4-Toluenesulfonic Acid Anhydride

Lingxian Chemical

Specifications

HS Code	340557
Name	4-Toluenesulfonic Acid Anhydride
Molecular Formula	C14H14O5S2
Molecular Weight	326.39
Appearance	White to off - white solid
Odor	Pungent
Melting Point	122 - 125 °C
Boiling Point	Decomposes
Solubility In Water	Reacts with water
Solubility In Organic Solvents	Soluble in many organic solvents like dichloromethane, chloroform
Acidity	Highly acidic due to sulfonic acid anhydride structure
Stability	Stable under normal conditions but reacts with moisture and bases

Packing & Storage

Packing	1 kg of 4 - Toluenesulfonic Acid Anhydride packaged in a sealed, corrosion - resistant container.
Storage	4 - Toluenesulfonic Acid Anhydride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption, as it can react with water. Separate from incompatible substances to avoid potential hazardous reactions. Regularly check storage conditions to ensure product integrity.
Shipping	4 - Toluenesulfonic Acid Anhydride should be shipped in tightly - sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper insulation and protection from heat, moisture, and physical damage.

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General Information

Historical Development

4-Toluenesulfonic anhydride, the rise of this substance, began in the modern era of chemical refinement. In the past, chemists studied the physical properties and explored the wonderful method of synthesis. After years of research, repeated trials and errors, the technique of making 4-toluenesulfonic anhydride was obtained.
At the beginning, the preparation was difficult, the yield was quite low, and it could only be done in small quantities in the laboratory. However, the public worked tirelessly to improve the process and optimize the process. With the advance of science and technology, the chemical equipment was gradually refined, and the reaction conditions were easier to control, so its output increased and its application became more and more widespread. From industrial manufacturing to scientific research, it has been seen in many fields, such as organic synthesis, and plays a key role. It is an important product in the development of chemistry.

Product Overview

"Description of 4-Toluenesulfonic Acid Anhydride"
4-Toluenesulfonic Acid Anhydride is a useful chemical in organic synthesis. It is a white crystalline solid with a specific melting point and boiling point. This product is prepared by dehydration and condensation of 4-toluenesulfonic acid.
In the field of organic synthesis, 4-Toluenesulfonic Acid Anhydride is often used as a sulfonylation reagent. It can react with alcohols, amines and other compounds to introduce sulfonyl groups to form corresponding sulfonates or sulfonamides. This reaction condition is mild and has good selectivity. It can help to synthesize many organic compounds with special structures and properties, and has important applications in pharmaceutical chemistry, materials science and many other fields. The balance of its reactivity and stability makes it an indispensable tool in organic synthetic chemistry.

Physical & Chemical Properties

4-Toluenesulfonic anhydride, this material property is very different. Its color is white, as pure as frost and snow. Shape like fine powder, smooth tentacles. In terms of its physical properties, the melting point is suitable, about [specific melting point value], at this temperature it melts into a liquid, flowing freely. And has a certain degree of volatility, at a specific temperature, the smell can be felt.
In terms of its chemical properties, it is very active. In contact with water, it is easy to hydrolyze, and 4-toluenesulfonic acid and other substances are produced. Its acid anhydride properties can react with alcohols, amines, etc., to form esters and amides. This reaction is widely used in organic synthesis, and it can pave the way for the preparation of many compounds. It is like a clever tool for craftsmen. It blooms in the field of chemistry and contributes to various scientific research and production.

Technical Specifications & Labeling

4-Toluenesulfonic anhydride is an important chemical substance. Its process specifications and identification (product parameters) are extremely critical. As far as process specifications are concerned, it is necessary to ensure that the reaction conditions are precisely controlled. When synthesizing, the ratio of raw materials should strictly follow a specific ratio, and the reaction temperature should be maintained in a certain precise range to prevent side reactions from breeding, thereby improving product purity.
In terms of identification, its name, molecular formula, molecular weight and other basic information must be clearly marked. Key parameters such as product purity and impurity content cannot be missed, so as to provide users with accurate product information, so as to facilitate the accurate use of various application scenarios and ensure the smooth progress of experiments or production. This is the essence of 4-toluenesulfonic anhydride product process specifications and identification (product parameters).

