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What is the chemical structure of 4- {4- [ (R) - (4-chlorophenyl) (pyridine-2-yl) methoxy] piperidin-1-yl} butyrate benzenesulfonate (1:1)
In order to solve the problem of this chemical structure, it is necessary to analyze the chemical groups and reactions involved in the stem of the question in detail. "4- {4- [ (R) - (4-cyanobenzyl) (to its -2-yl) acetyl] and its -1-yl} benzyl butyrate (1:1) ", among which "cyanobenzyl" "acetyl" and other groups are of great significance in the construction of organic chemical structures.
According to the simple and elegant text of "Tiangong Kaiwu", it should be analyzed in the following way. In this compound, "4-butyrate" is the main framework, and one end is connected with a complex group. "{ 4 - [ (R) - (4 - cyanobenzyl) (to its - 2 - group) acetyl group] and its - 1 - group} "part," (R) "chirality, suggesting the presence of enantiomers in this structure. In" cyanobenzyl ", cyano (-CN) has strong electron-withdrawing properties, while benzyl is benzyl, which introduces aromatics to the structure. In" (to its - 2 - group) acetyl group ", acetyl (-COCH) can participate in a variety of reactions, and" to its - 2 - group "indicates the connection position with other groups.
From the perspective of the overall structure, this compound fuses aromatic hydrocarbons, carbonyl groups, cyanyl groups and other functional groups, and the interaction of each functional group gives it unique chemical properties. Its structure may be optically active due to the existence of chiral centers. The spatial arrangement and interaction of each group determine its physical and chemical behavior. The complex and delicate structure of this compound is like a treasure carefully carved by a craftsman. The synergistic effect of all parts may have potential application value in organic synthesis, medicinal chemistry and other fields.
What are the physical properties of 4- {4- [ (R) - (4-chlorophenyl) (pyridine-2-yl) methoxy] piperidin-1-yl} butyrate benzenesulfonate (1:1)
The properties of this compound are important, let me say.
The name of this compound is 4- {4- [ (R) - (4-methoxyphenyl) (its-2-yl) ethoxyphenyl] and its - 1-yl} phenyl butyrate (1:1). For one thing, the physical properties are often in a specific shape, or the crystals are not uniform, and the crystal form is complete. Under appropriate lighting, the surface luminosity can be special. The refraction light is at a specific angle and brightness, which is caused by the orderly arrangement of its molecules.
Second, the important physical characteristics of fusion. Under certain conditions, the substance will be melted into a liquid at a fixed temperature, such as even-even interaction. The value of this melting is determined by the molecular force, including Vander force, etc. The interaction of the bases in the molecule makes the attractive force of the molecule to a certain extent, which determines the level of melting.
Third, the solubility cannot be ignored. In different solubilities, this substance shows different degrees of solubility. In the soluble solution, there is a certain solubility due to the interaction of some groups in the molecule, such as even-even interaction. In the non-soluble solution, the solubility is poor due to the mismatch of molecular forces.
Fourth, density is also one of the physical properties. The density of this compound is determined by its molecular weight and molecular density, reflecting the amount of matter in a specific location. In specific applications and tasks, density has important test values in material calculation, mixing ratio, etc. Therefore, the physical rationality of this compound is determined by its fine molecules, and it plays an important role in the multi-domain.
What is the use of 4- {4- [ (R) - (4-chlorophenyl) (pyridine-2-yl) methoxy] piperidin-1-yl} butyrate benzenesulfonate (1:1)
The content of this question is rather unconventional and complex, and it seems to contain professional or specially coded information in a specific field, and it is mixed with garbled characters or uncommon expressions. Try to interpret it in the classical Chinese style of "Tiangong Kaiwu", or as follows:
Looking at this question, the words are obscure, and the meaning is difficult to understand. Among them, the symbols of "4-%7B4-%5B%28R%29-%284-%E6%B0%AF%E8%8B%AF%E5%9F%BA%29%28%E5%90%A1%E5%95%B6-2-%E5%9F%BA%29%E7%94%B2%E6%B0%A7%E5%9F%BA%5D%E5%93%8C%E5%95%B6-1-%E5%9F%BA%7D%E4%B8%81%E9%85%B8%E8%8B%AF%E7%A3%BA%E9%85%B8%E7%9B%90%281%3A1%29" are mixed with strange characters, and I don't know what they refer to.
