4,5-Dihydroxynaphthalene-2,7-Disulphonic Acid

4,5-diaminopyrimidine-2,7-disulfonic acid is an organic compound with the following chemical properties:
One is acidic. Because its molecule contains a sulfonic acid group (-SO 🥰 H), the sulfur atom in the sulfonic acid group has strong electron-absorbing properties, which greatly increases the polarity of oxygen and hydrogen bonds in the hydroxyl group. Hydrogen is easily dissociated in the form of protons, so it is acidic and can be neutralized with bases. If reacted with sodium hydroxide, the hydrogen in the sulfonic acid group combines with hydroxide to form water to form the corresponding sodium salt.
The second is the activity of nucleophilic substitution. The pyrimidine ring nitrogen atom has a lone pair of electrons, so that the ring has a certain electron cloud density, which can attract electrophilic reagents to attack. When the electrophilic reagent is present, the electrophilic substitution reaction is easy to occur at a specific position in the pyrimidine ring. For example, under suitable conditions, the halogen atom in the halogenated reagent can replace the hydrogen atom on the pyrimidine ring.
The third is the coordination ability. The nitrogen atom in the molecule can be used as a ligand, using its lone pair electrons to form coordination bonds with metal ions to form complexes. This property has important applications in many fields, such as in catalytic reactions, the formed metal complexes can be used as high-efficiency catalysts.
The fourth is solubility. The presence of sulfonic acid groups makes the compound soluble in water. The sulfonic acid group is a hydrophilic group that can form hydrogen bonds with water molecules, which helps it disperse in water. However, its specific solubility is also affected by the structure of other parts of the molecule and external conditions such as temperature and pH value.

4,5-diaminopyrimidine-2,7-disulfonic acid is a common organic compound, and its common routes are as follows:
1. ** Pharmaceutical synthesis **: This is an important pharmaceutical intermediate. It plays a key role in the preparation of many drugs, such as in the synthesis of some antibacterial drugs. The 4,5-diaminopyrimidine-2,7-disulfonic acid structural unit can impart specific antibacterial activity to drugs. By interacting with key enzymes or metabolic pathways in bacteria, it inhibits the growth and reproduction of bacteria and achieves antibacterial effect.
2. ** Dye preparation **: It is widely used in the field of dye industry. Due to its special molecular structure, it can generate dyes with specific colors and properties after appropriate chemical modification and reaction. This type of dye is widely used in textile, printing and dyeing industries, making fabrics rich in color, and has good color fastness and dyeing properties.
3. ** Organic Synthesis Reagents **: As an important reagent in organic synthesis, it plays an important role in the construction of complex organic molecules. Its special functional groups can participate in various organic reactions, such as nucleophilic substitution, electrophilic addition, etc., providing an effective way for the synthesis of organic compounds with specific structures and functions, and assisting chemists in synthesizing new materials and bioactive molecules.
4. ** Field of Materials Science **: With the development of materials science, 4,5-diaminopyrimidine-2,7-disulfonic acid has emerged in the research and development of new materials. For example, through rational molecular design and assembly, materials with unique electrical, optical, or mechanical properties can be prepared for use in cutting-edge fields such as electronic devices and optical sensors, promoting progress and innovation in materials science.

If you want to make 4- (2,5-difluorobenzyl) -2,7-dibromonaphthalene, the method is as follows.
First take an appropriate amount of 2,7-dibromonaphthalene, place it in a clean reactor, fill it with nitrogen, drive out the air in the kettle, and create an inert atmosphere. This is to prevent material oxidation. Then, add an appropriate amount of organic solvent, such as dichloromethane, to facilitate the reaction to proceed uniformly.
Under low temperature stirring, slowly add a specific base, such as potassium carbonate, which can activate the activity of 2,7-dibromonaphthalene check point. While stirring continuously, 2,5-difluorobenzyl halide, such as 2,5-difluorobenzyl chloride or bromide, is added dropwise to the reaction system. This process requires strict temperature control to prevent side reactions. Add dropwise, raise to a suitable temperature, and maintain a certain time to make the reaction sufficient.
After the reaction is completed, pour the reaction solution into a mixture of an appropriate amount of water and an organic solvent, shake to separate the liquid, and collect the organic phase. Dry the organic phase with anhydrous sodium sulfate to remove the moisture. Then, the organic solvent is distilled under reduced pressure to obtain a crude product.
The crude product was purified by column chromatography. The appropriate silica gel was selected as the stationary phase, and the mixture of n-hexane and ethyl acetate in a specific proportion was used as the mobile phase for elution. The eluent containing the target product was collected, and the solvent was evaporated to obtain a pure 4- (2,5-difluorobenzyl) -2,7-dibromonaphthalene. This synthesis method, with fine operation in each step, can obtain satisfactory yield and purity.

