5-Amino-2-Anilinobenzenesulfonic Acid

5-Amino-2-mercaptobenzothiazolic acid is an important compound in the field of chemistry and has key uses in many industrial and scientific fields.
In the rubber industry, it is often used as a vulcanization accelerator. Vulcanization accelerators can accelerate the vulcanization process of rubber, reduce the temperature and time required for vulcanization, and also improve the physical and mechanical properties of vulcanized rubber, such as hardness, strength, and wear resistance. 5-Amino-2-mercaptobenzothiazolic acid interacts with sulfur and other compounding agents in rubber to form a cross-linked structure, which transforms rubber from linear polymer to bulk polymer to achieve the purpose of vulcanization. This can greatly enhance the durability and stability of rubber products, and is widely used in the production of various rubber products such as tires, hoses, tapes, etc.
In the field of medicine, this compound also shows potential medicinal value. Some studies have shown that it has certain antibacterial, anti-inflammatory and anti-tumor activities. Its mechanism of action may be related to interfering with cell metabolism and affecting enzyme activity. For example, in antibacterial, it may be able to destroy the synthesis of bacterial cell walls or cell membranes, thereby inhibiting bacterial growth and reproduction; in anti-tumor research, it may play a role by inducing tumor cell apoptosis and inhibiting tumor angiogenesis. Although there are no mature drugs with it as the main ingredient on the market, as a lead compound, it provides an important direction and foundation for the development of new drugs.
In addition, in the field of metal corrosion inhibition, 5-amino-2-mercaptobenzothiazolic acid can act as a metal corrosion inhibitor. The amino and mercapto groups contained in its molecular structure can chemically adsorb on the metal surface to form a dense protective film, blocking the contact between corrosive media and metals, thereby slowing down the corrosion rate of metals. In chemical equipment, pipelines, and marine engineering, the use of corrosion inhibitors containing this compound can effectively prolong the service life of metal materials and reduce maintenance costs.

5-Hydroxy-2-mercaptobenzothiazolic acid, which is white to light yellow crystalline powder. Its melting point is quite high, about 180-182 ° C, and it can remain relatively stable in high temperature environments. It is not easy to decompose rapidly or change its properties due to heat.
From the perspective of solubility, it is slightly soluble in water, which indicates that the interaction between water molecules and the substance molecules is weak, making it difficult to disperse it in large quantities in water. However, it is soluble in organic solvents such as methanol, ethanol, and acetone. In these organic solvents, the substance molecules can form a relatively stable interaction with the solvent molecules, thus achieving dissolution.
This substance has a certain degree of acidity, which is determined by the hydroxyl groups and other functional groups in its molecular structure. In chemical reactions, these functional groups can release hydrogen ions, thus exhibiting acidic characteristics, which can neutralize with bases and generate corresponding salts.
In terms of stability, it is relatively stable under normal conditions, but it needs to avoid contact with strong oxidants. Due to the strong ability of strong oxidants to obtain electrons, they will undergo oxidation-reduction reactions with 5-hydroxy-2-mercaptobenzothiazolic acids, changing their molecular structure and affecting their original physical and chemical properties.
Because of its unique physical properties, it is often used as a vulcanization accelerator in the rubber industry. Utilizing its ability to participate in the vulcanization reaction of rubber under specific conditions can effectively accelerate the vulcanization rate, improve the physical and mechanical properties of rubber products, such as hardness, strength, and wear resistance, etc., so that rubber products have better quality and practical performance.

5-Amino-2-benzothiazolyl benzothiazole shows acid. This material property is also related to the quality of chemistry. Its color state may be crystalline. As for the color, it is often light or nearly colorless. The point of melting and boiling is also one of its characteristics. The number of melting points is mostly in a specific field, and varies slightly due to the degree of refining and the measurement method. The boiling point also has its value under normal pressure, but it often needs specific conditions to measure it.
Solubility, in water, the degree of solubility is quite slight, and its molecular structure has a hydrophobic part. However, in organic solvents, such as alcohols and ethers, it is easier to dissolve. Alcohols have hydrogen bonds with molecules, resulting in increased solubility. The solubility of ethers is also due to the attractive force between molecules.
Its chemical activity, the amino group is basic and can form salts with acids. The ring of benzothiazole is aromatic and can react with electrophilic substitution. In the case of electrophilic reagents, the hydrogen on the ring can be replaced, and the substitution position is controlled by the localization effect of the group on the ring. In addition, this molecule contains nitrogen and sulfur heteroatoms, which can complex with metal ions to form stable complexes. This property is useful in analytical chemistry and material chemistry. It can be used for the detection and separation of metal ions, and is also used as a ligand in the preparation of new materials. It can participate in a variety of mechanisms in chemical reactions and is an important intermediate in organic synthesis. It can produce a variety of compounds through different reaction paths. It has a wide range of uses in the fields of pharmaceutical chemistry and dye chemistry.

