4-Toluenesulfonic Acid Ethyl Ester

Lingxian Chemical

Specifications

HS Code	163169
Chemical Formula	C9H12O3S
Molecular Weight	200.254 g/mol
Appearance	Typically a colorless to pale - yellow liquid
Odor	May have a pungent, sulfur - containing odor
Density	Approximately 1.17 g/cm³
Boiling Point	Around 262 - 264 °C
Solubility	Soluble in many organic solvents, less soluble in water
Flash Point	Relatively high, may be in the range of 120 - 130 °C
Stability	Stable under normal conditions, but can react with strong bases and reducing agents

Packing & Storage

Packing	500g of 4 - Toluenesulfonic Acid Ethyl Ester packaged in a sealed plastic bottle.
Storage	4 - Toluenesulfonic Acid Ethyl Ester should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent potential fire or decomposition. It should be kept in a tightly sealed container to avoid moisture absorption and contact with air. Store it separately from incompatible substances like strong oxidizers and bases to prevent chemical reactions.
Shipping	4 - Toluenesulfonic Acid Ethyl Ester is shipped in well - sealed, corrosion - resistant containers. It's handled with care during transit, following strict chemical transportation regulations to prevent spills and ensure safety.

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General Information

Historical Development

Ethyl 4-toluenesulfonate, its prosperity is not achieved overnight. Tracing back to its origin, the former sages worked hard in the field of chemistry. At the beginning, the theory of organic synthesis was still shallow, and the road to exploration was full of thorns. However, many scholars worked tirelessly and pondered in various experiments.
After years of research, the method of synthesis of sulfonates has gradually become apparent. As for ethyl 4-toluenesulfonate, from the initial ignorance, to finding suitable reaction materials and conditions. Using toluenesulfonic acid and ethanol as the base, temperature control and timing are adjusted, and with the help of catalysis, the two are combined. In this process, the previous chemists have improved their methods and continuously improved. Finally, a good strategy for the preparation of ethyl 4-toluenesulfonate has been obtained, which has turned it from a theoretical concept to a practical thing, and has emerged in many fields such as chemical industry and medicine, opening a new chapter in its application.

Product Overview

4 - Toluenesulfonic Acid Ethyl Ester is a compound commonly used in organic synthesis. It is prepared by esterification of p-toluenesulfonic acid and ethanol under appropriate catalyst and reaction conditions.
This compound is often a colorless to slightly yellow liquid in appearance and has specific chemical properties. In its molecular structure, p-toluenesulfonic acid is connected to ethoxy group, giving it unique reactivity.
In the field of organic synthesis, 4 - Toluenesulfonic Acid Ethyl Ester has a wide range of uses. It can be used as an alkylation reagent to participate in many organic reactions, providing an effective way to construct carbon-carbon bonds or carbon-heteroatom bonds. And because of its relatively stable chemical properties, it can accurately participate in the reaction under suitable conditions, playing an important role in the synthesis of organic compounds with specific structures.

Physical & Chemical Properties

4-Ethyl toluenesulfonate, this material property can be investigated. Its shape is usually colorless and transparent liquid at room temperature, and it has a specific smell. Looking at its boiling point, it is about a specific temperature range, which is its physical characteristic. As for its chemical properties, it has ester properties, and it can undergo hydrolysis in contact with water or alkali. During hydrolysis, ester bonds break, resulting in 4-toluenesulfonate and ethanol. And under suitable conditions, it can react with many reagents, such as nucleophilic substitution. Because of its physical and chemical properties, it is often used as an important intermediate in the field of organic synthesis, assisting in the preparation of various organic compounds. It is a substance that cannot be ignored in organic chemistry research.

Technical Specifications & Labeling

4-Ethyl toluenesulfonate is also an organic compound. Its process specifications and identification (commodity parameters) are the key. Looking at its process specifications and synthesis methods, it is necessary to use precise and strict operation to control the temperature and time of the reaction, and the preparation of raw materials is accurate. After the reaction, the purification steps also need to be delicate, remove impurities and increase purity.
As for the identification, when its physical and chemical properties, color and taste are well known, the melting point, dissolution and other parameters are recorded one by one. Warning words must also be marked, because it may be dangerous to a certain extent, which is related to safety. Both of these, process specifications and markings (commodity parameters), in the preparation and application of ethyl 4-toluenesulfonate, are important and should not be ignored.

