What are the main uses of 4-methoxyaniline-3-sulfonic acid?
4-Acetoxyphenylboronic acid-3-sulfonic acid has a wide range of main uses.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to its unique structure, it can exhibit active chemical properties in many reactions, such as participating in the Suzuki-Miyaura coupling reaction. Reactors are an important means of building carbon-carbon bonds and play a pivotal role in drug synthesis, materials science and many other fields. 4-Acetoxyphenylboronic acid-3-sulfonic acid, with its boric acid group, can be coupled with halogenated aromatics or other electrophilic reagents in the presence of suitable catalysts and bases to prepare complex aromatic compounds, which lay the foundation for the creation of new drug molecules or functional materials.
In pharmaceutical chemistry, this compound has also attracted much attention. Its structure can be cleverly modified and modified to meet the needs of specific drug targets. Or its sulfonic acid group can be used to form hydrogen bonds, ionic bonds, etc. with specific parts of biomacromolecules to enhance the affinity between the drug and the target and improve the efficacy of the drug; or the modification of the acetoxybenzene part can improve the lipid solubility of the drug, promote drug transmembrane transportation, and optimize the pharmacokinetic properties of the drug.
In the field of materials science, 4-acetoxyphenylboronic acid-3-sulfonic acid also has its uses. It can be introduced into the structure of polymer materials to give the materials special properties. For example, by using boric acid groups and diol compounds to form reversible covalent bonds, smart materials with self-healing properties can be prepared; or by participating in polymerization reactions, polymer materials with specific morphologies and functions can be constructed for use in sensors, separation membranes and other fields, exhibiting unique recognition and separation properties.
What are the physical properties of 4-methoxyaniline-3-sulfonic acid?
4-Methoxyphenylpropionic acid-3-sulfonic acid is an organic compound. Its physical properties are complex, so let me talk about them one by one.
The first thing is the appearance. This compound is often in the state of white to quasi-white crystalline powder, with a fine appearance and pure color. This characteristic is quite critical in the identification of many chemical substances, just like the appearance of a human being, and is the main identification mark.
Solubility is also an important property. 4-Methoxyphenylpropionic acid-3-sulfonic acid exhibits good solubility in water and can mix harmoniously with water to form a uniform and stable solution. Due to the existence of polar groups in the molecular structure, hydrogen bonds can be formed with water molecules and other interactions, so it can be soluble in polar solvent water. In terms of organic solvents, such as ethanol, acetone and other common organic solvents, their solubility varies according to specific conditions. At moderate ethanol concentration, it can be partially dissolved, but in non-polar organic solvents such as n-hexane, the solubility is extremely poor and almost insoluble, which is determined by the principle of similar miscibility.
Melting point is also an important physical parameter of this compound. After precise determination, its melting point is in a specific temperature range, which is of great significance for the identification of compound purity. If the purity of the compound is extremely high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point decreases and the range becomes wider, just like pure gold mixed with debris, its melting point will also change.
In addition, 4-methoxyphenylpropionic acid-3-sulfonic acid has a certain degree of hygroscopicity. Because the polar groups in the molecule are easily attracted to water molecules in the air, in a high humidity environment, it will absorb water, causing its own weight to increase, morphology to change, or from dry powder to a slightly humid state. This hygroscopicity needs to be taken into account when storing and using the compound, and it must be properly stored to prevent its quality and performance from being affected by moisture absorption.
In summary, the physical properties of 4-methoxyphenylpropionic acid-3-sulfonic acid, such as appearance, solubility, melting point, and hygroscopicity, are indispensable factors in chemical research, industrial production, and related application fields.
Is 4-methoxyaniline-3-sulfonic acid chemically stable?
4-Methoxyphenylpropene-3-carboxylic acid, this is an organic compound. Its chemical properties are relatively stable, and the reasons are as follows:
First, its molecular structure is analyzed. In this compound, the benzene ring has a conjugated system, and the conjugated structure endows the molecule with additional stability. The π electrons can be delocalized in the conjugated system, which reduces the energy of the molecule, making the benzene ring part relatively stable and less susceptible to general chemical reactions. The methoxy group is connected to the benzene ring, and the oxygen atom in the methoxy group has lone pair electrons, which can occur p-π conjugation effect with the benzene ring, which further enhances the electron cloud density of the benzene ring and improves the stability of the benzene At the same time, this conjugation also affects the electron cloud distribution of the o-para-site of the benzene ring, thereby affecting the reactivity and selectivity of the compound.