Today there are four things, called 4% 2C5-diaminopyrimidine, called 2% 2C7-dihydroxynaphthalene, and the market price has its own range. If you want to know the range of its price, you must consider various things, such as the production of materials, the supply and demand of the time, and the complexity and simplicity of the system.
The production of the husband's materials is related to the abundance of the source. If the origin is wide and the source is sufficient, the price is flat; if the production is narrow and the source is thin, the price will rise. The supply and demand of the time is also the main reason. If the demand is prosperous and the supply is small, the price will be high; if the supply exceeds the demand, the price will drop. As for the complexity and simplicity of the system, the complexity will cost labor and money, and the price will be expensive; the simplicity will save industry and money, and the price will be cheap.
It is difficult to determine the range of its exact price. However, it can be deduced that if the product is wide, sufficient and simple, the price will be low; if the product is narrow, abundant and complex, the price will be high. In short, the market prices of 4% 2C5-diaminopyrimidine and 2% 2C7-dihydroxynaphthalene vary according to the above factors, and the range of their prices may vary from low to high, depending on the situation of the city.

4-2,5-dihydroxyacetophenone-2,7-dinaphthalenesulfonic acid should pay attention to the following things during storage and transportation:
First, this material has its unique properties. Both 4-2,5-dihydroxyacetophenone and 2,7-dinaphthalenesulfonic acid have specific chemical activities. 4-2,5-dihydroxyacetophenone contains hydroxy groups and acetophenone structures, which are prone to reaction or deterioration in case of oxidants. When storing, place in a sealed container to avoid coexistence with strong oxidants. During transportation, also ensure that the packaging is intact and free from oxidant contamination. 2,7-Dinaphthalenesulfonic acid contains sulfonic acid groups, which are acidic and may corrode metals. Storage containers should be made of corrosion-resistant materials, such as plastic, glass, etc. Do not use metal containers that are easily corroded. When transporting, prevent the container from being damaged, causing acid leakage and corroding surrounding objects.
Second, temperature and humidity have a great impact. If the temperature is too high, 4-2,5-dihydroxyacetophenone may decompose or polymerize, resulting in quality damage. Storage should be controlled in a cool place, with a temperature of 5-25 ° C. Although the stability of 2,7-dinaphthalenesulfonic acid is slightly higher, high temperature may also change its crystalline form or accelerate moisture absorption. In terms of humidity, both should be avoided in high-humidity environments. After 4-2,5-dihydroxyacetophenone absorbs moisture or affects the purity and activity, 2,7-dinaphthalenesulfonic acid absorbs moisture or agglomerates, affecting the use. The humidity at the storage place should be controlled at 40% -60%.
Third, the packaging and identification cannot be ignored. The packaging must be tight to prevent leakage and external substances from invading. 4-2,5-dihydroxyacetophenone and 2,7-dinaphthalenesulfonic acid should be clearly marked with the name, chemical formula, dangerous characteristics, etc. Such as 2,7-dinaphthalenesulfonic acid should be marked with acidic, corrosive, etc. When transporting, transportation vehicles and tools should ensure that they are clean, free of residues of substances that may react with them, and hazardous chemical labels should be posted as required to facilitate the identification of transporters and regulators.
Fourth, transportation compliance is extremely critical. Transportation of 4-2,5-dihydroxyacetophenone and 2,7-dinaphthalenesulfonic acid requires transportation enterprises and personnel to have corresponding qualifications. Transportation routes should be planned in advance to avoid densely populated areas and environmentally sensitive areas. During transportation, it is necessary to regularly check whether the packaging is in good condition. If there is any abnormality such as leakage, it should be dealt with in a timely manner, and action should be taken according to the emergency plan to ensure the safety of personnel and the environment is not polluted.