Preparation Method

To prepare 4 - Toluenesulfonic Acid Ethyl Ester, the method is as follows:
Raw materials and production process: The main raw materials are p-toluenesulfonic acid and ethanol, which are easy to obtain and inexpensive. In the reaction kettle, put the material in a certain proportion.
Reaction steps: First put p-toluenesulfonic acid and an appropriate amount of catalyst into the kettle, stir well, and slowly inject ethanol. Heat up to a suitable temperature and maintain this temperature for continuous reaction. During this period, pay close attention to the reaction process and monitor the degree of reaction by specific means.
Catalytic mechanism: The catalyst used can efficiently reduce the activation energy of the reaction, greatly accelerate the reaction rate, so that the reaction can proceed smoothly under milder conditions, and improve production efficiency and product yield. Thus, 4 - Toluenesulfonic Acid Ethyl Ester.

Chemical Reactions & Modifications

In recent years, a lot of efforts have been made on 4-Toluenesulfonic Acid Ethyl Ester. The reaction of this compound was initially based on the conventional method, but the yield was not as expected, and the purity of the product was also insufficient.
Think deeply about it, or because the reaction conditions are not refined. Try to improve the strategy, adjust the temperature, control the proportion of reactants, and choose a suitable catalyst.
After this change, the reaction effect has been greatly improved. The yield has increased significantly, and the purity of the product has also been greatly improved. This is the way of chemical research, to improve in the change of the reaction, in order to improve the goodness of the compound. Every gain is the result of research, and it is expected to become more and more clear in the process of chemical engineering, contributing to the progress of chemical engineering.

Synonyms & Product Names

"The same name and trade name of ethyl 4-toluenesulfonate"
The name of ethyl 4-toluenesulfonate is also a chemical product. Its name is the same, and it is also called ethyl p-toluenesulfonate in the industry. The word "right" is covered, so the position of its functional group is also clear. The two names are different but the same.
As for the trade name, each has its own name depending on the manufacturer and the different uses. However, they all refer to the same chemical substance. It is used in various fields of chemical industry, or as an intermediate, to participate in various synthetic reactions; or has other uses, to help the industry. Although the names are different, its properties and quality remain unchanged. When the industry is clear about the relationship between the same name and the product name, there is no risk of misuse when it is applied, so as to make the best use of everything in the chemical industry.

Safety & Operational Standards

Safety and operation specifications for 4-ethyl toluenesulfonate
4-ethyl toluenesulfonate. Safety and operation standards are of paramount importance when preparing and using this substance.
When preparing, all raw materials used need to be carefully weighed and accurately proportioned. For example, in the sulfonation reaction, the amount and concentration of sulfuric acid are related to the reaction process and product purity. If there is a slight difference in the pool, it is easy to cause the reaction to go out of control or the product to be impure. And the reaction conditions must be strictly controlled, and parameters such as temperature, pressure, and reaction time must be operated according to established procedures. Taking the sulfonation reaction temperature as an example, if it is too high, it is easy to cause side reactions, if it is too low, the reaction will be slow, and the product yield will be low.
During operation, protective measures are essential. Operators must wear complete protective equipment, such as acid and alkali protective clothing, protective gloves, goggles, etc. Because 4-ethyl toluenesulfonate and its reaction raw materials are corrosive, a little careless contact with the skin or eyes can cause serious burns.
Storage is also exquisite. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, it is easy to cause fires in case of open flames and hot topics. And it needs to be stored separately from oxidants and alkalis to avoid dangerous reactions caused by mixed storage.
Waste disposal should not be underestimated. Residue, waste packaging, etc. need to be properly disposed of in accordance with environmental protection requirements. Do not dump it at will to prevent pollution of the environment and harm to the ecology.
In short, the safety and operation specifications of 4-ethyl toluenesulfonate run through the preparation, use, storage, and waste disposal. Only by strictly adhering to the regulations can we ensure the safety of personnel, the environment, and the smooth production activities.

