4-Methyl-Benzenesulfonic Acid 2-(Aminocarbonyl)Hydrazide

4-Methyl-benzenesulfonic acid 2 - (aminocarbonyl) hydrazide, which is widely used. In the field of medicine, it can be used as a key intermediate to create new drugs. Because of its specific chemical structure and reactivity, it can interact with many bioactive molecules. Therefore, when developing antibacterial, antiviral, anti-tumor and other drugs, it is often used as a starting material or key structural fragment. Through a series of chemical reactions, complex drug molecules with precise pharmacological activity are constructed.
In the field of materials science, it also plays an important role. For example, in the synthesis of polymer materials, it can act as a functional monomer, participate in the polymerization reaction, and endow the polymer material with unique properties, such as improving the solubility and thermal stability of the material, or endowing it with the ability to adsorb and recognize specific substances, etc., thereby expanding the application of polymer materials in many fields, such as separation membranes, sensors, etc.
It is also an important research object at the level of scientific research and exploration. With the help of in-depth investigation of its chemical properties and reaction mechanism, researchers deepen their understanding of the laws of organic chemical reactions, develop novel synthesis methods and strategies, and contribute to the development of organic synthetic chemistry. At the same time, it can be used as a reference material or analytical reagent in the field of analytical chemistry for qualitative and quantitative analysis, enabling researchers to more accurately analyze the composition and structure of complex samples.

4-Methyl-benzenesulfonic acid 2 - (aminocarbonyl) hydrazide, which has unique chemical properties. Its appearance is often white to off-white crystalline powder, which is quite stable at room temperature and pressure.
In terms of solubility, it has a certain solubility in water, because the polar groups contained in the molecule, such as amino, carbonyl and sulfonic acid groups, can interact with water molecules through hydrogen bonds, so it can be dispersed to a certain extent in water. In some organic solvents, such as polar organic solvents such as ethanol, it also has certain solubility, but in non-polar organic solvents such as n-hexane, the solubility is not good.
From the perspective of chemical activity, its amino group and acyl hydrazide group have high reactivity. Amino groups can participate in a variety of nucleophilic substitution reactions, such as reaction with halogenated hydrocarbons to generate corresponding substitution products; they can also condensate with aldose and ketone to form nitrogen-containing heterocycles or Schiff base compounds. Acyl hydrazide groups can react with aldose and ketone to form hydrazone derivatives, which are often used in organic synthesis to construct new carbon-nitrogen bonds. And because its structure contains benzene ring, it can undergo typical reactions of aromatic hydrocarbons, such as halogenation, nitrification, sulfonation and other electrophilic substitution reactions. Through these reactions, their structures can be modified to prepare derivatives with different functions. The sulfonic acid group gives this compound a certain acidity. Under appropriate conditions, it can neutralize with bases to generate corresponding sulfonates. This property is of great application value in the preparation of ionic compounds or the regulation of water solubility of compounds.
Overall, the chemical properties of 4-methyl-benzenesulfonic acid 2 - (aminocarbonyl) hydrazide are rich, providing various possibilities for research and application in the fields of organic synthesis, pharmaceutical chemistry, etc.

4-Methyl-benzenesulfonic acid 2 - (aminocarbonyl) hydrazide, in synthesis, is often used as an acylation reagent. This reagent contains active groups such as amino, hydrazide and sulfonic acid groups, with unique properties and high reactivity, and is widely used in the field of organic synthesis.
It can be used to construct compounds containing specific functional groups. With its amino and hydrazide activities, it can acylate with many compounds containing carbonyl, carboxyl and other groups. Through this kind of acylation reaction, important chemical bonds such as amide bonds can be cleverly constructed, and then organic compounds with diverse structures can be prepared.
In the field of medicinal chemistry, it can participate in the synthesis of specific active drug molecules. By acylation with other biologically active fragments, novel compounds can be obtained, which can be screened for subsequent activity, or lead compounds with potential medicinal value can be discovered.
In the field of materials science, through the acylation reaction it participates in, functional polymer materials can be prepared. For example, by reacting with compounds containing polymerizable double bonds, it can be introduced into the polymer skeleton, giving the material unique physical and chemical properties, such as improving the solubility and thermal stability of the material. In conclusion, 4-methyl-benzenesulfonic acid 2 - (aminocarbonyl) hydrazide plays a key role as an acylating reagent in many fields of organic synthesis due to its unique structure and high reactivity, providing an effective way for the creation of new compounds and the development of new materials.

