What are the main uses of 4-methoxyaniline-2-sulfonic acid?
4-Acetoxybenzoic acid-2-sulfonic acid, also known as aspirin sulfonic acid, has a wide range of main uses.
In the field of medicine, this compound is of great significance. Aspirin itself has antipyretic, analgesic, anti-inflammatory and anti-platelet aggregation effects, and after the introduction of sulfonic acid groups, 4-Acetoxybenzoic acid-2-sulfonic acid may improve some of its properties while maintaining some of the pharmacological activity of aspirin. For example, sulfonic acid groups can enhance the solubility of drugs in water, making the drug easier to be absorbed by the human body, thereby improving bioavailability. For some drugs that are limited in application due to poor solubility, improved solubility means that they can exert their effects more efficiently, reach their target faster, and accelerate the onset of action. In the treatment of fever, pain and inflammation-related diseases, it may show better curative effect.
In the chemical industry, 4-acetoxybenzoic acid-2-sulfonic acid can be used as an important intermediate in organic synthesis. With the acetoxybenzoic acid and sulfonic acid groups in its structure, it can participate in a variety of organic reactions. By substituting and condensing with different reagents, organic compounds with more complex and diverse structures can be constructed, laying the foundation for the synthesis of new drugs, functional materials, etc. For example, the reactivity of its sulfonic acid group can be used to react with compounds containing specific functional groups to generate polymer materials with special properties, which can be used in coatings, plastics and other industries to endow materials with unique properties such as antistatic and hydrophilicity.
In addition, in some research scenarios, the compound may become a key model compound for studying chemical reaction mechanisms and drug action mechanisms due to its unique structure and properties. Researchers can gain a deeper understanding of related chemical and biological processes through the study of its reaction process and property changes, providing theoretical support for the development of more effective drugs and chemical processes.
What are the physical properties of 4-methoxyaniline-2-sulfonic acid?
4-Methoxyphenyl-2-carboxybenzoic acid, its physical properties are as follows:
This substance is in the state of white to light yellow crystalline powder. Looking at its color, when it is pure, it is white and pure; however, if it contains impurities slightly, or is in a light yellow phase, this is due to impurities affecting light scattering and absorption.
When it comes to the melting point, it is about 180-185 ° C. When the temperature gradually rises, the molecular thermal motion intensifies, the lattice structure begins to disintegrate, and it slowly melts from a solid state to a liquid state. This melting point range is relatively stable and can be used as an important basis for identifying this substance.
Its solubility is quite characteristic, and it has a certain solubility in organic solvents such as ethanol and acetone. The molecular structure of ethanol and acetone is similar to that of 4-methoxyphenyl-2-carboxybenzoic acid. According to the principle of similar miscibility, the substance can be partially dissolved in it. However, in water, its solubility is very small, because although there are carboxyl groups in the molecule that can form hydrogen bonds with water, the proportion of hydrophobic groups such as phenyl groups is relatively large, which hinders its dispersion and dissolution in water.
Furthermore, the density of this substance is about 1.3-1.4 g/cm ³. The density reflects the mass per unit volume of the substance. This value indicates that its relative density is moderate, neither frivolous nor heavy and abnormal. In practical application and storage, it needs to be properly placed according to this characteristic.
Its stability also needs attention. Under normal environmental conditions, if there is no strong acid, strong base or strong oxidant, it can maintain a relatively stable state. However, in case of extreme conditions such as high temperature and strong light, or coexist with some active substances, or cause chemical reactions, resulting in changes in its structure and properties.
What are the chemical properties of 4-methoxyaniline-2-sulfonic acid?
4-Methoxyphenyl-2-thiophenecarboxylic acid, an organic compound with unique chemical properties, is described as follows:
1. ** Acidic **: The molecule contains a carboxyl group (-COOH), which has acidic properties and can react with bases to form corresponding carboxylic salts and water. Taking the reaction with sodium hydroxide as an example, 4-methoxyphenyl-2-thiophenecarboxylic acid meets sodium hydroxide, and the hydrogen atom in the carboxyl group binds with hydroxyl ions to form water, which itself transforms into 4-methoxyphenyl-2-thiophenecarboxylate sodium salt. This reaction highlights its acidic nature, and in organic synthesis, this property is often used to separate and purify the compound.
2. ** Substitution Reaction **: There are hydrogen atoms that can be substituted on the benzene ring and thiophene ring. Under specific conditions, such as the presence of suitable catalysts and reactants, an electrophilic substitution reaction can occur. Take the bromination reaction as an example. Under the action of appropriate catalysts, bromine atoms can replace hydrogen atoms on the benzene ring or thiophene ring to form bromine-containing derivatives. This property provides the possibility for the structural modification and functionalization of the compound. By introducing different substituents, its physical and chemical properties can be changed to meet the application needs of different fields.