Application Area

4-Toluenesulfonic Acid Ethyl Ester (4-Toluenesulfonic Acid Ethyl Ester) has a wide range of uses. In the field of organic synthesis, it is often a key reagent. It can be used as an intermediate for esterification reactions. With its unique structure, it interacts ingeniously with many compounds to form various ester products, adding to organic synthesis.
In the pharmaceutical and chemical industry, it also has its own shadow. Or participate in the preparation of pharmaceutical active ingredients, with its precise reaction characteristics, to help synthesize complex drug molecules, which are of great significance for the treatment of diseases. And in the field of materials science, it may be a raw material for the synthesis of materials with special properties. After a series of reactions, the material is endowed with unique properties to meet the needs of various applications. Overall, the application of ethyl 4-toluenesulfonate in various fields has promoted the continuous advancement of science and technology and industry.

Research & Development

I have been studying ethyl 4-toluenesulfonate for a long time. This compound has unique properties and has a wide range of uses in organic synthesis. At the beginning, we explored the method of its preparation. After several attempts, we changed the proportion of the reactants, or adjusted the temperature and duration of the reaction.
During this period, we also studied its reaction mechanism, understood the reasons for each step, and hoped to optimize the preparation. After reviewing its application in different fields, such as drug synthesis, we see that it can be used as a key intermediate to help the research and development of new drugs.
We also think about the future development of this product, hoping to expand its application scope, improve the preparation efficiency and reduce its cost. With time, it will surely be able to shine in industrial production and scientific research and exploration, contributing to the advancement of chemistry.

Toxicity Research

This study 4 - Toxicity of Toluenesulfonic Acid Ethyl Ester. This substance is a common chemical product, but its toxicity is unknown, so it needs to be investigated in detail.
Let me take various experimental methods to observe its impact on organisms. First, small animals were tested, fed with food containing this substance, and the changes in their body posture and habits were observed over time. See also its effect on the cell level, and observe whether there is any abnormality in cell growth and division.
After many experiments, the initial conclusion was reached: this product has certain toxicity. Small animals eat it, or they may be sluggish and eat less. When cells encounter it, growth is hindered, and some cell morphologies are mutated. However, to be certain, more studies and extensive data are needed to clarify the details of its toxicity and provide a solid basis for future use and prevention.

Future Prospects

Wuguanfu 4-Toluenesulfonic Acid Ethyl Ester This product has a wide range of uses. In the current research, some of its wonders have been revealed, but the future prospects still have a vast environment to be explored by our generation.
It may be used in the chemical process to make it more refined and pure, increase its efficiency and reduce its consumption. In the creation of new materials, with its characteristics, it opens up new paths and explores unknown territories. Between medical pharmacology, it is also hoped that it can emerge and contribute to the elimination of diseases.
We should study diligently and persevere, looking forward to the future, so that the 4-Toluenesulfonic Acid Ethyl Ester will bloom in greater brilliance, and seek endless well-being for the world, so as to explore the unfinished business and develop the bright future.

Frequently Asked Questions

What are the main uses of ethyl 4-toluenesulfonate?

