (-CH ² CH 😉), which is substituted with a methyl group (-CH 😉) at position 4, and a hydroxyl group (-OH) at position 1, that is, -CH (OH) CH ² CH 😉, and this structure is then connected to a methyl group to form a structure of -CH (OH) - CH (OH) CH.
Look again at the "N - [4 - methyl - 3 - [4 - (3 - butyl) - 2 - propyl] amino] phenyl]" part. This is a structure attached to the acetamide nitrogen atom (N). "4 - methyl - 3 - [[4 - (3 - butyl) - 2 - propyl] amino] phenyl" means that on another phenyl ring, there is a methyl substitution at position 4 and a nitrogen-containing substituent at position 3. In this nitrogen-containing substituent, [4- (3-butyl) - 2-propyl] is a complex alkyl structure, that is, there is first a butyl (- CH ³ CH ³ CH ³ CH ³) connected to the 4th position, and the 2nd position is substituted with a propyl group (- CH ³ CH ³ CH ³), which is then connected to the amino group to form - NH - C H - CH < unk > (wherein the 3 position on the benzene ring is connected with the - NHR structure, R is [4 - (3 - butyl) - 2 - propyl] structure).
Overall, the chemical structure of this compound is phenylacetamide as the core, and there are complex substituents on the benzene ring. Its structural characteristics reflect the diversity and complexity of the structure of organic compounds. The interaction of each group endows the compound with unique physical and chemical properties.
4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] -benzamide, what is the use of monomethanesulfonate
"Tiangong Kaiwu" says: "4-%5B%284-%E7%94%B2%E5%9F%BA-1-%E5%93%8C%E5%97%AA%E5%9F%BA%29%E7%94%B2%E5%9F%BA%5D-N-%5B4-%E7%94%B2%E5%9F%BA-3-%5B%5B4-%283-%E5%90%A1%E5%95%B6%E5%9F%BA%29-2-%E5%98%A7%E5%95%B6%E5%9F%BA%5D%E6%B0%A8%E5%9F%BA%5D%E8%8B%AF%E5%9F%BA%5D-%E8%8B%AF%E7%94%B2%E9%85%B0%E8%83%BA+%E5%8D%95%E7%94%B2%E7%A3%BA%E9%85%B8%E7%9B%90%E7%9A%84%E7%94%A8%E9%80%94%E6%98%AF%E4%BB%80%E4%B9%88."
Looking at this formula, although it is complicated and difficult to understand, it may be related to the reaction and application of many chemical substances. In "4 -% 5B% 284 - ethyl - 1 - amino - yl% 29ethyl% 5D - N -% 5B4 - ethyl - 3 -% 5B% 5B4 - (3 - methoxy) - 2 - propoxy% 5D hydroxy% 5D phenyl% 5D - benzyl phenylacetate", this may be the name of a specific organic compound. And "monoacetic anhydride", this may be a kind of acid anhydride with special chemical properties.
The use of monoacetic anhydride, one of which may be used in organic synthesis reactions. In many organic synthesis paths, acid anhydride is often used as an acylating agent, which can transfer acyl groups to other compounds, and then build new chemical bonds to generate various organic compounds with specific structures and functions. Second, in some polymerization reactions, monoacetic anhydride may participate in it, affecting the structure and properties of the polymer, or adjusting the molecular weight and segment structure of the polymer to meet the needs of different industrial production or scientific research. Third, in the field of medicinal chemistry, monoethyl anhydride may be a key intermediate for the synthesis of specific drug molecules. By modifying it through a series of chemical reactions, pharmacologically active pharmaceutical ingredients can be prepared.
In short, although monoethyl anhydride is not well known in the forest of chemical substances, it may play an indispensable role in many fields such as organic synthesis, materials science, and pharmaceutical research and development. Its use is extensive and critical, promoting the development and progress of related fields.
4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] -benzamide, what are the pharmacological characteristics of monomethanesulfonate
The name of this drug is 4- [ (4-methyl-1-piperazinyl) methyl] -N - [4-methyl-3- [[4 - (3-pyridyl) -2-pyrimidinyl] amino] phenyl] benzamide-methanesulfonic acid. The pharmacological properties of monomethanesulfonate are as follows:
This compound has a specific chemical structure, and each part of its structure plays an important role in pharmacological properties. In terms of mechanism of action, it is highly likely to exert its pharmacological effects by precisely acting on specific biological targets. For example, certain groups in the structure may be able to bind to specific receptors on the cell surface, like a key and a lock, which in turn triggers a series of intracellular signaling pathways that regulate the physiological function of the cell.
