What are the main uses of 4-Aminobenzenesulfonic Acid?
4-Aminobenzenesulfonic acid, also known as p-aminobenzenesulfonic acid, is widely used.
In the dye industry, it is a key intermediate. It can be used to synthesize a variety of azo dyes, such as direct dyes, acid dyes, reactive dyes, etc. By coupling reaction with different diazonium salts, dyes with various colors and properties can be prepared to meet the diverse needs of textile, printing and dyeing industries for color fastness, brightness and application performance of dyes.
In the field of medicine, it also has important uses. It is a raw material for the synthesis of many drugs, such as some sulfonamides, which have antibacterial and anti-inflammatory effects and can be used to treat a variety of bacterial infections. 4-Aminobenzenesulfonic acid provides a key structural fragment in drug synthesis, and through a series of chemical transformations, imparts specific pharmacological activity and therapeutic efficacy to the drug.
In analytical chemistry, 4-aminobenzenesulfonic acid is often used as a raw material for acid-base indicators. Because of its certain acid-base properties, it can present different colors through structural changes to indicate changes in the pH of solutions, helping researchers to accurately determine the endpoint of chemical reactions and ensure the accuracy and reliability of analytical results.
In addition, 4-aminobenzenesulfonic acid is also used in surfactants, photosensitive materials and other industries. In the synthesis of surfactants, it participates in the construction of molecular structures with specific properties to improve the surface activity, emulsification, dispersion and other properties of the product; in the manufacture of photosensitive materials, it may participate in the construction of photosensitive layer components, which affects the photosensitive properties and imaging quality of photosensitive materials. In short, 4-aminobenzenesulfonic acid plays an important role in many industrial and scientific research fields, and plays a key role in promoting the development of various industries.
What are the physical properties of 4-Aminobenzenesulfonic Acid?
4-Aminobenzenesulfonic acid, also known as p-aminobenzenesulfonic acid, is a kind of organic compound. It has the following physical properties:
In appearance, it is a white to off-white crystalline powder under normal conditions, with fine and uniform texture. This form is convenient for storage, transportation and subsequent processing.
The melting point is quite high, about 288 ° C. The high melting point indicates that the intermolecular force is strong, the structure is relatively stable, and the phase state transition occurs at higher temperatures. This property is of great significance in industrial processes or experimental operations involving high temperature treatment, which can ensure that its solid-state properties are maintained within a certain temperature range. In terms of solubility, it is slightly soluble in cold water and slightly more soluble in hot water. It is soluble in basic solutions such as ammonia and sodium hydroxide, but extremely insoluble in organic solvents such as ethanol and ether. This difference in solubility stems from the strong polarity of the sulfonic acid group in its molecular structure and the certain polarity of the amino group. Sulfonic acid groups easily form hydrogen bonds with water molecules, but due to the hydrophobicity of the benzene ring, the solubility in cold water is limited; the energy provided by hot water prompts the molecular movement to intensify, increasing the chance of contact with water molecules, and the solubility is improved. Alkaline solutions can react with sulfonic acid groups or amino groups, thereby increasing their solubility; the non-polar structure of organic solvents does not match the polar structure of 4-aminobenzenesulfonic acid, resulting in insolubility.
Odor, its own smell is weak, which can reduce the trouble caused by odor in many application scenarios. Whether it is used in industrial production or as an experimental reagent, it will not interfere with the production environment or experimental operation due to strong odor.
The density is moderate, and the specific value will vary slightly due to factors such as purity. The appropriate density plays an important role in the measurement, mixing of materials and the quality control of related products, ensuring the accurate ratio in the production process and the stability of product quality.
4-Aminobenzenesulfonic acid These physical properties are interrelated, and together determine its application mode and scope in many fields such as chemical industry, medicine, dyes, etc., which is of great significance to the development of related industries.
What are the chemical properties of 4-Aminobenzenesulfonic Acid?
4-Aminobenzenesulfonic acid, which is white in color and has needle-like or flake-like crystals. It is quite stable at room temperature and soluble in water, but difficult to dissolve in ethanol and ether.
This substance has the characteristics of an acid. Because its sulfonic acid group can dissociate hydrogen ions, it can neutralize and react with bases to form corresponding salts. For example, by reacting with sodium hydroxide, 4-aminobenzenesulfonic acid can be obtained.