He speculates on the original meaning of this question, or seeks the use of a certain substance (speculated from phrases such as "acid naphthalene shows acid anhydride (1:1) "). I am reluctant to know the details of the information. If you want to clarify the reason, you should describe it in more detailed and standardized language, so that the meaning of the question is obvious, and the purpose can be discussed. If you only ask the current appearance, it is difficult to find out. Even if you have ingenuity, it is difficult to apply your skills. I hope the inquirer will sort it out in detail to find out.
What is the synthesis method of 4- {4- [ (R) - (4-chlorophenyl) (pyridine-2-yl) methoxy] piperidin-1-yl} butyrate benzenesulfonate (1:1)
To prepare 4- {4- [ (R) - (4-methoxybenzyl) (p-2-yl) acetoxy] benzyl} -benzyl benzoate (1:1), the synthesis method is as follows:
First, it is necessary to prepare suitable starting materials, that is, benzyl compounds containing specific substituents and benzoic acid derivatives with corresponding activity check points.
In a clean and dry reaction vessel, dissolve the starting materials with suitable organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. The choice of organic solvents should consider the solubility of the raw materials and the requirements of the subsequent reaction process.
Then, add an appropriate amount of catalyst. The catalyst may be an organic base, such as triethylamine, pyridine, or a combination of metal catalysts and their ligands, depending on the specific reaction mechanism. The role of the catalyst is to promote the reaction and reduce the activation energy of the reaction.
Heat the reaction system to a suitable temperature, usually between room temperature and 80 ° C. The reaction temperature is crucial. If it is too high, it may cause more side reactions, and if it is too low, the reaction rate will be too slow.
During the reaction process, the reaction progress needs to be monitored in real time by thin layer chromatography (TLC) or high performance liquid chromatography (HPLC). When the raw material points are significantly reduced and the product points appear and tend to be stable, it can be determined that the reaction has reached the expected degree.
After the reaction is completed, pour the reaction solution into an appropriate amount of quenching agent, such as dilute acid solution, to terminate the reaction. Subsequently, the extraction operation is carried out. The commonly used extracting agents are ethyl acetate, ether, etc. After multiple extractions, the product is enriched in the organic phase.
The organic phase is collected and dried with anhydrous sodium sulfate or magnesium sulfate to remove the moisture. Then, the organic solvent is distilled under reduced pressure to obtain a crude product.
The crude product needs to be purified by column chromatography or recrystallization. During column chromatography, appropriate silica gel and eluent are selected to effectively separate the product from impurities; for recrystallization, appropriate solvents are selected to crystallize the product under suitable conditions, resulting in pure 4- {4- [ (R) - (4-methoxybenzyl) (p-2-yl) acetoxy] benzyl} -benzyl benzoate (1:1).
Synthesis requires careful control of the conditions of each link and attention to detail to obtain satisfactory yield and purity.
What is the safety of 4- {4- [ (R) - (4-chlorophenyl) (pyridine-2-yl) methoxy] piperidin-1-yl} butyrate benzenesulfonate (1:1)
Looking at the description of this chemical structure formula, it is a complicated and in-depth problem. The chemical groups involved, such as\ (4 - \){\( 4 - \)[\(( R )\) - \(( 4 -\) cyanobenzyl\ () \) (to its\ (-2 -\) group\ () \) acetyl}, these groups are combined to form a specific chemical substance.
The safety of this substance (\ (1:1\)) needs to be explored from many aspects. The first to bear the brunt is cyanobenzyl, which is chemically active and toxic. If it dissociates in the body or interacts with biomacromolecules, it can be life-threatening. The structure and properties of its\ (-2 -\) group also affect the overall safety. If this group is prone to chemical reactions, or forms new compounds with substances in the body, or alters the metabolic pathway of substances, causing changes in biological effects.
Acetyl groups are relatively common, and acetylation reactions are quite important in some metabolic processes in organisms. However, in this specific chemical structure, the interaction of acetyl groups with other groups should not be underestimated. Or affect the stability and solubility of the substance, which in turn affects its absorption, distribution, metabolism and excretion in the body.
In addition, the safety of the substance varies in different environments. Under in vitro experimental conditions, cytotoxicity experiments, genotoxicity experiments, etc. can be used to preliminarily evaluate its effects on cell growth and gene stability. In vivo experiments, the overall effect in animal models needs to be considered, including the impact on the function of each organ.
However, it is difficult to make an absolute judgment on its safety only based on the description of existing structural formulas. Further experimental studies are required, including chemical analysis to clarify its purity and impurity; biological experiments to investigate its toxicity and pharmacological activity. Only then can we have a comprehensive and accurate understanding of the safety of the substance (1:1).