Viewed from the perspective of activity, it exhibits a high degree of biological activity. In relevant in vitro cell experiments and animal experiments, the drug has shown significant therapeutic effects on specific disease models. For example, in studies on certain tumor cell lines, it can effectively inhibit the proliferation of tumor cells and induce tumor cell apoptosis, demonstrating potential anti-tumor activity.
In terms of selectivity, this drug has excellent selectivity. It can act on the target target with high specificity, with little effect on other unrelated biomolecules and cellular processes. This means that during the treatment process, the adverse effects on normal cells and tissues can be significantly reduced, the side effects of the drug can be reduced, and the safety and effectiveness of the treatment can be improved.
The solubility of the drug is also critical. The form of monomethanesulfonate can improve the solubility of the drug to a certain extent, making it easier to absorb and distribute in the body. Good solubility can help the drug enter the blood circulation quickly and reach the site of action efficiently, so as to exert the pharmacological effect faster and improve the bioavailability of the drug.
In summary, 4 - [ (4 - methyl - 1 - piperazinyl) methyl] - N - [4 - methyl - 3 - [[4 - (3 - pyridyl) - 2 - pyrimidinyl] amino] phenyl] benzamide - methanesulfonic acid, monomethanesulfonate has potential important applications in the treatment of related diseases due to its unique structure, high activity, excellent selectivity and good solubility.
What is the safety of 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] -benzamide, monomethanesulfonate
In order to clarify the safety of this compound, its structure and properties need to be analyzed in detail. Looking at this formula "4- [ (4-methyl-1-imidazolyl) methyl] -N - [4-methyl-3- [[4 - (3-pyridyl) -2 -pyrrolidinyl] amino] phenyl] benzoamide-benzoaniline + monomethyl retinaldehyde", its structure is complex and contains a variety of groups.
Methyl, imidazolyl, pyridyl, pyrrolyl, amino, benzamido and other groups have their own properties. From the perspective of organic chemistry, methyl groups have electron-pushing properties, which affect molecular charge distribution and lipophilicity; imidazolyl, pyridyl, pyrrolyl as nitrogen-containing heterocycles have certain basicity and coordination ability; amino groups can participate in hydrogen bond formation and nucleophilic reactions; benzamido groups have certain stability and biological activity-related characteristics.
However, its safety is difficult to determine only according to its structure. Compound safety is often involved in toxicity, irritation, allergenicity, genetic toxicity and other aspects. To be sure, experimental verification is required. It can be first screened by in vitro experiments, such as cytotoxicity experiments, to observe its effects on the growth, proliferation and apoptosis of various cell lines; to measure its mutagenicity, use Ames experiments, etc. After in vivo experiments, animals are used as models to observe acute toxicity, subacute toxicity, chronic toxicity, etc.
In summary, only according to this structural formula, before the experimental data are obtained, it is difficult to determine the safety of "4- [ (4-methyl-1-imidazolyl) methyl] -N - [4-methyl-3- [[4- (3-pyridyl) -2-pyrrolidino] amino] phenyl] benzoamide-benzoylaniline + monomethyl retinaldehyde", which must be investigated experimentally.
What is the market for 4- [ (4-methyl-1-piperazinyl) methyl] -N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] -benzamide, monomethanesulfonate?
There are now four things, and their names are complicated, and they are remembered by symbols: 4 -% [ (4 - methyl - 1 - heptyl) methyl] - N - [4 - methyl - 3 - [[4 - (3 - pyridyl) - 2 - quinolinyl] amino] phenyl] -benzoamide - phenylacetic anhydride, and mono-acetic tartrate anhydride. How are these two in the city? Let me tell you in detail.
Fu 4 -% [ (4 - methyl - 1 - heptyl) methyl] - N - [4 - methyl - 3 - [[4 - (3 - pyridyl) - 2 - quinolinyl] amino] phenyl] -benzamide - phenylacetic anhydride, is the product of organic synthesis, with exquisite structure. In the city, it is often required by scientific research institutes and pharmaceutical companies. Its use involves the field of drug research and development, and can be used as a lead compound, which is the basis for the creation of new agents. However, due to its complex synthesis and huge preparation resources, the stock in the city is very small and the price is also high. Most of them are stored in professional chemical reagents for those who specialize in pharmaceuticals and organic synthesis.
Tartaric anhydride monoacetic acid is also an organic chemical. It is used in the food and pharmaceutical industries. In the food industry, it can be used as an additive to adjust the taste and ensure the quality. In the pharmaceutical industry, it can give shape to drugs and increase their stability. Its market situation is wider than the former, and there are many consumers. It is common in the chemical raw material market, and different grades are available to meet the needs of all parties. Because of its slightly easier preparation, the price is more affordable and the supply is more sufficient.
To sum up, the two are in the market, one is expensive and less quantity because of special use, and the other is affordable and abundant because of wide access, each with its own market conditions.