Furthermore, although the carboxyl group has a certain activity, due to the separation of the propylene group from the benzene ring, the interaction between the benzene ring and the carboxyl group is buffered to a certain extent. Although the carbon-carbon double bond in the propylene group has a certain reactivity, its reactivity is not very high due to factors such as conjugation effect and steric hindrance. Under normal conditions, 4-methoxyphenylpropene-3-carboxylic acid is difficult to chemically react without specific reaction conditions and reagents.
For example, at room temperature and pressure without catalysts or special reagents, it will not spontaneously react significantly with common substances such as oxygen and water in the air. However, under certain conditions, such as in the presence of strong acids, strong bases or high temperatures and catalysts, its carboxyl groups can undergo esterification, neutralization and other reactions, and carbon-carbon double bonds can also undergo addition and oxidation reactions. However, in conventional environments, the chemical properties of 4-methoxyphenylpropene-3-carboxylic acids are relatively stable.
What is the preparation method of 4-methoxyaniline-3-sulfonic acid?
To prepare 4-methoxybenzaldehyde-3-sulfonic acid, you can follow the following method.
First take an appropriate amount of p-methoxybenzaldehyde and place it in the reactor. Under appropriate temperature and stirring conditions, slowly add fuming sulfuric acid. The amount of fuming sulfuric acid needs to be precisely controlled, and it should be added in a specific proportion according to the amount of p-methoxybenzaldehyde. This ratio is determined by repeated tests and calculations to ensure that the reaction is sufficient and there are few side reactions.
Add it up to maintain the reaction system in a certain temperature range. This temperature needs to be strictly controlled. If it is too low, the reaction will be slow, and if it is too high, it will easily cause frequent side reactions. Continue stirring during this period to make the reactants fully contact to promote the smooth progress of the reaction.
The reaction process is monitored in real time by means of thin-layer chromatography. When the raw material point almost disappears and the product point is significant and stable, the reaction can be regarded as reaching the expected level.
Then, slowly pour the reaction solution into an appropriate amount of ice water. This operation needs to be cautious, because the reaction solution will exothermic violently when mixed with ice water. After pouring, stir well to make the product evenly dispersed in the system.
Next, with an appropriate alkali solution, such as sodium hydroxide solution, carefully adjust the pH value of the system to a specific range to promote the product to precipitate in a suitable form.
The precipitated solids are collected by suction filtration, and then washed with an appropriate amount of cold water several times to remove impurities.
The resulting crude product is recrystallized with a suitable organic solvent. The choice of this organic solvent is crucial, and it needs to have good solubility to the product, and the solubility varies significantly at different temperatures. After recrystallization, 4-methoxybenzaldehyde-3-sulfonic acid with high purity can be obtained. The whole process requires fine operation and strict control of temperature, dosage, time and other factors to obtain satisfactory results.
What is the price range of 4-methoxyaniline-3-sulfonic acid in the market?
In today's market, the price of 4-methylaminobenzoic acid-3-sulfonic acid is quite popular. However, its price is not constant and often changes for various reasons.
The abundance of raw materials here has a huge impact on its price. If the raw materials are widely available and easy to obtain, the price may be flat; if the raw materials are scarce and difficult to find, the price will rise sharply. Furthermore, the supply and demand of the market also affect its price. Those who need it are numerous, and the supply is small, the price will be high; if there are few requests, and the stock is like a mountain, the price will inevitably fall.
And the technology of production is also related to its price. If the new technology can greatly increase the production efficiency and reduce the cost, the price may be close to the people; on the contrary, if the technology is stagnant, the cost will be huge, and the price will be difficult to drop.
Looking at the current market conditions, the price of 4-methylaminobenzoic acid-3-sulfonic acid is about tens to hundreds of dollars per catty. However, this is only a rough number, and the market conditions are ever-changing, or it may be easier. When traders trade, they should carefully observe the market conditions and weigh the reasons before they can get the appropriate price.