The presence of amino groups in 4-aminobenzenesulfonic acid makes it also have the properties of a certain base and can react with acids. The amino group is the power supply group, which has an impact on the electron cloud distribution of the benzene ring, increasing the density of the electron cloud in the adjacent and para-position of the benzene ring, so electrophilic substitution reactions can occur, such as halogenation, nitrification, sulfonation, etc., and the substitution mostly occurs in the para-position of the amino group. Due to the large volume of the sulfonic acid group, the ortho-steric resistance is large.
It is also reductive, and the amino group can be oxidized by the oxidant, resulting in changes in the structure and properties. In the dye industry, 4-aminobenzenesulfonic acid is often an important intermediate. It can produce many dyes through a series of reactions. With the reactivity of the amino group and the sulfonic acid group in its structure, it participates in the construction of the color system of
What is the production method of 4-Aminobenzenesulfonic Acid?
4-Aminobenzenesulfonic acid, also known as p-aminobenzenesulfonic acid, is prepared by two common methods.
One is to use aniline as the starting material and prepare it by sulfonation reaction. In the reaction kettle, put an appropriate amount of aniline and slowly add concentrated sulfuric acid. This process requires strict temperature supervision. At the beginning, the temperature should be controlled at 180-200 ° C, and concentrated sulfuric acid and aniline can undergo electrophilic substitution reaction. The amino group of aniline is an ortho-para-site group. Due to the steric resistance and electronic effects, the sulfonic acid group is mostly introduced into the amino para-site to produce 4-aminobenzenesulfonic acid. After the reaction, the pure product can be obtained through cooling, crystallization, filtration, washing and other processes. The key to this reaction lies in the precise regulation of temperature. If the temperature is too high, it is easy to cause side reactions to occur, resulting in meta-or multi-sulfonation products; if the temperature is too low, the reaction rate will be slow and time-consuming.
The second is to use nitrobenzene as raw material, first sulfonate to obtain m-nitrobenzene sulfonic acid, and then reduce it to obtain 4-aminobenzene sulfonic acid. First, the nitrobenzene is co-placed in the reactor with fuming sulfuric acid, and at an appropriate temperature, the nitrobenzene is sulfonated. The nitro group of m-nitrobenzene sulfonic acid is reduced to an amino group to obtain 4-aminobenzene sulfonic acid. In this path, the reduction step is crucial, and the amount of reducing agent and reaction conditions will affect the purity and yield of the product. When reducing iron powder, it is necessary to pay attention to the acidity, temperature and stirring rate of the reaction system to ensure the smooth progress of the reduction reaction and the good quality of the product.
4-Aminobenzenesulfonic Acid in storage and transportation
4-Aminobenzenesulfonic acid is an important organic compound. When storing and transporting, many points need careful attention.
In terms of storage, the first environment is dry. Because of its certain water absorption, if the environment is humid, it is easy to cause moisture and agglomeration, which will affect the quality and use. Therefore, it should be placed in a dry warehouse, away from water sources and moisture.
Secondly, it is necessary to pay attention to the appropriate temperature. Excessive temperature may cause changes in its chemical properties, or even cause it to decompose. Generally speaking, it should be stored in a cool place, and the temperature should not exceed 30 ° C.
Furthermore, ensure that the storage environment is well ventilated. 4-Aminobenzenesulfonic acid or volatilizes a special odor. Good ventilation can avoid odor accumulation, ensure the air quality of the storage space, and help prevent potential hazards caused by gas accumulation.
And it needs to be stored separately from oxidants, acids, alkalis and other substances. Because of its active chemical nature, contact with these substances may cause severe chemical reactions, resulting in serious consequences such as fire and explosion.
When transporting, the packaging must be firm. Suitable packaging materials should be used to ensure that it is not damaged and leaked due to vibration, collision during transportation.
The transportation vehicle should also be kept clean and dry to avoid the reaction of other residual chemical substances with it.
The transportation process should avoid high temperature periods and road sections to prevent transportation safety from being endangered due to excessive temperature.
The escort personnel also need to have professional knowledge and be familiar with the characteristics of 4-aminobenzenesulfonic acid and emergency treatment methods, so that they can respond quickly and properly in case of emergencies to ensure the safety of storage and transportation.