What is the chemical structure of 4- [ (4-Methyl-1-Piperazinyl) Methyl] -N- [4-Methyl-3- [[4- (3-Pyridinyl) -2-Pyrimidinyl] Amino] Phenyl] -Benzamide Monomethanesulfonate
This is an organic compound with a rather complex chemical structure. The full name of the compound is 4- [ (4-methyl-1-piperazinyl) methyl] -N - [4-methyl-3- [[4 - (3-pyridyl) -2 -pyrimidinyl] amino] phenyl] -benzamide monomethanesulfonate.
To clarify its chemical structure, it is necessary to analyze each part one by one. " 4 - [ (4-methyl-1-piperazinyl) methyl] ", indicating that at position 4 of the molecular structure, there is a substituent with 4-methyl-1-piperazinyl as the parent and connected by methylene. Piperazine is a six-membered heterocyclic ring containing two nitrogen atoms, and 4-methyl means that there is a methyl substitution at position 4 of the piperazine ring.
"N- [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl]" section, showing that the nitrogen atom of the compound is connected to a phenyl group. The phenyl group has a methyl group at position 4, and a complex structure is connected at position 3, that is, a 4- (3-pyridyl) -2-pyrimidinyl group is connected to a phenyl group through an amino group. Pyridine is a six-membered aromatic ring containing one nitrogen atom, while pyrimidine is a six-membered aromatic ring containing two nitrogen atoms. Here 3-pyridyl indicates that the 3-position of the pyridyl ring is connected to the 4-position of the pyridyl ring.
"Benzamide" indicates that the core structure of this compound is benzamide, that is, the benzene ring is connected to the amino group through the carbonyl group. And "mono-methylsulfonate" indicates that the compound forms a salt with methanesulfonic acid, and the sulfonic acid group of methanesulfonic acid is combined with the group that can form a salt in the compound.
In this way, after careful analysis of each part, the chemical structure of this compound gradually becomes clear Its complex structure and many substituents are interconnected endow the compound with specific chemical and physical properties, which may be of great significance in the fields of medicinal chemistry.
What are the pharmacological effects of 4- [ (4-Methyl-1-Piperazinyl) Methyl] -N- [4-Methyl-3- [[4- (3-Pyridinyl) -2-Pyrimidinyl] Amino] Phenyl] -Benzamide Monomethanesulfonate
4 - [ (4 - methyl - 1 - piperazinyl) methyl] - N - [4 - methyl - 3 - [[4 - (3 - pyridyl) - 2 - pyrimidinyl] amino] phenyl] -benzamide monomethylsulfonate, which is worth exploring in terms of pharmacological efficacy. It may be unique to the pharmacological effects of the nervous system, and the structure of piperazinyl is often associated with the regulation of neurotransmitters. In many pharmacological studies in the past, piperazine compounds have been found to regulate neural conduction pathways, and can affect the transmission of transmitters such as dopamine and serotonin. Therefore, the compounds may have potential value in the treatment of psychiatric diseases such as depression and anxiety.
Furthermore, the combination of pyrimidine and pyrimidinyl groups is directional in targeting specific receptors or enzymes. Pyrimidine and pyrimidine structures are widely found in a variety of bioactive molecules, which can often act precisely on specific targets in cells, or can regulate cell signaling pathways, such as those involved in tumor cell proliferation and survival. Therefore, the compound can also be used in the field of anti-tumor pharmacology, or can inhibit tumor cell-specific signaling to achieve the purpose of inhibiting tumor growth and spread. The form of its monomethanesulfonate may affect the solubility and stability of the drug, and then have effects on pharmacokinetic processes such as drug absorption, distribution, and metabolism, which is related to its actual pharmacological efficacy in vivo.
What are the applicable conditions of 4- [ (4-Methyl-1-Piperazinyl) Methyl] -N- [4-Methyl-3- [[4- (3-Pyridinyl) -2-Pyrimidinyl] Amino] Phenyl] -Benzamide Monomethanesulfonate
4- [ (4-methyl-1-piperazinyl) methyl] -N - [4-methyl-3- [[4- (3-pyridyl) -2-pyrimidinyl] amino] phenyl] -benzamide monomethanesulfonate, which is often used in a variety of diseases.
It has attracted much attention in the field of cancer, such as for specific types of cancer, such as some solid tumor patients, it can play a positive role. In the process of cancer cell proliferation, this substance can interfere with relevant signaling pathways, thereby inhibiting the growth and spread of tumor cells. In the case of certain tumors carrying specific genetic mutations, this drug can precisely target the mutated target, hindering the survival and proliferation of cancer cells.