Preparation Method

The method of making 4 - Toluenesulfonic Acid Anhydride is related to the raw materials and production process, reaction steps and catalytic mechanism. First take an appropriate amount of p-toluenesulfonic acid as raw material, supplemented by acetic anhydride. In a clean vessel, mix the two according to a specific ratio, and the ratio needs to be accurately measured. Then, put the mixture in a suitable temperature environment and heat it gently to promote the reaction. During this process, the temperature needs to be strictly controlled, and it should not be overheated or overcooled to prevent the reaction deviation. And it should be stirred in a timely manner to make the material fully in contact. During the reaction, the catalytic mechanism is very important, and a specific catalyst is added to accelerate the reaction process. After the reaction is completed, through the steps of fine separation and purification, the impurities are removed to obtain a pure 4-Toluenesulfonic Acid Anhydride product. In this way, the best preparation method for this product is obtained.

Chemical Reactions & Modifications

In the study of modern chemistry, the study of the chemical reaction and modification of 4-Toluenesulfonic Acid Anhydride is quite important. Fu 4-Toluenesulfonic Acid Anhydride has unique properties and is an active agent in various chemical reactions.
Looking at its reaction, it often encounters nucleophiles to form new compounds. If it encounters alcohols, it produces sulfonates. This reaction can be used in organic synthesis to produce a variety of organic compounds. And its modification method also has a wonderful advantage. Borrowing the conditions of the reaction, such as temperature and solvent, can change the rate and selectivity of the reaction.
Furthermore, the catalytic method can enhance the efficiency of the reaction and increase the rate of the product. Chemists have studied the chemical behavior of 4-Toluenesulfonic Acid Anhydride, hoping to understand and use it to contribute to the progress of chemistry.

Synonyms & Product Names

4-Toluenesulfonic anhydride, this substance is also known as another name. Its name is sulfonylation reagent, which often appears in the field of organic synthesis. In the ancient books, or those who are called "p-toluenesulfonic anhydride" refer to the same thing.
This agent has a wide range of uses, and can demonstrate its effectiveness in many organic reactions such as esterification and etherification, and can be used as a high-efficiency catalyst. In the chemical industry, the preparation of many products also depends on this agent.
Its properties are stable, and it will react when exposed to water or moisture. Therefore, when storing, it should be placed in a dry place to avoid water vapor intrusion to ensure its quality. In the process of organic synthesis, by virtue of its nickname, chemists frequently mention it in ancient books and studies, and explore its application methods to achieve a new realm of organic synthesis.

Safety & Operational Standards

4 - Toluenesulfonic Acid Anhydride Safety and Operation Specifications
4 - Toluenesulfonic Acid Anhydride (p-toluenesulfonic anhydride) is also a commonly used raw material in the chemical industry. Regarding its safety and operation specifications, do not be careless.
#1. Storage Rules
This substance should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. The storage place should be separated from oxidants, alkalis, etc., and must not be mixed to avoid the risk of chemical reactions. The package must be sealed to prevent moisture and deterioration. During storage, it should be checked regularly. If the package is damaged or there is a leak, it should be disposed of as soon as possible.
#2. Qualification of operation
Operators must have professional training, be well versed in operating procedures, and strictly abide by safety regulations. When operating, wear protective gloves and goggles in front of appropriate protective clothing to prevent contact with skin and eyes. Operate in a fume hood to ensure air circulation and reduce the accumulation of harmful gases. When using this object, the action should be slow to avoid dust. Weighing should be accurate, and the dosage should not be increased or decreased at will. If there is spillage in the operation, do not contact it directly with your hands. When collecting it with special tools, deal with it according to regulations.
#3. Emergency measures
In case of accidental contact with the skin, you should immediately take off the contaminated clothes, rinse with a large amount of flowing water, and seek medical treatment. If splashed into the eyes, quickly rinse with plenty of water, at least fifteen minutes, and then seek medical attention. In case of fire, due to the flammability of p-toluenesulfonic anhydride, dry powder fire extinguishers and carbon dioxide fire extinguishers should be used to extinguish the fire, and no water should be used.
All operations involving 4-Toluenesulfonic Acid Anhydride should be based on safety and strict regulations to ensure the safety of personnel and the environment.

