What are the main uses of 4-methylbenzenesulfonic acid 4-aminophenyl ester?
4-Methylcoumarin-4-hydroxycoumarin are both coumarin compounds and have important uses in many fields such as medicine and chemical industry.
In the field of medicine, they have shown excellent anticoagulant effect. Its anticoagulant principle is to prevent blood coagulation by inhibiting the synthesis of vitamin K-dependent coagulation factors in the liver. For example, in the treatment and prevention of thrombotic diseases, such as deep vein thrombosis and pulmonary embolism, 4-methylcoumarin-4-hydroxycoumarin is widely used. Clinical practice has shown that the rational use of such drugs can significantly reduce the mortality and disability rates of patients with thrombotic diseases.
At the same time, they also have outstanding performance in the field of antibacterial. It can inhibit the growth and reproduction of a variety of bacteria, including common Gram-positive and Gram-negative bacteria. Studies have found that its mechanism of action may be related to destroying the cell wall and cell membrane of bacteria and interfering with the metabolic process of bacteria. In the development and production of some topical antibacterial drugs, 4-methylcoumarin-4-hydroxycoumarin is often regarded as an important active ingredient, helping to solve skin infections, wound infections and other problems.
In the chemical industry, 4-methylcoumarin-4-hydroxycoumarin is often used as a fluorescent whitening agent. Due to its unique molecular structure, it can emit bright fluorescence under specific wavelengths of light, which can significantly improve the whiteness and gloss of paper, plastics, textiles and other materials. In the paper industry, the addition of such substances can make paper appear more white and bright, greatly improving the quality and market competitiveness of paper.
In addition, in the fragrance industry, they also play an important role. 4-Methylcoumarin-4-hydroxycoumarin has a unique aroma, which can add a pleasant fragrance to perfumes, air fresheners, detergents and other products, creating a more comfortable and pleasant living environment for people.
What are the physical properties of 4-methylbenzenesulfonic acid 4-aminophenyl ester?
4-Methylbenzaldehyde and 4-hydroxybenzaldehyde are both organic compounds with considerable characteristics. There are many differences in physical properties between the two.
Let's talk about 4-methylbenzaldehyde first. It is usually a colorless to light yellow liquid at room temperature, exuding a special aroma like bitter almonds. Due to the presence of methyl groups, its molecular polarity is slightly weaker. The boiling point is about 204 ° C, and the melting point is about -6 ° C. It is difficult to dissolve in water, but it is easily soluble in organic solvents such as ethanol and ether. This is because methyl groups are hydrophobic groups, resulting in a weak force between the whole molecule and water molecules, but it can form a similar miscibility effect with organic solvents.
As for 4-hydroxybenzaldehyde, it is mostly white to pale yellow crystalline powder under normal conditions. Due to the hydroxyl group, hydrogen bonds can be formed between molecules, and the polarity is relatively stronger. The boiling point is about 240 ° C, and the melting point is 116-118 ° C, which is higher than that of 4-methylbenzaldehyde. The hydrophilicity of the hydroxyl group makes it slightly more soluble in water than 4-methylbenzaldehyde, and it can also be soluble in common organic solvents such as ethanol.
The difference in physical properties between the two lies in the difference in their substituents. Methyl as the electron carrier group has some influence on the electron cloud density distribution of the benzene ring, while the hydroxyl group not only has the electron carrier conjugation effect, but also has hydrophilicity, which has a significant impact on the physical properties such as intermolecular force and solubility. Due to their different physical properties, the two have different applications in chemical, pharmaceutical, fragrance and other fields.
What is the chemical synthesis method of 4-methylbenzenesulfonic acid 4-aminophenyl ester?
To prepare 4-aminobenzenesulfonamide with 4-methylbenzenesulfonate, the method is as follows:
Take toluene first and sulfonate it with concentrated sulfuric acid to obtain 4-methylbenzenesulfonate. This step of the reaction requires proper temperature control so that the sulfonic acid group is precisely substituted in the methyl para-position. The methyl group in the cover toluene is an ortho-para-position group. Under high temperature and suitable conditions, the sulfonic acid group mostly falls in the para-position.
The reaction of 4-methylbenzenesulfonate with phosphorus pentachloride is reacted with acylation and chlorination to obtain 4-methylbenzenesulfonyl chloride. This reaction is violent, and it must be in a low temperature, dry environment,
Then 4-methylbenzenesulfonyl chloride is mixed with concentrated ammonia water and converted into 4-methylbenzenesulfonamide through ammonolysis reaction. During this process, pay attention to the amount of ammonia and the reaction time to ensure the complete reaction.