It also shows potential value in neurological diseases. For some neurodegenerative diseases, such as Alzheimer's disease-related neuropathy, it can modulate specific neurotransmitters and signaling within the nervous system, reduce nerve cell damage, and then improve patients' cognitive function and neurological symptoms.
In addition, in the prevention and treatment of cardiovascular diseases, it has a regulatory effect on the function of vascular endothelial cells. It can promote the normal physiological state of vascular endothelial cells and reduce the risk of cardiovascular diseases. For example, for vascular damage caused by hypertension, it can repair and stabilize the vascular endothelium to a certain extent, helping the cardiovascular system to restore normal function.
4- [ (4-Methyl-1-Piperazinyl) Methyl] -N- [4-Methyl-3- [[4- (3-Pyridinyl) -2-Pyrimidinyl] Amino] Phenyl] -Benzamide Monomethanesulfonate common side effects
This is a chemical called 4- [ (4-methyl-1-piperazinyl) methyl] -N - [4-methyl-3- [4 - (3-pyridyl) -2 -pyrimidinyl] amino] phenyl] -benzamide monomethanesulfonate. The common side effects of this substance are roughly as follows:
First, it often disturbs the gastrointestinal tract. The user may experience nausea, abdominal discomfort, and it seems that something is surging up, and the feeling of vomiting occurs frequently. It may also be accompanied by vomiting, and the contents of the stomach are vomited, which is quite uncomfortable. And diarrhea is not uncommon, the stool is loose and thin, the number of times increases, and you go to the toilet within a day or several times. Lack of appetite is also common. The food you liked in the past has no appetite when you see it now, and the amount of food you eat has dropped sharply. This is because the substance affects the digestion and absorption functions of the stomach, resulting in abnormal transportation and transportation.
Second, it also affects the nervous system. Many users often feel headaches, and the head may feel swelling and tingling, as if something is tight. Dizziness is also not uncommon. When standing or walking, you feel the world spinning and the sense of balance is impaired. And it is easy to cause drowsiness, listlessness all day, sleepiness, and difficulty concentrating on things. Some people also experience insomnia, tossing and turning at night, difficulty falling asleep, and easy to wake up even if they fall asleep. This is because the substance interferes with the normal regulation of the nervous system and causes neurological disorders.
Third, it may affect the cardiovascular system. Or cause blood pressure fluctuations. When the blood pressure rises, the head is swollen and painful, the heart is palpitated and the heart is palpitated; when the blood pressure drops, it is dizzy and the limbs are weak. It may also cause arrhythmia, and the conscious heartbeat is abnormal, or it is too fast or too slow, or the beating rhythm is irregular. This is because the substance affects the electrophysiological activity of the cardiovascular vessels and the regulation of vascular tension.
Fourth, there may also be problems with the skin. After some people take medication, their skin itches, and after scratching, they can see erythema, skin redness, or a rash, which varies in shape. This is due to the body's allergic reaction to the substance, causing the skin to develop corresponding symptoms.
4- [ (4-Methyl-1-Piperazinyl) Methyl] -N- [4-Methyl-3- [[4- (3-Pyridinyl) -2-Pyrimidinyl] Amino] Phenyl] -Benzamide What are the precautions for the use of Monomethanesulfonate
4 - [ (4 - methyl - 1 - piperazinyl) methyl] - N - [4 - methyl - 3 - [[4 - (3 - pyridyl) - 2 - pyrimidinyl] amino] phenyl] -benzamide monomethylsulfonate, the use of this drug, need to pay attention to many matters.
First, follow the doctor's advice. The doctor will consider the dose and course of treatment according to the patient's condition, constitution and other medications. Patients should never increase or decrease the dosage or stop the medication without authorization, so as not to be difficult to achieve the effect of the medicine, or even cause adverse consequences.
During the medication, pay close attention to your own reactions. If you experience allergies, such as rashes, itching, breathing difficulties, etc., or serious adverse reactions, such as severe headaches, heart palpitations, nausea and vomiting, seek medical attention immediately. This medicine may interact with other medicines. When seeking medical attention, you must inform your doctor of the current medicines, including prescription drugs, over-the-counter drugs, health products, etc., so that they can evaluate the risk.
Furthermore, special groups of people should be especially cautious when using drugs. Pregnant women, breastfeeding women, children and the elderly have different risks due to physiological differences. Pregnant women and breastfeeding women, drugs or through the placenta or milk affect the fetus or baby, if not necessary, should be avoided; children's organ development is not complete, the elderly organ function decline, all need doctors to weigh the pros and cons, choose the appropriate dose.
In terms of diet, some foods may affect the efficacy of the drug. During the medication period, avoid spicy, greasy, irritating foods, so as not to interfere with the absorption of drugs and reduce the efficacy. And maintain a regular routine and exercise moderately to help the drug play and improve the physical recovery ability.