Application Area

4-Toluenesulfonic anhydride is also a chemical product. Its application field is quite extensive. In the field of organic synthesis, it is often used as a sulfonation reagent, which can make many compounds obtain sulfonic acid groups to change the properties and activities of compounds.
In the field of drug development, 4-toluenesulfonic anhydride can participate in the preparation of key intermediates. Through its sulfonation, the structure of drug molecules is more suitable for pharmacological needs, and the efficacy and stability of drugs are improved.
In materials science, it also has important uses. It can help improve the surface properties of materials, such as enhancing the hydrophilicity of materials or giving them special functional groups, thereby expanding the application of materials in different scenarios.
Looking back at the past, many parties have continuously explored the application of 4-toluenesulfonic anhydride in their experiments and research, making it increasingly valuable in various fields, benefiting many industries, and contributing greatly to the advancement of science and technology and the prosperity of production.

Research & Development

In recent years, I have made great progress in my research on 4-Toluenesulfonic Acid Anhydride. This compound is unique in nature and widely used. At the beginning of research, I feel that the method of its preparation is quite critical. All kinds of attempts, either from the selection of raw materials, or the conditions of the reaction.
After a long time of exploration, the optimization path is gradually clear. The reaction temperature, duration, and catalyst are all considered. If the temperature is too high, the product is impure; if the duration is insufficient, the reaction is not completed. And the wonder of the catalyst can promote the reaction to speed up and improve the yield.
The field of its application is also the focus of research. In organic synthesis, it is often used as a key reagent to help form a variety of compounds. Looking to the future, we hope to expand its use, generate light and heat in new fields, promote the sustainable development of this compound, and contribute to the progress of chemistry.

Toxicity Research

Recently, in the field of chemical industry, it is quite important to study the toxicity of 4 - Toluenesulfonic Acid Anhydride. The study of the nature of this compound is related to the safety of everyone and the state of the environment.
Taste its quality, contact with various things, or change. On the way into the body, there are ways to suck it, touch it, and eat it. If it is inhaled, it may harm the system of breathing; if it touches the skin, it may cause damage; if it is eaten in the abdomen, the viscera will also suffer from it.
It is also harmful when it is in the environment, scattered in air, water, and soil. In water, it can be a source of sewage, which is harmful to the spirit of aquatic life; in air, or stain the atmosphere, it will damage the quality of air. Although it is widely used, the risk of toxicity cannot be ignored. When researching, the protective measures must be strict to minimize the harm and ensure people's safety and peace.

Future Prospects

Fu 4 - Toluenesulfonic Acid Anhydride is also a new material. Its properties are unique, and its uses are not limited. We have high hopes for the development of the future.
This compound has the potential to be synthesized in the field of synthesis, or it can develop its extraordinary power. It can be used as a catalyst to promote the general reaction and make the synthesis process more efficient. It is in the field of materials science, and it may also have new applications to assist in the research of new materials with excellent performance.
With the continuous improvement of science and technology, the research path is not limited. It is not possible to explore more of its capabilities and expand its use. Or in the field of research and development, the power of new systems; or in the field of energy, to help develop new energy materials. In addition, 4 - Toluenesulfonic Acid Anhydride has not yet been developed, and it is possible to fill it up. We will wait and see.

Frequently Asked Questions

What are the main uses of 4-toluenesulfonic anhydride?

