5-O-Methanesulfonate-2,3-O-Isopropylidene-2-C-Methyl-D-Ribonic-Gamma-Lactone

5-O-mesylate-2,3-O-isopropylidenyl-2-C-methyl-D-ribonucleic acid - γ - is a key intermediate in organic synthetic chemistry. It has a wide range of uses and is often the cornerstone of the creation of new drugs in the field of medicinal chemistry. Taking the development of antiviral drugs as an example, many nucleoside analogs with unique structures rely on this intermediate for their synthesis pathways. Because of its specific stereochemical structure and functional groups, it can lay a good foundation for subsequent reactions, so that the synthesized nucleoside analogs precisely fit the target required for virus replication, so as to achieve the effect of inhibiting virus replication.
In the field of total synthesis of natural products, this lactone also plays a crucial role. The structure of natural products is complex and diverse, and the synthesis is quite difficult. The special structure of 5-O-mesylate-2,3-O-isopropylidenyl-2-C-methyl-D-ribonucleic acid - γ - lactone can gradually build the core skeleton of natural products through ingenious organic reactions. Through precise control of its functional groups, it can achieve efficient total synthesis of complex natural products, facilitate the research and development of active ingredients of natural products, and provide a rich source for new drug discovery.
Furthermore, in the field of materials science, this compound can be used to prepare functional materials after being modified by specific chemical reactions. Because of its unique molecular structure and properties, it may endow materials with special optical and electrical properties, thus expanding its application potential in optoelectronic devices, sensors and other fields.

The synthesis of 5-O-methylsulfonate-2,3-O-isopropylidenyl-2-C-methyl-D-ribonolactone - γ - is a delicate and complex chemical process. This synthesis method often requires a multi-step reaction. According to Tiangong Kaiji, chemical synthesis is also a delicate technique, requiring careful step by step.
The choice of starting materials is critical, and sugars with suitable substituents are often used as the starting point. First, the specific hydroxyl groups of carbohydrates are protected. For the formation of 2,3-O-isopropylene groups, acetone and carbohydrates are often reacted with acid catalysis to form isopropylene groups by condensation of 2,3 hydroxyl groups. This step is like craftsmen carefully carving utensils to lay the foundation for subsequent reactions.
Subsequently, methanesulfonate groups are introduced for the 5-position hydroxyl groups. In general, carbohydrates can be reacted with methanesulfonic anhydride in the presence of a suitable base. The sulfonic acid group in methanesulfonic anhydride replaces the hydrogen of the 5-position hydroxyl group to form a 5-O-methanesulfonate structure. This process requires attention to the precise control of reaction conditions, such as temperature, amount of base, etc. A slight deviation may affect the yield and purity.
The introduction of 2-C-methyl is often assisted by suitable methylating reagents, such as methyl halide or methyl lithium reagents. Under specific reaction conditions, methyl replaces the hydrogen atom on the 2-position carbon. This step needs to consider the activity and selectivity of the reagent to avoid unnecessary side reactions.
Finally, the γ-lactone structure is formed by suitable oxidation and lactation steps. The oxidation process can be selected with suitable oxidants, such as Dess-Martin reagents, etc., to oxidize sugar acids, and then under acidic or basic conditions, the intramolecular hydroxyl groups and carboxyl groups undergo endoesterification reactions to form the target 5-O-mesylate-2,3-O-isopropylene-2-C-methyl-D-ribonic acid - γ - lactone.
The entire synthesis process requires chemists, such as the skilled craftsmen in "Tiangong Kaiwu", to carefully control each step of the reaction in order to successfully prepare this complex compound.