Then, with an appropriate oxidant, such as potassium permanganate or potassium dichromate, in a suitable acid-base environment, the methyl of 4-methylbenzenesulfonamide is oxidized to a carboxyl group to obtain 4-carboxylbenzenesulfonamide. This oxidation step requires strict conditions and close monitoring to prevent excessive oxidation.
Finally, 4-carboxybenzenesulfonamide is degraded by Hoffmann, that is, by co-heating with alkaline solutions such as sodium hypobromite or sodium hypochlorite, the amide group can be converted into an amino group, and the final 4-aminobenzenesulfonamide is obtained. This series of reactions involves many steps, and each step requires fine control of the reaction conditions, such as temperature, pH, ratio of reactants, and reaction time, to achieve satisfactory yield and purity.
What are the precautions for 4-aminophenyl 4-methylbenzenesulfonate during storage and transportation?
4-Methylbenzaldehyde and 4-nitrobenzaldehyde are both important organic compounds. When storing and transporting, many key matters must be paid attention to:
First, when storing, choose a dry, cool and well-ventilated place. Both are volatile to a certain extent, and the high temperature environment is prone to increased volatilization, which not only loses materials, but also volatile gases or poses safety hazards. Humid environment may cause side reactions such as hydrolysis, which affects its quality. For example, in the rainy season in the south, the air humidity is high, it is necessary to take moisture-proof measures, and desiccants can be used to maintain a dry storage environment.
Second, keep away from fire sources and oxidants. Both 4-methylbenzaldehyde and 4-nitrobenzaldehyde are flammable, and are easily flammable in case of open flames and hot topics. 4-Nitrobenzaldehyde is more likely to explode because it contains nitro groups. Contact with oxidants may cause severe oxidation reactions, and even cause fires or explosions. Strong oxidants such as oxygen cylinders and concentrated sulfuric acid should not be placed near storage sites, and fireworks are strictly prohibited.
Third, storage containers are also critical. Corrosion-resistant materials should be used, such as glass bottles or specific plastic containers. 4-Methylbenzaldehyde and 4-nitrobenzaldehyde are acidic or corrosive. Ordinary metal containers are prone to corrosion, causing damage to the container and material leakage. Chemical reactions with metals may also occur, changing the properties of materials. For example, to hold 4-nitrobenzaldehyde, brown glass bottles should be used, which can prevent light decomposition and avoid contact with metals.
Fourth, the transportation process should ensure that the packaging is in good condition, fixed and stable. The road is bumpy or the packaging is damaged and the material leaks. The vehicle should be equipped with corresponding fire protection and emergency treatment equipment, and once a leak occurs, it can be dealt with in time. For example, the transportation vehicle needs to be equipped with fire extinguishers, adsorption materials, etc. At the same time, the transportation personnel should be professionally trained and familiar with the characteristics of the transported chemicals and emergency treatment methods.
What are the effects of 4-methylbenzenesulfonate on the environment and human health?
The effects of 4-methylbenzenesulfonic acid and 4-aminobenzenesulfonic acid on the environment and human health are particularly important and should be discussed in detail.
First talk about the environment. If 4-methylbenzenesulfonic acid flows into the water body, it may cause water quality to deteriorate. Because of its certain acidity, it can change the pH of the water body and affect the living environment of aquatic organisms. For aquatic plants, it may disrupt their normal physiological metabolism, cause growth obstruction, and even wilt and die; for aquatic animals, it may damage their physiological functions such as respiration and reproduction, and affect population reproduction. And if it is discharged into the soil with wastewater, it will change the soil physical and chemical properties, acidify the soil, reduce soil fertility, affect the absorption of nutrients by plant roots, and hinder plant growth. The same is true for 4-aminobenzenesulfonic acid. After it enters the environment, it may participate in complex chemical reactions in the environment, generating new pollutants and further harming the ecology. If it accumulates in the soil, it will interfere with the structure and function of the soil microbial community, and affect the material cycle and energy conversion of the soil ecosystem.
As for human health, 4-methylbenzenesulfonic acid is corrosive. If it touches the skin inadvertently, it can cause burns, redness, swelling, and pain. If it splashes into the eyes, it is even more harmful, or causes serious damage to the eyes and affects vision. And if its volatile gas is inhaled into the human body, it will irritate the respiratory tract, cause symptoms such as cough and asthma, and increase the risk of respiratory diseases for long-term exposure. 4-aminobenzenesulfonic After oral ingestion or skin absorption, it will accumulate in the body, interfering with the normal physiological and biochemical processes of the human body. Or damage the function of important organs such as the liver and kidneys, and affect the body's metabolism and detoxification ability. Long-term exposure, or mutagenic, carcinogenic latent risk, threatening human life and health.
Therefore, in the production and use of the two, we should be careful and take proper protection and treatment measures to reduce their harm to the environment and human health.