Magnesium 4-aminosalicylate has a wide range of main uses. In the field of medicine, this drug is often used to treat tuberculosis. When the anti-tuberculosis drugs of the past were not as abundant and diverse as they are today, magnesium 4-aminosalicylate played a key role. It can effectively inhibit the growth and reproduction of Mycobacterium tuberculosis, and block its metabolic pathway by interfering with the folic acid synthesis process of Mycobacterium tuberculosis, so as to achieve the effect of anti-tuberculosis.
According to the ancient saying, magnesium 4-aminosalicylate is a good medicine for doctors to fight tuberculosis. "Tuberculosis" is the same as tuberculosis today. In the past, tuberculosis was rampant, causing a disaster to the world, and physicians struggled to find a cure to control it. The emergence of magnesium 4-aminosalicylate, like the star fire in the dark night, adds a sharp weapon to the fight against tuberculosis. Its properties can inhibit the growth of tuberculosis bacteria, disturb the combination of folic acid, and cut off its vitality.
And magnesium 4-aminosalicylate is also used in the treatment of some inflammatory bowel diseases. Inflammatory bowel disease, the disease is in the intestines, and the symptoms include abdominal pain, diarrhea, mucus, pus, blood, etc. Magnesium 4-aminosalicylate can regulate the intestinal immune response, reduce intestinal inflammation, and relieve patient discomfort. This medicine is used in the intestines and organs, such as a good doctor's operation, reconciles yin and yang, calms the disturbance of inflammation, and gradually restores the function of the intestines and organs. Therefore, magnesium 4-aminosalicylate is used in medicine to bring hope of recovery to many patients, which is a good prescription for the world.

What are the physical properties of 4-toluenesulfonic anhydride?

4-Methylimidazole hydrochloride is a compound. Its physical properties are quite unique.
Looking at its shape, it is usually in the shape of a white crystalline powder, with a fine texture. Under the light, there is an occasional slight shimmer, like a fine star sprinkling down on it.
Smell its smell, the substance is almost odorless, only by smelling it closely, or under certain conditions, it may have a very light smell. However, this smell is difficult to describe exactly, only slightly fresh, and there is no pungent or unpleasant odor.
As for solubility, 4-methylimidazole hydrochloride is easily soluble in water, just like salt is quickly and evenly integrated into water. When placed in water, with a little stirring, it disappears immediately, fuses with water, and forms a clear and transparent solution. In addition, it also has certain solubility in some organic solvents, such as ethanol, which can slowly dissolve in ethanol to form a stable system.
When it comes to the melting point, it is about a certain temperature range, which is the critical range for its transformation from solid to liquid. When the external temperature gradually rises to this range, 4-methylimidazole hydrochloride gradually softens and then melts into a liquid state. This process is quite wonderful, like melting ice and snow.
The physical properties of 4-methylimidazole hydrochloride are of great significance in many fields. Due to its good solubility, it can be used as an excellent reactant or catalyst carrier in chemical synthesis to help the reaction proceed more efficiently. Its morphology and stability also make it relatively convenient to store and transport, and it only needs to follow the storage specifications of general chemicals to ensure that its quality is not affected.

What are the chemical properties of 4-toluenesulfonic anhydride?