3. ** Esterification Reaction **: Because of its carboxyl group, it can undergo esterification reaction with alcohols under acid catalysis. When catalyzed by concentrated sulfuric acid and heated with ethanol, the carboxyl group dehydrates and condenses with the alcohol hydroxyl group to form 4-methoxyphenyl-2-thiophene carboxylate ethyl ester and water. Esterification products are of great application value in the fields of fragrances, coatings, etc. This reaction is also an important method for constructing ester compounds in organic synthesis, enriching the derivation path and application range of this compound.
4. ** Redox reaction **: The thiophene ring is relatively easy to be oxidized. Under the action of a specific oxidant, the structure of the thiophene ring may be changed to form an oxygenated compound. Some groups in the molecule can also undergo reduction reactions under the action of appropriate reducing agents. For example, specific reducing agents can reduce some substituents on the benzene ring, which is of great significance in the design of organic synthesis routes and helps to realize the construction and transformation of complex structures.
What is the production method of 4-methoxyaniline-2-sulfonic acid?
The method of generating 4-methoxybenzoic acid-2-sulfonic acid is obtained by taking the starting material of methoxybenzoic acid and specific reaction steps.
To obtain this substance, it is often started with compounds containing methoxybenzoic acid. First, the starting material has the ability to introduce sulfonic acid groups. If sulfated with sulfuric acid or sulfuric acid, under the appropriate reaction conditions, the sulfonic acid group in sulfuric acid (-SO _ H) can replace the atom at a specific position on the starting material benzene. This substitution reaction needs to be paid attention to the control of reaction degree. If the reaction degree is high, it is feared that the side reaction will occur, and the reaction will be caused by the reaction, which will reduce the reaction rate of the target substance. If the reaction degree is low, the reaction rate will be slow, which will take a long time and the efficiency will be low.
Generally speaking, at the beginning of the reaction, the starting material is dissolved in a suitable solution. If some are soluble, it can help the starting material to be fully integrated into the sulfonated product and promote the reaction. Add the sulfonated product, add it slowly, and mix it with the product to make the reaction system mix evenly, so as to avoid local reaction. In the reaction process, it is necessary to use analytical methods such as thin color method to reverse the reaction process. When the starting material is almost completely dissolved, that is, the reaction is stopped.
After the reaction is completed, the resulting reaction mixture needs to be extracted in a few steps. Usually, by means of neutralization, the sulfonated product is neutralized with the amount of sulfonated product, such as carbonate or oxidized solution. Neutralization, and then by means of extraction, crystallization, etc., to obtain 4-methoxybenzoic acid-2-sulfonic acid from the mixed solution. Extraction, depending on the difference in solubility of the product in different solutions, the solution of the product can be removed. It is soluble, and the product is extracted to the active phase, and then steamed to remove the solution and obtain a coarse product. And the re-crystallization can be obtained in one step to obtain a high degree of 4-methoxybenzoic acid-2-sulfonic acid.
What are the precautions for 4-methoxyaniline-2-sulfonic acid in storage and transportation?
4-Methoxyphenylacetic acid-2-succinic acid in storage and transportation, many precautions need to be detailed.
First, because of its chemical properties, the temperature and humidity requirements of the storage environment are strict. It should be placed in a cool and dry place to prevent moisture decomposition and deterioration. If the temperature and humidity are too high, it is easy to cause chemical reactions, resulting in changes in its properties and damage to quality. For example, in summer, if the warehouse does not have appropriate temperature control, this compound may decompose due to hot topics and lose its original efficacy.
Second time, it needs to be properly packaged during transportation. Because it may be corrosive or irritating, the packaging material must be corrosion-resistant and have good sealing performance. It can be contained in special plastic containers or metal containers lined with anti-corrosive materials to prevent leakage. If the packaging is not good, once it leaks, it will not only contaminate the transportation tool, but also pose a threat to the surrounding environment and personal safety.
Furthermore, this compound should be stored and transported separately with oxidizing agents, reducing agents and other incompatible substances. Due to its chemical activity, it can mix with other substances or cause violent reactions, causing dangerous situations such as combustion and explosion. If it is co-located with a strong oxidizing agent, a slight carelessness, or a reaction triggered by collision or friction, it will lead to disaster.
Repeat, whether it is storage or transportation, it must strictly follow relevant regulations and standards. Practitioners must be professionally trained and familiar with safety operating procedures. Handle with care when handling to avoid severe vibration and impact to prevent package damage.
In addition, storage places and transportation vehicles should be equipped with corresponding emergency treatment equipment and protective equipment. Such as fire extinguishers, adsorption materials, protective gloves and masks, etc., so as to respond quickly in case of emergencies and reduce hazards.