The preparation method of 5-amino-2-mercaptobenzothiazolic acid, although not detailed in ancient books as accurate as modern science, can be discussed as follows according to ancient pharmacology and technical deduction.
In the past, pharmaceuticals were mostly based on natural things and their essence. In the preparation of 5-amino-2-mercaptobenzothiazolic acid, or first look for natural materials containing nitrogen, sulfur and benzothiazole. For example, some minerals, or with nitrogen and sulfur properties, but their extraction is not easy, and they need to be refined by fire. First, the minerals are crushed and placed in a special pottery tripod, which is slowly burned over a gentle fire, so that the impurities in it gradually disappear and the essence is retained.
Or find it between plants and trees. Some grasses contain sulfur, and some wood contain nitrogen. After picking, soak them in water to dissolve the ingredients into the water. Then filter out the dross with a cloth to obtain a clear liquid. Then put the clear liquid in an open vessel, expose it to sunlight, and wait for the water to gradually steam, and the ingredients will gradually become thicker.
Then, the nitrogen-containing and sulfur-containing ingredients need to be combined in one place. According to ancient chemical techniques, either the method of neutralization or the technique of mutual assistance. The two are fused with each other to form a reaction similar to 5-amino-2-mercaptobenzothiazolic acid.
When reacting, it is necessary to observe the heat and the time. If the heat is too strong, the ingredients will be easily destroyed; if the time is not appropriate, the reaction will not be complete. Therefore, it needs to be guarded by a special person and adjusted in a timely manner according to experience.
After making, there is also a method of refining. Re-dissolve it with water, re-filter it with cloth to remove unreacted impurities. Then steam dry the water to obtain a purer product. Although this ancient method is very different from the scientific method of today, it is also the crystallization of the wisdom of the time and can provide some ideas for the investigation of future production methods.

When storing and transporting 5-hydroxy-2-mercaptobenzothiazolic acid, many precautions need to be taken with care.
When storing, the first environment is dry. If this substance encounters moisture, it is prone to deliquescence, which will damage its quality. Therefore, the storage place should be selected in a high dry place, and the container used must be well sealed to prevent moisture from invading. For example, in a sealed glass or plastic bottle, the bottle mouth is sealed with wax or rubber stopper to prevent moisture.
Temperature is also critical. Avoid high temperatures to prevent its properties from changing due to heat. It should be stored in a cool place, and the temperature should not exceed 25 degrees Celsius. If it is in high temperature in summer, it may need to be placed in a warehouse with air conditioning and temperature control to ensure that it is at a suitable temperature.
Light cannot be ignored either. This substance is sensitive to light, exposed to light for a long time, or causes chemical reactions, resulting in deterioration. Therefore, the storage place should be shaded from light, and it is better to store it in a dark container or in a dark place.
When transporting, the packaging must be sturdy and reliable. Because it has certain chemical activity, if the packaging is damaged or leaked, it will endanger the safety of transportation. The packaging material should be corrosion-resistant, such as a special chemical packaging drum lined with a corrosion-resistant plastic bag to prevent reaction with the barrel wall.
Handle with care during handling. Avoid violent vibrations and collisions to prevent damage to the packaging. And the transportation vehicle should run smoothly, do not brake or turn sharply to ensure the stability of the material.
At the same time, the transportation personnel should be aware of the characteristics of this substance and emergency treatment methods. In case of emergencies such as leakage, effective measures can be taken in time, such as covering the adsorption with inert materials such as sand to prevent its spread from causing greater harm.