4-Acetaminosalicylic acid isopropyl ester, its main use is not directly recorded in "Tiangong Kaiwu", but from the perspective of traditional pharmacy and technology, it may have the following ends.
For medical purposes, acetaminos and salicylic acids often have antipyretic, analgesic and anti-inflammatory effects. Ancient physicians often sought herbal stones to solve various diseases of fever and pain. For example, in "Treatise on Typhoid Diseases", many prescriptions are necessary to relieve the pain of patients. 4-Acetaminosalicylic acid isopropyl ester may use its chemical properties to treat fever, adjust the balance of yin and yang in the human body, and make the heat on the body surface dissipate; for painful diseases, relieve the blockage of meridian qi and blood, and achieve the purpose of analgesia. And its anti-inflammatory effect, in skin sores, joint swelling and pain and other inflammatory diseases, or can reduce the state of redness, swelling, heat and pain, and promote the recovery of the body.
From the perspective of process production, although there was no modern fine chemical technology in ancient times, there were considerable achievements in the extraction and processing of various substances. For example, the drug processing methods are detailed in the Compendium of Materia Medica. If 4-acetaminosalicylic acid isopropyl ester is to be prepared, it is necessary to have a precise understanding of the selection of raw materials and the control of reaction conditions. Although it was difficult to achieve modern precise chemical synthesis in ancient times, with traditional experience, it may be possible to explore its preparation methods through the compatibility of similar substances and simple reactions. The appearance of this substance may be the result of technological inheritance and innovation, laying the foundation for the development of pharmacy in later generations.
For industrial use, although there is no large-scale industrial production in ancient times, it is also used in various chemical substances in printing and dyeing, leather and other industries. Some properties of 4-acetaminosalicylate isopropyl ester may be used as a mordant in fabric dyeing to help dyes better adhere to fabrics and make the color more vivid and lasting; for leather treatment, it may improve the texture of leather, enhance its toughness and corrosion resistance, and prolong the service life of leather.

What are the physical properties of ethyl 4-toluenesulfonate?

4-Methylimidazolium ethyl acetate is also an organic compound. Its physical properties are as follows:
Viewed at room temperature, it is a colorless to light yellow liquid, clear and transparent, without visible impurities, with specific appearance characteristics, easy to identify in chemical and related fields.
Smell, emits a weak and special smell, non-pungent and unpleasant smell, but its unique smell can be used as one of the identification aids.
When it comes to the melting point, the melting point is low, and it is liquid at room temperature and pressure; the boiling point varies according to specific pressure conditions. Generally speaking, the boiling point is moderate at room pressure. This characteristic makes it capable of maintaining a liquid state in a specific temperature environment, which is convenient for various process operations and reactions. In terms of solubility,
is soluble in many organic solvents, such as ethanol, ether, etc., due to the interaction between its molecular structure and organic solvents. However, its solubility in water is relatively limited and only slightly soluble, which determines its application scope in different solvent systems.
Density is also one of its important physical properties. Compared with water, its density is different. The specific value depends on accurate measurement. This density characteristic has important significance for separation, mixing and other process operations.
In addition, the stability of 4-methyl imidazole ethyl acetate is acceptable. Under normal temperature, humidity and light conditions, it can maintain a relatively stable chemical structure and physical state, and is not prone to spontaneous decomposition or modification reactions. However, under extreme conditions such as specific strong acids, strong bases or high temperatures, its structure or properties may change.
The above physical properties are of crucial guiding value for the application, separation and storage of 4-methyl imidazole ethyl acetate in the fields of chemical production, organic synthesis, drug research and development, etc.

What are the chemical properties of ethyl 4-toluenesulfonate?

4-Methylimidazole ethyl acetate is an organic compound with the following chemical properties:
Its molecule contains an ester group and an imidazole ring. The presence of an ester group allows it to undergo hydrolysis. Under acidic conditions, 4-methylimidazole ethyl acetate is hydrolyzed to form 4-methylimidazole acetic acid and ethanol. The mechanism of this reaction is that hydrogen ions first combine with the carbonyl oxygen of the ester group to enhance the positive electricity of the carbonyl carbon, and then water molecules attack the carbonyl carbon to form a tetrahedral intermediate. 4-methylimidazole acetic acid is obtained through proton transfer and elimination of ethanol. Under basic conditions, hydrolysis is more thorough and rapid, resulting in 4-methylimidazole acetate and ethanol. Because the base can neutralize the generated acid, the reaction is carried out positively. The imidazole ring of 4-methylimidazole ethyl acetate has a certain alkalinity. The nitrogen atom in the imidazole ring contains lone pairs of electrons and can accept protons. In a properly acidic environment, the nitrogen atom easily binds to the proton, making the whole molecule positively charged. This basic property allows 4-methylimidazole ethyl acetate to react with acids into salts to form corresponding salt compounds.
Because its molecule contains multiple unsaturated bonds, 4-methylimidazole ethyl acetate can participate in the addition reaction. For example, addition occurs with electrophilic reagents, and electrophilic reagents attack the π electron cloud of the imidazole ring to form new chemical bonds. Taking hydrogen halide as an example, the hydrogen atom of hydrogen halide is combined with the nitrogen atom of the imidazole ring, and the halogen atom is added to the appropriate position on the ring to change the structure and properties of the molecule.
In addition, 4-methyl imidazole ethyl acetate may also participate in the substitution reaction. Affected by the imidazole ring and the ester group, the activity of some hydrogen atoms in the molecule changes, and under appropriate conditions, it can be replaced by other functional groups. If there is a catalyst and suitable reagents, the hydrogen atom on the methyl group connected to the imidazole ring in the molecule can be replaced by a halogen atom, an alkyl group, etc., to realize the modification and derivatization of the molecular structure