4-Methylimidazole, which has special physical properties and is related to food safety, is valued by the world. Its shape is colorless to light yellow crystal, stable under normal conditions, with a certain melting point, about 142 ° C. If heated beyond this temperature, there may be a phase change.
4-Methylimidazole is easily soluble in water and alcohols. This property can form hydrogen bonds between nitrogen atoms, water molecules and alcohol molecules in the molecular structure. In organic synthesis, its solubility helps it participate in various reactions. Its chemical activity is derived from the imidazole ring. The nitrogen atom on the ring has a lone pair of electrons, which can be used as a nucleophilic reagent. It can be nucleophilic substituted with electrophilic reagents such as halogenated hydrocarbons to form new nitrogen-containing compounds, which is of great significance in the creation of medicines and pesticides.
4-Methylimidazole is weakly basic, because the nitrogen atom in the ring can accept protons, it shows this property in acid-base reactions, and can form salts with acids. In some drug formulations, salts can be used to improve drug solubility and stability. And it can participate in a variety of heterocyclic construction reactions, such as condensation with aldose and ketone, to construct complex nitrogen-containing heterocyclic structures, paving the way for the synthesis of novel biologically active substances.
However, 4-methylimidazole may be generated in the production of caramel color, and it exists in food, which is of concern for safety. Although within a certain dose, the human body can metabolize it, but excessive intake may threaten health. Therefore, countries have set strict standards for the content of 4-methylimidazole in food to ensure the safety of people's diet.

What is the synthesis method of 4-toluenesulfonic anhydride?

To prepare 4-methylimidazole zinc acetate, follow the ancient method as follows. First take an appropriate amount of 4-methylimidazole and place it in a clean container. The 4-methylimidazole needs to be pure and free of other distractions. Then, measure a certain amount of acetic acid and slowly pour it into a container containing 4-methylimidazole. The amount of acetic acid, when added in a ratio suitable to 4-methylimidazole, needs to be accurately measured, which is related to the purity and yield of the product.
After mixing the two, slowly heat them with mild heat. Do not burn violently to prevent the loss of reactants or the occurrence of side reactions. During the heating process, stir the glass rod slowly to make the two fully blend and the reaction is uniform. It can be seen that the solution gradually changes, or there is a slight change in color, or the escape of bubbles, which are all signs of the reaction.
When the reaction is completed asymptotically, take another zinc salt, such as zinc sulfate and zinc chloride. To prepare it into a solution of appropriate concentration, it is also necessary to precisely control its concentration. Then, slowly, drop the zinc salt solution into the mixture obtained by the above reaction. When dripping, closely observe the state of the solution, and it can be seen that there are new substances gradually emerging, or there is precipitation, or there is a change in color.
During this process, pay attention to the reaction environment, temperature and humidity can affect the reaction. After the reaction is complete, the product can be separated by a suitable method. Filtration and centrifugation can be selected according to the nature of the product and impurities. If the product is precipitated, the crude product can be obtained by filtration. The obtained crude product is refined by recrystallization. Choose an appropriate solvent, dissolve the crude product, heat it to dissolve, and then slowly cool down to recrystallize the product, leaving impurities in the mother liquor. This is repeated several times to obtain high-purity 4-methylimidazole zinc acetate. The whole process requires careful operation and accurate measurement before the preparation of this compound can be obtained.

What should be paid attention to when storing and transporting 4-toluenesulfonic anhydride?

4 - For those with methylnaphthalic acid, if you hide it, you should pay attention to the following things.
One of them is that if you hide it, it must be dry, clean and well-connected. If you are in a tidal environment, you are prone to deliquescence, which will cause it to be damaged. For example, in the southern summer season, if you do not pay attention to moisture prevention, the soil will be changed due to moisture absorption or moisture absorption, which will affect the effect. The storage temperature should not be too high, because the high temperature will accelerate the decomposition of the ingredients of the mixture. Such as in midsummer, if the mixture is placed in the light exposure or the temperature exceeds the specified temperature, the active ingredients may be damaged. And avoid the same with other smelly things to prevent odors from staining the product.
Second, it is also necessary to be extra careful. In this case, it is necessary to ensure that the package is in good condition. If the package is damaged, it is vulnerable to external factors on the way. In case of road bumps, the products may be scattered or affected. The environment of the tool part should also be controlled, and it is necessary to keep dry and dry. If it is used in this way, it has a good tightness ability to prevent damage caused by blowing, rain, day and temperature. People are also familiar with the characteristics of the product. Avoid strong shocks during the journey, and operate carefully to ensure that the 4-methylnaphthenic acid can still be used when it arrives at the destination.