5 - O - methanesulfonate - 2,3 - O - isopropylenyl - 2 - C - methyl - D - ribonucleic acid - γ - lactone, which is a very important organic compound in fine chemicals, and is used in many fields such as pharmaceutical synthesis. Its purity standard is extremely critical, which is related to product quality and performance.
According to the chemical method contained in ancient books, the purity standard of this compound needs to reach a very high degree. When it is used in pharmaceutical synthesis, impurities may affect the efficacy of the drug or even cause adverse reactions. Therefore, its purity often needs to reach more than 98% to be qualified. Under the requirements of this purity standard, the production process requires multiple fine steps.
The first step is the synthesis reaction stage, which requires strict control of reaction conditions, such as temperature, pressure, and the proportion of reactants. If there is a slight difference in the pool, it is easy to produce side reactions, resulting in an increase in impurities. After the reaction, multiple purification steps such as extraction, distillation, and crystallization are required. Extraction is used to separate the target product and impurities, and distillation is further purified to remove impurities with different boiling points. The crystallization process is particularly critical, and the temperature and solvent need to be precisely controlled to make the target product precipitate with high-purity crystals.
And in each step, the purity needs to be detected by precise analytical means. Commonly used methods such as high-performance liquid chromatography (HPLC) can accurately determine its purity. Only through such a rigorous process can 5-O-methanesulfonate-2,3-O-isopropylene-2-C-methyl-D-ribonucleic acid - γ - meet the specified purity standards to meet the needs of high-end fields such as medicine.

5 - O - methylsulfonate - 2,3 - O - isopropylenyl - 2 - C - methyl - D - ribonucleic acid - γ - lactone is a fine chemical, and many key matters should be paid attention to when storing it.
Temperature and humidity of the first environment. This substance is quite sensitive to temperature and humidity, and high temperature or high humidity environment can easily cause its properties to change and quality to be damaged. It should be stored in a cool and dry place. The ideal temperature is about 2 - 8 ° C, and the humidity is maintained at 40% - 60%. In this way, its chemical structure can be kept stable and deterioration can be delayed.
Times and the influence of light. The substance should be stored away from light. Due to light or luminescent chemical reactions, it will decompose or change its structure. Therefore, the storage container should be made of dark, light-shielding materials, such as brown glass bottles, or stored in a dark place.
Furthermore, to prevent mixing with other substances. This compound has specific chemical properties and comes into contact with or reacts with certain substances. When storing, it should be separated from oxidizing agents, reducing agents, acids, bases, etc., to avoid being placed in the same storage area.
At the same time, the storage area needs to be well ventilated. If the storage space is poorly ventilated, volatile gases will accumulate, or increase the risk of explosion and poisoning, and affect the stability of the substance itself.
In addition, proper labeling is also indispensable. The container should be clearly marked with the name of the substance, specifications, storage conditions, production date, valid period and other information for easy management and traceability to prevent misuse.
In short, 5-O-methanesulfonate-2,3-O-isopropylidenyl-2-C-methyl-D-ribonucleic acid - γ - lactone storage needs to be carefully controlled in terms of temperature and humidity, light, isolation, ventilation and identification to ensure its quality and stability.

I am inquiring about the market price range of "5 - O - Methanesulfonate - 2,3 - O - Isopropylidene - 2 - C - Methyl - D - Ribonic - Gamma - Lactone". However, this product is a specific compound in the field of fine chemicals or biomedicine, and its price often varies according to quality, purity, supply and demand, purchase volume and sales channels.
If the purity is normal, the price per gram may be in the hundreds of yuan in the case of small purchases. If the purchase quantity is quite large and the purity requirements are not very high, the unit price may be reduced to about 100 yuan per gram. If the purity requirements are strict, reaching a high purity level, suitable for high-end scientific research or specific pharmaceutical production, the price per gram may exceed 1,000 yuan.
Furthermore, market supply and demand also affect its price. If the demand for this product is strong and the supply is limited, the price will rise; if the supply is sufficient and the demand is normal, the price may stabilize or drop. Sales channels are also key, purchased directly from the manufacturer, or because there is no intermediate link and the price is excellent; after the dealer changes hands, the price may be slightly higher.
However, the exact price range still needs to be consulted in detail with relevant chemical raw material suppliers, reagent sellers, or professional chemical product trading platforms to obtain accurate numbers.