The preparation methods of 4-methyl-benzenesulfonic acid 2 - (aminocarbonyl) hydrazide are as follows:
First, it can be obtained by reacting 4-methylbenzenesulfonyl chloride with 2 - (aminocarbonyl) hydrazine. This reaction needs to be carried out in a suitable solvent, such as anhydrous ethyl ether or dichloromethane and other inert organic solvents. During the reaction, 4-methylbenzenesulfonyl chloride is slowly added dropwise to a solution containing 2 - (aminocarbonyl) hydrazine, and attention should be paid to the control of the reaction temperature. Generally, low temperature is appropriate, such as 0 ° C to 5 ° C. Due to the high activity of 4-methylbenzenesulfonyl chloride, After the dropwise addition is completed, let the reaction mixture continue to stir at room temperature for several hours to make the reaction sufficient. After that, the target product can be obtained by regular separation and purification methods, such as filtration, washing, drying, etc.
Second, 4-methylbenzenesulfonic acid is used as the starting material, and it is first converted into the corresponding sulfonyl halogen derivative. Usually, phosphorus pentachloride or sulfinyl chloride can be used to react with it to generate 4-methylbenzenesulfonyl chloride. This step needs to be operated in an anhydrous environment to avoid hydrolysis. Then, 4-methylbenzenesulfonyl chloride is reacted with 2 - (aminocarbonyl) hydrazine according to the above method, and the product is obtained by subsequent treatment.
Third, it can also be prepared by ester exchange method. First, 4-methylbenzenesulfonic acid is made into the corresponding ester, such as 4-methylbenzenesulfonic acid methyl ester. After that, 4-methylbenzenesulfonic acid methyl ester and 2 - (aminocarbonyl) hydrazine undergo ester exchange reaction under the action of basic catalysts. Commonly used basic catalysts include sodium methoxide, sodium ethanol, etc. The reaction is carried out under appropriate temperature and time conditions. After completion, the separation and purification process is completed to obtain 4-methyl-benzenesulfonic acid 2 - (aminocarbonyl) hydrazide. In the
preparation process, the reaction conditions of each step, such as temperature, proportion of reactants, reaction time, etc., need to be finely regulated, and the separation and purification step is also crucial, which is related to the purity and yield of the product.

4-Methyl-benzenesulfonic acid 2 - (aminocarbonyl) hydrazide, which is related to safety risks, needs to be investigated in detail.
Although this chemical substance has no name in "Tiangong Kaiwu", it can also be obtained by using ancient principles to understand the current situation. Chemical substances have their own unique properties, or are toxic, or flammable, or perishable, all of which are related to safety.
4-Methyl-benzenesulfonic acid 2 - (aminocarbonyl) hydrazide has a complex structure and each of the inner groups has its own properties. The aminocarbonyl hydrazide part, or involved in reactivity, encounters with other substances, and is afraid of unexpected changes. Such as ancient alchemy, the combination of various pharmaceutical phases, a little bit of poor pool, it will cause disaster. And the genus of benzenesulfonic acid and methyl group also needs to be considered. The benzene ring structure is stable but easy to hide hidden dangers, the sulfonic acid group is acidic, and the methyl group is simple, or modified.
If this substance is involved in production, from the accumulation of raw materials to the sequence of synthesis, all links need to be cautious. The quality of the raw materials, the accuracy of the dosage, the temperature, pressure, and time of the reaction, are slightly improper, or the reaction is out of control, such as splashing in the kettle, and the gas is scattered in the chamber, which are all dangerous.
When storing, it also needs to be According to its nature, choose a suitable place to store it. Avoid water and fire, and keep away from other things to prevent its deterioration and reaction. If it is in a humid place, or adjacent to something that is resistant to each other, it will cause an instant disaster.
As for the use, the operator must understand its nature and act according to the regulations. Prepare protective equipment, such as ancient armor, to protect against danger. If used carelessly, it touches the skin, enters the mouth and nose, and endangers the human body.
To sum up, 4-methyl-benzenesulfonic acid 2 - (amino carbonyl) hydrazide is a safety risk, and it needs to be treated with scientific methods and caution at all ends of production, storage, and use, so as to ensure safety.