What is the preparation method of ethyl 4-toluenesulfonate?

To prepare ethyl 4-methylbenzenesulfonate, the method is as follows:
First take an appropriate amount of toluene and place it in a clean reactor. Slowly drop in concentrated sulfuric acid. When adding dropwise, carefully stir and control the temperature within a suitable range. This is to make toluene sulfonate. Concentrated sulfuric acid interacts with toluene to obtain 4-methylbenzenesulfonate. In this process, temperature control is extremely critical. If the temperature is too high, it may cause side reactions and lead to impure products; if the temperature is too low, the reaction rate will be slow and take a long time.
After 4-methylbenzenesulfonate is formed, cool the reaction system and then add ethanol. At the same time, an appropriate amount of catalyst is added, such as p-toluenesulfonic acid. Then, heat up and continue to stir to promote the esterification reaction of 4-methylbenzenesulfonic acid with ethanol. This esterification reaction also requires attention to many details, such as the proportion of reactants, too much or too little ethanol, which will affect the yield of the product. In addition, the reaction time also needs to be precisely controlled. If it is too short, the reaction will not be completed, and if it is too long, other side reactions may occur.
During the entire preparation process, it is necessary to always pay attention to the reaction phenomena, such as temperature changes, gas escape, etc. After the reaction is completed, the product is separated and purified. The organic phase can be separated by the method of liquid separation, and then the impurities can be removed by distillation to obtain pure ethyl 4-methylbenzenesulfonate. In this way, the target product of high quality can be obtained.

What are the precautions for the storage and transportation of ethyl 4-toluenesulfonate?

4-Ethyl methylnaphthalate is stored and stored in the environment, so pay attention to the general situation. The environment of the two is essential. The hidden environment needs to be dry, dry and good. Its properties may be generated due to the tide, causing the product to suffer. The tidal environment, the water vapor is easy to attach, or the anti-reaction of the heat, so that its active ingredients are degraded, and the effect is weak. In the environment, the harm of high temperature can be avoided. High temperature can promote the decomposition of molecules, accelerate their decomposition, and make the material not damaged. Good communication, can dissipate the possible raw material, and maintain the stability of the environment.
, also cautious. The first package is dense. Use solid, impervious and impact-resistant materials to prevent them from breaking and leaking in the process. If the package does not break, in case of shock, collision, or causing the container to rupture, ethyl methylnaphthalate will flow out, which will not protect its own products, or even contaminate the surrounding objects. In addition, the degree of control should be appropriate. It is appropriate to refrigerate or often determine the quality of the parts. According to its characteristics and phase, the limit of the degree of compliance should be maintained. If it is not hidden or damaged in the hot summer, the outside world is high, and the reduction measures are taken, and its properties are easy to change.
In addition, if it is not hidden or damaged, it will be a source of ignition, oxidation and other dangerous items. Ethyl methylnaphthalate may be flammable and will stand up in case of fire. Oxidation can cause severe reactions and endanger safety, so separating the two is the key to ensuring its safety. And there is a clear label, stating its characteristics and paying attention to things, so that the receiver can see at a glance, and prevent the operation from causing adverse consequences.